Imatinib and regression of type 2 diabetes [7]

New England Journal of Medicine

Volumn 352, Issue 10, 2005, Pages 1049-1050

  Veneri, Dino ^a   Franchini, Massimo ^b   Bonora, Enzo ^a  

^a UNIVERSITY OF VERONA   (Italy)

^b Verona Hospital   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

IMATINIB; INSULIN; ORAL ANTIDIABETIC AGENT; ANTINEOPLASTIC AGENT; BCR ABL TYROSINE KINASE; BCR-ABL TYROSINE KINASE; PIPERAZINE DERIVATIVE; PROTEIN KINASE INHIBITOR; PROTEIN TYROSINE KINASE; PYRIMIDINE DERIVATIVE;

AGED; CASE REPORT; CHRONIC MYELOID LEUKEMIA; CLINICAL FEATURE; DIABETES CONTROL; DIET THERAPY; DISEASE COURSE; DRUG DOSE REDUCTION; DRUG MECHANISM; DRUG WITHDRAWAL; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; HUMAN; INHIBITION KINETICS; LETTER; LONG TERM CARE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; TREATMENT OUTCOME; DRUG ANTAGONISM;

AGED; ANTINEOPLASTIC AGENTS; DIABETES MELLITUS, TYPE 2; FEMALE; HUMANS; LEUKEMIA, MYELOID, CHRONIC; PIPERAZINES; PROTEIN KINASE INHIBITORS; PROTEIN-TYROSINE KINASES; PYRIMIDINES;

EID: 14744281398     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJM200503103521023     Document Type: Letter

References (5)

1. Druker BJ, Talpaz M, Resta DJ, et al. Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N Engl J Med 2001;344:1031-7.
2. Bohmer FD, Karagyozov L, Uecker A, et al. A single amino acid exchange inverts susceptibility of related receptor tyrosine kinases for the ATP site inhibitor STI-571. J Biol Chem 2003;278:5148-55.
3. Sanz-Gonzalez SM, Castro C, Perez P, Andres V. Role of E2F and ERK1/2 in STI571-mediated smooth muscle cell growth arrest and cyclin A transcriptional repression. Biochem Biophys Res Commun 2004;317:972-9.
4. Evans JL, Goldfine ID, Maddux BA, Grodsky GM. Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes. Endocr Rev 2002;23:599-622.
5. Lassila M, Allen TJ, Cao Z, et al. Imatinib attenuates diabetes-associated atherosclerosis. Arteriosder Thromb Vase Biol 2004;24: 935-42.