Is older age associated with a worse prognosis due to different patterns of care? A long-term study of 1346 patients with glioblastomas or brain metastases

Cancer

Volumn 103, Issue 6, 2005, Pages 1234-1244

  Lutterbach, Johannes ^a,d   Bartelt, Susanne ^a   Momm, Felix ^b   Becker, Gerhild ^c   Frommhold, Hermann ^a   Ostertag, Christoph ^c  

^a Department of Radiotherapy   (Germany)

^b Interdisc Palliative Care Res Grp   (Germany)

^c UNIVERSITY OF FREIBURG   (Germany)

^d Abteilung Strahlenheilkunde   (Germany)

Author keywords

Age; Brain metastases; Glioblastoma; Prognosis; Radiotherapy

Indexed keywords

COBALT;

ADULT; AGED; ARTICLE; BRAIN METASTASIS; CANCER SURVIVAL; CHI SQUARE DISTRIBUTION; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; FEMALE; GLIOBLASTOMA; HEALTH CARE ACCESS; HUMAN; LINEAR ACCELERATOR; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROGNOSIS; RADIATION DOSE FRACTIONATION; SIMULATION; STATISTICAL SIGNIFICANCE; TREATMENT OUTCOME; TREATMENT PLANNING;

ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; BRAIN NEOPLASMS; COHORT STUDIES; COMBINED MODALITY THERAPY; DISEASE-FREE SURVIVAL; FEMALE; GLIOBLASTOMA; HUMANS; IMMUNOHISTOCHEMISTRY; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; NEOPLASM STAGING; NEUROSURGICAL PROCEDURES; PROGNOSIS; RADIOTHERAPY, ADJUVANT; RETROSPECTIVE STUDIES; RISK ASSESSMENT; SURVIVAL ANALYSIS;

EID: 14744272781     PISSN: 0008543X     EISSN: None     Source Type: Journal    
DOI: 10.1002/cncr.20895     Document Type: Article

References (29)

1. Laws ER, Parney IF, Huang W, et al. Survival following surgery and prognostic factors for recently diagnosed malignant glioma: data from the Glioma Outcomes Project. J Neurosurg. 2003;99:467-473.
2. Curran WJ Jr., Scott CB, Horton J, et al. Recursive partitioning analysis of prognostic factors in three Radiation Therapy Oncology Group malignant glioma trials. J Natl Cancer Inst. 1993;85:704-710.
3. Gaspar L, Scott C, Rotman M, et al. Recursive partitioning analysis (RPA) of prognostic factors in three Radiation Therapy Oncology Group (RTOG) brain metastases trials. Int J Radiat Oncol Biol Phys. 1997;37:745-751.
4. Maly RC, Leake B, Silliman RA. Health care disparities in older patients with breast carcinoma: informational support from physicians. Cancer. 2003;97:1517-1527.
5. Gagnon B, Mayo NE, Hanley J, MacDonald N. Pattern of care at the end of life: does age make a difference in what happens to women with breast cancer? J Clin Oncol. 2004; 22:3458-3465.
6. Hutchins LF, Unger JM, Crowley JJ, Coltman CA Jr., Albain KS. Underrepresentation of patients 65 years of age or older in cancer-treatment trials. N Engl J Med. 1999;341:2061-2067.
7. United Nations. World population ageing 1950-2050. New York: United Nations Population Division, 2002.
8. Anderson GF, Hussey PS. Health and population aging: a multinational comparison. New York: Commonwealth Fund, 1999.
9. Brandes AA, Monfardini S. The treatment of elderly patients with high-grade gliomas. Semin Oncol. 2003:30(Suppl 19): 58-62.
10. Lutterbach J, Weigel P, Guttenberger R, Hinkelbein W. Accelerated hyperfractionated radiotherapy in 149 patients with glioblastomas multiforme. Radiother Oncol. 1999;53:49-52.
11. Lutterbach J, Sauerbrei W, Guttenberger R. Multivariate analysis of prognostic factors in patients with glioblastomas. Strahlenther Onkol. 2003;179:8-15.
12. Lutterbach J, Bartelt S, Stancu E, Guttenberger R. Patients with brain metastases: hope for recursive partitioning analysis (RPA) class 3. Radiother Oncol. 2002;63:339-345.
13. Krzyzanowska MK, Weeks JC, Earle CC. Treatment of locally advanced pancreatic cancer in the real world: population-based practices and effectiveness. J Clin Oncol. 2003;21:3409-3414.
14. Surawicz TS, Davis F, Freels S, Laws ER Jr., Menck HR. Brain tumor survival: results from the National Cancer Data Base. J Neurooncol. 1998;40:151-160.
15. Stenning SP. Prognostic factors for high-grade malignant glioma: development of a prognostic index. A Report of the Medical Research Council Brain Tumour Working Party. J Neurooncol. 1990;9:47-55.
16. Ohgaki H, Dessen P, Jourde B, et al. Genetic pathways to glioblastoma: a population-based study. Cancer Res. 2004; 64:6892-6899.
17. Lacroix M, Abi-Said D, Fourney DR, et al. A multivariate analysis of 416 patients with glioblastomas multiforme: prognosis, extent of resection, and survival. J Neurosurg. 2001;95:190-198.
18. Lagerwaard FJ, Levendag PC, Nowak PJ, Eijkenboom WM, Hanssens PE, Schmitz PI. Identification of prognostic factors in patients with brain metastases: a review of 1292 patients. Int J Radiat Oncol Biol Phys. 1999;43:795-803.
19. Steinfeld AD, Donahue B, Walker I. Delay in the diagnosis of glioblastoma multiforme: is age a factor? Cancer Invest. 1996;14:317-319.
20. Lowry JK, Snyder JJ, Lowry PW. Brain tumors in the elderly: recent trends in a Minnesota cohort study. Arch Neurol. 1998;55:922-928.
21. Cowan JA Jr., Dimick JB, Leveque JC, Thompson BG, Upchurch GR Jr., Hoff JT. The impact of provider volume on mortality after intracranial tumor resection. Neurosurgery. 2003;52:48-53.
22. Long DM, Gordon T, Bowman H, et al. Outcome and cost of craniotomy performed to treat tumors in regional academic referral centers. Neurosurgery. 2003;52:1056-1063.
23. Paszat L, Laperriere N, Groome P, Schulze K, Mackillop W, Holowaty E. A population-based study of glioblastoma multiforme. Int J Radiat Oncol Biol Phys. 2001;51:100-1007.
24. Mahaley MS Jr., Mettlin C, Natarajan N, Laws ER Jr., Peace BB. National survey of patterns of care for brain-tumor patients. J Neurosurg. 1989;71:826-836.
25. McKeever PE, Junck L, Strawderman MS, et al. Proliferation index is related to patient age in glioblastoma. Neurology. 2001;56:1216-1218.
26. Barker FG 2nd, Simmons ML, Chang SM, et al. EGFR overexpression and radiation response in glioblastoma multiforme. Int J Radiat Oncol Biol Phys. 2001;51:410-418.
27. Shono T, Tofilon PJ, Bruner JM, Owolabi O, Lang FF. Cyclooxygenase-2 expression in human gliomas: prognostic significance and molecular correlations. Clin Cancer Res. 2001; 4375-4381.
28. Petersen C, Petersen S, Milas L, Lang FF, Tofilon PJ. Enhancement of intrinsic tumor cell radiosensitivity induced by a selective cyclooxygenase-2 inhibitor. Cancer Res. 2000;6:2513-2520.
29. Vuorinen V, Hinkka S, Farkkila M, Jaaskelainen J. Debulking or biopsy of malignant glioma in elderly people - a randomised study. Acta Neurochir (Wien). 2003;145:5-10.