Assessment of the long-term safety of topical retinoids

Cutis

Volumn 75, Issue 2 SUPPL., 2005, Pages 25-31

  Bhawan, Jag ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN; ELASTIN; MELANIN; MUCIN; RETINOIC ACID; RETINOID;

CELL COUNT; CELL DEGENERATION; CLINICAL TRIAL; COLLAGEN SYNTHESIS; COMPARATIVE STUDY; DRUG EFFICACY; DRUG SAFETY; DRUG USE; ELASTOSIS; ELECTRON MICROSCOPY; HISTOLOGY; HUMAN; INFLAMMATORY INFILTRATE; KERATINOCYTE; LANGERHANS CELL; MELANOCYTE; MICROSCOPY; MORPHOLOGY; PATHOPHYSIOLOGY; RADIATION INJURY; REVIEW; SIDE EFFECT; SKIN INFECTION; SKIN INJURY; SKINFOLD THICKNESS; STRATUM CORNEUM; VASCULARIZATION;

ADMINISTRATION, TOPICAL; BIOLOGICAL AVAILABILITY; BIOPSY, NEEDLE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; FEMALE; FOLLOW-UP STUDIES; HUMANS; IMMUNOHISTOCHEMISTRY; LONG-TERM CARE; MALE; RETINOIDS; RISK ASSESSMENT; SKIN ABSORPTION; SKIN AGING; ULTRAVIOLET RAYS;

EID: 14744268845     PISSN: 00114162     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (17)

1. Kurban RS, Bhawan J. Histologic changes in skin associated with aging. J Dermatol Surg Oncol. 1990;16:908-914.
2. Bhawan J, Andersen W, Lee J, et al. Photoaging versus intrinsic aging: a morphologic assessment of facial skin. J Cutan Pathol. 1995;22:154-159.
3. Bhawan J, Oh CH, Lew R, et al. Histopathologic differences in the photoaging process in facial versus arm skin. Am J Dermatopathol. 1992;14:224-230.
4. Toyoda M, Bhawan J. Ultrastructural evidence for the participation of Langerhans cells in cutaneous photoaging processes: a quantitative comparative study. J Dermatol Sci. 1997;14:87-100.
5. Toyoda M, Bhawan J. Electron-microscopic observations of cutaneous photoaging versus intrinsic aging. J Geriatr Dermatol. 1995;3:131-143.
6. Braverman IM. Elastic fiber and microvascular abnormalities in aging skin. Dermatol Clin. 1986;4:391-405.
7. Yamamoto O, Bhawan J, Hara M, et al. Keratinocyte degeneration in human facial skin: documentation of new ultrastructural markers for photodamage and their improvement during topical tretinoin therapy. Exp Dermatol. 1995;4:9-19.
8. Suwabe H, Serizawa A, Kajiwara H, et al. Degenerative process of elastic fibers in sun-protected and sun-exposed skin: immunoelectron microscopic observation of elastin, fibrillin-1, amyloid P component, lysozyme and alpha1-antitrypsin. Pathol Int. 1999;49:391-402.
9. Sellheyer K. Pathogenesis of solar elastosis: synthesis or degradation? J Cutan Pathol. 2003;30:123-127.
10. Montagna W, Carlisle K. Structural changes in aging human skin. J Invest Dermatol. 1979;73:47-53.
11. Bhawan J, Gonzalez-Serva A, Nehal K, et al. Effects of tretinoin on photodamaged skin. a histologic study. Arch Dermatol. 1991;127:666-672.
12. Griffiths CE, Russman AN, Majmudar G, et al. Restoration of collagen formation in photodamaged human skin by tretinoin (retinoic acid). N Engl J Med. 1993;329:530-535.
13. Bhawan J, Palko MJ, Lee J, et al. Reversible histologic effects of tretinoin on photodamaged skin. J Geriatr Dermatol. 1995;3:62-67.
14. Yamamoto O, Bhawan J, Solares G, et al. Ultrastructural effects of topical tretinoin on dermo-epidermal junction and papillary dermis in photodamaged skin. a controlled study. Exp Dermatol. 1995;4:146-154.
15. Woodley DT, Zelickson AS, Briggaman RA, et al. Treatment of photoaged skin with topical tretinoin increases epidermal-dermal anchoring fibrils. a preliminary report. JAMA. 1990;263:3057-3059.
16. Bhawan J, Olsen E, Lufrano L, et al. Histologic evaluation of the long term effects of tretinoin on photodamaged skin. J Dermatol Sci. 1996;11:177-182.
17. Bhawan J. Short- and long-term histologic effects of topical tretinoin on photodamaged skin. Int J Dermatol. 1998;37:286-292.