Understanding the fundamentals of perfluorocarbons and perfluorocarbon emulsions relevant to in vivo oxygen delivery

Artificial Cells, Blood Substitutes, and Immobilization Biotechnology

Volumn 33, Issue 1, 2005, Pages 47-63

  Riess, Jean G ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BUBBLES (IN FLUIDS); ELECTRONIC STRUCTURE; HYDROPHOBICITY; IMAGING TECHNIQUES; OXYGEN; SOLUBILITY; ULTRASONICS;

INERTNESS; OXYGEN DISSOLVING CAPACITY; PERFLUOROCARBONS (PFC); ULTRASOUND IMAGING;

FLUOROCARBONS;

CONTRAST MEDIUM; FLUORINE; FLUOROCARBON; FS 069; OXYGEN; PERFLEXANE; PERFLUOROOCTYL BROMIDE; PERFLUTREN; POLITEF; SONOVUE; WATER;

CARDIOPULMONARY BYPASS; CLINICAL TRIAL; DISSOLUTION; DRUG STABILITY; ECHOGRAPHY; EMULSION; ERYTHROCYTE TRANSFUSION; GENERAL SURGERY; HUMAN; HYDROPHOBICITY; IN VIVO STUDY; LIPOPHILICITY; OXYGEN CONSUMPTION; OXYGEN TRANSPORT; REVIEW; SOLUBILITY; VAPOR PRESSURE;

BLOOD SUBSTITUTES; EMULSIONS; FLUOROCARBONS; HUMANS; OXYGEN; OXYGEN CONSUMPTION;

ANIMALIA;

EID: 14644430987     PISSN: 10731199     EISSN: None     Source Type: Journal    
DOI: 10.1081/BIO-200046659     Document Type: Review

References (8)

1. Krafft, M.P., Riess, J.G., Weers, J.G. (1998). The design and engineering of oxygen-delivering fluorocarbon emulsions, in Submicronic Emulsions in Drug Targeting and Delivery, S. Benita, Ed., Harwood Academic Publ.: Amsterdam, pp. 235-333.
2. Riess, J.G., Krafft, M.P. (1999). Fluorocarbons and fluorosurfactants for in vivo oxygen transport (blood substitutes), imaging and drug delivery. Mat. Res. Soc. Bull. 24: 42-48.
3. Riess, J.G. (2001). Injectable oxygen carriers (blood substitutes)-Raison d'être, chemistry, and some physiology - Chem. Rev. 101: 2797-2920.
4. Riess, J.G. (2002). Fluorous micro- and nanophases with a biomedical perspective. Tetrahedron 58: 4113-4131.
5. Spahn, D.R., Waschke, K.F., Standl, T., Motsch, J., Van Huynegem, L., Welte, M., Gombotz, H., Coriat, P., Verkh, L., Faithfull, S., Keipert, P. (2002). Use of perflubron emulsion to decrease allogeneic blood transfusion in high-blood-loss non-cardiac surgery: Results of a European Phase 3 study. Anesthesiology 97: 1338-1349.
6. Schutt, E.S., Klein, D.H., Mattrey, R.M., Riess, J.G. (2003). Injectable microbubbles as contrast agents for diagnostic ultrasound imaging: The key role of perfluorochemicals. Angew. Chem. Int. Ed. 42: 3218-3235.
7. Riess, J.G. Biomedical applications of fluorous materials, in Handbook of Fluorous Chemistry, J.A. Gladysz, D.P. Curran, I. Horváth, Eds., Wiley-VCH, pp. 521-573.
8. Krafft, M.P., Chittofrati, A., Riess, J.G. (2003). Emulsions and microemulsions with a fluorocarbon phase. Curr. Opin. Colloid Interf. Sci. 8: 251-258.