High-hydrostatic pressure refolding of proteins

Genetic Engineering News

Volumn 25, Issue 4, 2005, Pages 46-47

  Hesterberg, Lyndal K ^a   Seefeldt, Matthew B ^a   Carpenter, John F ^b   Randolph, Theodore W ^c  

^a BaroFold Inc   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c UCB 450   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RECOMBINANT PROTEIN; ULINASTATIN;

DRUG DECOMPOSITION; DRUG FORMULATION; DRUG PURIFICATION; DRUG SAFETY; DRUG STABILITY; FERMENTATION; HUMAN; HYDROSTATIC PRESSURE; NONHUMAN; PROCESS TECHNOLOGY; PROTEIN AGGREGATION; PROTEIN EXPRESSION; PROTEIN FOLDING; SHORT SURVEY;

EID: 14644425414     PISSN: 02706377     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Short Survey

References (4)

1. De Bernardez Clark, E. Protein refolding for industrial processes. Curr Opin Biotechnol 12:202-207 (2001).
2. St. John R.J. et al. High pressure fosters protein refolding from aggregates at high concentrations. Proc Natl Acad Sci USA 96(23)13029-13033 (1999).
3. St. John R.J. et al. High pressure refolding of recombinant human growth hormone from insoluble aggregates. J Biol Chem 276(50):46856-46863 (2001).
4. Seefeldt, M.B. et al. High-pressure refolding of bikunin: Efficacy and thermodynamics. Protein Sci 13:2639-2650 (2004).