Can cisplatin and infused 5-fluorouracil be replaced by oxaliplatin and capecitabine in the treatment of advanced oesophagogastric cancer? The REAL 2 trial

Clinical Oncology

Volumn 17, Issue 2, 2005, Pages 79-80

  Chong, G ^a   Cunningham, David ^a  

^a ROYAL MARSDEN HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CAPECITABINE; CISPLATIN; EPIRUBICIN; FLUOROURACIL; FOLINIC ACID; OXALIPLATIN;

ADVANCED CANCER; ANTINEOPLASTIC ACTIVITY; CANCER COMBINATION CHEMOTHERAPY; CANCER INHIBITION; CANCER SURVIVAL; CLINICAL TRIAL; DIARRHEA; DRUG DOSE REGIMEN; DRUG EFFICACY; DRUG METABOLISM; DRUG RESPONSE; DYSESTHESIA; EDITORIAL; ERYTHEMA; ESOPHAGUS CANCER; FEBRILE NEUTROPENIA; HUMAN; MAXIMUM TOLERATED DOSE; NEPHROTOXICITY; NEUTROPENIA; OTOTOXICITY; PERIPHERAL NEUROPATHY; PRIORITY JOURNAL; STOMACH CANCER; STOMATITIS; VOMITING;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CISPLATIN; DEOXYCYTIDINE; ESOPHAGEAL NEOPLASMS; ESOPHAGOGASTRIC JUNCTION; FLUOROURACIL; HUMANS; ORGANOPLATINUM COMPOUNDS; RANDOMIZED CONTROLLED TRIALS; STOMACH NEOPLASMS;

EID: 14644415510     PISSN: 09366555     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clon.2004.12.004     Document Type: Editorial

References (14)

1. J.S. Waters A. Norman D. Cunningham et al., Long-term survival after epirubicin, cisplatin and fluorouracil for gastric cancer: Results of a randomized trial Br J Cancer 80 1999 269-272
2. P. Ross M. Nicolson D. Cunningham et al., Prospective randomized trial comparing mitomycin, cisplatin, and protracted venous-infusion fluorouracil (PVI 5-FU) with epirubicin, cisplatin, and PVI 5-FU in advanced esophagogastric cancer J Clin Oncol 20 2002 1996-2004
3. A. Webb D. Cunningham J.H. Scarffe et al., Randomized trial comparing epirubicin, cisplatin, and fluorouracil versus fluorouracil, doxorubicin, and methotrexate in advanced esophagogastric cancer J Clin Oncol 15 1997 261-267
4. P.J. O'Dwyer S.W. Johnson Current status of oxaliplatin in colorectal cancer Semin Oncol 30 3 Suppl 6 2003 78-87
5. S.E. Al Batran A. Atmaca S. Hegewisch-Becker et al., Phase II trial of biweekly infusional fluorouracil, folinic acid, and oxaliplatin in patients with advanced gastric cancer J Clin Oncol 22 2004 658-663
6. Y. Chao K.H. Yeh C.J. Chang et al., Phase II study of weekly oxaliplatin and 24-h infusion of high-dose 5-fluorouracil and folinic acid in the treatment of advanced gastric cancer Br J Cancer 91 2004 453-458
7. C. Louvet T. Andre J.M. Tigaud et al., Phase II study of oxaliplatin, fluorouracil, and folinic acid in locally advanced or metastatic gastric cancer patients J Clin Oncol 20 2002 4543-4548
8. T. Ishikawa M. Utoh N. Sawada et al., Tumor selective delivery of 5-fluorouracil by capecitabine, a new oral fluoropyrimidine carbamate, in human cancer xenografts Biochem Pharmacol 55 1998 1091-1097
9. J. Cassidy C. Twelves E. Van Cutsem et al., First-line oral capecitabine therapy in metastatic colorectal cancer: A favorable safety profile compared with intravenous 5-fluorouracil/leucovorin Ann Oncol 13 2002 566-575
10. Y.S. Hong S.Y. Song S.I. Lee et al., A phase II trial of capecitabine in previously untreated patients with advanced and/or metastatic gastric cancer Ann Oncol 15 2004 1344-1347
11. T.W. Kim Y.K. Kang J.H. Ahn et al., Phase II study of capecitabine plus cisplatin as first-line chemotherapy in advanced gastric cancer Ann Oncol 13 2002 1893-1898
12. T.R. Evans G. Pentheroudakis J. Paul A. McInnes R. Blackie N. Raby et al., A phase I and pharmacokinetic study of capecitabine in combination with epirubicin and cisplatin in patients with inoperable oesophago-gastric adenocarcinoma Ann Oncol 13 2002 1469-1478
13. N. Tebbutt A. Norman D. Cunningham T. Iveson M. Nicolson T. Hickish Randomised, multicentre phase III study comparing capecitabine with fluorouracil and oxaliplatin with cisplatin in patients with advanced oesophago-gastric cancer; interim analysis (abstract 523) Proc Am Soc Clin Oncol 2004 21
14. K.A. Sumpter C. Harper-Wynne D. Cunningham J. Oates N. Tebbutt T. Iveson Randomised, multicenter phase III study comparing capecitabine with fluorouracil and oxaliplatin with cisplatin in patients with advanced oesophagogastric cancer: Confirmation of dose escalation (abstract 1031) Proc Am Soc Clin Oncol 2004 22