Use of the antioxidant BHT in asymmetric membrane tablet coatings to stabilize the core to the acid catalyzed peroxide oxidation of a thioether drug

Pharmaceutical Development and Technology

Volumn 10, Issue 1, 2005, Pages 115-125

  Puz, Michael J ^a   Johnson, Barbara A ^a   Murphy, Brendan J ^a  

^a PFIZER INC   (United States)

Author keywords

Assymetric membrane; BHT; Polyethylene glycol 3350 (PEG3350); Sulfoxide degradation product

Indexed keywords

4 [3 [4 (2 METHYLIMIDAZOL 1 YL)PHENYLTHIO]]PHENYL 3,4,5,6 TETRAHYDRO 2H PYRAN 4 CARBOXAMIDE; ANTIOXIDANT; BUTYLCRESOL; DRUG ADDITIVE; EDETIC ACID; FERROUS SULFATE; MACROGOL 3350; PEROXIDE; SULFIDE; SULFOXIDE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CONTROLLED DRUG RELEASE; DRUG COATING; DRUG DEGRADATION; DRUG SOLUBILITY; DRUG STABILITY; OXIDATION; PRIORITY JOURNAL; TABLET FORMULATION;

ANTIOXIDANTS; BUTYLATED HYDROXYTOLUENE; PEROXIDES; SULFIDES; TABLETS, ENTERIC-COATED;

EID: 14644399287     PISSN: 10837450     EISSN: None     Source Type: Journal    
DOI: 10.1081/PDT-200049690     Document Type: Article

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