Ability of fourteen chemical agents used in dental practice to induce chromosome aberrations in Syrian hamster embryo cells

Journal of Pharmacological Sciences

Volumn 97, Issue 1, 2005, Pages 146-152

  Hikiba, Hirohito ^a   Watanabe, Eiko ^a   Barrett, J Carl ^b   Tsutsui, Takeki ^a  

^a NIPPON DENTAL UNIVERSITY   (Japan)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Chemical agents used in dentistry; Chromosome aberration; Syrian hamster embryo cell

Indexed keywords

ANTIINFECTIVE AGENT; CAMPHOR; CARBOL CAMPHOR; EUGENOL; FORMALDEHYDE; GLUTARALDEHYDE; GUAIACOL; HYDROGEN PEROXIDE; IODOFORM; META CRESOL; THYMOL; UNCLASSIFIED DRUG; ZINC OXIDE;

ANIMAL CELL; ARTICLE; CHROMOSOME ABERRATION; COLONY FORMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DENTISTRY; EMBRYO; EMBRYO CELL; GENOTOXICITY; METAPHASE; MOUTH MUCOSA; NONHUMAN; SYRIAN HAMSTER;

EID: 14644399256     PISSN: 13478613     EISSN: None     Source Type: Journal    
DOI: 10.1254/jphs.FPJ04044X     Document Type: Article

References (28)

1. Galloway SM, Aardema MJ, Ishidate M Jr, Ivett JL, Kirkland DJ, Morita T, et al. Report from working group on in vitro tests for chromosomal aberrations. Mutat Res. 1994;312:241-261.
2. Tsutsui T, Barrett JC. Detection of non-mutagenic carcinogens using cultured Syrian hamster embryo cells. AATEX (Alternatives to Animal Testing and Experimentation). 1991;1:65-73.
3. Tsutsui T, Hayashi N, Maizumi H, Huff J, Barrett JC. Benzene-, catechol-, hydroquinone- and phenol-induced cell transformation, gene mutations, chromosome aberrations, aneuploidy, sister chromatid exchanges and unscheduled DNA synthesis in Syrian hamster embryo cells. Mutat Res. 1997;373:113-123.
4. Tsutsui T, Suzuki N, Maizumi H, McLachlan JA, Barrett JC. Alteration in diethylstilbestrol-induced mutagenicity and cell transformation by exogenous metabolic activation. Carcinogenesis. 1986;7:1415-1418.
5. Fukuda S. Assessment of the carcinogenic hazard of 6 substances used in dental practices. (I) Morphological transformation, DNA damage and sister chromatid exchanges in cultured Syrian hamster embryo cells induced by carbol camphor, eugenol, thymol, EDTA, benzalkonium chloride and benzethonium chloride. Odontology. 1987;74:1365-1384. (text in Japanese with English abstract)
6. NCI (National Cancer Institute). Bioassay of phenol for possible carcinogenicity [CAS No. 108-95-2], TRNo. 203. Washington DC: US Department of Health and Human Services, National Institutes of Health; 1980.
7. Huff JE. Carcinogenesis results on seven amines, two phenols, and one diisocyanate used in plastics and synthetic elastomers. In: Jarvisalo J, Pfaffi P, Vainio H, editors. Industrial hazards of plastics and synthetic elastomers. New York: Alan R Liss; 1984. p. 347-363.
8. IARC (International Agency for Research on Cancer). Phenol. In: IARC monographs on the evaluation of carcinogenic risk to humans. Vol 47, Lyon: International Agency for Research on Cancer; 1989. p. 263-287.
9. Goel HC, Singh S, Singh SP. Radiomodifying influence of camphor on sister-chromatid exchange induction in mouse bone marrow. Mutat Res. 1989;224:157-160.
10. Yamaguchi F, Tsutsui T. Cell-transforming activity of fourteen chemical agents used in dental practice in Syrian hamster embryo cells. J Pharmacol Sci. 2003;93:497-500.
11. Hamaguchi F, Tsutsui T. Assessment of genotoxicity of dental antiseptics: ability of phenol, guaiacol, p-phenolsulfonic acid, sodium hypochlorite, p-chlorophenol, m-cresol or formaldehyde to induce unscheduled DNA synthesis in cultured Syrian hamster embryo cells. Jpn J Pharmacol. 2000;83:273-276.
12. Degen GH, Wong A, Eling TE, Barrett JC, McLachlan JA. Involvement of prostaglandin synthetase in the peroxidative metabolism of diethylstilbestrol in Syrian hamster embryo fibroblast cell culture. Cancer Res. 1983;43:992-996.
13. Haworth S, Lawlor T, Mortelmans K, Speck W, Zeiger E. Salmonella mutagenicity test results for 250 chemicals. Environ Mutagen. 1983;5 Suppl 1:1-142.
14. Ishidate M Jr editor. Chromosomal Aberration Test in Vitro. Tokyo: LIC Inc; 1987.
15. Swanson AB, Chambliss DD, Blomquist JC, Miller EC, Miller JA. The mutagenicities of safrole, estragole, eugenol, transanethole, and some of their known or possible metabolites for Salmonella Typhimurium mutants. Mutat Res. 1979;60:143-153.
16. 1 mice (Feed studies) (NTP/TR No. 223; NIH No. 84-1779). Washington DC: US Department of Health and Human Services, National Institutes of Health; 1983.
17. Phillips DH. Further evidence that eugenol does not bind to DNA in vivo. Mutat Res. 1990;245:23-26.
18. IARC (International Agency for Research on Cancer). Formaldehyde. In: IARC monographs on the evaluation of carcinogenic risk of chemicals to humans. Vol 29, Lyon: International Agency for Research on Cancer; 1982. p. 345-389.
19. Nakano H, Umebayashi C, Nakata M, Nishizaki Y, Noda K, Okano Y, et al. Formaldehyde-induced shrinkage of rat thymocytes. J Pharmacol Sci. 2003;91:83-86.
20. Bos RP, Hulshof CTJ, Theuws JLG, Henderson PTh. Mutagenicity of creosote in the Salmonella/microsome assay. Mutat Res. 1983;119:21-25.
21. IARC (International Agency for Research on Cancer). Hydrogen peroxide. In: IARC monographs on the evaluation of carcinogenic risk of chemicals to humans. Vol 36, Lyon: International Agency for Research on Cancer; 1985. p. 285-314.
22. Yamamoto T, Tsutsui T. Assessment of the genotoxicity of chemical substances used in dental practice - studies on the ability of chlorhexidine, glutaraldehyde, hydrogen peroxide, iodine, sodium arsenite, erythrosine B, fuchsin acid and fuchsin basic to induce unscheduled DNA synthesis in cultured Syrian hamster embryo cells. Odontology. 2000;87:587-596. (text in Japanese with English abstract)
23. Suzuki H. Assessment of the carcinogenic hazard of 6 substances used in dental practices. (II) Morphological transformation, DNA damage and sister chromatid exchanges in cultured Syrian hamster embryo cells induced by formocresol, iodoform, zinc oxide, chloroform, chloramphenicol and tetracycline hydrochloride. Odontology. 1987;74:1385-1403. (text in Japanese with English abstract)
24. Tai KW, Huang F-M, Huang M-S, Chang Y-C. Assessment of the genotoxicity of resin and zinc-oxide eugenol-based root canal sealers using an in vitro mammalian test system. J Biomed Mater Res. 2002;59:73-77.
25. Tsutsui T, Suzuki N, Ohmori M, Maizumi H. Cytotoxicity, chromosome aberrations and unscheduled DNA synthesis in cultured human diploid fibroblasts induced by sodium fluoride. Mutat Res. 1984;139:193-198.
26. Stammati A, Bonsi P, Zucco F, Moezelaar R, Alakomi HL, von Wright A. Toxicity of selected plant volatiles in microbial and mammalian short-term assays. Food Chem Toxicol. 1999;37:813-823.
27. Vergnes JS, Baliantyne B. Genetic toxicology studies with glutaraldehyde. J Appl Toxicol. 2002;22:45-60.
28. Isfort RJ, Kerckaert GA, Le Boeuf RA. Comparison of the standard and reduced pH Syrian hamster embryo (SHE) cell in vitro transformation assays in predicting the carcinogenic potential of chemicals. Mutat Res. 1996;356:11-63.