Grandisine A and B, novel indolizidine alkaloids with human δ-opioid receptor binding affinity from the leaves of the Australian rainforest tree Elaeocarpus grandis

Journal of Organic Chemistry

Volumn 70, Issue 5, 2005, Pages 1889-1892

  Carroll, Anthony R ^a   Arumugan, Garrie ^a   Quinn, Ronald J ^a   Redburn, Joanne ^a   Guymer, Gordon ^b   Grimshaw, Paul ^b  

^a GRIFFITH UNIVERSITY   (Australia)

^b QUEENSLAND HERBARIUM   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STRUCTURE (COMPOSITION);

ELAEOCARPUS GRANDIS; TETRACYCLIC SKELETON;

NITROGEN COMPOUNDS;

ALKALOID; DELTA OPIATE RECEPTOR; FUNCTIONAL GROUP; GRANDISINE A; GRANDISINE B; INDOLIZIDINE ALKALOID; INDOLIZINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG ISOLATION; DRUG RECEPTOR BINDING; DRUG STRUCTURE; HIGH THROUGHPUT SCREENING; MEDICINAL PLANT; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PLANT LEAF; RAIN FOREST; RECEPTOR AFFINITY; STEREOCHEMISTRY; STRUCTURE ANALYSIS; TREE;

ALKALOIDS; BINDING, COMPETITIVE; DRUG EVALUATION, PRECLINICAL; ELAEOCARPACEAE; HUMANS; INDOLIZINES; MODELS, MOLECULAR; MOLECULAR CONFORMATION; OLIGOPEPTIDES; PLANT LEAVES; RECEPTORS, OPIOID, DELTA; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 14544300945     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo048525n     Document Type: Article

References (6)

1. Williams, M.; Kowaluk, E. A.; Arneric, S. P. J. Med. Chem. 1999, 42, 1481-1500.
2. Collins, D. J.; Culvenor, C. C. J.; Lamberton, J. A.; Loder, J. W.; Price, J. R. Plants for Medicine; CSIRO Publications: Melbourne, 1990.
3. Johns, S. R.; Lamberton, J. A. In The Alkaloids; Manske, R. H. F., Ed.; Academic Press: New York, 1993; Vol. 14, pp 324-346.
4. Johns, S. R.; Lamberton, J. A.; Sioumis, A. A. Aust. J. Chem. 1969, 22, 793-800.
5. Robertson, G. B.; Tooptakong, U.; Lamberton, J. A.; Geewananda, Y. A.; Gunawardana, P.; Bick, I. R. C. Tetrahedron Lett. 1984, 2695-2696.
6. Thomas, J. B.; Herault, X. M.; Rothman, R. B.; Atkinson, R. N.; Burgess, J. P.; Mascarella, S. W.; Dersch, C. M.; Xu, H.; Flippen-Anderson, J. L.; George, C. F.; Carroll, F. I. J. Med. Chem. 2001, 44, 972-987.