Bacteriostatic saline containing benzyl alcohol decreases the pain associated with the injection of propofol

Anesthesia and Analgesia

Volumn 100, Issue 3, 2005, Pages 683-686

  Minogue, Sean C ^a,b   Sun, Deidre A ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b ADELAIDE AND MEATH HOSPITAL   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

BENZYL ALCOHOL; GLYCEROL; LIDOCAINE; PHENOL DERIVATIVE; PHOSPHOLIPID; PLACEBO; PROPOFOL; SODIUM CHLORIDE; SOYBEAN OIL;

ADULT; AGE DISTRIBUTION; ANALGESIA; ARTICLE; BACTERIOSTASIS; BODY MASS; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; DRUG FORMULATION; FEMALE; HUMAN; INJECTION PAIN; LOCAL ANESTHESIA; MAJOR CLINICAL STUDY; MALE; PREMEDICATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SEX RATIO; TREATMENT OUTCOME;

EID: 14544296588     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/01.ANE.0000148617.98716.EB     Document Type: Article

References (24)

1. Briggs L, White M. The effect of premedication on anaesthesia with propofol (Diprivan). Postgrad Med J 1985;61:35-7.
2. Mangar D, Holak EJ. Tourniquet at 50 mm Hg followed by intravenous lidocaine diminishes hand pain associated with propofol injection. Anesth Analg 1992;74:250-2.
3. Doenicke AW, Roizen MF, Rau J, et al. Reducing pain during propofol injection: the role of the solvent. Anesth Analg 1996; 82:472-4.
4. Scott RP, Saunders DA, Norman J. Propofol: clinical strategies for preventing the pain of injection. Anaesthesia 1988;43:492-4.
5. Klement W, Arndt JO. Pain on injection of propofol: effects of concentration and diluent. Br J Anaesth 1991;67:281-4.
6. Picard P, Tramèr M. Prevention of pain on injection with propofol: a quantitative systematic review. Anesth Analg 2000; 90:963-9.
7. King SY, Davis FM, Wells JE, et al. Lidocaine for the prevention of pain due to injection of propofol. Anesth Analg 1992;74: 246-9.
8. Parmar AK, Koay CK. Pain on injection of propofol: a comparison of cold propofol with propofol premixed with lignocaine. Anaesthesia 1998;53:79-83.
9. Lyons B, Lohan D, Flynn C, McCarroll M. Modification of pain on injection with propofol. Anaesthesia 1996;51:394-5.
10. Lee T, Loewenthal A, Strachan J. Pain during injection of propofol: the effect of prior administration of thiopentone. Anaesthesia 1994;49:817-8.
11. Macht DI. A pharmacological and therapeutic study of benzyl alcohol as a local anesthetic. J Pharmacol Exp Ther 1918;11: 263-79.
12. Wightman MA, Vaughan RW. Comparison of compounds used for intradermal anesthesia. Anesthesiology 1976;45:687-9.
13. Fein JA, Boardman CR, Stevenson S, et al. Saline with benzyl alcohol as intradermal anesthesia for intravenous line placement in children. Pediatr Emerg Care 1998;14:119-22.
14. Nuttall GA, Barnett MR, Smith RL, et al. Establishing intravenous access: a study of local anesthetic efficacy. Anesth Analg 1993;77:950-3.
15. Bartfield JM, May-Wheeling HE, Raccio-Robak N, et al. Benzyl alcohol with epinephrine as an alternative to lidocaine with epinephrine. J Emerg Med 2001;21:375-9.
16. Martin S, Wilson L. Benzyl alcohol with epinephrine as an alternative local anesthetic. Ann Emerg Med 1999;33:495.
17. Kimura ET, Darby TD, Krause RA, Brondyk HD. Parenteral toxicity studies with benzyl alcohol. Toxicol Appl Pharmacol 1971;18:60-8.
18. Novak E, Stubbs SS, Sanborn EC, Eustice RM. The tolerance and safety of intravenously administered benzyl alcohol in methylprednisolone sodium succinate formulations in normal human subjects. Toxicol Appl Pharmacol 1972;23:54-61.
19. Benzyl alcohol: toxic agent in neonatal units. Pediatrics 1983;72: 356-8.
20. Wilson J, Solimando D, Edwards M. Parenteral benzyl alcohol induced hypersensitivity reaction. Drug Intell Clin Pharm 1986; 20:689-91.
21. Shmunes E. Allergic dermatitis to benzyl alcohol in an injectable solution. Arch Dermatol 1984;120:1200-1.
22. Hetherington N, Dooley M. Potential for patient harm from intrathecal administration of preserved solutions. Med J Aust 2000;173:141-3.
23. Gehan G, Karoubi F, Quinet A, et al. Optimal dose of lidocaine for preventing pain on injection of propofol. Br J Anaesth 1991; 66:324-6.
24. Johnson RA, Harper NJN, Chadwick S. Pain on injection of propofol: methods of alleviation. Anaesthesia 1990;45:439-42.