High frequency of partial DIIIa and DAR alleles found in sickle cell disease patients suggests increased risk of alloimmunization to RhD

Transfusion Medicine

Volumn 15, Issue 1, 2005, Pages 49-55

  Castilho, L ^a   Rios, M ^b,c   Rodrigues, A ^a   Pellegrino Jr , J ^a   Saad, S T O ^a   Costa, F F ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

^b NEW YORK BLOOD CENTER   (United States)

^c CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

D variants; DAR; DIIIa; Rh blood group system; Sickle cell disease

Indexed keywords

GENOMIC DNA; RHESUS ANTIGEN; RHESUS D ANTIBODY;

ALLELE; ALLOIMMUNIZATION; ARTICLE; CONTROLLED STUDY; GENE MUTATION; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; PHENOTYPE; POLYMERASE CHAIN REACTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SEQUENCE ANALYSIS; SICKLE CELL ANEMIA;

ALLELES; ANEMIA, SICKLE CELL; BLOOD TRANSFUSION; DIABETES MELLITUS, TYPE 1; GENE FREQUENCY; HUMANS; IMMUNIZATION; RH-HR BLOOD-GROUP SYSTEM; RISK FACTORS;

EID: 14544290059     PISSN: 09587578     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-3148.2005.00548.x     Document Type: Article

References (26)

1. Avent, N.D. (2001) Molecular biology of the Rh blood group system. Journal of Pediatric Hematology/Oncology, 23, 394-402.
2. Avent, N.D. & Reid, M.E. (2000) The Rh blood group system: A review. Blood, 95, 375-387.
3. Cartron, J.-P. (1994) Defining the Rh blood group antigens: Biochemistry and molecular genetics. Blood, 8, 199-212.
4. Castilho, L., Rios, M., Bianco, C., J. Alberto F.L. Saad S.T.O. & Costa F.F. (2002) DNA-based typing of blood groups for the management of multiply-transfused sickle cell disease patients. Transfusion, 42, 232-238.
5. Chiu, R.W. Murphy, M.F. Fidler, C. Zee, B.C. Wainscoat, J.S. & Lo, Y.M. (2001) Determination of RhD zygosity: Comparison of a double amplification refractory mutation system approach and a multiplex real time quantitative PCR approach. Clinical Chemistry, 47, 667-672.
6. Daniels, G. (2002) Human Blood Groups (2nd edn). Blackwell, Oxford.
7. Denomme, G.A. Rios, M. & Reid, M. (2000) Molecular Protocols in Transfusion Medicine. Academic Press, London.
8. Flegel, W.A. & Wagner, F.F. (2002) Molecular biology of partial D and weak D: Implications for blood bank practice. Clinical Laboratory, 48, 53-59.
9. Greenwalt, T.J. & Zelinski, K.R. (1984) Transfusion support for haemoglobinopathies. Clinical Haematology, 13, 151-165.
10. Hemker, M.B. Ligthart, P.C. Berger, L. van Rhenen, D.J. van der School, C.E. & Maaskant-van Wijk, P.A. (1999) DAR, a new RhD variant involving exons 4, 5, and 7, often in linkage with ceAR, a new Rhce variant frequent found in African Blacks. Blood, 94, 4337-4342.
11. Huang, C.-H. (1997) Molecular insights into the Rh protein family and associated antigens. Current Opinion in Hematology, 4, 94-103.
12. IIIa erythrocytes: RhD protein is associated with multiple dispersed amino acid variations. American Journal of Hematology, 55, 139-145.
13. Jones, J. & Filbey, D. (1996) Selection of monoclonal antibodies for the identification of D variants: Ability to detect weak D and to split epD2, epD5 and epD6/7. Vox Sanguinis, 70, 173-179.
14. Matheson, K.A. & Denomme, G.A. (2002) Novel 3′ Rhesus box sequences confound RHD zygosity assignment. Transfusion, 42, 645-650.
15. Nagel, R.L. & Fleming, A.F. (1992). Genetic epidemiology of the beta s gene. Baillieres Clinical Haematology, 5, 331-365.
16. Perco, P. Shao, C.-P. Mayr, W. R. Panzer, S. & Legler, T.J. (2003) Testing for the D zygosity with three different methods revealed altered Rhesus boxes and a new weak D type. Transfusion, 43, 335-339.
17. Reid, M.E. & Lomas-Francis, C. (2003) The Blood Group Antigen Facts Book (2nd edn). Elsevier, London.
18. Reid, M.E. Storry, J.R. Sausais, L. Tossas, E. Rios M. Hue-Roye K. Gloster E.S. Miller S.T. Wolf C. & Lomas-Francis C. (2003) DAL, a new low-incidence antigen in the Rh blood group system. Transfusion, 43, 1394-1397.
19. Scott, M.L. Voak, D. Jones, J.W. Avent, N.D. Liu, W. Hughes-Jones, N. & Sonneborn, H. (1996) A structural model for 30 Rh D epitopes based on serological and DNA sequence data from partial D phenotypes. Transfusion Clinique et Biologique, 3, 391-396.
20. Tippett, P. Lomas-Francis, C. & Wallace, M. (1996) The Rh antigen D: Partial D antigens and associated low incidence antigens. Vox Sanguinis, 70, 123-131.
21. Wagner, F.F. Eicher, N.I. Jorgensen, J.R. Lonicer, C.B. & Flegel, W. (2002b) DNB: A partial D with anti-D frequent in Central Europe. Blood, 15, 2253-2256.
22. Wagner, F.F. & Flegel, W.A. (2000) RHD gene deletion occurred in the Rhesus box. Blood, 95, 3662-3668.
23. Wagner, F.F. & Flegel, W.A. (2004) The molecular basis of the Rh blood group phenotypes. Immunohematology, 20, 23-36. (Review)
24. Wagner, F.F. Ladewig, B. Angert, K.S. Heymann, G.A. Eicher, N.I. & Flegel, W. (2002a) The DAU allele cluster of the RHD gene. Blood, 1, 306-311.
25. Wagner, F.F. Moulds, J.M. Tounkara, A. Bourema, K. & Flegel, W. (2003) RHD allele distribution in Africans of Mali. BMC Genetics, 4, 1-7.
26. Winters, J.L. Pineda, A.A. Gorden, L.D. Bryant, S.C. Melton, L.J., Vamvakas, E.C. & Moore, S.B. (2001) RBC alloantibody specificity and antigen potency in Olmsted County, Minnesota. Transfusion, 41, 1413-1420.