Elevated lymphocyte expression of CLIP is associated with type 1 diabetes and may be a useful marker of autoimmune susceptibility

Annals of the New York Academy of Sciences

Volumn 1037, Issue , 2004, Pages 65-68

  Silva, Diego G ^a   Socha, Luis ^a   Correcha, Manuel ^a   Petrovsky, Nikolai ^a,b  

^a The Australian National University   (Australia)

^b FLINDERS MEDICAL CENTRE   (Australia)

Author keywords

Antigen processing; Autoimmunity; CLIP; Type 1 diabetes

Indexed keywords

FLUORESCEIN ISOTHIOCYANATE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PROTEIN CLIP; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANTIGEN BINDING; ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; AUTOIMMUNITY; CLINICAL ARTICLE; CONFERENCE PAPER; CONTROLLED STUDY; DISEASE PREDISPOSITION; FLOW CYTOMETRY; HAPLOTYPE; HUMAN; HUMAN CELL; HYPERGLYCEMIA; INSULIN DEPENDENT DIABETES MELLITUS; MONOCYTE; MOUSE STRAIN; NON INSULIN DEPENDENT DIABETES MELLITUS; T LYMPHOCYTE;

EID: 14544286489     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1337.009     Document Type: Conference Paper

References (6)

1. KHALIL, I., L. D'AURIOL, M. GOBET, et al. 1990. A combination of HLA-DQ beta Asp57-negative and HLA DQ alpha Arg52 confers susceptibility to insulin-dependent diabetes mellitus. J. Clin. Invest. 85: 1315-1319.
2. RIBERDY, J.M., J.R. NEWCOMB, M.J. SURMAN, et al. 1992. HLA-DR molecules from an antigen-processing mutant cell line are associated with invariant chain peptides. Nature 360: 474-477.
3. GAUTAM, A.M., C. PEARSON, V. QUINN, et al. 1995. Binding of an invariant-chain peptide, CLIP, to I-A major histocompatibility complex class II molecules. Proc. Natl. Acad. Sci. USA 92: 335-339.
4. GHOSH, P., M. AMAYA, E. MELLINS & D.C. WILEY. 1995. The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3. Nature 378: 457-462.
5. SANDERSON, F., M.J. KLEIJMEER, A. KELLY, et al. 1994. Accumulation of HLA-DM, a regulator of antigen presentation, in MHC class II compartments. Science 266: 1566-1569.
6. BHATNAGAR, A., P.J. MILBURN, M. LOBIGS, et al. 2001. Nonobese diabetic mice display elevated levels of class II-associated invariant chain peptide associated with I-Ag7 on the cell surface. J. Immunol. 166: 4490-4497.