In vitro and in vivo modulation of growth regulation in the human breast cancer cell line MCF-7 by estradiol metabolites

Breast Cancer

Volumn 6, Issue 2, 1999, Pages 87-92

  Suto, Akihiko ^a,b   Telang, Nitin T ^c   Tanino, Hirokazu ^a   Takeshita, Toshio ^b   Ohmiya, Harumi ^b   Osborne, Michael P ^c   Kubota, Tetsuro ^a  

^a KEIO UNIVERSITY   (Japan)

^b Yamato Municipal Hospital   (Japan)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Estradiol metabolites; Growth regulation; Human breast cancer

Indexed keywords

EID: 14544276752     PISSN: 13406868     EISSN: 18804233     Source Type: Journal    
DOI: 10.1007/BF02966913     Document Type: Article

References (27)

1. Siiteri PK, Simberg N, Murai J: Estrogen and breast cancer. Ann NY Acad Sci 464:100-105, 1992.
2. Mauvais-Jarvis P, Kuttenn F, Gompel A: Estradiol/progesterone interaction in normal and pathologic breast cells. Ann NY Acad Sci 464:152-167, 1986. (Pubitemid 17197629)
3. Banerjee MR: Responses of mammary cells to hormones. Int Rev Cytol 4:1-97, 1976.
4. Sekeris CE: Hormonal steroids act as tumor promotors by modulating oncogene expression. J Cancer Res Clin Oncol 117:96-101, 1991.
5. Suto A, Bradlow HL, Wong GY, et al: Persistent estrogen responsiveness of ras oncogene-transformed mouse mammary epithelial cells. Steroids 57:262-268, 1992.
6. Telang NT, Suto A, Wong GY, et al: Induction by estrogen metabolite 16α-hydroxyestrone of genotoxic damage and aberrant proliferation in mouse mammary epithelial cells. J Natl Cancer Inst 84:634-638, 1992.
7. Bradlow HL, Hershcopf RJ, Martucci CP, et al: Estradiol 16α-hydroxylation in the mouse correlates with mammary tumor incidence, and presence of murine mammary tumor virus; A possible model for hormonal etiology of breast cancer in humans. Proc Natl Acad Sci USA 82:6295-6299, 1985. (Pubitemid 16222871)
8. Bradlow HL, Hershcopf RJ, Martucci CP, et al: 16 a - hydroxylation on estradiol; A possible risk marker for breast cancer. Ann NY Acad Sci 464:138-151, 1989.
9. Schneider J, Kinne D, Fraccia A, et al: Abnormal oxidative metabolism of estradiol in women with breast cancer. Proc Natl Acad Sci USA 79:3047-3051, 1982. (Pubitemid 12058614)
10. Kubota T, Fukutomi F, Koh J, et al: Human breast carcinoma (MCF-7) serially transplanted into nude mice. Jpn J Surg 13:381-384, 1983. (Pubitemid 14244717)
11. Geran RI, Greenberg NH, Schumacher AM, et al: Protocols for screening chemical agents and natural products against animal tumors and other biological system. Cancer Chemother Rep 3:51-61, 1972.
12. Telang NT, Bradlow HL, Kurihara H, et al: In vitro biotransformation of estradiol by explant cultures of murine mammary tissue. Breast Cancer Res Treat 13:173-181, 1989. (Pubitemid 19120109)
13. Telang NT, Kurihara H, Wong GY, et al: Preneoplastic transformation in mouse mammary tissue; Identification and validation of intermediate biomarkers for chemoprevention. Anticancer Res 11:1021-1028, 1991.
14. Osborne MP, Bradlow HL, Wong GYC, et al: Upregulation of estradiol C16α-hydroxylation in human breast tissue; A potential biomarker of breast cancer risk. J Natl Cancer Inst 85:1917-1920, 1993.
15. Telang NT, Bradlow HL, Osborne MP: Molecular and endocrine biomarkers in non-involved breast; Relevance to cancer chemoprevention. J Cell Biochem 16 G: 161-169, 1992.
16. Suto A, Bradlow HL, Wong GYC, et al: Experimental down-regulation of intermediate biomarkers of carcinogenesis in mouse mammary epithelial cells. Breast Cancer Res Treat 27:193-202, 1993. (Pubitemid 23355306)
17. Zhu BT, Conney AH: Is 2-methoxyestradiol an endogenous estrogen metabolite that inhibits mammary carcinogenesis? Cancer Res 58:2269-2277, 1998. (Pubitemid 28252677)
18. Imoto S: Biological effects of estrogen metabolites in human breast cancer. Jpn J Surg 93:505-517, 1992 (in Japanese).
19. Dubic D, Shiu RPC: Mechanism of estrogen activation of c-myc oncogene expression. Oncogene 7:1587-1594, 1992.
20. Gaub MP, Bellard M, Scheuer J, et al: Activation of the ovalbumin gene by estrogen receptor involves the fos-jun complex. Cell 63:1267-1276, 1990. (Pubitemid 120035075)
21. Weisz A, Bresciani F: Estrogen regulation of protooncogenes coding for nuclear proteins. Crit Rev Oncogenesis 4:361-388, 1993.
22. Imoto S, Ueda M, Enomoto K, et al Upregulation of TGF-P by catechol estrogen in breast cancer cell lines. Breast Cancer Res Treat 32:79, 1994. Abstract.
23. Telang NT, Osborne MP, Sweterlitsch L, et al: Neoplastic transformation of mouse mammary epithelial cells by deregulated myc expression. Cell Regulation 1:863-872, 1990.
24. Koh J, Kubota T, Sasano H, et al: Stimulation of human tumor xenograft growth by local estrogen biosynthesis in stromal cells. Anticancer Res 18:2375-2380, 1998. (Pubitemid 28386523)
25. Schneider J, Huh MM, Bradlow HL, et al: Antiestrogen action of 2-hydroxyestrone on MCF-7 human breast cancer cells. J Biol Chem 259:4840-4845, 1984. (Pubitemid 14144204)
26. Swaneck GE, Fishman J: Covelent binding of the endogenous estrogen 16a-hydroxyestrone to estradiol receptor in human breast cancer cells; Characterization and intranuclear localization. Proc Natl Acad Sci USA 85:7831-7835, 1988.
27. Clark JH, Pasko Z, Peck EJ: Nuclear binding and estrogen receptor complex; Relation to agonistic and antagonistic properties of estradiol. Endocrinology 100:91-96, 1977. (Pubitemid 8013081)