A modified equilibrium dialysis technique for measuring plasma protein binding: Experimental evaluation with diazepam and nortriptyline

Pharmaceutical Research

Volumn 15, Issue 10, 1998, Pages 1643-1646

  Chow, Hsiao Hui ^a   Khor, Soo Peang ^a,b   Lee, Hui Chih ^a   Mayersohn, Michael ^a  

^a UNIVERSITY OF ARIZONA   (United States)

^b PFIZER INC   (United States)

Author keywords

Diazepam; Modified equilibrium dialysis; Nortriptyline; Protein binding of drugs

Indexed keywords

BUFFER; DIAZEPAM; NORTRIPTYLINE;

ARTICLE; DRUG DETERMINATION; DRUG PROTEIN BINDING; EQUILIBRIUM DIALYSIS; PRIORITY JOURNAL;

BLOOD PROTEINS; DIALYSIS; DIAZEPAM; HUMANS; NORTRIPTYLINE; PROTEIN BINDING;

EID: 14444285063     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1011979822478     Document Type: Article

References (4)

1. S. P. Khor, H. J. Wu, and H. Boxenbaum. Fluid shift and protein leakage corrections in protein binding equilibrium dialysis experiments. Int. J. Pharm. 30:189-197 (1986).
2. F. D. Boudinot and W. J. Jusko. Fluid shifts and other factors affecting plasma protein binding of predisolone by equilibrium dialysis. J. Pharm. Sci. 73:774-780 (1984).
3. S. Øie and T. W. Guentert. Comparison of equilibrium times in dialysis experiments using spiked plasma or spiked buffer. J. Pharm. Sci. 71:127-128 (1982).
4. P J. McNamara and J. B. Bogardus. Effect of initial conditions and drug-protein binding on the time to equilibrium in dialysis systems. J. Pharm. Sci. 71:1066-1068 (1982).