Alloantibody from a patient with severe von Willebrand disease inhibits von Willebrand factor-FVIII interaction

Annals of Hematology

Volumn 75, Issue 3, 1997, Pages 111-115

  Batlle, J ^a   Loures E ^a   Vila, P ^b   Hernandez M C ^b   Mendez J A ^b   Torea, J ^a   Rendal, E ^a   Couselo, M J ^a   Filgueira, A ^a   Lopez Fernandez M F ^a  

^a HOSPITAL JUAN CANALEJO   (Spain)

^b Allergology Section   (Spain)

Author keywords

Alloantibody; FVIII; FVIII binding; Inhibitor; vWF

Indexed keywords

ALLOANTIBODY; BLOOD CLOTTING FACTOR 8; BLOOD CLOTTING FACTOR 8 INHIBITOR; IMMUNOGLOBULIN G; MONOCLONAL ANTIBODY; POLYCLONAL ANTIBODY; VON WILLEBRAND FACTOR;

ARTICLE; BINDING COMPETITION; CASE REPORT; COMPARATIVE STUDY; CONTROLLED STUDY; DOSE RESPONSE; ENZYME LINKED IMMUNOSORBENT ASSAY; HEMOPHILIA A; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN IMMOBILIZATION; PROTEIN PROTEIN INTERACTION; RABBIT; STEREOSPECIFICITY; VON WILLEBRAND DISEASE;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGEN-ANTIBODY REACTIONS; FACTOR VIII; HOMOZYGOTE; HUMANS; ISOANTIBODIES; PROTEIN BINDING; RABBITS; VON WILLEBRAND DISEASE; VON WILLEBRAND FACTOR;

EID: 14444274587     PISSN: 09395555     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002770050323     Document Type: Article

References (25)

1. Algiman M, Dietrich G, Nydegger UE, Boieldieu D, Sultan Y, Kazatchkine (1992) Natural antibodies to factor VIII (antihemophilic factor) in healthy individuals. Proc Natl Acad Sci USA 89:3795-3799
2. Bahou WF, Ginsburg D, Sikkink R, Litwiller R, Pass DN (1991) A monoclonal antibody to von Willebrand factor (vWF) inhibits factor VIII binding. Localization of its antigenic determinant to a nonadecapeptide at the amino terminus of the mature vWF polypeptide. J Clin Invest 84:56-61
3. Batlle J, López Fernández MF (1989). Laboratory assays for von Willebrand factor. In: Zimmerman TS, Ruggeri ZM (eds) Coagulation and bleeding disorders. The role of factor VIII and von Willebrand factor. Marcel Dekker, New York, pp 325-342
4. Batlle J, Gómez E, Castiñeira P, Lourés E, Couselo M, Vila P, Sedano C, Tusell X, Magallón M, Quintana M, González-Boullosa R, López Fernández MF (1996) Antibodies to factor VIII in plasma of patients with hemophilia A and normal subjects. Ann Hematol 72:321-326
5. Budde U, Effenberg W, Oldenburg J, Schneppenheim R, van Genderen P, Drewke E, Brackmann HH (1995) An alloantibody to von Willebrand factor selectively inhibiting the binding of von Willebrand factor to collagen in a patient with severe von Willebrand disease. Thromb Haemost 73:1161 (abstract)
6. Foster PA, Fulcher CA, Marti T, Titani K, Zimmerman TS (1987) A major factor VIII binding domain resides within the amino-terminal 272 amino acid residues of von Willebrand factor. J Biol Chem 262:8443-8446
7. Foster PA, Fulcher CA, Hounghten RA, Zimmerman TS (1990) A synthetic factor VIII peptide of eight amino acid residues (1677-1684) contains the binding region of an anti-factor VIII antibody which inhibits the binding of factor VIII to von Willebrand factor. Thromb Haemost 63:403-406
8. Fulcher CA, Zimmerman TS (1982) Characterization of the human factor VIII procoagulant protein with a heterologous precipitating antibody. Proc Natl Acad Sci USA 79:1648-1652
9. Fulcher CA, De Graaf Mahoney S, Roberts JR, Kasper KCK, ZimmermanTS (1985) Localization of human factor VIII inhibitor epitopes to two polypeptide fragments. Proc Natl Acad Sci USA 82:7728-7732
10. Gill JC, Stephany K, Newton-Nash D, Foster PA (1995) Apparent IgG anti-factor VIII antibodies in normal individuals are specific for ABO blood group substances. Blood 86:611a (abstract)
11. Hanna WT (1989) Replacement therapy for surgery in type III von Willebrand patient with inhibitors to factor VIII procoagulant. Thromb Haemost 62:224 (abstract)
12. Kasper CK, Aledort LM, Counts RB, Edson JR, Fratantoni J, Green D, Hampton JW, Hilgartner M, Lazerson J, Levine PH, McMillan CW, Pool JG, Shapiro SS, Shulman NR, van Eys J (1975) A more uniform measurement of factor VIII inhibitors. Thromb Diath Haemorrh 34:869-872
13. Klein U (1991) Production and characterization of recombinant factor VIII. Semin Hematol 28 [Suppl 1]: 17-21
14. López Fernández MF, Martín R, López Berges C, Ramos F, de Bosch N, Batlle J (1988) Further specificity characterization of von Willebrand factor inhibitors developed in two patients with severe von Willebrand disease. Blood 72:116-120
15. López Fernández MF, Blanco López MJ, Castiñeira MP, Batlle J (1992) Further evidence for recessive inheritance of von Willebrand disease with abnormal binding of von Willebrand factor to factor VIII. Am J Hematol 40:20-27
16. Mannucci PM, Mari D (1991) Alloantibodies in congenital von Willebrand's disease. In: Lusher JM, Kessler CM (eds) Hemophilia and von Willebrand's disease in the 1990s. A new decade of hopes and challenges. Excerpta Medica, Amsterdam, pp 481-487
17. Mazurier C, Dieval J, Jorieux S, Delobel J, Goudemand M (1990) A new von Willebrand factor (vWF) defect in a patient with factor VIII (FVIII) deficiency but with normal levels and multimeric patterns of both plasma and platelet vWF. Characterization of abnormal vWF/FVIII interaction. Blood 75:20-26
18. Mazurier C, Gaucher C, Jorieux S, Parquet-Gernez A, Goudemand M (1990) Evidence for a von Willebrand factor defect in factor VIII binding in three members of a family previously misdiagnosed as mild hemophilia A and hemophilia A carriers: consequences for therapy and genetic counselling. Br J Haematol 76:372-379
19. Nishino M, Girma JP, Rothschild C, Fressinaud E, Meyer D (1989) New variant of von Willebrand disease with defective binding to factor VIII. Blood 74:1591-1599
20. Pérez Casai M, Daily M, Peake I, Batlle J (1995) A case of recessive type 2N von Willebrand's disease due to Arg 53 Trp substitution. Am J Hematol 48:140
21. Ruggeri ZM, Ware J (1992) The structure and function of von Willebrand factor. Thromb Haemost 67:594-599
22. Stratton RD, Wagner RH, Webster WP, Brinkhous KM (1975) Antibody nature of circulating inhibitor of plasma von Willebrand factor. Proc Natl Acad Sci USA 72:4167
23. Weinstein MJ, Chute LE (1984) Two distinct forms of factor VIII coagulant protein in human plasma. Cleavage by thrombin and differences in coagulant activity and association with von Willebrand factor. J Clin Invest 73:307-316
24. Weiss HJ, Sussmann II, Hoyer LW (1977) Stabilization of factor VIII in plasma by the von Willebrand factor. J Clin Invest 60:390-404
25. Zimmerman TS (1988) Purification of factor VIII by monoclonal antibody affinity chromatography. Semin Hematol 24 [Suppl 1]:25-26