In vivo retrovirus-mediated herpes simplex virus thymidine kinase gene therapy approach for adult T cell leukemia in a rat model

Japanese Journal of Cancer Research

Volumn 88, Issue 5, 1997, Pages 492-500

  Murata, Ken ^a   Fujita, Masatoshi ^c   Yamada, Yasuaki ^a   Higami, Yoshikazu ^b   Shimokawa, Isao ^b   Tsukasaki, Kunihiro ^a   Tanaka, Yuetsu ^d   Maeda, Michiyuki ^e   Furukawa, Koichi ^b   Yoshiki, Takashi ^f   Shiku, Hiroshi ^g   Tomonaga, Masao ^a  

^a NAGASAKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NAGASAKI UNIVERSITY   (Japan)

^c AICHI CANCER CENTER HOSPITAL   (Japan)

^d KITASATO UNIVERSITY   (Japan)

^e KYOTO UNIVERSITY   (Japan)

^f HOKKAIDO UNIVERSITY   (Japan)

^g MIE UNIVERSITY   (Japan)

Author keywords

Adult T cell leukemia; Gene therapy; Herpes simplex virus thymidine kinase; HTLV I tax

Indexed keywords

ACICLOVIR; GANCICLOVIR; THYMIDINE KINASE; VIRUS ENZYME;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER THERAPY; CONTROLLED STUDY; DRUG SENSITIVITY; GENE THERAPY; HERPES SIMPLEX VIRUS; IMMUNOBLOTTING; INTRAPERITONEAL DRUG ADMINISTRATION; LONG TERMINAL REPEAT; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RETROVIRUS; SOUTHERN BLOTTING; T CELL LEUKEMIA; TUMOR GROWTH; TUMOR REGRESSION;

EID: 14444274099     PISSN: 09105050     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1349-7006.1997.tb00408.x     Document Type: Article

References (43)

1. Uchiyama, T., Yodoi, J., Sagawa, K., Takatsuki, K. and Uchino, H. Adult T-cell leukemia: clinical and hematologic features of 16 cases. Blood, 50, 481-492 (1977).
2. Yamada, Y. Phenotypic and functional analysis of leukemic cells from 16 patients with adult T-cell leukemia/ lymphoma. Blood, 61, 192-199 (1983).
3. Yoshida, M., Seiki, M., Yamaguchi, K. and Takatsuki, K. Monoclonal integration of human T-cell leukemia provirus in all primary tumors of adult T-cell leukemia suggests causative role of human T-cell leukemia virus in the disease. Proc. Natl. Acad. Sci. USA, 81, 2534-2537 (1984).
4. Poiesz, B. J., Ruscetti, F. W., Gazdar, A. F., Bunn, P. A., Minna, J. D. and Gallo, R. C. Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma. Proc. Natl. Acad. Sci. USA, 77, 7415-7419 (1980).
5. Miyoshi, I., Kubonishi, I., Yoshimoto, S., Akaga, T., Ohtsuki, Y., Shiraishi, Y., Nagata, K. and Hinuma, Y. Type C virus particles in a cord T-cell line derived by co-cultivating normal human cord leukocytes and human leukaemic T cells. Nature, 294, 770-771 (1981).
6. Yoshida, M., Miyoshi, I. and Hinuma, Y. Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease. Proc. Natl. Acad. Sci. USA, 79, 2031-2035 (1982).
7. Seiki, M., Hikikoshi, A., Taniguchi, T. and Yoshida, M. Expression of the pX gene of HTLV-I: general splicing mechanism in the HTLV family. Science, 228, 1532-1534 (1985).
8. Felber, B. K., Paskalis, H., Kleinman-Ewing, C., Wong-Staal, F. and Pavlakis, G. N. The pX protein of HTLV-I is a transcriptional activator of its long terminal repeats. Science, 229, 675-679 (1985).
9. Sodroski, J., Rosen, C. A., Goh, W. C. and Haseltine, W. A. A transcriptional activator protein encoded by the x-lor region of the human T-cell leukemia virus. Science, 228, 1430-1434 (1985).
10. Seiki, M., Inoue, J., Takeda, T. and Yoshida, M. Direct evidence that p40x of human T-cell leukemia virus type I is a trans-acting transcriptional activator. EMBO J., 5, 561-565 (1986).
11. Inoue, J., Seiki, M., Taniguchi, T., Tsuru, S. and Yoshida, M. Induction of interleukin 2 receptor gene expression by p40x encoded by human T-cell leukemia virus type 1. EMBO J., 5, 2883-2888 (1986).
12. Siekevitz, M., Feinberg, M. B., Holbrook, N., Wong-Staal, F. and Greene, W. C. Activation of interleukin 2 and interleukin 2 receptor (Tac) promoter expression by the trans-activator (tat) gene product of human T-cell leukemia virus, type I. Proc. Natl. Acad. Sci. USA, 84, 5389-5393 (1987).
13. Fujii, M., Sassone-Corsi, P. and Verma, I. M. c-fos promoter trans-activation by the taxi protein of human T-cell leukemia virus type I. Proc. Natl. Acad. Sci. USA, 85, 8526-8530 (1988).
14. Grassmann, R., Dengler, C., Müller-Fleckenstein, I., Fleckenstein, B., McGuire, K., Dokhelar, M.-C., Sodroski, J. G. and Haseltine, W. A. Transformation to continuous growth of primary human T lymphocytes by human T-cell leukemia virus type I X-region genes transduced by a Herpesvirus saimiri vector. Proc. Natl. Acad. Sci. USA, 86, 3351-3355 (1989).
15. Akagi, T. and Shimotohno, K. Proliferative response of tax1-transduced primary human T cells to anti-CD3 antibody stimulation by an interleukin-2-independent pathway. J. Virol., 67, 1211-1217 (1993).
16. Murata, K., Fujita, M., Honda, T., Yamada, Y., Tomonaga, M. and Shiku, H. Rat primary T cells expressing HTLV-I tax gene transduced by a retroviral vector: in vitro and in vivo characterization. Int. J. Cancer, 68, 102-108 (1996).
17. Tanaka, A., Takahashi, C., Yamaoka, S., Nosaka, T., Maki, M. and Hatanaka, M. Oncogenic transformation by the tax gene of human T-cell leukemia virus type I in vitro. Proc. Natl. Acad. Sci. USA, 87, 1071-1075 (1990).
18. Lymphoma Study Group. Major prognostic factors of patients with adult T-cell leukemia-lymphoma: a cooperative study. Leuk. Res., 15, 81-90 (1991).
19. Field, A. K., Davies, M. E., DeWitt, C., Perry, H. C., Liou, R., Germershausen, J., Karpas, J. D., Ashton, W. T., Johnston, D. B. R. and Tolman, R. L. 9-{[2-Hydroxy-1-(hydroxymethyl)ethoxy]methyl} guanine: a selective inhibitor of herpes group virus replication. Proc. Natl. Acad. Sci. USA, 80, 4139-4143 (1983).
20. Moolten, F. L. and Wells, J. M. Curability of tumors bearing herpes thymidine kinase genes transferred by retroviral vectors. J. Natl. Cancer Inst., 82, 297-300 (1990).
21. Culver, K. W., Ram, Z., Wallbridge, S., Ishi, H., Oldfield, E. H. and Blaese, R. M. In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors. Science, 256, 1550-1552 (1992).
22. Caruso, M., Panis, Y., Gagandeep, S., Houssin, D., Salzmann, J.-L. and Klatzmann, D. Regression of established macroscopic liver metastases after in situ transduction of a suicide gene. Proc. Natl. Acad. Sci. USA, 90, 7024-7028 (1993).
23. Ram, Z., Culver, K. W., Walbridge, S., Blaese, R. M. and Oldfield, E. H. In situ retroviral-mediated gene transfer for the treatment of brain tumors in rats. Cancer Res., 53, 83-88 (1993).
24. Chen, S.-H., Shine, H. D., Goodman, J. C., Grossman, R. G. and Woo, S. L. C. Gene therapy for brain tumors: regression of experimental gliomas by adenovirus-mediated gene transfer in vivo. Proc. Natl. Acad. Sci. USA, 91, 3054-3057 (1994).
25. O'Malley, Jr., B. W., Chen, S.-H., Schwartz, M. R. and Woo, S. L. C. Adenovirus-mediated gene therapy for human head and neck squamous cell cancer in a nude mouse model. Cancer Res., 55, 1080-1085 (1995).
26. Kaneko, S., Hallenbeck, P., Kotani, T., Nakabayashi, H., McGarrity, G., Tamaoki, T., Anderson, W. F. and Chiang, Y. L. Adenovirus-mediated gene therapy of hepatocellular carcinoma using cancer-specific gene expression. Cancer Res., 55, 5283-5287 (1995).
27. Fujita, M., Murata, K. and Shiku, H. Selective inhibition of human T-lymphotropic virus type I-transformed human T-cell growth by a tax-targeted conditionally cytotoxic recombinant retrovirus. Blood, 84, 2591-2596 (1994).
28. Tateno, M., Kondo, N., Itoh, T., Chubachi, T., Togashi, T. and Yoshiki, T. Rat lymphoid cell lines with human T cell leukemia virus production. 1. Biological and serological characterization. J. Exp. Med., 159, 1105-1116 (1984).
29. Tanaka, Y., Tozawa, H., Konagai, Y. and Shida, H. Recognition of human T cell leukemia virus type I (HTLV-I) gag and pX gene products by MHC-restricted cytotoxic T lymphocytes induced in rats against syngeneic HTLV-I-infected cells. J. Immunol., 144, 4202-4211 (1990).
30. Imada, K., Takaori-Kondo, A., Akagi, T., Shimotohno, K., Sugamura, K., Hattori, T., Yamabe, H., Okuma, M. and Uchiyama, T. Tumorigenicity of human T-cell leukemia virus type I-infected cell lines in severe combined immunodeficient mice and characterization of the cells proliferating in vivo. Blood, 86, 2350-2357 (1995).
31. Miller, A. D. and Rosman, G. J. Improved retroviral vectors for gene transfer and expression. BioTechniques, 7, 980-990 (1989).
32. Tanaka, Y., Masuda, M., Yoshida, A., Shida, H., Nyunoya, H., Shimotohno, K. and Tozawa, H. An antigenic structure of the trans-activator protein encoded by human T-cell leukemia virus type-I (HTLV-I), as defined by a panel of monoclonal antibodies. AIDS Res. Hum. Retroviruses, 8, 227-235 (1992).
33. Huber, B. E., Richards, C. A. and Krenitsky, T. A. Retroviral-mediated gene therapy for the treatment of hepatocellular carcinoma: an innovative approach for cancer therapy. Proc. Natl. Acad. Sci. USA, 88, 8039-8043 (1991).
34. Ido, A., Nakata, K., Kato, Y., Nakao, K., Murata, K., Fujita, M., Ishii, N., Tamaoki, T., Shiku, H. and Nagataki, S. Gene therapy for hepatoma cells using a retrovirus vector carrying herpes simplex virus thymidine kinase gene under the control of human α-fetoprotein gene promoter. Cancer Res., 55, 3105-3109 (1995).
35. Tanaka, T., Kanai, F., Okabe, S., Yoshida, Y., Wakimoto, H., Hamada, H., Shiratori, Y., Lan, K.-H., Ishitobi, M. and Omata, M. Adenovirus-mediated prodrug gene therapy for carcinoembryonic antigen-producing human gastric carcinoma cells in vitro. Cancer Res., 56, 1341-1345 (1996).
36. Chen, S.-H., Chen, X. H. L., Wang, Y., Kosai, K., Finegold, M. J., Rich, S. S. and Woo, S. L. C. Combination gene therapy for liver metastasis of colon carcinoma in vivo. Proc. Natl. Acad. Sci. USA, 92, 2577-2581 (1995).
37. 1 and herpes simplex thymidine kinase followed by ganciclovir. Hum. Gene Ther., 7, 1-10 (1996).
38. Oka, T., Sonobe, H., Iwata, J., Kubonishi, I., Satoh, H., Tanaka, M., Tanaka, Y., Tateno, M., Tozawa, H., Mori, S., Yoshiki, T. and Ohtsuki, Y. Phenotypic progression of a rat lymphoid cell line immortalized by human T-lymphotropic virus type I to induce lymphoma/leukemia-like disease in rats. J. Virol, 66, 6686-6694 (1992).
39. Kinoshita, T., Shimoyama, M., Tobinai, K., Ito, M., Ito, S., Ikeda, S., Tajima, K., Shimotohno, K. and Sugimura, T. Detection of mRNA for the tax1/rex1 gene of human T-cell leukemia virus type I in fresh peripheral blood mononuclear cells of adult T-cell leukemia patients and viral carriers by using the polymerase chain reaction. Proc. Natl. Acad. Sci. USA, 86, 5620-5624 (1989).
40. Ohshima, K., Suzumiya, J., Izumo, S., Murai, Y., Tashiro, K. and Kikuchi, M. Detection of human T-lymphotropic virus type I DNA and mRNA in the lymph nodes; using polymerase chain reaction in situ hybridization (PCR/ ISH) and reverse transcription (RT-PCR/ISH). Int. J. Cancer, 66, 18-23 (1996).
41. Shirono, K., Hattori, T., Hata, H., Nishimura, H. and Takatsuki, K. Profiles of expression of activated cell antigens on peripheral blood and lymph node cells from different clinical stages of adult T-cell leukemia. Blood, 73, 1664-1671 (1989).
42. Yoshida, M. Expression of the HTLV-I genome and its association with a unique T-cell malignancy. Biochim. Biophys. Acta, 907, 145-161 (1987).
43. Smith, M. R. and Greene, W. C. Molecular biology of the type I human T-cell leukemia virus (HTLV-I) and adult T-cell leukemia. J. Clin. Invest., 87, 761-766 (1991).