Resistance to densification, tensile strength and capsule-filling performance of some pharmaceutical diluents

Journal of Pharmacy and Pharmacology

Volumn 50, Issue 7, 1998, Pages 713-721

  Nikolakakis, I ^a   Ballesteros Aragon, O ^a   Malamataris, S ^a  

^a ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

DILUENT; LACTOSE; MICROCRYSTALLINE CELLULOSE; STARCH; TALC;

ARTICLE; CAPSULE FILLING; COMPRESSION; GRAVITY; PARTICLE SIZE; TENSILE STRENGTH;

EID: 14444269004     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.2042-7158.1998.tb07131.x     Document Type: Article

References (19)

1. Ashton, M. D., Farlley, R. F., Valentin, F. H. H. (1964) An improved apparatus for measuring the tensile strength of powders. J. Sci. Instr. 41: 763-765
2. Carr, R. L. (1965) Evaluating flow properties of solids. Chem. Eng. 18: 163-168
3. Cheng, D. C.-H. (1968) The tensile strength of powders. Chem. Eng. Sci. 23: 1405-1420
4. Chowan, Z. T., Chow, Y. P. (1980) Powder flow studies I. Powder consolidation ratio and its relationship to capsule filling-weight variation. Int. J. Pharm. 4: 317-326
5. Chowan, Z. T., Young, I. C. (1981) Powder flow studies. III: Tensile strength, consolidation ratio, flow rate and capsule-filling-weight variation relationships. J. Pharm. Sci. 70: 927-930
6. Eaves, T., Jones, T. M. (1972) Effect of moisture on tensile strength of bulk solids I: sodium chloride and effect of particle size. J. Pharm. Sci. 61: 256-261
7. Hausner, H. H. (1967) Friction conditions in a mass of metal powder. Int. J. Powder Metall. 3: 7-13
8. Irwin, G. M., Dodsom, G. J., Ravin, L. J. (1970) Encapsulation of clomacran phosphate. I: Effect of flowability of powder blends, lot-to-lot variability, and concentration of active ingredients on weight variation of capsules filled on an automatic capsule-filling machine. J. Pharm. Sci. 59: 547-550
9. Jollife, I. G., Newton, J. M., Walters, J. K. (1980) Theoretical considerations of the filling of pharmaceutical hard-gelatin capsules. Powder Technol. 27: 189-195
10. Kawakita, K., Eudde, K. H. (1970/71) Some consideration on powder compression equations. Powder Technol. 4: 57-60
11. Krupp, H. (1967) Particle adhesion theory and experiment. Adv. Colloid Interface Sci. 1: 111-239
12. Kurihara, K., Ichikawa, I. (1978) Effect of powder flowability on capsule-filling-weight-variation. Chem. Pharm. Bull. 26: 1250-1256
13. Malamataris, S., Pilpel, N. (1980) The effect of temperature on the tensile strength and densification of lactose powders coated with fatty acids. Powder Technol. 26: 205-211
14. Patel, R., Podczeck, F. (1996) Investigation of the effect of type and source of microcrystalline cellulose on capsule filling. Int. J. Pharm. 128: 123-127
15. Podczeck, F., Lee-Amies, G. (1996) The bulk volume change of powders by granulation and compression with respect to capsule filling. Int. J. Pharm. 42: 97-102
16. Tan, S. B. (1987) Filling of Hard-gelatin Capsules with Powders of Different Flow Properties. PhD Thesis, University of London
17. Tan, S. B., Newton, J. M. (1990) Powder flowability as an indication of capsule filling performance. Int. J. Pharm. 61: 145-155
18. Varthalis, S., Pilpel, N. (1976) Anomalies in some properties of powder mixtures. J. Pharm. Pharmacol. 28: 415-419
19. Yamashiro, M., Yuasa, Y., Kawakita, K. (1983) An experimental study on the relationships between compressibility. fluidity, and cohesion of powder solids at small tapping numbers. Powder Technol. 34: 225-231