Stability of the O-octanoyl group of rat ghrelin during chemical synthesis: Counter-ion-dependent alteration of an ester bond breakage

Letters in Peptide Science

Volumn 10, Issue 1, 2003, Pages 41-50

  Ishimaru, Masanori ^a   Yoshizawa Kumagaye, Kumiko ^a   Kubo, Shigeru ^a   Kitani, Tetsuya ^a   Chino, Naoyoshi ^a   Kangawa, Kenji ^b   Kimura, Terutoshi ^a  

^a Peptide Institute Inc   (Japan)

^b NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

Author keywords

Acylated peptide; Chemical synthesis; Counter ion dependent stability; De acylation; Dehydration; Octanoyl group; Post translational modification

Indexed keywords

9 FLUORENYLMETHYL CHLOROFORMATE; ACETIC ACID; ALANINE; CARBONYL DERIVATIVE; ESTER DERIVATIVE; GHRELIN; HYDROXYL GROUP; O OCTANOYL GROUP; OCTANOIC ACID; SERINE; SOLVENT; TERT BUTYLCARBONYL DERIVATIVE; TRIFLUOROACETIC ACID; UNCLASSIFIED DRUG; WATER;

ACYLATION; ARTICLE; BIOASSAY; DEACYLATION; DEHYDRATION; DISSOLUTION; FREEZE DRYING; PEPTIDE SYNTHESIS; PROTEIN PROCESSING; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; TEMPERATURE;

EID: 1442350568     PISSN: 09295666     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:LIPS.0000014028.70584.15     Document Type: Article

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