Ultraviolet Radiation Causes Less Immunosuppression in Patients with Polymorphic Light Eruption Than in Controls

Journal of Investigative Dermatology

Volumn 122, Issue 2, 2004, Pages 291-294

  Palmer, Roy A ^a,b   Friedmann, Peter S ^a  

^a SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

^b ST THOMAS HOSPITAL   (United Kingdom)

Author keywords

2,4 dinitrochlorobenzene; Diphenylcyclopropenone; Immunosuppression; Polymorphic light eruption; Ultraviolet radiation

Indexed keywords

1 CHLORO 2,4 DINITROBENZENE; PHENYL GROUP;

ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DELAYED HYPERSENSITIVITY; DRUG SENSITIZATION; ERYTHEMA; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; IRRADIATION; LIGHT; PHOTODERMATOSIS; PHOTOREACTIVITY; PRIORITY JOURNAL; SENSITIZATION; SKINFOLD; STATISTICAL ANALYSIS; ULTRAVIOLET RADIATION;

EID: 1442348090     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0022-202X.2004.22213.x     Document Type: Article

References (15)

1. Cooper KD, Oberhelman L, Hamilton TA, et al: UV exposure reduces immunization rates and promotes tolerance to epicutaneous antigens in humans: Relationship to dose, CD1a-DR+ epidermal macrophage induction, and Langerhans cell depletion. Proc Natl Acad Sci USA 89:8497-8501, 1992
2. Damian DL, Halliday GM, Barnetson RS: Broad-spectrum sunscreens provide greater protection against ultraviolet-radiation induced suppression of contact hypersensitivity to a recall antigen in humans. J Invest Dermatol 109:146-151, 1997
3. Epstein S: Studies in abnormal human sensitivity to light. IV. Photoallergic concept of prurigo aestivalis. J Invest Dermatol 5:289-298, 1942
4. Friedmann PS: Clinical aspects of allergic contact dermatitis. In: Dean JH, Luster MI, Munson AE, Kimber I (eds). Immunotoxicology and Immunopharmacology, 2nd edn. New York: Raven Press Ltd, 1994
5. Friedmann PS, White SI, Parker S, Moss C, Matthews JNS: Antigenic-stimulation during ultraviolet therapy in man does not result in immunological-tolerance. Clin Exp Immunol 76:68-72, 1989
6. Gonzalez-Amaro R, Baranda L, Salazar-Gonzalez JF, et al: Immune sensitisation against epidermal antigens in polymorphous light eruption. J Am Acad Dermatol 24:70-73, 1991
7. Kelly DA, Walker SL, McGregor JM, Young AR: A single exposure of solar simulated radiation suppresses contact hypersensitivity responses both locally and systemically in humans: Quantitative studies with high-frequency ultrasound. J Photochem Photobiol B Biol 44:130-142, 1998
8. Kelly DA, Young AR, McGregor JM, et al: Sensitivity to sunburn is associated with susceptibility to ultraviolet-radiation induced suppression of cutaneous cell-mediated immunity. J Exp Med 191:561-566, 2000
9. Kolgen W, Weelden HV, Hengst SD, et al: CD11b+ cells and ultraviolet-B-resistant CD1a+ cells in skin of patients with polymorphous light eruption. J Invest Dermatol 113:4-10, 1999
10. Moss C, Friedmann PS, Shuster S, Simpson JM: Susceptibility and amplification of sensitivity in contact dermatitis. Clin Exp Immunol 61:232-241, 1985
11. Norris PG, Morris J, McGibbon DM, et al: Polymorphic light eruption: An immunopathological study of evolving lesions. Br J Dermatol 120:173-183, 1989
12. Rees JL, Friedmann PS, Matthews JNS: Sex differences in susceptibility to development of contact hypersensitivity to dinitrochlorobenzene (DNCB). Br J Dermatol 120:371-374, 1989
13. Rees J, Friedmann PS, Matthews JN: Contact sensitivity to dinitrochlorobenzene is impaired in atopic subjects. Controversy revisited. Arch Dermatol 126:1173-1175, 1990
14. Ullrich SE: Modulation of immunity by ultraviolet radiation: Key effects on antigen presentation. J Invest Dermatol 105:30S-36S, 1995
15. Vermeer M, Schmieder GJ, Yoshikawa T, et al: Effects of ultraviolet B light on cutaneous immune responses of humans with deeply pigmented skin. J Invest Dermatol 97:729-734, 1991