N-acetylcysteine attenuates lung injury in a rodent model of fracture

Acta Orthopaedica Scandinavica

Volumn 75, Issue 1, 2004, Pages 61-65

  Timlin, Marcus ^a   Condron, Claire ^a   Toomey, Deirdre ^a   Power, Colm ^a   Thornes, Brian ^a   Kearns, Stephen ^a   Street, John ^a   Murray, Paraic ^a   Bouchier Hayes, David ^a  

^a BEAUMONT HOSPITAL   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ANTIOXIDANT; MYELOPEROXIDASE;

ANALYSIS OF VARIANCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; FEMUR FRACTURE; GENERAL ANESTHESIA; HISTOPATHOLOGY; INTRAMEDULLARY NAILING; LUNG INJURY; LUNG LAVAGE; LUNG PARENCHYMA; MALE; NONHUMAN; RAT; TREATMENT OUTCOME;

ACETYLCYSTEINE; ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; DISEASE MODELS, ANIMAL; FEMORAL FRACTURES; FRACTURE FIXATION, INTRAMEDULLARY; FREE RADICAL SCAVENGERS; LUNG; MALE; ORGAN SIZE; PEROXIDASE; RATS; RATS, SPRAGUE-DAWLEY; RESPIRATORY DISTRESS SYNDROME, ADULT;

EID: 1442331931     PISSN: 00016470     EISSN: None     Source Type: Journal    
DOI: 10.1080/00016470410001708120     Document Type: Article

References (26)

1. Behrman S W, Fabian T C, Kudsk K A, et al. Improved outcome with femur fractures: early versus delayed fixation. J Trauma 1990; 30: 792.
2. Bernard G R. N-acetyl cysteine in experimental and clinical acute lung injury. Am J Med (Suppl 3c) 1991; 91: 54S-9S.
3. Bone L B, Johnson K D, Weigelt J, Scheinberg R. Early versus delayed stabilization of femoral fractures: a prospective randomised study. J Bone Joint Surg (Am) 1989; 71: 336-40.
4. Christie J, Robinson C M, Pell A C H, Mc Birnie J, Burnett R. Transcardiac echocardiography during invasive intramedullary procedures. J Bone Joint Surg (Br) 1995; 77: 440-5.
5. Clark G C, Schecter W P, Trunkey D D. Variables affecting outcome in blunt chest trauma: flat chest vs pulmonary contusion. J Trauma 1988; 28: 298-304.
6. Davreux C J, Soric I, Nathens A B, et al. N-acetyl cysteine attenuates acute lung injury in the rat. Shock 1997; 8-6: 432-8.
7. Fonte D A, Hausberger F X. Pulmonary free fatty acids in experimental fat embolism. J Trauma 1971; 11: 668-72.
8. Fowler A A, Hamman R F, Good J T, et al. Adult respiratory distress syndrome: risk with common predispositions. Ann Int Med 1983; 98: 593-97.
9. Gitin T A, Seidel T, Cera P J, Glidewel O J, Smith J L. Pulmonary microvascular fat: the significance? Crit Care Med 1993; 21: 673-7.
10. Grisham M B, Hernandez L A, Granger G N. Xanthine oxidase and neutrophil infiltration in intestinal ischemia. Am J Physiol 1986; 251: G567.
11. 2+) I signalling and oxidative burst by human fracture fluids. J Trauma 1999; 47: 854-8.
12. Jepsen S, Herlevsen P, Knudsen P, Bud M I, Klausen N O. Antioxidant treatment with N-acetyl cysteine during adult respiratory distress syndrome: a prospective, randomised, placebo-controlled study. Crit Care Med 1992; 20: 918-23.
13. Kearns S, Condron C, Kelly C, Murray P. N-acetyl cysteine reduces muscle injury in an experimental model of compartment syndrome. J Bone Joint Surg (Br) (Suppl) 2001; 83: P357.
14. Lauterberg B H, Corcoran G B, Mitchell J R. Mechanism of action of N-acetyl cysteine in the protection against the hepatotoxicity of acetaminophen in rats in vivo. J Clin Invest 1983; 71: 980-91.
15. Pape H C, Auf'm'Kolk M, Paffrath T, et al. Primary intramedullary femur fixation in multiple trauma patients with associated lung contusion: a cause of posttraumatic ARDS? J Trauma 1993; 34: 540.
16. Partrick D A, Moore F A, Moore E E, Barnett C C, Stillman CC. Neutrophil priming and activation in the pathogenesis of post injury multiple organ failure. New Horizons 1996; 4-2: 194-210.
17. Pepe P E, Potkin R T, Reus D H, Hudson L D, Carrico C J. Clinical predictors of the adult respiratory distress syndrome. Am J Surg 1982; 144: 124-30.
18. Pepe P E, Thomas R G, Stager M A, Hudson L D, Carrico C J. Early prediction of the adult respiratory distress syndrome by a simple scoring method. Ann Emerg Med 1983; 12: 749-55.
19. Robinson C M. Current concepts of respiratory insufficiency syndromes after fracture. J Bone Joint Surg (Br) 1969; 83; 6: 781-91.
20. Schemitsch E H, Jain R, Turchin D C, et al. Pulmonary effects of fixation of a fracture with a plate compared with intrameduallary nailing: a canine model of fat embolism and fracture fixation. J Bone Joint Surg (Am) 1997; 79: 984-96.
21. Schemitsch E H, Turchin D C, Anderson G I, et al. Pulmonary and systemic fat embolism after medullary canal pressurisation: a haemodynamic and histologic investigation in the dog. J Trauma 1998; 45: 738-42.
22. Simon LM, Suttorp N. Lung cell oxidant injury: Decrease in oxidant-mediated cytotoxicity by N-acetyl cysteine. Eur J Respir Dis (Suppl 139) 1985; 66: 132-5.
23. Sutter P M, Domenighetti G, Schaller M D, Laverriere M C, Ritz R, Perre C. N-acetyl cysteine enhances recovery from acute lung injury in man. Chest 1994; 105: 190-4.
24. Timlin M. Fracture haematoma is a potent pro-inflammatory mediator. MCh Thesis 2002 Royal College of Surgeons in Ireland.
25. Wenda K, Henrichs K J, Biegler M, Erbel R. Recording of bone marrow embolism during intramedullary nailing of the femur by transoesophageal echocardiography. Unfallchiurgie 1989; 15: 73-6.
26. Willis B H, Carden D L, Sadasivan K K. Effect of femoral fracture and intrameduallary fixation on lung capillary leak. J Trauma 1999; 46 (4): 687-92.