The compulsive-like aspect of the head dipping emission in rats with chronic eletrolytic lesion in the area of the median raphe nucleus

Brazilian Journal of Medical and Biological Research

Volumn 37, Issue 2, 2004, Pages 245-250

  Hoshino, K ^a   Uga, D A ^a   de Paula, H M G ^a  

^a SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

Author keywords

Electrolytic lesion; Head dipping; Median raphe nucleus; Rat; Repetitive behavior

Indexed keywords

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY; ARTICLE; BRAIN STEM INJURY; CAGE; CONTROLLED STUDY; DEPTH PERCEPTION; EXPERIMENTAL ANIMAL; LATENT PERIOD; MALE; MEDIAN RAPHE NUCLEUS; NONHUMAN; RAT; RAT STRAIN; RISK ASSESSMENT; STATISTICAL SIGNIFICANCE;

ANIMALIA; RATTUS NORVEGICUS;

EID: 1442331009     PISSN: 0100879X     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/S0100-879X2004000200012     Document Type: Article

References (20)

1. Hoshino K & Sugizaki M (1986). Ulcerogenic effects of the lesion of the median raphe nucleus in fasted rats. Brazilian Journal of Medical and Biological Research, 19: 123-130.
2. Sugizaki M & Hoshino K (1981). Hiperatividade motora e úlceras gástricas induzidas pela lesão do núcleo mediano da rafe de ratos. Revista de Ciências Biomédicas, 2: 23-29.
3. Griebel G, Rodgers RJ, Perrault G & Sanger DJ (1997). Risk assessment behavior evaluation of utility in the study of 5-HT-related drugs in the rat elevated plus-maze test. Pharmacology, Biochemistry and Behavior, 57: 817-827.
4. Andrade TGCS (1997). Participação do núcleo mediano da rate na modulação, de respostas comportamentais, viscerais, endócrinas e imunológicas, frente a estímulos aversivos. Doctoral thesis, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.
5. Paxinos G & Watson C (1985). The Rat Brain in Stereotaxic Coordinates. Academic Press, Sydney, Australia.
6. Weiss SM, Wadsworth G, Fletcher A & Dourish CT (1998). Utility of ethological analysis to overcome locomotor confounds in elevated maze models of anxiety. Neuroscience and Biobehavioral Reviews, 23: 265-271.
7. Andrews N, Hogg S, Gonzalez LE & File SE (1994). 5-HT1A receptors in the median raphe nucleus and dorsal hippocampus may mediate anxiolytic and anxiogenic behaviours, respectively. European Journal of Pharmacology, 264: 259-264.
8. Andrade TGCS & Graeff FG (2001). Effect of electrolytic and neurotoxic lesions of the median raphe nucleus on anxiety and stress. Pharmacology, Biochemistry and Behavior, 70: 1-14.
9. Bilkei-Gorzo A & Gyertyan I (1996). Some doubts about the basic concept of hole-board test. Neurobiology, 4: 405-415.
10. de Paula HMG & Hoshino K (2002). Correlation between the fighting rates of REM sleep-deprived rats and susceptibility to the 'wild running' of audiogenic seizures. Brain Research, 926: 80-85.
11. Andrade TG, Silva AM, Silva CL & Graeff FG (1999). Effect of electrolytic lesion of the median raphe nucleus on behavioral and physiological measures of stress. Acta Physiologica, Pharmacologica et Therapeutica Latinoamericana, 49: 279-289.
12. Szechtman H, Sulis W & Eilam D (1998). Quinpirole induces compulsive checking behavior in rats: a potential animal model of obsessive-compulsive disorder (OCD). Behavioral Neuroscience, 112: 1475-1485.
13. American Psychiatric Association (1995). DSM-IV: Manual de Diagnóstico e Estatístico dos Transtornos Mentais. 4th edn. Artes Médicas, Porto Alegre, RS, Brazil.
14. Zohar J & Westenberg HG (2000). Anxiety disorders: a review of tricyclic antidepressants and selective serotonin reuptake inhibitors. Acta Psychiatrica Scandinavica, 403 (Suppl): 39-49.
15. Dahlström A & Fuxe K (1964). Evidence for the existence of monoamine containing neurons in the central nervous system. I. Demonstration of monoamines in cell bodies of brain stem neurons. Acta Physiologica Scandinavica, 62 (Suppl 232): 1-55.
16. Kaplan HI (1997). Compêndio de Psiquiatria: Ciências do Comportamento e Psiquiatria Clínica, 7th edn. Artes Médicas, Porto Alegre, RS, Brazil.
17. Graybiel AM & Saka E (2002). A genetic basis for obsessive grooming. Neuron, 33: 1-2.
18. Asin KE & Fibiger HC (1983). An analysis of neuronal elements within the median nucleus of the raphe that mediate lesion-induced increases in locomotor activity. Brain Research, 268: 211-223.
19. Avanzi V, Castilho VM, de Andrade TGCS & Brandão, ML (1998). Regulation of contextual conditioning by the median raphe nucleus. Brain Research, 790: 178-184.
20. Graham S, Ho MY, Bradshaw CM & Szabadi E (1994). Facilitated acquisition of a temporal discrimination following destruction of the ascending 5-hydroxytryptaminergic pathways. Psychopharmacology, 116: 373-378.