Enhanced Expression of Angiopoietin-2 and the Tie2 Receptor but Not Angiopoietin-1 or the Tie1 Receptor in a Rat Model of Myocardial Infarction

Journal of Biomedical Science

Volumn 11, Issue 2, 2004, Pages 163-171

  Shyu, Kou Gi ^a,b   Liang, Yao Jen ^c   Chang, Hang ^a   Wang, Bao Wei ^a   Leu, Jyh Gang ^c   Kuan, Peiliang ^a  

^a SHIN KONG WU HO SU MEMORIAL HOSPITAL   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

Angiogenesis; Angiopoietin 1; Angiopoietin 2; Myocardial infarction; Tie receptor

Indexed keywords

ANGIOPOIETIN 1; ANGIOPOIETIN 2; ANGIOPOIETIN RECEPTOR; BIOLOGICAL MARKER; MESSENGER RNA; RECEPTOR PROTEIN; TIE 1 RECEPTOR; UNCLASSIFIED DRUG;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY LIGATION; DISEASE MARKER; DISEASE MODEL; HEART INFARCTION; HEART LEFT VENTRICLE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LEFT ANTERIOR DESCENDING CORONARY ARTERY; MALE; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; WESTERN BLOTTING;

ANGIOPOIETIN-1; ANGIOPOIETIN-2; ANIMALS; HEART VENTRICLES; MALE; MYOCARDIAL INFARCTION; MYOCARDIAL ISCHEMIA; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, TIE-1; RECEPTOR, TIE-2; RNA, MESSENGER; TIME FACTORS; UP-REGULATION;

EID: 1442328774     PISSN: 10217770     EISSN: 14230127     Source Type: Journal    
DOI: 10.1159/000076028     Document Type: Article

References (33)

1. Asahara T, Chen D, Takahashi T, Fujikawa K, Kearney M, Magner M, Yancopoulos GD, Isner JM. Tie2 receptor ligands, angiopoietin-1 and angiopoietin-2, modulate VEGF-induced postnatal neovascularization. Circ Res 83:233-240;1998.
2. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159;1987.
3. Davis S, Aldrich TH, Jones PF, Acheson A, Compton DL, Jain V, Ryan TE, Bruno J, Radziejewski C, Maisonpierre PC, Yancopoulos GD. Isolation of angiopoietin-1, a ligand for the TIE2 receptor by secretion-trap expression. Cell 87:1161-1169;1996.
4. Dumont DJ, Fong GH, Puri MC, Gradwohl G, Alitalo K, Breitman ML. Vascularization of the mouse embryo: A study of flk-1, tek, tie, and vascular endothelial growth factor expression during development. Dev Dyn 203:80-92;1995.
5. Dumont DJ, Gradwohl G, Fong GH, Puri MC, Gertsenatein M, Auerbach A, Breitman ML. Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo. Genes Dev 8:1897-1909;1994.
6. Hanahan D. Signaling vascular morphogenesis and maintenance. Science 277:48-50;1997.
7. Heba G, Krezeminski T, Porc M, Grzyb J, Ratajska A, Dembinska-Kiec A. The time course of tumor necrosis factor-alpha, inducible nitric oxide synthase at vascular endothelial growth factor expression in an experimental model of chronic myocardial infarction in rats. J Vasc Res 38:288-300;2001.
8. Hojo Y, Ikeda U, Zhu Y, Okada M, Ueno S, Arakawa H, Fujikawa H, Katsuki TA, Shimada K. Expression of vascular endothelial growth factor in patients with acute myocardial infarction. J Am Coll Cardiol 35:968-973;2000.
9. Holash J, Maisonpierre PC, Compton D, Boland P, Alexander CR, Zagzag D, Yanocopoulos GD, Wiegand SJ. Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF. Science 284:1994-1998;1999.
10. Kim I, Kim HG, Moon SO, Chae SW, So JN, Koh KN, Ahn BC, Koh GY. Angiopoietin-1 induces endothelial cell sprouting through the activation of focal adhesion kinase and plasmin secretion. Circ Res 86:952-959;2000.
11. Kim I, Kim JH, Moon SO, Kwak HJ, Kim NG, Koh GY. Angiopoietin-2 at high concentration can enhance endothelial cell survival through the phosphatidylinositol 3′-kinase/Akt signal transduction pathway. Oncogene 19:4549-4552;2000.
12. Kim I, Kim JH, Shin Y, Ryu YS, Liu M, Koh GY. Tumor necrosis factor-α upregulates angiopoietin-2 in human umbilical endothelial cells. Biochem Biophys Res Commun 269:361-365;2000.
13. Koblizek TI, Weiss C, Yancopoulos GD, Deutsch U, Risau W. Angiopoietin-1 induces sprouting angiogenesis in vitro. Curr Biol 8:529-532;1998.
14. Krikun G, Schatz F, Finlay T, Kadner S, Mesia A, Gerrets R, Lockwood CJ. Expression of angiopoietin-2 by human endometrial endothelial cells: Regulation by hypoxia and inflammation. Biochem Biophys Res Commun 275:159-163;2000.
15. Kwak HJ, Lee SJ, Lee YH, Ryu LH, Koh KN, Choi HY, Koh GY. Angiopoietin-1 inhibits irradiation- and mannitol-induced apoptosis in endothelial cells. Circulation 101:2317-2324;2000.
16. Li J, Brown LF, Hibberd MG, Grossman JD, Morgan JP, Simons M. VEGF, flk-1, and flt-1 expression in a rat myocardial infarction model of angiogenesis. Am J Physiol 270:H1803-H1811;1996.
17. Lobov IB, Brooks PC, Lang RA. Angiopoietin-2 displays VEGF-dependent modulation of capillary structure and endothelial cell survival in vivo. Proc Natl Acad Sci USA 99:11205-11210;2002.
18. Loughna S, Sato TN. Angiopoietin and Tie signaling pathways in vascular development. Matrix Biol 20:319-325;2001.
19. Maisonpierre P, Suri C, Jones P, Bartunkova S, Wiegand SJ, Radziejewki C, Compton D, McClain J, Aldrich TH, Papadopoulos N, Daly TJ, Davies S, Sato TN, Yancopoulos GD. Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. Science 277:55-60;1997.
20. Oh H, Takagi H, Suzuma K, Otani A, Matsumura M, Honda Y. Hypoxia and vascular endothelial growth factor selectively up-regulate angiopoietin-2 in bovine microvascular endothelial cells. J Biol Chem 274:15732-15739;1999.
21. Papapetropoulos A, Fulton D, Mahboubi K, Kalb RG, O'Connor DS, Li F, Altieri DC, Sessa WC. Angiopoietin-1 inhibits endothelial cell apoptosis via the Akt/Survivn pathway. J Biol Chem 275:9102-9105;2000.
22. Papapetropoulos A, Garcia-Cardena G, Dengler TJ, Maisonpierre PC, Yancopoulos GD, Sessa WC. Direct actions of angiopoietin-1 on human endothelium: Evidence for network stabilization, cell survival, and interaction with other angiogenic growth factors. Lab Invest 79:213-223;1999.
23. Sato TN, Tozawa Y, Deutsch U, Wolburg-Buchholz K, Fujiwara Y, Gendron-Maguire M, Gridley T, Wolburg H, Risau W, Qin Y. Distinct roles of the receptor tyrosine kinases Tie1 and Tie2 in blood vessel formation. Nature 376:70-74;1995.
24. Shweiki D, Itin A, Neufeld H, Gitay-Goren H, Keshet E. Patterns of expression of vascular endothelial growth factor (VEGF) and VEGF receptors in mice suggest a role in hormonally regulated angiogenesis. J Clin Invest 91:2235-2243;1993.
25. Shweiki D, Itin A, Soffer D, Keshet E. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 359:843-845;1992.
26. Shyu KG, Chang CC, Wang BW, Kuan P, Chang H. Increased expression of angiopoietin-2 and Tie2 in a rat model of myocardial ischemia-reperfusion. Clin Sci 105:287-294;2003.
27. Stanton LW, Garrard LJ, Damm D, Garrick BL, Lam A, Kapoun AM, Zheng Q, Protter AA, Schreiner GF, White RT. Altered patterns of gene expression in response to myocardial infarction. Circ Res 86:939-945;2000.
28. Suri C, Jones PF, Patan S, Bartunkova S, Maisonpierre PC, Davis S, Sato TN, Yancopoulos GD. Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis. Cell 87:1171-1180;1996.
29. Thurston G, Rudge J, Ioffe E, Zhou H, Ross L, Croll SD, Glazer N, Holash J, McDonald OM, Yancopoulos GD. Angiopoietin-1 protects the adult vasculature against plasma leakage. Nat Med 6:460-463;2000.
30. Veikkola T, Alitalo K. Dual role of Ang2 in postnatal angiogenesis and lymphangiogenesis. Dev Cell 3:302-304;2002.
31. Willam C, Koechne P, Jurgensen JS, Grafe M, Wagner KD, Bachmann S, Frei U, Eckardt KU. Tie2 receptor expression is stimulated by hypoxia and proinflammatory cytokines in human endothelial cells. Circ Res 87:370-377;2000.
32. Wong AL, Haroon ZA, Werner S, Dewhirst MW, Greenberg CS, Peters KG. Tie2 expression and phosphorylation in angiogenic and quiescent adult tissues. Circ Res 81:567-574;1997.
33. Yancopoulos GD, Davis S, Gale NW, Rudge JS, Wiegand SJ, Holash J. Vascular-specific growth factors and blood vessel formation. Nature 407:242-248;2000.