Lack of Protective Effects of Interleukin-4 -589-C/T Polymorphism against HIV-1-Related Disease Progression and Central Nervous System Impairment, in Children

Journal of Infectious Diseases

Volumn 189, Issue 4, 2004, Pages 587-592

  Singh, Kumud K ^a   Hughes, Michael D ^c   Chen, Jie ^c   Spector, Stephen A ^a,b  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c CENTER FOR BIOSTATISTICS IN AIDS RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RECOMBINANT INTERLEUKIN 4;

ALLELE; ARTICLE; BRAIN INJURY; CHILD; CLINICAL TRIAL; COHORT ANALYSIS; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE COURSE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; ETHNOLOGY; GENETIC POLYMORPHISM; HISPANIC; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFECTION COMPLICATION; MAJOR CLINICAL STUDY; MULTICENTER STUDY; NEGRO; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SEROPREVALENCE;

ACQUIRED IMMUNODEFICIENCY SYNDROME; AFRICAN CONTINENTAL ANCESTRY GROUP; AIDS DEMENTIA COMPLEX; CHILD; CHILD, PRESCHOOL; DISEASE PROGRESSION; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; HISPANIC AMERICANS; HUMANS; INFANT; INTERLEUKIN-4; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; UNITED STATES;

EID: 1442325334     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/381460     Document Type: Article

References (14)

1. Banchereau J, Briere F, Galizzi JP, Miossec P, Rousset F. Human interleukin 4. J Lipid Mediat Cell Signal 1994; 9:43-53.
2. Del Prete G, Maggi E, Parronchi P, et al. IL-4 is an essential factor for the IgE synthesis induced in vitro by human T cell clones and their supernatants. J Immunol 1988; 140:4193-8.
3. Abehsira-Amar O, Gibert M, Joliy M, Theze J, Jankovic DL. IL-4 plays a dominant role in the differential development of Th0 into Th1 and Th2 cells. J Immunol 1992; 148:3820-9.
4. Essner R, Rhoades K, McBride WH, Morton DL, Economou JS. IL-4 down-regulates IL-1 and TNF gene expression in human monocytes. J Immunol 1989; 142:3857-61.
5. Damle NK, Doyle LV. Distinct regulatory effects of IL-4 and TNF-alpha during CD3-dependent and CD3-independent initiation of human T-cell activation. Lymphokine Res 1989; 8:85-97.
6. Valentin A, Lu W, Rosati M, et al. Dual effect of interleukin 4 on HIV-1 expression: implications for viral phenotypic switch and disease progression. Proc Natl Acad Sci USA 1998; 95:8886-91.
7. + T lymphocytes and enhance HIV-1 replication. J Leukoc Biol 1998; 64:642-9.
8. Nakayama EE, Hoshino Y, Xin X, et al. Polymorphism in the interleukin-4 promoter affects acquisition of human immunodeficiency virus type 1 syncytium-inducing phenotype. J Virol 2000; 74:5452-9.
9. Nakayama EE, Meyer L, Iwamoto A, et al. Protective effect of interleukin-4 -589T polymorphism on human immunodeficiency virus type 1 disease progression: relationship with virus load. J Infect Dis 2002; 185: 1183-6.
10. Englund JA, Baker CJ, Raskino C, et al. Clinical and laboratory characteristics of a large cohort of symptomatic, human immunodeficiency virus-infected infants and children. AIDS Clinical Trials Group Protocol 152 Study Team. Pediatr Infect Dis J 1996; 15:1025-36.
11. McKinney RE Jr, Johnson GM, Stanley K, et al. A randomized study of combined zidovudine-lamivudine versus didanosine monotherapy in children with symptomatic therapy naive HIV-1 infection. The Pediatric AIDS Clinical Trials Group Protocol 300 Study Team. J Pediatr 1998; 133:500-8.
12. Singh KK, Barroga CF, Hughes MD, et al. Genetic influence of CCR5, CCR2, and SDF1 variants on human immunodeficiency virus 1 (HIV-1)-related disease progression and neurological impairment, in children with symptomatic HIV-1 infection. J Infect Dis 2003; 188:1461-72.
13. Soriano A, Martinez C, Garcia F, et al. Plasma stromal cell-derived factor (SDF)-1 levels, SDF1-3′A genotype, and expression of CXCR4 on T lymphocytes: their impact on resistance to human immunodeficiency virus type 1 infection and its progression. J Infect Dis 2002; 186:922-31.
14. Kwa D, Van Rij RP, Boeser-Nunnink B, Vingerhoed J, Schuitemaker H. Association between an interleukin-4 promoter polymorphism and the acquisition of CXCR4 using HIV-1 variants. AIDS 2003; 17:981-5.