Expression of staphylococcal clumping factor A impedes macrophage phagocytosis

Microbes and Infection

Volumn 6, Issue 2, 2004, Pages 188-195

  Palmqvist, Niklas ^a   Patti, Joseph M ^b   Tarkowski, Andrzej ^a   Josefsson, Elisabet ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b Inhibitex Inc   (United States)

Author keywords

Cfu; ClfA; Clumping factor A; Colony forming units; Counts per minute; Cpm; FBS; Fetal bovine serum; H.i.; Heat inactivated; Lactate dehydrogenase; LDH; Macrophages; Mice; PBS; Phagocytosis; Phosphate buffered saline; Spleen; Staphylococcus aureus

Indexed keywords

BINDING PROTEIN; CLUMPING FACTOR A; FIBRINOGEN; LIGAND; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BACTERIAL STRAIN; BACTERIAL VIRULENCE; BACTERIUM MUTANT; CONTROLLED STUDY; FEMALE; IMMUNOSTIMULATION; INFLAMMATION; MACROPHAGE FUNCTION; MEDIATOR RELEASE; MOUSE; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; STAPHYLOCOCCUS AUREUS;

ANIMALS; COAGULASE; MACROPHAGES; MICE; MICE, INBRED STRAINS; PHAGOCYTOSIS; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; VIRULENCE;

BACTERIA (MICROORGANISMS); BOVINAE; STAPHYLOCOCCUS; STAPHYLOCOCCUS AUREUS;

EID: 1442323885     PISSN: 12864579     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.micinf.2003.11.005     Document Type: Article

References (24)

1. Doolittle R.F., Everse S.J., Spraggon G. Human fibrinogen: anticipating a 3-dimensional structure. FASEB J. 10:1996;1464-1470.
2. Hawiger J., Timmons S., Strong D.D., Cottrell B.A., Riley M., Doolittle R.F. Identification of a region of human fibrinogen interacting with staphylococcal clumping factor. Biochemistry. 21:1982;1407-1413.
3. McDevitt D., Nanavaty T., House-Pompeo K., Bell E., Turner N., McIntire L., Foster T., Hook M. Characterization of the interaction between the Staphylococcus aureus clumping factor (ClfA) and fibrinogen. Eur. J. Biochem. 247:1997;416-424.
4. Hartford O., Francois P., Vaudaux P., Foster T.J. The dipeptide repeat region of the fibrinogen-binding protein (clumping factor) is required for functional expression of the fibrinogen-binding domain on the Staphylococcus aureus cell surface. Mol. Microbiol. 25:1997;1065-1076.
5. McDevitt D., Francois P., Vaudaux P., Foster T.J. Molecular characterization of the clumping factor (fibrinogen receptor) of Staphylococcus aureus. Mol. Microbiol. 11:1994;237-248.
6. McDevitt D., Francois P., Vaudaux P., Foster T.J. Identification of the ligand-binding domain of the surface-located fibrinogen receptor (clumping factor) of Staphylococcus aureus. Mol. Microbiol. 16:1995;895-907.
7. Bayer A.S., Sullam P.M., Ramos M., Li C., Cheung A.L., Yeaman M.R. Staphylococcus aureus induces platelet aggregation via a fibrinogen-dependent mechanism which is independent of principal platelet glycoprotein IIb/IIIa fibrinogen-binding domains. Infect. Immun. 63:1995;3634-3641.
8. O'Brien L., Kerrigan S.W., Kaw G., Hogan M., Penades J., Litt D., Fitzgerald D.J., Foster T.J., Cox D. Multiple mechanisms for the activation of human platelet aggregation by Staphylococcus aureus: roles for the clumping factors ClfA and ClfB, the serine-aspartate repeat protein SdrE and protein A. Mol. Microbiol. 44:2002;1033-1044.
9. Moreillon P., Entenza J.M., Francioli P., McDevitt D., Foster T.J., Francois P., Vaudaux P. Role of Staphylococcus aureus coagulase and clumping factor in pathogenesis of experimental endocarditis. Infect. Immun. 63:1995;4738-4743.
10. Josefsson E., Hartford O., O'Brien L., Patti J.M., Foster T. Protection against experimental Staphylococcus aureus arthritis by vaccination with clumping factor A, a novel virulence determinant. J. Infect. Dis. 184:2001;1572-1580.
11. Bremell T., Abdelnour A., Tarkowski A. Histopathological and serological progression of experimental Staphylococcus aureus arthritis. Infect. Immun. 60:1992;2976-2985.
12. Goldenberg D.L. Infectious arthritis complicating rheumatoid arthritis and other chronic rheumatic disorders. Arthritis Rheum. 32:1989;496-502.
13. Verdrengh M., Tarkowski A. Role of neutrophils in experimental septicemia and septic arthritis induced by Staphylococcus aureus. Infect. Immun. 65:1997;2517-2521.
14. Lissner C.R., Swanson R.N., O'Brien A.D. Genetic control of the innate resistance of mice to Salmonella typhimurium: expression of the Ity gene in peritoneal and splenic macrophages isolated in vitro. J. Immunol. 131:1983;3006-3013.
15. Lansdorp P.M., Aarden L.A., Calafat J., Zeiljemaker W.P. A growth-factor dependent B-cell hybridoma. Curr. Top. Microbiol. Immunol. 132:1986;105-113.
16. Helle M., Boeije L., Aarden L.A. Functional discrimination between interleukin 6 and interleukin 1. Eur. J. Immunol. 18:1988;1535-1540.
17. Underhill D.M., Ozinsky A., Hajjar A.M., Stevens A., Wilson C.B., Bassetti M., Aderem A. The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens. Nature. 401:1999;811-815.
18. Schwandner R., Dziarski R., Wesche H., Rothe M., Kirschning C.J. Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2. J. Biol. Chem. 274:1999;17406-17409.
19. Takeuchi O., Hoshino K., Akira S. Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection. J. Immunol. 165:2000;5392-5396.
20. Verdrengh M., Tarkowski A. Role of macrophages in Staphylococcus aureus-induced arthritis and sepsis. Arthritis Rheum. 43:2000;2276-2282.
21. Möller G., Landvall P. The polyclonal B-cell-activating property of protein A is not due to its interaction with the Fc part of immunoglobulin receptors. Scand. J. Immunol. 6:1977;357-366.
22. Dziarski R., Dziarski A. Mitogenic activity of staphylococcal peptidoglycan. Infect. Immun. 23:1979;706-710.
23. Firth J.D., Ebert B.L., Ratcliffe P.J. Hypoxic regulation of lactate dehydrogenase A. Interaction between hypoxia-inducible factor 1 and cAMP response elements. J. Biol. Chem. 270:1995;21021-21027.
24. Brouillette E., Lacasse P., Shkreta L., Belanger J., Grondin G., Diarra M.S., Fournier S., Talbot B.G. DNA immunization against the clumping factor A (ClfA) of Staphylococcus aureus. Vaccine. 20:2002;2348-2357.