Bromazepam determination in human plasma by high-performance liquid chromatography coupled to tandem mass spectrometry: A highly sensitive and specific tool for bioequivalence studies

Journal of Mass Spectrometry

Volumn 39, Issue 2, 2004, Pages 168-176

  Laurito, Tiago L ^a   Mendes, Gustavo D ^a,b   Santagada, Vincenzo ^c   Caliendo, Giuseppe ^c   de Moraes, Maria Elisabete A ^d   De Nucci, Gilberto ^a,b,e  

^a UNIVERSITY OF CAMPINAS   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^d FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

^e NONE   (Brazil)

Author keywords

Bioequivalence; Bromazepam; High performance liquid chromatography; Tandem mass spectrometry

Indexed keywords

ABSORPTION; ETHERS; EXTRACTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY;

TABLET FORMULATIONS;

DRUG PRODUCTS;

BROMAZEPAM; DIAZEPAM; ETHER; HEXANE;

ADULT; ANALYTIC METHOD; AREA UNDER THE CURVE; ARTICLE; BIOEQUIVALENCE; CALIBRATION; CLINICAL TRIAL; COLUMN CHROMATOGRAPHY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG FORMULATION; DRUG ISOLATION; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; FEMALE; FILM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; LIQUID LIQUID EXTRACTION; MALE; NORMAL HUMAN; OPEN STUDY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RANDOMIZED CONTROLLED TRIAL; SENSITIVITY AND SPECIFICITY; STANDARD; TABLET; TANDEM MASS SPECTROMETRY; THICKNESS; TIME; VOLUNTEER;

ADULT; ANTI-ANXIETY AGENTS; AREA UNDER CURVE; BROMAZEPAM; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FEMALE; HUMANS; MALE; MIDDLE AGED; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; THERAPEUTIC EQUIVALENCY;

EID: 1442300947     PISSN: 10765174     EISSN: None     Source Type: Journal    
DOI: 10.1002/jms.590     Document Type: Article

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