Characterization of Drug Release and Diffusion Mechanism Through Hydroxyethylmethacrylate/Methacrylic Acid pH-Sensitive Hydrogel

Drug Delivery: Journal of Delivery and Targeting of Therapeutic Agents

Volumn 11, Issue 1, 2004, Pages 53-58

  Varshosaz, Jaleh ^a   Hajian, Mahmood ^b  

^a ISFAHAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b UNIVERSITY OF ISFAHAN   (Iran)

Author keywords

Controlled Release; Diffusion; Drug Delivery; Hydrogel; Swelling Interface Number

Indexed keywords

2 HYDROXYETHYL METHACRYLATE; COPOLYMER; EPHEDRINE; ETHYLENE GLYCOL DIMETHACRYLATE; INDOMETACIN; METHACRYLIC ACID;

ARTICLE; CROSS LINKING; DIFFUSION COEFFICIENT; DRUG DIFFUSION; DRUG RELEASE; DRUG SOLUBILITY; HYDROGEL; PARTITION COEFFICIENT; PH; POLYMERIZATION; PRIORITY JOURNAL; STATISTICAL ANALYSIS; WATER CONTENT;

CHEMISTRY, PHARMACEUTICAL; DIFFUSION; DRUG DELIVERY SYSTEMS; EPHEDRINE; HYDROGELS; HYDROGEN-ION CONCENTRATION; INDOMETHACIN; METHACRYLATES; NITRILES; PERMEABILITY; SILANES; SOLUBILITY; WATER;

EID: 1442300738     PISSN: 10717544     EISSN: None     Source Type: Journal    
DOI: 10.1080/10717540490265298     Document Type: Article

References (21)

1. Brazel, C. S., and Peppas, N. A. 2000. Modeling of drug release from swellable polymers. Eur. J. Pharm. Biopharm. 49:47-58.
2. Davidson III, G. W. R., and Peppas, N. A. 1986a. Solute and penetrant diffusion in swellable polymers. V. Relaxation-controlled transport in P (HEMA-co-MMA) copolymers. J. Control. Rel. 3:243-258.
3. Davidson III, G. W. R., and Peppas, N. A. 1986b. Solute and penetrant diffusion in swellable polymers. VI. Deborah and swelling interface numbers as indicators of the order of biomolecular release. J. Control. Rel. 3:259-271.
4. Dong, L. C., and Hoffman, A. S. 1990. Synthesis and application of thermally reversible hydrogels for drug delivery. J. Control. Rel. 13:21-31.
5. Falamarzian, M., and Varshosaz, J. 1996. Swelling characteristics of hydroxyethyl-methacrylate/methacrylic acid pH-sensitive hydrogel as a drug delivery system. Daru 6(1-2):1-9.
6. Kim, C. J., and Lee, P. I. 1992. Composite poly(vinyl alcohol) beads for controlled drug delivery. Pharm. Res. 9:10-16.
7. Korsmeyer, R. W., and Peppas, N. A. 1981. Effect of the morphology of hydrophilic polymer matrices on the diffusion and release of water-soluble drugs. J. Membr. Sci. 9:211-227.
8. Korsmeyer, R. W., Gurny, R., Doelker, E., Buri, P., and Peppas, N. A. 1986. Hydrogels in Medicine and Pharmacy, vol. 3, FL: CRC Press.
9. Kwon, I. C., Bae, Y. H., and Kim, S. W. 1991. Electrically erodible polymer gel for controlled release of drugs. Nature 354:291-293.
10. Lee, P. I. 1985. Kinetics of drug release from hydrogel matrices. J. Control. Rel. 2:277-288.
11. Lee, P. I., and Kim, C. J. 1990. Probing the mechanisms of drug release from hydrogels. J. Control. Rel. 16:229-236.
12. Lustig, S. R., and Peppas, N. A. 1987. Solute and penetrant diffusion in swellable polymers. VII. A free volume-based model with mechanical relaxation. J. Appl. Polym. Sci. 33:533-549.
13. Martin, A., Swarbrick, J., and Cammarata, A. 1993. Physical pharmacy. Physical chemical principles in pharmaceutical sciences. Philadelphia: Lea & Febiger.
14. Peppas, N. A., and Moyniahan, H. J. 1985. Solute diffusion in swollen membranes. IV. Theories for moderately swollen networks. J. Appl. Polym. Sci. 30:2589-2606.
15. Peppas N. A., and Korsmeyer, R.W. 1986. Hydrogels in Medicine and Pharmacy, vol. 3, FL: CRC Press.
16. Peppas, N. A., and Lustig, S. R. 1986. Hydrogels in Medicine and Pharmacy, vol. 1, FL: CRC Press.
17. Peppas, L. B., and Peppas, N. A. 1989. Solute and penetrant diffusion in swellable polymers. IX. The mechanisms of drug release from pH-sensitive swelling-controlled systems. J. Control. Rel. 8:267-274.
18. Ratner, B. D., and Miller, I. F. 1973. Transport through cross-linked poly (2-hydroxyethyl methacrylate) hydrogel membranes. J. Biomed. Res. 7(4):353-367.
19. Ritger, P. L., and Peppas, N. A. 1987. A simple equation for description of solute release. II. Fickian and anomalous release from swellable devices. J. Control. Rel. 5:37-42.
20. Sato, S., and Kim, S. W. 1984. Macromolecular diffusion through polymer membrane. Int. J. Pharm. 22:229-255.
21. Wilke, C. R. 1949. Estimation of liquid diffusion coefficient. Chem. Eng. Prog. 54(3):218-224.