Self-assembling Lipid Microtubules Based on Cyclobolaphile That Mimics Archaeal Membrane Lipid

Chemistry Letters

Volumn 32, Issue 12, 2003, Pages 1170-1171

  Miyawaki, Kazuhiro ^a   Goto, Rie ^a   Shibakami, Motonari ^a  

^a NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYL GROUP; LIPID; MEMBRANE LIPID; PHOSPHATIDYLCHOLINE;

ARTICLE; CHEMICAL COMPOSITION; ELASTICITY; HYDROPHILICITY; HYDROPHOBICITY; MICROTUBULE;

EID: 1442288754     PISSN: 03667022     EISSN: None     Source Type: Journal    
DOI: 10.1246/cl.2003.1170     Document Type: Article

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32. 4 cantilever having a spring constant of 0.09 N/m was used.
33. The AFM images suggest that the rod-like assembly lies on a lipid sheet with a thickness of ca. 3.9 nm. We presume that successful AFM measurement of the rod-like assembly is partly due to the immobilization of the assembly on this sheet during scanning. The formation mechanism of the sheet remains to be clarified.
34. The apparent diameter of the assembly was much larger than those found in the TEM and SEM images. We presume that the observed increase in a diameter of the tubule stems from (i) swelling due to hydration, (ii) deformation of tubular structure by absorption onto the monolayer sheet, or (iii) deformation by pressure produced by the tip during scanning.
35. The ripple section was observed, when a set point amplitude of 2.3 V was used (Figure 3a). Currently we believe that this phenomenon is due to elasticity of the tubule.