Successful Treatment of μ-Heavy Chain Disease with Fludarabine Monophosphate: A Case Report

International Journal of Hematology

Volumn 79, Issue 2, 2004, Pages 174-177

  Yanai, Machi ^a   Maeda, Akinori ^a   Watanabe, Naoko ^a   Sugimoto, Naoshi ^a   Matsushita, Akiko ^a   Nagai, Kenichi ^a   Oida, Tatsuo ^a   Takahashi, Takayuki ^a  

^a KOBE CITY MEDICAL CENTER GENERAL HOSPITAL   (Japan)

Author keywords

Fludarabine monophosphate; Rocket immunoselection assay; Splenomegaly; Thrombocytopenia; Heavy chain disease

Indexed keywords

AZATHIOPRINE; BLEOMYCIN; CHLORAMBUCIL; CORTISONE; CYCLOPHOSPHAMIDE; FLUDARABINE PHOSPHATE; MELPHALAN; PREDNISONE; VINCRISTINE;

ADULT; AGED; ARTICLE; B LYMPHOCYTE; CASE REPORT; CLINICAL ARTICLE; CLINICAL TRIAL; FEMALE; HEAVY CHAIN DISEASE; HUMAN; LYMPHATIC LEUKEMIA; LYMPHOPROLIFERATIVE DISEASE; MALE; MU HEAVY CHAIN DISEASE; PROGNOSIS; SPLENOMEGALY; SYNTHESIS; THROMBOCYTOPENIA; TREATMENT OUTCOME; TUMOR CELL;

EID: 1442286016     PISSN: 09255710     EISSN: None     Source Type: Journal    
DOI: 10.1532/IJH97.03053     Document Type: Article

References (22)

1. Wahner-Roedler DL, Kyle RA. Heavy chain diseases. In: Wiernik PH, Canellos GP, Dulcher JP, et al, eds. Neoplastic Diseases of the Blood. 3rd ed. New York, NY: Churchill Livingstone; 1996:613-633.
2. Fermand JP, Brouet JC. Heavy-chain diseases. Hematol Oncol Clin North Am. 1999;13:1281-1294.
3. Preud'homme JL, Baumens M, Dumont G, Goujon M, Dreyfus B, Touchard G. Cast nephropathy in μ heavy chain disease. Clin Nephrol. 1997;48:118-121.
4. Okamolo Y, Matsuoka Y, Umegaki K, et al. A case of μ-chain disease [in Japanese with English abstract]. Clin Immunol. 1981;13:1055-1062.
5. Iwasaki T, Hamano T, Kobayashi K, Kakishita E. A case of μ-heavy chain disease: combined features of μ-heavy chain disease and macroglobulinemia. Int J Hematol. 1997;66:359-365.
6. Miyoshi M, Kobayashi M, Machida K, Sakurabayashi I. A case of IgA type multiple mycloma associated with free μ heavy chain in the serum. Jpn J Electrophor. 1995;39:13-18.
7. Witzens M, Egerer G, Stahl D, Werle E, Goldschmil H, Haas R. A case of μ heavy-chain disease associated with hemoglobulinemia, anemia, and a positive Coombs test. Ann Hematol. 1998;77:231-234.
8. Brouet JC, Seligmann M, Danon F, Belpomme D, Fine JM. μ-Chain disease: report of two new cases. Arch Intern Med. 1979;139:672-674.
9. Wahner-Roedler DL, Kyle RA. μ-Heavy chain disease: presentation as a benign monoclonal gammopathy. Am J Hematol. 1992;40:56-60.
10. Radl J. Light chain typing of immunoglobulins in small samples of biological material. Immunology. 1970;19:137-149.
11. Gale DSJ, Versey JMB, Hobbs JR. Rocket immunoselection for detection of heavy-chain diseases. Clin Chem. 1974;20:1292-1294.
12. Keating MJ, Kantarjian H, O'Brien S, et al. Fludarabine: a new agent with marked cytoreductive activity in untreated chronic lymphocylic leukemia. J Clin Oncol. 1991;9:44-49.
13. Chun HG, Leyland-Jones B, Cheson BD. Fludarabine phosphate: a synthetic purine antimetabolite with significant activity against lymphoid malignancies. J Clin Oncol. 1991;9:175-188.
14. Wendtner C-M, Schmitt B, Bergmann M, Rohnisch T, Buhmann R, Hallek M. New aspects on the pathogenesis, diagnostic procedures, and therapeutic management of chronic lymphocytic leukemia. Int J Hematol. 2001;73:32-38.
15. Ballard HS, Hamillon LM, Marcus AJ, Illes CH. A new variant of heavy-chain disease (μ-chain disease). N Engl J Med. 1970;282:1060-1062.
16. Lee SL, Rosner F, Ruberman W, Glasberg S. Mu-chain disease. Ann Intern Med. 1971;75:407-414.
17. Josephson AS, Nicastri A, Price E, Biro L. H Chain fragment and monoclonal IgA in a lymphoproliferative disorder. Am J Med. 1973;54:127-135.
18. Bonhomme J, Seligmann M, Mihaesco C, et al. Mu-chain disease in an African patient. Blood. 1974;43:485-492.
19. Dammacco F, Bonomo L, Franklin E. A new case of mu heavy chain disease: clinical and immunochemical studies. Blood. 1974;43:713-719.
20. Jonsson V, Videbek A, Axelsen NH, Harboe M. μ-Chain disease in a case of chronic lymphocytic leukemia and malignant histiocytoma. I: clinical aspects. Scand J Haematol. 1976;16:209-217.
21. Pruzanski W, Hasselback R, Kalz A, Parr DM. Multiple myeloma (light chain disease) with rheumatoid-like amyloid arthropathy and μ-heavy chain fragment in the serum. Am J Med. 1978;65:334-341.
22. Leach IH, Jenkins JS, Murray-Leslie CF, Powell RJ. Mu-heavy chain disease and monoclonal IgG K paraproteinaemia in systemic lupus erythematosus. Br J Rheumatol. 1987;26:460-462.