Age-related changes in the activity of antioxidant and redox enzymes in rats

Molecules and Cells

Volumn 16, Issue 3, 2003, Pages 278-284

  Kim, Hong Gyum ^a   Hong, Sung Min ^a   Kim, Su Jung ^a   Park, Hey Jung ^a   Jung, Haeng Im ^a   Lee, Yuk Young ^a   Moon, Jeong Su ^a   Lim, Hye Won ^a   Park, Eun Hee ^b   Lim, Chang Jin ^a  

^a Kangwon National University   (South Korea)

^b Sookmyung Women's University   (South Korea)

Author keywords

Aging; Antioxidant; Brain; Cellular Defense System; Liver; Rat; Redox enzyme

Indexed keywords

CATALASE; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE REDUCTASE; GLUTATHIONE SYNTHASE; GLUTATHIONE TRANSFERASE; OXIDOREDUCTASE; SUPEROXIDE DISMUTASE; THIOREDOXIN REDUCTASE; TRANSFERASE; ANTIOXIDANT; GLUTATHIONE;

AGING; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN; CELLULAR IMMUNITY; ENZYME ACTIVITY; LIVER; NONHUMAN; RAT; ANIMAL; MALE; METABOLISM; OXIDATION REDUCTION REACTION; SPRAGUE DAWLEY RAT;

ANIMALIA;

AGING; ANIMALS; ANTIOXIDANTS; BRAIN; GLUTATHIONE; GLUTATHIONE TRANSFERASE; LIVER; MALE; OXIDATION-REDUCTION; RATS; RATS, SPRAGUE-DAWLEY;

EID: 1442282910     PISSN: 10168478     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Angelucci, S., Sacchetta, P., Moio, P., Melino, S., Petruzzelli, R., Gervasi, P., and Di Ilio, C. (2000) Purification and characterization of glutathione transferase from the sea bass (Dicentrarchus labrax) liver. Arch. Biochem. Biophys. 373, 435-441.
2. Bandyopadhyay, S., Starke, D. W., Mieyal, J. J., and Gronostajski, R. M. (1998) Identification of a conserved oxidation-sensitive cysteine residue in the NFI family of DNA-binding proteins. J. Biol. Chem. 273, 392-397.
3. Decker, K., Gromer, S., Schirmer, R. H., and Müller, S. (2000) Thioredoxin reductases as a pathological factor and drug target. Eur. J. Biochem. 267, 6118-6125.
4. Bradford, M. M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-254.
5. Carlberg, I. and Mannervik, B. (1985) Glutathione reductase. Methods Enzymol. 113, 484-490.
6. Cho, Y.-W., Park, E.-H., and Lim, C.-J. (2000) Catalase, glutathione S-transferase and thioltransferase respond differently to oxidative stress in Schizosaccharomyces pombe. J. Biochem. Mol. Biol. 33, 344-348.
7. Das, K. C. and Das, C. K. (2000) Thioredoxin, a singlet oxygen quencher and hydroxyl radical scavenger: redox independent functions. Biochem. Biophys. Res. Commun. 277, 443-447.
8. DeLeve, L. and Kaplowitz, N. (1991) Glutathione metabolism and its role in hepatotoxicity. Pharmacol. Ther. 52, 287-305.
9. Flohé, L. and Günzler W. A. (1984) Assay of glutaredoxin peroxidase. Methods Enzymol. 105, 114-121.
10. Freemerman, A. J. and Powis, G. (2000) A redox-inactive thioredoxin reductase reduces growth and enhances apoptosis in WEHI7.2 cells. Biochem. Biophys. Res. Commun. 274, 136-141.
11. Gumuslu, S., Bilmen, S., Korgun, D. K., Yargicoglu, P., and Agar, A. (2001) Age-related changes in antioxidant enzyme activities and lipid peroxidation in lungs of control and sulfur dioxide exposed rats. Free Radical Res. 34, 621-627.
12. Habig, W. H., Pabst, M. J., and Jakoby, W. B. (1974) Glutathione S-transferase. The first enzymatic step in mercapturic acid formation. J. Biol. Chem. 249, 7130-7139.
13. Halliwell, B. (1987) Oxidants and human disease: some new concepts. FASEB J. 1, 358-364.
14. Hayashi, T., Ueno, Y., and Okamoto, T. (1993) Oxidoreductive regulation of nuclear factor kappa B. Involvement of a cellular reducing catalyst thioredoxin. J. Biol. Chem. 268, 11380-11388.
15. Holmgren, A. (1979) Glutathione-dependent synthesis of dioxyribonucleotides. Purification and characterization of glutaredoxin from Escherichia coli. J. Biol. Chem. 254, 3664-3671.
16. Kokoszka, J. E., Coskun, P., Esposito, L. A., and Wallace, D. C. (2001) Increased mitochondrial oxidative stress in the Sod2 (+/-) mouse results in the age-related decline of mitochondrial function culminating in increased apoptosis. Proc. Natl. Acad. Sci. USA 98, 2278-2283.
17. Lee, Y.-Y., Kim, H.-G., Jung, H.-I., Shin, Y. H., Hong, S.-M., Park, E.-H., Sa, J.-H., and Lim, C.-J. (2002) Activities of antioxidant and redox enzymes in human normal hepatic and hepatoma cell lines. Mol. Cells 14, 305-311.
18. Liu, R. and Choi, J. (2000) Age-associated decline in gamma-glutamylcysteine synthetase gene expression in rats. Free Radical Biol. Med. 28, 566-574.
19. Meister, A. (1985) Glutathione synthetase from rat kidney. Methods Enzymol. 113, 393-399.
20. Meister, A. (1988) Glutathione metabolism and its selective modification. J. Biol. Chem. 263, 17205-17208.
21. Melov, S., Ravenscroft, J., Malik, S., Gill, M. S., Walker, D. W., Clayton, P. E., Wallace, D. C., Malfroy, B., Doctrow, S. R., and Lithgow, G. J. (2000) Extension of life-span with superoxide dismutase/catalase mimetics. Science 289, 1567-1569.
22. Nakamura, H., Nakamura, K., and Yodoi, J. (1997) Redox regulation of cellular activation. Ann. Rev. Immunol. 15, 351-369.
23. Nakamura, T., Ohno, T., Hirota, K., Nishiyama, A., Nakamura, H., Wada, H., and Yodoi, J. (1999) Mouse glutaredoxin-cDNA cloning, high level expression in E. coli and its possible implication in redox regulation of the DNA binding activity in transcription factor PEBP2. Free Radic. Res. 31, 357-365.
24. Pennincks, M. (2000) A short review on the role of glutathione in the response of yeasts to nutritional, environmental, and oxidative stresses. Enzyme Microb. Technol. 26, 737-742.
25. Powis, G., Oblong, J. E., Gasdaska, P. Y., Berggren, M., Hill, S. R., and Kirkpatrick, D. L. (1994) The thioredoxin/thioredoxin reductase redox system and control of cell growth. Oncol. Res. 6, 539-544.
26. Powis, G., Mustacich, D., and Coon, A. (2000) The role of the redox protein thioredoxin in cell growth and cancer. Free Radical Biol. Med. 29, 312-322.
27. Punchard, N. A. and Kelly, F. J. (1996) in Superoxide dismutase, pp. 241-255, Free Radicals.
28. Rao, M. V., Paliyath, G., and Ormrod, D. P. (1996) Ultraviolet-B and ozone-induced biochemical changes in antioxidant enzymes of Arabidopsis thaliana. Plant Physiol. 110, 125-136.
29. Rodriguez-Manzaneque, M. T., Ros, J., Cabiscol, E., Sorribas, A., and Herrero, E. (1999) Grx5 glutaredoxin plays a central role in protection against protein oxidative damage in Saccharomyces cerevisiae. Mol. Cell. Biol. 19, 8180-8190.
30. Ross, S. J., Findlay, V. J., Malakasi, P., and Morgan, B. A. (2000) Thioredoxin peroxidase is required for the transcriptional response to oxidative stress in budding yeast. Mol. Biol. Cell 11, 2631-2642.
31. Sanz, N., Diez-Fernandez, C., Andres, D., and Cascales, M. (2002) Hepatotoxicity and aging: endogenous antioxidant systems in hepatocytes from 2-, 6-, 12-, 18- and 30-month-old rats following a necrogenic dose of thioacetamide. Biochim. Biophys. Acta 1587, 12-20.
32. Seelig, G. F. and Meister, A. (1985) Glutathione biosynthesis: γ-glutamylcysteine synthetase from rat kidney. Methods Enzymol. 113, 379-390.
33. Sies, H. and Akerboom, T. P. (1984) Glutathione disulfide (GSSG) efflux from cells and tissues. Methods Enzymol. 105, 445-451.
34. Slivka, A., Mytilineou, C., and Cohen, G. (1987) Histochemical evaluation of glutathione in brain. Brain Res. 409, 275-284.
35. Smirnova, G. V., Muzyka, N. G., Glukhovchenko, M. N., and Oktyabrsky, U. N. (2000) Effects of menadione and hydrogen peroxide on glutathione status in growing Escherichia coli. Free Radical Biol. Med. 28, 1009-1016.
36. Tamura, T. and Stadtman, T. C. (1996) A new selenoprotein from human lung adenocarcinoma cells: purification, properties, and thioredoxin activity. Proc. Natl. Acad. Sci. USA 93, 1006-1011.
37. Tsay, H. J., Wang, P., Wang, S. L., and Ku, H. H. (2000) Age-associated changes of superoxide dismutase and catalase activities in the rat brain. J. Biomed. Sci. 7, 466-474.
38. Yokomizo, A., Kohno, K., Wada, M., Ono, M., Morrow, C. S., Cowan, K. H., and Kuwano, M. (1995) Markedly decreased expression of glutathione S-transferase π gene in human cancer cell lines resistant to buthionine sulfoximine, an inhibitor of cellular glutathione synthesis. J. Biol. Chem. 270, 19451-19453.
39. Zimniak, L., Awasthi, S., Strivastava, S. K., and Zimniak, P. (1997) Increased resistance to oxidative stress in transfected cultured cells overexpression glutathione S-transferase mGSTA4-40. Toxicol. Appl. Pharmacol. 143, 221-229.