Production and export of metabolites from liver and heart mitochondria and anaplerosis

Molecular and Cellular Biochemistry

Volumn 258, Issue 1-2, 2004, Pages 201-210

  MacDonald, Michael J ^a,b  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b 3459 Medical Science Center ^*  (United States)

Author keywords

Anaplerosis; Citric acid cycle; Export of metabolites from; Liver and heart mitochondria; Mitochondria; Pancreatic islet mitochondria; Pyruvate; Pyruvate carboxylase; Succinate

Indexed keywords

2 OXOGLUTARIC ACID; ASPARTIC ACID; CITRIC ACID; ISOCITRIC ACID; MALIC ACID; PYRUVATE CARBOXYLASE; PYRUVIC ACID; SUCCINIC ACID;

AMINO ACID TRANSPORT; ANIMAL TISSUE; ARTICLE; CELL METABOLISM; CITRIC ACID CYCLE; CONTROLLED STUDY; HEART MITOCHONDRION; HEART MUSCLE METABOLISM; LIVER FUNCTION; LIVER METABOLISM; LIVER MITOCHONDRION; MALE; NONHUMAN; PANCREAS ISLET CELL; RAT;

AMINO ACIDS; ANIMALS; CARBOXYLIC ACIDS; CITRIC ACID CYCLE; ISLETS OF LANGERHANS; MALE; MITOCHONDRIA, HEART; MITOCHONDRIA, LIVER; PYRUVATE CARBOXYLASE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 1442281869     PISSN: 03008177     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:MCBI.0000012856.31929.91     Document Type: Article

References (32)

1. MacDonald MJ: Feasibility of a mitochondrial pyruvate malate shuttle in pancreatic islets. J Biol Chem 270: 20051-20058, 1995
2. Owen OE, Kalhan SC, Hanson RW: The key role of anaplerosis and cataplerosis for citric acid cycle function. J Biol Chem 277: 30409-30412, 2002
3. Walter P, Paetkau V, Lardy HA: Paths of carbon in gluconeogenesis and lipogenesis. 3. The role and regulation of mitochondrial processes involved in supplying precursors of phosphoenolpyruvate. J Biol Chem 241: 2523-2532, 1966
4. Bobyleva V, Kneer N, Bellei M, Battelli D, Lardy HA: Concerning the mechanism of increased thermogenesis in rats treated with dehydroepiandrosterone. J Bioenergetics Biomembr 25: 313-332, 1993
5. Lardy HA, Paetkau V, Walter P: Paths of carbon in gluconeogenesis and lipogenesis: the role of mitochondria in supplying precursors of phosphoenolpyruvate. Proc Natl Acad Sci USA 53: 1410-1415, 1965
6. Wiese TJ, Wuensch SA, Ray PD: Synthesis of citrate from phosphoenolpyruvate and acetylcarnitine by mitochondria from rabbit, pigeon and rat liver: Implications for lipogenesis. Comp Biochem Physiol 114B: 417-422, 1996
7. MacDonald MJ, Chang C-M: Do pancreatic islets contain significant amounts of phosphoenol-pyruvate carboxykinase or ferroactivator activity? Diabetes 34: 246-250, 1985
8. MacDonald, MJ, McKenzie DI, Walker TM, Kaysen JH: Lack of glyconcogenesis in pancreatic islets: Expression of gluconeogenic enzyme genes in islets. Hormone Metab Res 24: 158-160, 1992
9. MacDonald MJ: Metabolism of the insulin secretagogue methyl succinate by pancreatic islets. Arch Biochem Biophys 300: 201-205, 1993
10. MacDonald MJ: Estimates of glycolysis, pyruvate (De)carboxylation, pentose phosphate pathway and methyl succinate metabolism in incapacitated pancreatic islets. Arch Biochem Biophys 305: 205-214, 1993
11. Khan A, Ling ZC, Landau BR: Quantifying the carboxylation of pyruvate in pancreatic islets. J Biol Chem 271: 2539-2542, 1996
12. 13C NMR isotopomer analysis reveals a connection between pyruvate cycling and glucose-stimulated insulin secretion (GSIS). Proc Natl Acad Sci 99: 2708-2713, 2002
13. MacDonald MJ: The export of metabolites from mitochondria and anaplerosis in insulin secretion. Biochim Biophys Acta 1619: 77-88, 2003
14. Davis EJ, Spydevoid O, Bremer J: Pyruvate carboxylase and propionyl-CoA carboxylase as anaplerotic enzymes in skeletal muscle mitochondria. Eur J Biochem 110: 255-262, 1980
15. Henslee JG, Srere PA: Resolution of rat mitochondrial matrix proteins by two-dimensional polyacrylamide gel electrophoresis. J Biol Chem 254: 5488-5497, 1979
16. MacDonald MJ: Evidence for the malate-asparate shuttle in pancreatic islets. Arch Biochem Biophys 213: 643-649, 1982
17. Johnson D, Lardy HA: Isolation of liver or kidney mitochondria. Meth Enzymol 10: 94-96, 1967
18. Passonneau JV, Lowry OH: In: Enzymatic Analysis, A Practical Guide. Humana Press, Totowa, NJ, 1993
19. Bergmeyer HU, Bergmeyer J, Grassl M: In: Methods of Enzymatic Analysis, 3rd edn, vol. 7; Metabolites 2: VCH, Verlagsgesellshaft, Weinheim, FRG, 1984
20. MacDonald MJ, Neufelt N, Park B, Berger M, Ruderman NB: Alanine metabolism and glucoenogenesis in the rat. Am J Physiol 231: 619-626, 1976
21. MacDonald MJ, Huang MT, Lardy HA: Hyperglycemic activity and metabolic effects of 3-aminopicolinic acid. Biochem J 176: 495-504, 1978
22. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ: Protein measurement with the Folin phenol reagent. J Biol Chem 193: 265-275, 1951
23. MacDonald MJ: Differences between mouse and rat pancreatic islets: Succinate responsiveness, malic enzyme and anaplerosis. Am J Physiol Endo Metab 283: E302-E310, 2002
24. Atkinson DE: In: J.M. Lowenstein (ed). Citric Acid Cycle: Control and Compartmentation. Marcel Dekker, New York, 1969, pp 137-162
25. MacDonald MJ, Al-Masri H, Jumelle-Laclau M, Cruz M: Oscillations in activities of enzymes in pancreatic islet subcellular fractions induced by physiological concentrations of effectors. Diabetes 46: 1996-2001, 1997
26. Fahien LA, MacDonald MJ, Kmiotek EH, Mertz RJ, Fahien CM: Regulation of insulin release by factors that also modify glutamate dehydrogenase. J Biol Chem 263: 13610-13614, 1988
27. Gylfe E: Comparison of the effects of leucines, non-metabolizable leucine analogues and other insulin secretagogues on the activity of glutamate dehydrogenase. Acta Diabetol Lat 13: 20-24, 1976
28. Malaisse-Lagae F, Sener A, Garcia-Morales P, Valverde I, Malaisse WJ: The stimulus-secretion coupling of amino acid-induced insulin release. Influence of a nonmetabolized analog of leucine on the metabolism of glutamine in pancreatic islets. J Biol Chem 257: 3754-3758, 1982
29. Lenzen S, Schmidt W, Panten U: Transamination of neutral amino acids and 2-keto acids in pancreatic B-cell mitochondria. J Biol Chem 260: 12629-12634, 1985
30. MacDonald MJ, Fahien LA: Glutamate is not a messenger in insulin secretion. J Biol Chem 275: 34025-34027, 2000
31. Fahien LA, Teller JK: Glutamate-malate metabolism in liver mitochondria. A model constructed on the basis of mitochondrial levels of enzymes, specificity, dissociation constants, and stoichiometry of hetero-enzyme complexes. J Biol Chem 267: 10411-10422, 1992
32. Williamson DH, Lund P, Krebs HA: The redox state of free nicotinamide-adenine dinucleotide in the cytoplasm and mitochondria of rat liver. Biochem J 103: 514-527, 1967