Changes of free cholesterol and neutral lipids after transient focal brain ischemia in rats

Acta Neurochirurgica, Supplementum

Volumn , Issue 86, 2003, Pages 177-180

  Kamada, H ^a   Sato, K ^a   Iwai, M ^a   Ohta, K ^a   Nagano, I ^a   Shoji, M ^a   Abe, K ^a  

^a OKAYAMA UNIVERSITY   (Japan)

Author keywords

Brain ischemia; Cholesterol; Lipid; Rat

Indexed keywords

CHOLESTEROL; ECTODYSPLASIN A; FILIPIN; FLUORESCENT DYE; GLIAL FIBRILLARY ACIDIC PROTEIN; MEMBRANE PROTEIN; MICROTUBULE ASSOCIATED PROTEIN; NILE RED; OXAZINE DERIVATIVE;

ANIMAL; ARTICLE; BRAIN; LIPID METABOLISM; MALE; METABOLISM; RAT; STAINING; TIME; TRANSIENT ISCHEMIC ATTACK; WISTAR RAT;

ANIMALS; BRAIN; CHOLESTEROL; ECTODYSPLASINS; FILIPIN; FLUORESCENT DYES; GLIAL FIBRILLARY ACIDIC PROTEIN; ISCHEMIC ATTACK, TRANSIENT; LIPID METABOLISM; MALE; MEMBRANE PROTEINS; MICROTUBULE-ASSOCIATED PROTEINS; OXAZINES; RATS; RATS, WISTAR; STAINING AND LABELING; TIME FACTORS;

EID: 1442279296     PISSN: 00651419     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-7091-0651-8_38     Document Type: Article

References (14)

1. Brierley JB, Brown AW (1982) The origin of lipid phagocytes in the central nervous system: the intrinsic microglia. J Comp Neurol 211: 397-406
2. Chait A, Heinccke J (1994) Lipoprotein modification cellular mechanisms. Curr Opin Lipidol 5: 365-370
3. Dietschy JM, Truly SD (2001) Cholesterol metabolism in the brain. Curr Opin Lipidol 12: 105-112
4. Fowler SD, Greenspan P (1985) Application of Nile Red, a fluorescent hydrophobic probe, for the detection of neutral lipid deposits in tissue section: comparison with oil red O. J Histo-chem Cyotchem 33: 833-836
5. Jurevics H, Bouldin TW, Toews AD, Morell P (1998) Regenerating sciatic nerve does not utilize circulating cholesterol. Neurochem Res 23:401-406
6. Kato H, Kogure K, Liu XH, Araki T, Itoyama Y (1996) Progressive expression of immunomolecules on activated microglia and invading leukocytes following focal cerebral ischemia in the rat. Brain Res 734: 203-212
7. Kitagawa H, Sasaki C, Sakai K, Mori A, Mitsumoto Y, Mori T, Fukuchi Y, Setoguchi Y, Abe K (1999) Adenovirus-mediated gene transfer of glial cell line-derived neurotrophic factor prevents ischemic brain injury after transient middle cerebral artery occlusion in rats. J Cereb Blood Flow Metab 19: 1364-1344
8. Kitagawa K, Matsumoto M, Kuwabara K, Ohtsuki T, Hori M (2001) Delayed, but marked, expression of apolipoprotein E is involved in tissue clearance after cerebral infarction. J Cereb Blood Flow Metab 21:1199-1207
9. Mahley RW (1988) Apolipoprotein E: Cholesterol transport protein with expanding role in cell biology. Science 240: 622- 630
10. Mauch DH, Nagler K, Schumacher S, Goritz C, Muller EC, Otto A, Pfrieger FW (2001) CNS synaptogenesis promoted by glia-derived cholesterol. Science 294: 1354-1357
11. Mori T, Paris D, Town T, Rojiani AM, Sparks L, Delledonne A, Crawford F, Abdullah LI, Humphrey JA, Dickson DW, Mullan MJ (2001) Cholesterol accumulates in senile plaque of Alzheimer disease patients and in transgenic APPsw mice. J Neuropathol E.xp Neurol 60: 778-785
12. Nishikawa K, Aral H, Inoue K (1990) Scavenger receptor- mediated uptake and metabolism of lipid vesicles containing acidic phospholipids by mouse peritoneal macrophages. J Biol Chem 265: 5226-5231
13. Poiricr J, Baccichet A, Dea D, Gauthier S (1993) Cholesterol synthesis and lipoprotein reuptake during synaptic remodeling in hippocampus in adult rats. Neuroscience 55: 81-90
14. Sun GY, MacQuarrie RA (1989) Dcacylation-reacylation of arachidonoyi groups in cerebral phospholipids. Ann NY Acad Sci 559: 37-55