Xanthine nucleotide-specific G-protein α-subunits: A novel approach for the analysis of G-protein-mediated signal transduction

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 369, Issue 2, 2004, Pages 141-150

  Gille, Andreas ^a   Seifert, Roland ^a  

^a UNIVERSITY OF KANSAS   (United States)

Author keywords

D N mutation (Asp Asn mutation); Guanine nucleotides; Heterotrimeric GTP binding protein (G protein); Q L mutation (Gln Leu mutation); Small GTP binding protein; Xanthine nucleotides

Indexed keywords

ASPARTIC ACID; GUANINE; GUANINE NUCLEOTIDE BINDING PROTEIN; NUCLEOTIDE DERIVATIVE; PROTEIN SUBUNIT; UNCLASSIFIED DRUG; XANTHINE; XANTHINE DERIVATIVE; XANTHOSINE; XANTHOSINE 5' (GAMMA BETA IMIDO)TRIPHOSPHATE; XANTHOSINE 5' (GAMMA THIO)TRIPHOSPHATE;

ALPHA CHAIN; AMINO ACID SEQUENCE; ANALYTIC METHOD; EUKARYOTIC CELL; GENE MUTATION; NUCLEOTIDE SEQUENCE; PROKARYOSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN STRUCTURE; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; GTP-BINDING PROTEIN ALPHA SUBUNITS; GTP-BINDING PROTEINS; MUTATION; PURINE NUCLEOTIDES; SIGNAL TRANSDUCTION; XANTHINES;

EID: 1442277672     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-003-0844-y     Document Type: Review

References (60)

1. Barbieri MA, Hoffenberg S, Roberts R, Mukhopadhyay A, Pomrehn A, Dickey BF, Stahl PD (1998) Evidence for a symmetrical requirement for Rab5-GTP in in vitro endosome-endosome fusion. J Biol Chem 273:25850-25855
2. Bartels C, Urlaub H, Luhrmann R, Fabrizio P (2003) Mutagenesis suggests several roles of Snul 14p in pre-mRNA splicing. J Biol Chem 278:28324-28334
3. Birnbaumer L, Abramowitz J, Brown AM (1990) Receptor-effector coupling by G proteins. Biochim Biophys Acta 1031:163-224
4. Bockaert J, Pin JP (1999) Molecular tinkering of G protein-coupled receptors: an evolutionary success. EMBO J 18:1723-1729
5. iα•GppNHp, autoinhibition in a Gα protein-substrate complex. J Biol Chem 274:16669-16672
6. Cornell SR, Trieber CA, Dinos GP, Einfeldt E, Taylor DE, Nierhaus KH (2003) Mechanism of Tet(O)-mediated tetracycline resistance. EMBO J 22:945-953
7. o in reconstituted phospholipid vesicles. J Biol Chem 264:3909-3915
8. Freissmuth M, Waldhoer M, Bofill-Cardona E, Nanoff C (1999) G protein antagonists. Trends Pharmacol Sci 20:237-245
9. Fulga TA, Sinning I, Dobberstein B, Pool MR (2001) SRβ coordinates signal sequence release from SRP with ribosome binding to the translocon. EMBO J 20:2338-2347
10. Gilchrist A, Vanhauwe JF, Li A, Thomas TO, Voyno-Yasenetskaya T, Hamm HE (2001) Gα minigenes expressing C-terminal peptides serve as specific inhibitors of thrombin-mediated endothelial activation. J Biol Chem 276:25672-25679
11. Gille A, Seifert R (2003a) 2′(3′)-O-(N-methylanthraniloyl)- substituted GTP analogs: a novel class of potent competitive adenylyl cyclase inhibitors. J Biol Chem 278:12672-12679
12. sα, proteins in Sf9 insect cells: limitations in comparison with fusion proteins. Biochim Biophys Acta 1613:101-114
13. s proteins. J Biol Chem 277: 34434-34442
14. s proteins. J Biol Chem 278:7822-7828
15. Gilman AG (1987) G proteins: transducers of receptor-generated signals. Annu Rev Biochem 56:615-649
16. Goody RS, Eckstein F, Schirmer RH (1972) The enzymatic synthesis of thiophosphate analog of nucleotides. Biochim Biophys Acta 276:155-161
17. sα. J Biol Chem 264:15475-15482
18. sα in Escherichia coli. Purification and properties of two forms of the protein. J Biol Chem 264:409-418
19. Hildebrandt JD (1997) Role of subunit diversity in signaling by heterotrimeric G proteins. Biochem Pharmacol 54:325-339
20. Hoffenberg S, Nikolova L, Pan JY, Daniel DS, Wessling-Resnick M, Knoll BJ, Dickey BF (1995) Functional and structural interactions of the Rab5 D136N mutant with xanthine nucleotides. Biochem Biophys Res Commun 215:241-249
21. Humphrey W, Dahlke A, Schulten K (1996) VMD - visual molecular dynamics. J Mol Graphics 14:33-38
22. Hwang YW, Miller DL (1987) A mutation that alters the nucleotide specificity of elongation factor Tu, a GTP regulatory protein. J Biol Chem 262:13081-13085
23. Jameson DM, Eccleston JF (1997) Fluorescent nucleotide analogs: synthesis and applications. Methods Enzymol 278:363-390
24. Jones AT, Mills IG, Scheidig AJ, Alexandrov K, Clague MJ (1998) Inhibition of endosome fusion by wortmannin persists in the presence of activated Rab5. Mol Biol Cell 9:323-332
25. Jones S, Litt RJ, Richardson CJ, Segev N (1995) Requirement of nucleotide exchange factor for Ypt1 GTPase mediated protein transport. J Cell Biol 130:1051-1061
26. Kalidas S, Smith DP (2002) Novel genomic cDNA hybrids produce effective RNA interference in adult drosophila. Neuron 33:177-184
27. 333 with Asn by site-directed mutagenesis changes the substrate specificity of Escherichia coli adenylosuccinate synthetase from guanosine 5′-triphosphate to xanthosine 5′-triphosphate. J Biol Chem 269:24046-24049
28. Kelleher DJ, Dudycz LW, Wright GE, Johnson GL (1986) Ability of guanine nucleotide derivatives to bind and activate bovine transducin. Mol Pharmacol 30:603-608
29. Kleuss C, Hescheler J, Ewel C, Rosenthal W, Schultz G, Wittig B (1991) Assignment of G-protein subtypes to specific receptors inducing inhibition of calcium currents. Nature 353:4348
30. Lee JH, Pestova TV, Shin BS, Cao C, Choi SK, Dever TE (2002) Initiation factor eIF5B catalyzes second GTP-dependent step in eukaryotic translation initiation. Proc Natl Acad Sci USA 99: 16689-16694
31. Legate KR, Falcone D, Andrews DW (2000) Nucleotide-dependent binding of the GTPase domain of the signal recognition particle receptor β-subunit to the α-subunit. J Biol Chem 275:27439-27446
32. αolf with GTP, ITP, and XTP. Biochem Pharmacol 64: 583-593
33. sαshort: consequences for receptor-coupling and adenylyl cyclase activation. J Neurochem 78:325-338
34. Maier T, Lottspeich F, Böck A (1995) GTP hydrolysis by HypB is essential for nickel insertion into hydrogenases of Escherichia coli. Eur J Biochem 230:133-138
35. Masters SB, Miller RT, Chi MH, Chang FH, Beiderman B, Lopez NG, Bourne HR (1989) Mutations in the GTP-binding site of Gsα alter stimulation of adenylyl cyclase. J Biol Chem 264: 15467-15474
36. i2. Biochem J 267:391-398
37. Offermanns S (2001) In vivo functions of heterotrimeric G-proteins: studies in Gα-deficient mice. Oncogene 20:1635-1642
38. p. Biochem J 284:327-332
39. Pieper U, Schweitzer T, Groll DH, Gast FU, Pingoud A (1999) The GTP-binding domain of McrB: more than just a variation on a common theme? J Mol Biol 292:547-556
40. Powers T, Walter P (1995) Reciprocal stimulation of GTP hydrolysis by two directly interacting GTPases. Science 269:1422-1424
41. Rens-Domiano S, Hamm HE (1995) Structural and functional relationships of heterotrimeric G-proteins. FASEB J 9:1059-1066
42. Rybin V, Ullrich O, Rubino M, Alexandrov K, Simon I, Seabra C, Goody R, Zerial M (1996) GTPase activity of Rab5 acts as a timer for endocytic membrane fusion. Nature 383:266-269
43. ras from guanosine to xanthosine nucleotides. Oncogene 12:87-96
44. sα splice variants. J Pharmacol Exp Ther 298:840-847
45. Seifert R, Wenzel-Seifert K (2002) Constitutive activity of G-protein-coupled receptors: cause of disease and common property of wild-type receptors. Naunyn-Schmiedebergs Arch Pharmacol 366:381-416
46. sα has properties of a constitutively active receptor. J Biol Chem 273:5109-5116
47. s interactions: evidence for multiple receptor conformations. Mol Pharmacol 56:348-358
48. Sprang SR (1997) G protein mechanisms: insights from structural analysis. Annu Rev Biochem 66:639-678
49. Sunahara RK, Dessauer CW, Whisnant RE, Kleuss C, Gilman AG (1997) Interaction of Gsα with the cytosolic domains of mammalian adenylyl cyclase. J Biol Chem 272:22265-22271
50. Sweet DJ, Gerace L (1996) A GTPase distinct from Ran is involved in nuclear protein import. J Cell Biol 133:971-983
51. 32P]GMP. Biochim Biophys Acta 562:11-31
52. Weijland A, Parmeggiani A (1994) Why do two EF-Tu molecules act in the elongation cycle of protein biosynthesis? Trends Biochem Sci 19:188-193
53. Weis K, Dingwall C, Lamond AI (1996) Characterization of the nuclear protein import mechanism using Ran mutants with altered nucleotide binding specificities. EMBO J 15:7120-7128
54. q-proteins. Mol Pharmacol 58:954-966
55. Yamanaka G, Eckstein F, Stryer L (1986) Interaction of retinal transducin with guanosine triphosphate analogues: specificity of the γ-phosphate binding region. Biochemistry 25:6149-6153
56. Yanachkov I, Pan JY, Wessling-Resnick M, Wright GE (1997) Synthesis and effect of nonhydrolyzable xanthosine triphosphate derivatives on prenylation of Rab5D136N. Mol Pharmacol 51:47-51
57. oα mutant with G protein-coupled receptors. J Biol Chem 273:30183-30188
58. Yu B, Slepak VZ, Simon MI (1997) Characterization of a Goα mutant that binds xanthine nucleotides. J Biol Chem 272: 18015-18019
59. 16. J Biol Chem 275:71-76
60. Zhong JM, Chen-Hwang MC, Hwang YW (1995) Switching nucleotide specificity of Ha-Ras p21 by a single amino acid substitution at aspartate 119. J Biol Chem 270:10002-10007