Methylmercury stimulates arachidonic acid release and cytosolic phospholipase A2 expression in primary neuronal cultures

NeuroToxicology

Volumn 25, Issue 3, 2004, Pages 399-406

  Shanker, Gouri ^a   Hampson, Robert E ^a   Aschner, Michael ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

Arachidonic acid; Cytosolic phospholipase A2; Hippocampal neurons; In vitro; Methylmercury; Neurotoxicity

Indexed keywords

ARACHIDONIC ACID; ARACHIDONYL TRIFLUOROMETHYL KETONE; METHYLMERCURY; PHOSPHOLIPASE A2;

ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; ASTROCYTE; CONTROLLED STUDY; DRUG SPECIFICITY; ENZYME ACTIVATION; HIPPOCAMPUS; HYDROLYSIS; NERVE CELL; NERVE CELL CULTURE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; WESTERN BLOTTING;

ANIMALS; ARACHIDONIC ACID; CELLS, CULTURED; CYTOSOL; HIPPOCAMPUS; METHYLMERCURY COMPOUNDS; NEURONS; PHOSPHOLIPASES A; RATS;

EID: 1442277109     PISSN: 0161813X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuro.2003.08.008     Document Type: Article

References (63)

1. Ali S.F., LeBel C.P., Bondy S.C. Reactive oxygen species formation as a biomarker of methylmercury and trimethyltin neurotoxicity. Neurotoxicology. 13:1992;637-648.
2. 3H -D-aspartate transporter in cultured astrocytes is reversed by the antioxidant catalase Brain Res. 902:2001;92-100.
3. Allen J.W., Shanker G., Aschner M. Methylmercury inhibits the in vitro uptake of the glutathione precursor, cystine, in astrocytes but not in neurons. Brain Res. 894:2001;131-140.
4. 2 mediates ischemic injury in the hippocampus: a regional difference of neuronal vulnerability. Eur. J. Neurosci. 13:2001;2319-2323.
5. Aschner M. Methylmercury in astrocytes-what possible significance ? Neurotoxicology. 17:1996;93-106.
6. Aschner M., Yao C.P., Allen J.W., Tan K.H. Methylmercury alters glutamate transport in astrocytes. Neurochem. Int. 37:2000;199-206.
7. Beal M.F., Hyman B.T., Koroshetz W.J. Do defects in mitochondrial energy metabolism underlie the pathology of neurodegenerative diseases. Trends Neurosci. 16:1993;125-131.
8. 2 and signal transduction. J. Am. Soc. Nephrol. 3:1992;128-150.
9. 2), a study in gerbil brain. Characterization of cytosolic and membrane associated forms and effects of ischemia and reperfusion on enzyme activity. J. Lipid Mediat. 6:1993;457-471.
10. 2 and methylmercury in astrocytes: selectivity and reversibility. J. Neurochem. 53:1989;1228-1233.
11. + channels in autonomic neurons: activation by an endogenous source of free fatty acids. J. Neurochem. 74:2000;1026-1033.
12. Charleston J.S., Bolender R.P., Mottet N.K., Body R.L., Vahter M.E., Burbacher T.M. Increases in the number of reactive glia in the visual cortex of Macaca fascicularis following sub-clinical long term methylmercury exposure. Toxicol. Appl. Pharmacol. 129:1994;196-206.
13. Charleston J.S., Body R.L., Bolender R.P., Mottet N.K., Vahter T.M., Burbacher T.M. Changes in the number of astrocytes and microglia in the thalamus of the monkey Macaca fascicularis following long-term sub-clinical methylmercury exposure. NeuroToxicology. 17:1996;127-138.
14. Colom L.V., Diaz M.E., Beers D.R., Neely A., Xie W.J., Appel S.H. Role of potassium channels in amyloid-induced cell death. J. Neurochem. 70:1998;1925-1934.
15. 2s in cell injury and death. J. Pharmacol. Exp. Ther. 294:2000;793-799.
16. Dave V., Mullaney K.J., Goderie S., Kimelberg H.K., Aschner M. Astrocytes as mediators of methylmercury neurotoxicity: effects on D-aspartate and serotonin uptake. Dev. Neurosci. 16:1994;222-231.
17. Deadwyler S.A., Hampson R.E., Bennett B.A., Edwards T.A., Mu J., Pacheco M.A., Ward S.J., Childers S.R. Cannabinoids modulate potassium current in cultured hippocampal neurons. Receptors Channels. 1:1993;121-134.
18. Fonteh A.N. Differential effects of arachidonyl trifluoromethyl ketone on arachidonic acid release and lipid mediator biosynthesis by human neutrophils. Evidence for different arachidonate pools. Eur. J. Biochem. 269:2002;3760-3770.
19. Garman R.H., Weiss B., Evans H.L. Alkylmercurial encephalopathy in the monkey: a histopathologic and autoradiographic study. Acta. Neuropathol. (Berlin). 32:1975;61-74.
20. 2+ pathway blockers differentially protect against methylmercury and mercuric chloride neurotoxicity. J. Neurosci. Res. 66:2001;135-145.
21. Heales S.J., Bolanos J.P., Stewart V.C., Brookes P.S., Land J.M., Clark J.B. Nitric oxide mitochondria and neurological disease. Biochim. Biophys. Acta. 1410:1999;215-228.
22. 2 activity and gene expression are stimulated by tumor necrosis factor: dexamethasone blocks the induced synthesis. Proc. Natl. Acad. Sci. U.S.A. 90:1993;4475-4479.
23. Kaever V., Firla U., Resch K. Sulfhydryl reagents as model substances for eicosanoid research. Eicosanoids. 1:1988;49-57.
24. 2 in brain cortical cultures. Biochem. J. 310:1995;83-90.
25. 2 messenger RNA mainly in neurons in the rat brain. Neuroscience. 92:1999;1061-1077.
26. 2 in the cytotoxic effects of oxalate in cultured renal epithelial cells. Kidney Int. 56:1999;1432-1441.
27. 4. Nature. 227:1970;680-685.
28. 2 does not participate in muscarinic receptor-mediated signaling in neurons. Brain Res. 809:1998;18-30.
29. LeBel C.P., Ali S.F., Bondy S.C. Deferoxamine inhibits methylmercury-induced increases in reactive oxygen species formation in rat brain. Toxicol. Appl. Pharmacol. 112:1992;161-165.
30. Lukiw W.J., Bazan N.G. Neuro-inflammatory signaling Upregulation in Alzheimer's disease. Neurochem. Res. 25:2000;1173-1184.
31. Malis C.D., Bonventre J.V. Mechanism of calcium potentiation of oxygen free radical injury to renal mitochondria A model for post-ischemic and toxic mitochondrial damage. J. Biol. Chem. 261:1986;14201-14208.
32. 2+ entry in rat cerebellar granule cells following in vitro exposure to methylmercury. Toxicol. Appl. Pharmacol. 147:1997;319-330.
33. 2+ as a probable contributor to decreased viability in cerebellar granule cells following acute exposure to mercury. Toxicol. Appl. Pharmacol. 150:1998;98-105.
34. Matsumura K., Cao C., Watanabe Y.u., Watanabe Y. Prostaglandin system in the brain: sites of biosynthesis and sites of action under normal and hyperthermic states. Prog. Brain Res. 115:1998;275-295.
35. Miller B., Sarantis M., Traynelis S.F., Attwell D. Potentiation of NMDA receptor currents by arachidonic acid. Nature. 355:1992;722-725.
36. Mullaney K.J., Fehm M.N., Vitarella D., Wagoner D.E. Jr., Aschner M. The role of -SH groups in methylmercuric chloride induced D-aspartate and rubidium release from rat primary astrocyte cultures. Brain Res. 641:1994;1-9.
37. Mundy W.R., Freudenrich T.M. Sensitivity of immature neurons in culture to metal-induced changes in reactive oxygen species and intracellular free calcium. Neurotoxicology. 21:2000;1135-1144.
38. 2. Biochem. Pharmacol. 62:2001;119-128.
39. Okuda S., Saito H., Katsuki H. Arachidonic acid: toxic and trophic effects on cultured hippocampal neurons. Neuroscience. 63:1994;691-699.
40. Ordway R.W., Singer J.J., Walsh J.V. Jr. Direct regulation of ion-channels by fatty acids. Trends Neurosci. 14:1991;96-100.
41. Park S.T., Lim K.T., Chung Y.T., Kim S.U. Methylmercury-induced neurotoxicity in cerebral neuron culture is blocked by antioxidants and NMDA receptor antagonists. Neurotoxicology. 17:1996;37-46.
42. Samanta S., Perkinton M.S., Morgan M., Williams R.J. Hydrogen peroxide enhances signal responsive arachidonic acid release from neurons: role of mitogen-activated protein kinase. J. Neurochem. 70:1998;2082-2090.
43. Sanfeliu C., Sebastia J., Kim S.U. Methylmercury neurotoxicity in cultures of human neurons, astrocytes, neuroblastoma cells. Neurotoxicology. 22:2001;317-327.
44. Sapirstein A., Bonventre J.V. Phospholipase A2 in ischemic and toxic brain injury. Neurochem. Res. 25:2000;745-753.
45. Sarafian T.A. Methylmercury-induced generation of free radicals: biological implications. Metal Ions Biol. Syst. 36:1999;415-444.
46. Sarafian T.A., Vartavarian L., Kane D.J., Bredeson D.E., Verity M.A. Bcl-2 expression decreases methylmercury-induced free radical generation and cell killing in a neural cell line. Toxicol. Lett. 74:1994;149-155.
47. 2. J. Biol. Chem. 270:1995;30749-30754.
48. 2 activity and gene expression in rat glomerular mesengial cells. Kidney Int. 46:1994;1644-1652.
49. Shanker G., Aschner M. Identification and characterization of uptake systems for cystine and cysteine in cultured astrocytes and neurons: evidence for methylmercury-targeted disruption of astrocytic transport. J. Neurosci. Res. 66:2001;998-1002.
50. Shanker G., Aschner M. Methylmercury-induced reactive oxygen species formation in neonatal cerebral astrocytic cultures is attenuated by antioxidants. Mol. Brain Res. 110:2003;85-91.
51. Shanker G., Allen J.W., Mutkus L.A., Aschner M. Methylmercury inhibits cysteine uptake in cultured primary astrocytes, but not in neurons. Brain Res. 914:2001;159-165.
52. 2 expression in primary cultures of neonatal astrocytes. Mol. Brain Res. 106:2002;1-11.
53. Shimizu T., Wolfe L.-S. Arachidonic acid cascade and signal transduction. J. Neurochem. 55:1990;1-15.
54. Sorg O., Schilter B., Honnegger P., Monnet-Tschudi F. Increased vulnerability of neuron and glial cells to low concentrations of methylmercury in a prooxidant situation. Acta Neuropathol. (Berl.). 96:1998;621-627.
55. 2) is expressed in human astrocytes. Brain Res. 637:1994;97-105.
56. Stone R., Stewart V.C., Hurst R.D., Clark J.B., Heales S.J. Astrocyte nitric oxide causes neuronal mitochondrial damage, but antioxidant release limits neuronal cell death. Ann. N.Y. Acad. Sci. 893:1999;400-403.
57. 2. Biochemistry. 32:1993;5935-5940.
58. 2 stimulation by methylmercury in neuron culture. J. Neurochem. 62:1994;705-714.
59. 2 in immortalized astrocytes (DITNC) revealed new properties of the calcium ionophore, A23187. Neurochem. Res. 24:1999;1285-1291.
60. Yamashita T., Ando Y., Sakashita N., Hirayama K., Tanaka Y., Tashima K., Uchino M., Ando M. Role of nitric oxide in the cerebellar degeneration during methylmercury intoxication. Biochim. Biophys. Acta. 1334:1997;303-311.
61. Yee S., Choi B.H. Oxidative stress in neurotoxic effects of methylmercury poisoning. Neurotoxicology. 17:1996;17-26.
62. + current in ceramide-induced caspase activation and apoptosis in cultured cortical neurons. J. Neurochem. 73:1999;933-941.
63. 2 isoforms in rat striatal astrocytes. Neurosci. Lett. 247:1998;83-86.