Hormesis - Basic, generalizable, central to toxicology and a method to improve the risk-assessment process

International Journal of Occupational and Environmental Health

Volumn 10, Issue 4, 2004, Pages 466-467

  Calabrese, Edward J ^a  

^a UNIVERSITY OF MASSACHUSETTS   (United States)

Author keywords

Biphasic; Hormesis; j shaped; Low doses; Risk assessment; Stimulatory; U shaped

Indexed keywords

CONFUSION; DECISION MAKING; DOSE RESPONSE; HORMESIS; PRIORITY JOURNAL; PUBLIC HEALTH; REVIEW; RISK ASSESSMENT; RISK MANAGEMENT; TOXICOLOGY;

EID: 14344266201     PISSN: 10773525     EISSN: None     Source Type: Journal    
DOI: 10.1179/oeh.2004.10.4.466     Document Type: Review

References (12)

1. Axelrod D, Burns K, Davis D, Von Larebeke N. "Hormesis" - an inappropriate extrapolation from the specific to the universal. Int J Occup Environ Health. 2004;10:335-9.
2. Calabrese EJ, Baldwin LA. Defining hormesis. Hum Exper Toxicol. 2002;21:91-7.
3. Chapman PM. Defining hormesis: comments on Calabrese and Baldwin. Hum Exper Toxicol. 2002;21:99-101.
4. Calabrese EJ. Hormesis:form marginalization to mainstream. A caseform hormesis as the default dose-response model in risk assessment. Toxicol Appl Pharmacol. 2004;197:125-36.
5. Calabrese EJ, Baldwin LA. The frequency of U-shaped dose-responses in the toxicological literature. Toxicol Sci. 2001;62:330-8.
6. Calabrese EJ, Baldwin LA. The hormetic dose response model is more common than the threshold model in toxicology. Toxicol Sci. 2003;71:246-50.
7. Calabrese EJ, Baldwin LA. Hormesis and high risk groups. Reg. Toxicol Pharmacol. 2002;35:414-28.
8. Calabrese EJ, Blain R. The hormesis database: an overview. Toxicol. Appl. Pharmacol. 2004, in press.
9. Calabrese EJ. Hormetic dose-response relationships in immunology: occurrence, quantitative features of the dose-response, mechanistic foundations and clinical implications. Crit Rev Toxicol. 2004, in press.
10. Calabrese EJ. Cancer biology and hormesis: human tumor cell lines commonly display hormetic (biphasic) dose responses. Crit Rev Toxicol. 2004, in press.
11. Calabrese E.J, Baldwin LA. (eds). Scientific foundations of hormesis. Crit Rev Toxicol. 2001;31(4/5):351-695.
12. Calabrese EJ, Baldwin LA. (eds). Hormesis: environmental and biomedical perspectives. Crit Rev Toxicol. 2003;133(3/4):213-467.