Chronic L-arginine supplementation improves endothelial cell vasoactive functions in hypercholesterolomic and atherosclerotic monkeys

Molecular and Cellular Biochemistry

Volumn 269, Issue 1, 2005, Pages 1-11

  Dhawan, Veena ^a   Handu, S S ^a   Nain, Chandra Kanwal ^a   Ganguly, Nirmal Kumar ^a  

^a POSTGRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH   (India)

Author keywords

Endothelium derived factors; Hypercholesterolemia; Nitric oxide; Oxygen free radicals (OFR)

Indexed keywords

ARGININE; CHOLESTEROL; CYCLIC GMP; DRINKING WATER; LIPID; MALONALDEHYDE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRITE; OXYGEN RADICAL; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA INTIMA; ARTERY INTIMA PROLIFERATION; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; BLOOD LEVEL; BUTTER; CAROTID ARTERY; CELL FUNCTION; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL INTAKE; COMPARATIVE STUDY; CONTROLLED STUDY; CORONARY ARTERY; DIET SUPPLEMENTATION; DIETARY INTAKE; DRUG BLOOD LEVEL; DRUG MECHANISM; ENDOTHELIUM CELL; ENZYME SUBSTRATE; HYPERCHOLESTEROLEMIA; LIPID PEROXIDATION; LONG TERM CARE; MALE; NONHUMAN; OXIDATIVE STRESS; RHESUS MONKEY; STATISTICAL SIGNIFICANCE; TENSION; THORACIC AORTA; VASCULAR ENDOTHELIUM; VASODILATATION;

ANIMALS; ARGININE; CHOLESTEROL, DIETARY; CORONARY ARTERIOSCLEROSIS; CYCLIC GMP; DIET, ATHEROGENIC; ENDOTHELIUM, VASCULAR; HYPERCHOLESTEROLEMIA; LIPID PEROXIDATION; MACACA MULATTA; MALE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OXIDATIVE STRESS; SUPEROXIDES;

EID: 14244267053     PISSN: 03008177     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11010-005-1810-4     Document Type: Article

References (51)

1. Mombouli JV, Vanhoutte PM Endothelial dysfunction from physiology to therapy. J Mol Cell Cardiol 31: 61-74, 1999 10.1006/jmcc.1998.0844
2. Stamler JS, Mendelsohn ME, Amarante P, Smick D, Andon NK, Davies PF, Cooke JP, Loscalzo J: N-acetylcysteine potentiates platelet inhibition by endothelium derived relaxing factor. Circ Res 65: 789-795, 1989
3. Bath PM, Hassall DG, Gladwin AM, Palmer RM, Martin JF: Nitric oxide and prostacyclin: Divergence of inhibitory effects on monocytes chemotaxis and adhesion to endothelium in vitro. Arterioscler Thromb 11: 254-260, 1991
4. Garg UC, Hassid A: Nitric oxide generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells. J Clin Invest 83: 1774-1777, 1989 1:CAS:528:DyaL1MXit12hsb4%3D
5. Schmidt W, Nau II, Withfoht W, Gerlach J, Prescher KE, Klein MM, Niroomand F, Bohme E: Arginine is a physiological precursor of endothelium derived nitric oxide. Eur J Pharmacol 154: 213-216, 1988 10.1016/0014-2999(88)90101-X
6. Moncada S, Palmer RMJ, Higgs EA: Nitric oxide: Physiology, pathology and pharmacology. Pharmacol Rev 43: 109-142, 1991 1:CAS:528:DyaK3MXmt1amtLw%3D
7. Gryglewski RJ, Bolting RM, Vane JR: Mediators produced by the endothelial cell. Hypertension 12: 530-548, 1988
8. Palmer RMJ, Ashton DS, Moncada S: Vascular endothelial cells synthesize nitric oxide from l-arginine. Nature 333: 664-666, 1988 10.1038/333664a0
9. Gold ME, Wood KS, Buga GM, Byrns RE, Ignaro LJ: L-arginine inhibits endothelium-dependent vascular smooth muscle relaxation. Biochem Biophys Res Commun 161: 536-543, 1989
10. G-methylarginine is a potent pressor agent in the guinea pig. Does nitric oxide regulate blood pressure in vivo? Biochem Biophys Res Commun 160: 881-886, 1989
11. Rees DD, Palmer RMJ, Moncada S: Role of endothelium derived nitric oxide in the regulation of blood pressure. Proc Natl Acad Sci USA 86: 3375-3378, 1989 1:CAS:528:DyaL1MXit12hsbo%3D
12. Amezcua JL, Palmer RMJ, DeSouja BM, Moncada S: Nitric oxide synthesized from l-arginine regulates vascular tone in the coronary circulation of the rabbit. Br J Pharmacol 97: 1119-1124, 1989
13. Chappell SP, Lewis MJ, Henderson AH: Effect of lipid feeding on endothelium-dependent vascular relaxation in rabbit aorta preparation. Circ Res 21: 34-38, 1987
14. Frieman PC, Mitcehll GC, Heistad DD, Armstrong ML, Harison DG: Atherosclerosis impairs endothelium-dependent vascular relaxation of acetylcholine and thrombin in primates. Circ Res 58: 783-789. 1986
15. Creager MA, Cooke JP, Mendelson ME, Gallagher SJ, Coleman SM, Loscalzo J, Dzau VJ: Impaired vasodilation of forearm resistance vessels in hypercholesterolemic humans. J Clin Invest 86: 228-234, 1990
16. Casino PR, Kilcoyne CM, Quyyumi AA, Hoeg JM, Panza JA: Role of nitric oxide in the endothelium-dependent vasodilation of hypercholesterolemic patients. Circulation 333: 664-666, 1993
17. Rubanyi GM: Reversal of hypercholesterolemia-induced endothelial dysfunction of l-arginine. Circulation 83: 1057-1062, 1991
18. Cooke JP, Audon NA, Girerd XJ, Hirsch AT, Creager MA: Arginine restores cholinergic relaxation of hypercholesterolemic rabbit thoracic aorta. Circulation 83: 1057-1062, 1991
19. Creager MA, Gallagher SJ, Girerd XJ, Coleman SM, Dzau VJ, Cooke JP: l-arginine improves Endothelium-dependent vasodilation in hypercholesterolemic humans. J Clin Invest 90: 1248-1253, 1992 1:STN:280:ByyD3MnosFY%3D
20. Manning PJ, Clarkson TB: Development, distribution and lipid content of diet-induced atherosclerotic lesions of rhesus monkeys. Exp Mol Pathol 17: 38-54, 1986
21. Ross R: The pathogenesis of atherosclerosis. An Update. N Engl J Med 314: 488-500, 1986
22. Shimokawa H, Vanhoutte PM: Impaired endothelium-dependent relaxation to aggregating platelets and related vasoactive substances in porcine coronary arteries in hypercholesterolemia and atherosclerosis. Circ Res 64: 900-914, 1989
23. Verbeuren TJ, Jordaens F, Zounekeyn L, VanHove C, Herman AG: Vascular responses and release of endothelium-derived relaxing factor in aortas and kidneys of atherosclerotic rabbits. Fed Proc 46: 502, 1987
24. Furchgott RF: Role of endothelium in responses of vascular smooth muscle. Circ Res 53: 557-573, 1983
25. 15 N] nitrate in biological fluids. Anal Biochem 126: 131-138, 1982 1:CAS:528:DyaL38XlvFGgtLY%3D
26. Boyum A: Isolation of mononuclear cells and granulocytes from human blood. Scand J Clin Invest 21: 77-89, 1968
27. Cheung K, Archibald AC, Robindson MF: Luminol-dependent chemiluminescence produced by PMNL's stimulated by immune complex. Aust J Exptl Biol Med Sci 62: 403-419, 1984
28. Witz G, Lawrie NJ, Zaccaria A, Ferrum HE, Goldstein BD: The reaction of 2-thiobarbituric acid with biologically active α, β-saturated aldehydes. Free Radic Biol Med 2: 33-39, 1986
29. Bode-Boger SM, Boger RH, Kienke S, Junker W, Frolich JC. Elevated l-arginine/dimethylarginine ratio contributes to enhanced systemic NO production by dietary l-arginine ratio in hypercholesterolemic rabbits. Biochem Biophys Res Commun 219: 598-603, 1996 10.1006/bbrc.1996.0279
30. Laal JK, Manohara S, Alan T and Tissa K: Endothelium-dependent relaxation in experimental atherosclerosis in the rabbits. Circulation Res 60: S251-S264, 1987
31. Dhawan V, Ganguly NK, Majumdar S, Chakrawarti RN: Short-term therapy of atherosclerosis with low dose indomethacin. An experimental study. J Med Primatol USA 19: 663-673, 1990
32. Paznansky M, Kirkwood D, Soloman AK: Modulation of red cell K cell transport by membrane lipids. Biochem Biophys Acta 330: 351-355, 1973
33. Jain MK, White HB: Long range order in biomembranes. Adv Lipid Res 15: 1-60, 1977
34. Yokoyama M, Henry PD: Sensitization of isolated canine coronary arteries to calcium ions after exposure to cholestesterol. Circ Res 45: 479-486, 1979
35. Zeiher AM, Drexler H, Wollschlager H, Just H: Modulation of coronary vasomotor tone in humans; Progressive endothelial dysfunction with different early stages of coronary atherosclerosis. Circulation 83: 391-401, 1991 1:STN:280:By6C387msFw%3D
36. Benjamin N, Vane J: Nitric oxide and hypertension. Circulation 94: 1197-1198, 1996
37. Lincoln TM, Komalavilas P, Boerth NJ, McMillan-Crow LA, Cornwell TL: cGMP signalling through cAMPand cGMP protein kinases. Adv.Pharmacol 34: 305-322, 1995
38. Hofmann F, ACmendola A, Schlossmann J: Rising behind NO: cGMP-dependent Protein Kinases. J Cell Sci 113: 1671-1676, 2000
39. Bussc R, Trogrsch G, Bassenge E: The role of endothelium in the control of vascular tone. Basic Res Cardiol 80: 475-490, 1985 1:CAS:528:DyaL28Xjs1Ki
40. Ignarro LJ, Harbison RJ, Wood KS, Kadowitz PJ: Activation of purified soluble guanylate cyclase by endothelium-derived relaxing factor from intrapulmonary artery and vein stimulation by acetylcholine, bradykinin and archidonic acid. J Pharmacol Exp Ther 237: 893-900, 1986 1:CAS:528:DyaL28Xkslehu7Y%3D
41. Furlong B, Henderson AH, LewisMJ, Smilt JA: Endothelium-derived relaxing factor inhibits invitro platelet aggregation. Br J Pharmacol 90: 687-692, 1987
42. Schimdt Kurt, Graier WF, Kostner GM, Mayer B, Kukovetz WR: Activation of soluble guanylate cyclase by nitrovasodilators is inhibited by oxidized-low density lipoprotein. Biochem Biophy Res Comm 172: 614-619, 1990
43. Boger RH, Bode-Boger SM, Mugge A, Kienke S, Braudes R, Dwenger A, Frolich JC: Supplementation of hypercholesterolaemic rabbits with l-arginine reduces the vascular releases of superoxide anions and restores nitric oxide production. Atherosclerosis 117: 273-284, 1995 10.1016/0021-9150(95)05582-H
44. Galle J, Busse R, Bassenge E: Hypercholesterolemia and atherosclerosis change vascular reactivity in rabbits by different mechanisms. Arterioscler Thromb 11: 1712-1718, 1991
45. Tsao PS, Mc Evoy LM, Drexler H: Enhanced endothelial adhesiveness in hypercholesterolemia is attenuated by l-arginine. Circulation 89: 2176-2182, 1994 1:CAS:528:DyaK2cXlsVyltbw%3D
46. Cooke PJ, Singer AH, Tsao PS: Antiatherogenic effects of l-arginine in the hypercholesterolemic rabbit. J Clin Invest 90: 1168-1172, 1992 1:CAS:528:DyaK38XlvVCls74%3D
47. 3 excretion as an indicator of nitric oxide formation in vivo during oral administration of l-arginine or L-NAME in rats. Clin Exp Pharmacol Physiol 23: 11-15, 1996
48. Chan JR, Boger RH, Bode-Boger SM: Assymetric dimethyl arginine increases mononuclear cell adhesiveness in hypercholesterolemic humans. Arteioscler Thromb Vasc Biol 20: 1183-1197, 2000
49. Ohara Y, Peterson TE, Harrison DG: Hypercholesterolaemia increases endothelial superoxide anion production. J Clin Invest 91: 546-2551, 1993
50. Darley Usmar VM, Hogg N, O'Leary VJ, Wilson MT, Moncada S: The simultaneous generation of superoxide and nitric oxide can initiate lipid peroxidation in human low density lipoprotein. Free Radic Res 17: 9-20, 1992
51. Boger RH, Bode-Boger SM, Phivthong-ngam L, Brandes RP, Schwedhelm E, Mugge A, Bohme M, Tsikas D, Frolich JC. Dietary l-arginine and α-tocopherol reduce vascular oxidative stress and preserve endothelial function in rabbits via different mechanisms. Atherosclerosis 141: 31-43, 1998