Synthesis and cardiovascular activity of new 8-alkylamino-1,3-dimethyl-7-(2-hydroxy-3-piperazinopropyl) -3,7-dihydro-1H-purine-2,6-diones

Polish Journal of Pharmacology

Volumn 56, Issue 6, 2004, Pages 755-766

  Chłoń Rzepa, Grazyna ^a   Pawłowski, Maciej ^a   Zygmunt, Małgorzata ^a   Filipek, Barbara ^a   Maciag, Dorota ^a  

^a JAGIELLONIAN UNIVERSITY   (Poland)

Author keywords

1 and 2 receptor ligands; Antiarrhythmics; Hipotensive agents; Purine 2,6 diones

Indexed keywords

7 (3 CHLORO 2 HYDROXY PROPYL) 1,3 DIMETHYL 8 (2 MORPHOLIN 4 YL ETHYLAMINO) 3,7 DIHYDRO 1H PURINE 2,6 DIONE; 7 (3 CHLORO 2 HYDROXY PROPYL) 1,3 DIMETHYL 8 (2 PYRIDIN 2 YL ETHYLAMINO) 3,7 DIHYDRO 1H PURINE 2,6 DIONE; 7 (3 CHLORO 2 HYDROXY PROPYL) 1,3 DIMETHYL 8 [(PYRIDIN 2 YL METHYL)AMINO] 3,7 DIHYDRO 1H PURINE 2,6 DIONE; 7 [2 HYDROXY 3 [4 (2 PHENOXYETHYL)PIPERAZIN 1 YL]PROPYL] 1,3 DIMETHYL 8 (2 MORPHOLIN 4 YL ETHYLAMINO) 3,7 DIHYDRO 1H PURINE 2,6 DIONE; 7 [2 HYDROXY 3 [4 (2 PHENOXYETHYL)PIPERAZIN 1 YL]PROPYL] 1,3 DIMETHYL 8 (2 PYRIDIN 2 YL ETHYLAMINO) 3,7 DIHYDRO 1H PURINE 2,6 DIONE; 7 [2 HYDROXY 3 [4 (2 PHENOXYETHYL)PIPERAZIN 1 YL]PROPYL] 1,3 DIMETHYL 8 [( PYRIDIN 2 YL METHYL)AMINO] 3,7 DIHYDRO 1H PURINE 2,6 DIONE; 7 [2 HYDROXY 3 [4 (2 PHENOXYETHYL)PIPERAZINYL 1 YL]PROPYL] 1,3 DIMETHYL 3,7 DIHYDRO 1H PURINE 2,6 DIONE; 8 (2 DIETHYLAMINO ETHYLAMINO) 7 [2 HYDROXY 3 [4 (2 PHENOXYETHYL)PIPERAZIN 1 YL]PROPYL] 1,3 DIMETHYL 3,7 DIHYDRO 1H PURINE 2,6 DIONE; 8 [(FURAN 2 YL METHYL)AMINO] 7 [2 HYDROXY 3 [4 (2 PHENOXYETHYL)PIPERAZIN 1 YL]PROPYL] 1,3 DIMETHYL 3,7 DIHYDRO 1H PURINE 2,6 DIONE; 8 AMINO 7 (3 CHLORO 2 HYDROXYPROPYL) 1,3 DIMETHYL 3,7 DIHYDRO 1H PURINE 2,6 DIONE; 8 AMINO 7 [2 HYDROXY 3 [4 (2 PHENOXYETHYL)PIPERAZIN 1 YL]PROPYL] 1,3 DIMETHYL 3,7 DIHYDRO 1H PURINE 2,6 DIONE; 8 BENZYLAMINO 7 [2 HYDROXY 3 [4 (2 PHENOXYETHYL)PIPERAZIN 1 YL]PROPYL] 1,3 DIMETHYL 3,7 DIHYDRO 1H PURINE 2,6 DIONE; ADRENALIN; ALPHA 1 ADRENERGIC RECEPTOR; ALPHA 2 ADRENERGIC RECEPTOR; BARIUM CHLORIDE; PURINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIARRHYTHMIC ACTIVITY; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; BINDING AFFINITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ECG ABNORMALITY; HEART ARRHYTHMIA; LD 50; MALE; MOUSE; NONHUMAN; RAT;

ANIMALS; ARRHYTHMIA; ARRHYTHMIAS, CARDIAC; BLOOD PRESSURE; CARDIOVASCULAR AGENTS; MALE; MICE; MOLECULAR STRUCTURE; PIPERAZINES; PROTEIN BINDING; PURINONES; RATS; RATS, WISTAR; RECEPTORS, ADRENERGIC, ALPHA; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 14244260754     PISSN: 12306002     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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