Simultaneous determination of bromhexine HCl and baicalin in Chinese compound medicine by a reversed-phase ion-pair HPLC

Journal of Food and Drug Analysis

Volumn 12, Issue 4, 2004, Pages 306-310

  Liu, Shujuan ^a   Zhao, Liang ^a   Liu, Xia ^a   Zhou, Feng ^a   Jiang, Shengxiang ^a  

^a LANZHOU INSTITUTE OF CHEMICAL PHYSICS   (China)

Author keywords

Baicalin; Bromhexine; HCl; HPLC; Pharmaceutical analysis

Indexed keywords

ACETONITRILE; BAICALIN; BROMHEXINE; CHINESE DRUG; PHOSPHORIC ACID; TRIETHYLAMINE; WATER;

ARTICLE; DRUG DETERMINATION; DRUG STRUCTURE; ELUTION; QUALITY CONTROL; QUANTITATIVE ANALYSIS; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

EID: 14244258695     PISSN: 10219498     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Lin, C. C. and Shieh, D. E. 1996. The anti-inflammatory activity of Scutellaria rivularis extracts and its active components, baicalin, baicalein and wogonin. Am. J. Chin. Med. 24: 31-36.
2. Shi, H. L., Zhao, B. L. and Xin, W. J. 1995. Scavenging effects of baicalin on free radicals and its protection on erythrocyte membrane from free radical injury. Biochem. Mol. Biol. Int. 35: 981-994.
3. Chan, F. L., Choi, H. L., Chen, Z. Y., Chan, Peter S. F. and Huang, Y. 2000. Induction of apoptosis in prostate cancer cell lines by a Flavonoid, baicalin. Cancer Lett. 160: 219-228.
4. Pospisilova, M., Polasek, M. and Jokl, V. 2001. Determination of ambroxol or bromhexine in pharmaceuticals by capillary isotachophoresis. J. Pharm. Biomed. Anal. 24: 421-428.
5. Xiao, Z. X. 2001. Study on quality standard of niuhuangshuang oral liquid. Hangtian Hangkong Yixue (Aerospace Medicine) 12: 196.
6. Song, X. Z., Wang, X. Q. and Ze, D. Y. 1999. Determination of aminophylline and bromhexine hydrochloride in Dingchuan Zhike Tablets by UV spectrophotometry. J. China Pharma. University 30: 100-102.
7. Yang, L. L., Yuan, Y. S. and Tu, X. D. 2000. Determination of bromhexine in plasma by gas chromatography-electron capture detection and pharmacokinetic studies. Chinese J. Chromatogr. 18: 543-545.
8. Eismen, M., Gallego, M. and Valcarcel, M. 1993. Automatic determination of amylocaine and bromhexine by atomic absorption spectrometry. J. Pharm. Biomed. Anal. 11: 301-305.
9. Nerin, C., Garnica, A. and Cacho, J. 1986. Indirect determination of nitrogenated drugs by atomic absorption spectrometry. Anal. Chem. 58: 2617-2621.
10. Arafat, T. 1990. Bromhexine determination by diazotization using potentionmetric titration: application to content uniformity. Anal. Lett. 23: 311-326.
11. Argekar, A. P. and Powar, S. G. 1998. Simultaneous determination of salbutamol sulfate and bromhexine hydrochloride in formulations by quantitative thin-layer chromatography. J. Planar Chromatography-Modern TLC 11: 254-257.
12. Berzas Nevado, J. J., Castaneda Penalvo, G. and Guzman Bernardo, F. J. 2001. Simultaneous determination of sulfamethoxypyridazine, sulfamethoxazole, sulfadimethoxine and their associated compounds by liquid chromatography. Anal. Chim. Acta 442: 241-248.
13. Li, X. J., Zhang, Y. P. and Yuan, Z. B. 2002. Determination of baicalin, chlorogenic acid and forsythin in Chinese medicinal preparation by capillary electrophoresis. Chromatographia 55: 453-456.
14. Perez-Ruiz, T., Martinez-Lozano, C., Sanz, A. and Bravo, E. 1997. Determination of bromhexine and ambroxol in pharmaceutical dosage forms, urine and blood serum. J. Chromatogr. B 692: 199-205.
15. Berzas Nevado, J. J., Castaneda Penalvo, G. and Guzman Bernardo, F. J. 2001. Determination of sulfametoxazole, sulfadiazine and associated compounds in pharmaceutical preparations by capillary zone electrophoresis. J. Chromatogr. A 918: 205-210.