-
1
-
-
0026668094
-
Disposition and metabolism of pravastatin sodium in rats, dogs and monkeys
-
T Komai, K Kawai, T Tokui, Y Tokui, C Kuroiwa, E Shigehara, M Tanaka. Disposition and metabolism of pravastatin sodium in rats, dogs and monkeys. Eur J Drug Metab Pharmacokinet 17: 103-113, 1992.
-
(1992)
Eur J Drug Metab Pharmacokinet
, vol.17
, pp. 103-113
-
-
Komai, T.1
Kawai, K.2
Tokui, T.3
Tokui, Y.4
Kuroiwa, C.5
Shigehara, E.6
Tanaka, M.7
-
2
-
-
0029608831
-
Evaluation of the uptake of pravastatin by perfused rat liver and primary cultured rat hepatocytes
-
M Ishigami, T Tokui, T Komai, K Tsukahara, M Yamazaki, Y Sugiyama. Evaluation of the uptake of pravastatin by perfused rat liver and primary cultured rat hepatocytes. Pharm Res 12: 1741-1745, 1995.
-
(1995)
Pharm Res
, vol.12
, pp. 1741-1745
-
-
Ishigami, M.1
Tokui, T.2
Komai, T.3
Tsukahara, K.4
Yamazaki, M.5
Sugiyama, Y.6
-
3
-
-
0029562420
-
Proton-cotransport of pravastatin across intestinal brush-border membrane
-
I Tarnai, H Takanaga, H Maeda, T Ogihara, M Yoneda, A Tsuji. Proton-cotransport of pravastatin across intestinal brush-border membrane. Pharm Res 12: 1727-1732, 1995.
-
(1995)
Pharm Res
, vol.12
, pp. 1727-1732
-
-
Tarnai, I.1
Takanaga, H.2
Maeda, H.3
Ogihara, T.4
Yoneda, M.5
Tsuji, A.6
-
4
-
-
0030862073
-
Biliary excretion of pravastatin in rats: Contribution of the excretion pathway mediated by canalicular multispecific organic anion transporter
-
M Yamazaki, S Akiyama, K Ni’inuma, R Nishigaki, Y Sugiyama. Biliary excretion of pravastatin in rats: contribution of the excretion pathway mediated by canalicular multispecific organic anion transporter. Drug Metab Dispos 25: 1123-1129, 1997.
-
(1997)
Drug Metab Dispos
, vol.25
, pp. 1123-1129
-
-
Yamazaki, M.1
Akiyama, S.2
Ni’inuma, K.3
Nishigaki, R.4
Sugiyama, Y.5
-
5
-
-
0027392882
-
Na(+)-independent multispecific anion transporter mediates active transport of pravastatin into rat liver
-
M Yamazaki, H Suzuki, M Hanano, T Tokui, T Komai, Y Sugiyama. Na(+)-independent multispecific anion transporter mediates active transport of pravastatin into rat liver. Am J Physiol 264: G36-44, 1993.
-
(1993)
Am J Physiol
, vol.264
, pp. G36-44
-
-
Yamazaki, M.1
Suzuki, H.2
Hanano, M.3
Tokui, T.4
Komai, T.5
Sugiyama, Y.6
-
6
-
-
0031723235
-
Prediction of pharmacokinetic alterations caused by drug-drug interactions: Metabolic interaction in the liver
-
K Ito, T Iwatsubo, S Kanarnitsu, K Veda, H Suzuki, Y Sugiyama. Prediction of pharmacokinetic alterations caused by drug-drug interactions: metabolic interaction in the liver. Pharmacol Rev 50: 387-412, 1998.
-
(1998)
Pharmacol Rev
, vol.50
, pp. 387-412
-
-
Ito, K.1
Iwatsubo, T.2
Kanarnitsu, S.3
Veda, K.4
Suzuki, H.5
Sugiyama, Y.6
-
7
-
-
85063537901
-
Inhibition of biliary excretion of methotrexate by probenecid in rats: Quantitative prediction of interaction from in vitro data
-
press
-
K Veda, Y Kato, K Komatsu, Y Sugiyama. Inhibition of biliary excretion of methotrexate by probenecid in rats: Quantitative prediction of interaction from in vitro data. J Pharmacol Exp Ther (in press).
-
J Pharmacol Exp Ther
-
-
Veda, K.1
Kato, Y.2
Komatsu, K.3
Sugiyama, Y.4
-
8
-
-
0031777718
-
Quantitative prediction of in vivo drug clearance and drug interactions from in vitro data on metabolism, together with binding and transport
-
K Ito, T Iwatsubo, S Kanamitsu, Y Nakajima, Y Sugiyama. Quantitative prediction of in vivo drug clearance and drug interactions from in vitro data on metabolism, together with binding and transport. Annu Rev Pharmacol Toxicol 38: 461-499, 1998.
-
(1998)
Annu Rev Pharmacol Toxicol
, vol.38
, pp. 461-499
-
-
Ito, K.1
Iwatsubo, T.2
Kanamitsu, S.3
Nakajima, Y.4
Sugiyama, Y.5
-
9
-
-
6544259277
-
The use of sacs of everted small intestine for the study of the transference of substances from the mucosal to serosal surface
-
T Wilson, G Wiselman. The use of sacs of everted small intestine for the study of the transference of substances from the mucosal to serosal surface. J Physiol 123: 116-125, 1954.
-
(1954)
J Physiol
, vol.123
, pp. 116-125
-
-
Wilson, T.1
Wiselman, G.2
-
10
-
-
0014734572
-
Intestinal drug absorption and metabolism. II. Kinetic aspects of intestinal glucoronide conjugation
-
WH Barr, S Riegelman. Intestinal drug absorption and metabolism. II. Kinetic aspects of intestinal glucoronide conjugation. J Pharm Sci 59: 164-168, 1970.
-
(1970)
J Pharm Sci
, vol.59
, pp. 164-168
-
-
Barr, W.H.1
Riegelman, S.2
-
11
-
-
0017066737
-
Ion transport by rabbit colon. I. Active and passive components
-
RA Frizzell, MJ Koch, SG Schultz. Ion transport by rabbit colon. I. Active and passive components. J Membr Biol 27: 297-316, 1976.
-
(1976)
J Membr Biol
, vol.27
, pp. 297-316
-
-
Frizzell, R.A.1
Koch, M.J.2
Schultz, S.G.3
-
12
-
-
0015311097
-
Ionic conductances of extracellular shunt pathway in rabbit ileum. Influence of shunt on transmural sodium transport and electrical potential differences
-
RA Frizzell, SA Schultz. Ionic conductances of extracellular shunt pathway in rabbit ileum. Influence of shunt on transmural sodium transport and electrical potential differences. J Gen Physiol 59: 318-346, 1972.
-
(1972)
J Gen Physiol
, vol.59
, pp. 318-346
-
-
Frizzell, R.A.1
Schultz, S.A.2
-
13
-
-
0033036416
-
GSH transport in immortalized mouse brain endothelial cells: Evidence for apical localization of a sodiumdependent GSH transporter
-
R Kannan, A Mittur, Y Bao, T Tsuruo, N Kaplowitz. GSH transport in immortalized mouse brain endothelial cells: evidence for apical localization of a sodiumdependent GSH transporter. J Neurochem 73: 390-399, 1999.
-
(1999)
J Neurochem
, vol.73
, pp. 390-399
-
-
Kannan, R.1
Mittur, A.2
Bao, Y.3
Tsuruo, T.4
Kaplowitz, N.5
-
14
-
-
0031809205
-
Characterization of efflux transport of organic anions in a mouse brain capillary endothelial cell line
-
H Kusuhara, H Suzuki, M Naito, T Tsuruo, Y Sugiyama. Characterization of efflux transport of organic anions in a mouse brain capillary endothelial cell line. J Pharmacol Exp Ther 285: 1260-1265, 1998.
-
(1998)
J Pharmacol Exp Ther
, vol.285
, pp. 1260-1265
-
-
Kusuhara, H.1
Suzuki, H.2
Naito, M.3
Tsuruo, T.4
Sugiyama, Y.5
-
15
-
-
0027133590
-
Mechanisms mediating renal secretion of organic anions and cations
-
JB Pritchard, DS Miller. Mechanisms mediating renal secretion of organic anions and cations. Physiol Rev 73: 765-796, 1993.
-
(1993)
Physiol Rev
, vol.73
, pp. 765-796
-
-
Pritchard, J.B.1
Miller, D.S.2
-
16
-
-
0027049962
-
Neutral amino acid transport by the blood-brain barrier. Membrane vesicle studies
-
MM Sanchez del Pino, RA Hawkins, DR Peterson. Neutral amino acid transport by the blood-brain barrier. Membrane vesicle studies. J Biol Chem 267: 25951-25957, 1992.
-
(1992)
J Biol Chem
, vol.267
, pp. 25951-25957
-
-
Sanchez del Pino, M.M.1
Hawkins, R.A.2
Peterson, D.R.3
-
17
-
-
0024348932
-
Transport studies with renal proximal tubular and small intestinal brush border and basolateral membrane vesicles: Vesicle heterogeneity, coexistence of transport system
-
H Murer, P Gmaj, B Steiger, B Hagenbuch. Transport studies with renal proximal tubular and small intestinal brush border and basolateral membrane vesicles: vesicle heterogeneity, coexistence of transport system. Methods Enzymol 172: 346-364, 1989.
-
(1989)
Methods Enzymol
, vol.172
, pp. 346-364
-
-
Murer, H.1
Gmaj, P.2
Steiger, B.3
Hagenbuch, B.4
-
18
-
-
0025684803
-
Characterizing mechanisms of hepatic bile acid transport utilizing isolated membrane vesicles
-
JL Boyer, PJ Meier. Characterizing mechanisms of hepatic bile acid transport utilizing isolated membrane vesicles. Methods Enzymol 192: 517-533, 1990.
-
(1990)
Methods Enzymol
, vol.192
, pp. 517-533
-
-
Boyer, J.L.1
Meier, P.J.2
-
19
-
-
0025613205
-
Isolation oflumenal and contralumenal plasma membrane vesicles from kidney
-
E Kinne-Saffran, RK Kinne. Isolation oflumenal and contralumenal plasma membrane vesicles from kidney. Methods Enzymol 191: 450-469, 1990.
-
(1990)
Methods Enzymol
, vol.191
, pp. 450-469
-
-
Kinne-Saffran, E.1
Kinne, R.K.2
-
20
-
-
0025606834
-
Preparation of basolateral (sinusoidal) and canalicular plasma membrane vesicles for the study of hepatic transport processes
-
PJ Meier, JL Boyer. Preparation of basolateral (sinusoidal) and canalicular plasma membrane vesicles for the study of hepatic transport processes. Methods Enzymol 192: 534-545, 1990.
-
(1990)
Methods Enzymol
, vol.192
, pp. 534-545
-
-
Meier, P.J.1
Boyer, J.L.2
-
21
-
-
0021250574
-
Mechanisms of taurocholate transport in canalicular and basolateral rat liver plasma membrane vesicles. Evidence for an electrogenic canalicular organic anion carrier
-
PJ Meier, A S1. Meier-Abt, C Barrett, JL Boyer. Mechanisms of taurocholate transport in canalicular and basolateral rat liver plasma membrane vesicles. Evidence for an electrogenic canalicular organic anion carrier. J Biol Chem 259: 10614-10622, 1984.
-
(1984)
J Biol Chem
, vol.259
, pp. 10614-10622
-
-
Meier, P.J.1
Meier-Abt, A.S.2
Barrett, C.3
Boyer, J.L.4
-
22
-
-
0024371025
-
The function of Gp170, the multidrug resistance gene product, in rat liver canalicular membrane vesicles
-
Y Kamimoto, Z Gatmaitan, J Hsu, JM Arias. The function of Gp170, the multidrug resistance gene product, in rat liver canalicular membrane vesicles. J Biol Chem 264: 11693-11698, 1989.
-
(1989)
J Biol Chem
, vol.264
, pp. 11693-11698
-
-
Kamimoto, Y.1
Gatmaitan, Z.2
Hsu, J.3
Arias, J.M.4
-
23
-
-
0025046860
-
Uptake of the cephalosporin, cephalexin, by a dipeptide transport carrier in the human intestinal cell line, Caco-2
-
AH Dantzig, L Bergin. Uptake of the cephalosporin, cephalexin, by a dipeptide transport carrier in the human intestinal cell line, Caco-2. Biochim Biophys Acta 1027: 211-217, 1990.
-
(1990)
Biochim Biophys Acta
, vol.1027
, pp. 211-217
-
-
Dantzig, A.H.1
Bergin, L.2
-
24
-
-
0025332938
-
Cell culture techniques for the study of drug transport
-
G Wilson. Cell culture techniques for the study of drug transport. Eur J Drug Metab Pharmacokinet 15: 159-163, 1990.
-
(1990)
Eur J Drug Metab Pharmacokinet
, vol.15
, pp. 159-163
-
-
Wilson, G.1
-
25
-
-
0033278620
-
Gastrointestinal absorption of drugs: Methods and studies
-
L Barthe, J Woodley, G Houin. Gastrointestinal absorption of drugs: methods and studies. Fundam Clin Pharmacol 13: 154-168, 1999.
-
(1999)
Fundam Clin Pharmacol
, vol.13
, pp. 154-168
-
-
Barthe, L.1
Woodley, J.2
Houin, G.3
-
26
-
-
0030761681
-
Molecular and functional characterization of intestinal Na(+)-dependent neutral amino acid transporter BO
-
R Kekuda, V Torres-Zamorano, YJ Fei, PD Prasad, HW Li, LD Mader, FH Leibach, V Ganapathy. Molecular and functional characterization of intestinal Na(+)-dependent neutral amino acid transporter BO. Am J Physiol 272: Gl463-1472, 1997.
-
(1997)
Am J Physiol
, vol.272
, pp. Gl463-1472
-
-
Kekuda, R.1
Torres-Zamorano, V.2
Fei, Y.J.3
Prasad, P.D.4
Li, H.W.5
Mader, L.D.6
Leibach, F.H.7
Ganapathy, V.8
-
27
-
-
0029117415
-
Participation of a proton-cotransporter, MCT1, in the intestinal transport of monocarboxylic acids
-
I Tarnai, H Takanaga, H Maeda, Y Sai, T Ogihara, H Higashida, A Tsuji. Participation of a proton-cotransporter, MCT1, in the intestinal transport of monocarboxylic acids. Biochem Biophys Res Commun 214: 482-489, 1995.
-
(1995)
Biochem Biophys Res Commun
, vol.214
, pp. 482-489
-
-
Tarnai, I.1
Takanaga, H.2
Maeda, H.3
Sai, Y.4
Ogihara, T.5
Higashida, H.6
Tsuji, A.7
-
28
-
-
0031941496
-
Develop- ment and utility of anti-PepTl anti-peptide polyclonal antibodies
-
SK Basu, J Shen, KJ Elbert, CT Okamoto, VH Lee, H von Grafenstein. Develop- ment and utility of anti-PepTl anti-peptide polyclonal antibodies. Phann Res 15: 338-342, 1998.
-
(1998)
Phann Res
, vol.15
, pp. 338-342
-
-
Basu, S.K.1
Shen, J.2
Elbert, K.J.3
Okamoto, C.T.4
Lee, V.H.5
von Grafenstein, H.6
-
29
-
-
0027181852
-
Functional expression of P-glycoprotein in apical membranes of human intestinal Caco-2 cells. Kinetics of vinblastine secretion and interaction with modulators
-
J Hunter, MA Jepson, T Tsuruo, NL Simmons, BH Hirst. Functional expression of P-glycoprotein in apical membranes of human intestinal Caco-2 cells. Kinetics of vinblastine secretion and interaction with modulators. J Biol Chem 268: 14991-14997, 1993.
-
(1993)
J Biol Chem
, vol.268
, pp. 14991-14997
-
-
Hunter, J.1
Jepson, M.A.2
Tsuruo, T.3
Simmons, N.L.4
Hirst, B.H.5
-
30
-
-
0028786481
-
The human intestinal epithelial cell line Caco-2: Phannacological and phannacokinetic applications
-
V Meunier, M Bourrie, Y Berger, G Fabre. The human intestinal epithelial cell line Caco-2: phannacological and phannacokinetic applications. Cell Biol Toxicol 11: 187-194, 1995.
-
(1995)
Cell Biol Toxicol
, vol.11
, pp. 187-194
-
-
Meunier, V.1
Bourrie, M.2
Berger, Y.3
Fabre, G.4
-
31
-
-
0031780682
-
Correlation between oral drug absorption in humans, and apparent drug penneability in TC-7 cells, a human epithelial intestinal cell line: Comparison with the parental Caco-2 cell line
-
MC Gres, B Julian, M Bourrie, V Meunier, C Roques, M Berger, X Boulenc, Y Berger, G Fabre. Correlation between oral drug absorption in humans, and apparent drug penneability in TC-7 cells, a human epithelial intestinal cell line: comparison with the parental Caco-2 cell line. Phann Res 15: 726-733, 1998.
-
(1998)
Phann Res
, vol.15
, pp. 726-733
-
-
Gres, M.C.1
Julian, B.2
Bourrie, M.3
Meunier, V.4
Roques, C.5
Berger, M.6
Boulenc, X.7
Berger, Y.8
Fabre, G.9
-
32
-
-
0027180795
-
Drug absorption limited by P-glycoprotein-mediated secretory drug transport in human intestinal epithelial Caco-2 cell layer
-
J Hunter, BH Hirst, NL Simmons. Drug absorption limited by P-glycoprotein-mediated secretory drug transport in human intestinal epithelial Caco-2 cell layer. Phann Res 10: 743-749, 1993.
-
(1993)
Phann Res
, vol.10
, pp. 743-749
-
-
Hunter, J.1
Hirst, B.H.2
Simmons, N.L.3
-
33
-
-
0025781413
-
Substrate specificity and some properties of phenol sulfotransferase from human intestinal Caco-2 cells
-
A Baranczyk-Kuzma, JA Garren, IJ Hidalgo, RT Borchardt. Substrate specificity and some properties of phenol sulfotransferase from human intestinal Caco-2 cells. Life Sci 49: 1197-1206, 1991.
-
(1991)
Life Sci
, vol.49
, pp. 1197-1206
-
-
Baranczyk-Kuzma, A.1
Garren, J.A.2
Hidalgo, I.J.3
Borchardt, R.T.4
-
34
-
-
0023925328
-
Epithelial polarity, villin expression, and enterocytic differentiation of cultured human colon carcinoma cells: A survey of twenty cell lines
-
I Chantret, A Barbat, E Dussaulx, MG Brattain, A Zweibaum. Epithelial polarity, villin expression, and enterocytic differentiation of cultured human colon carcinoma cells: a survey of twenty cell lines. Cancer Res 48: 1936-1942, 1988.
-
(1988)
Cancer Res
, vol.48
, pp. 1936-1942
-
-
Chantret, I.1
Barbat, A.2
Dussaulx, E.3
Brattain, M.G.4
Zweibaum, A.5
-
35
-
-
0026981085
-
Regulation of cytochrome P450IAI gene expression in a human intestinal cell line, Caco-2
-
X Boulenc, M Bourrie, I Fabre, C Roque, H Joyeux, Y Berger, G Fabre. Regulation of cytochrome P450IAI gene expression in a human intestinal cell line, Caco-2. J Phannacol Exp Ther 263: 1471-1478, 1992.
-
(1992)
J Phannacol Exp Ther
, vol.263
, pp. 1471-1478
-
-
Boulenc, X.1
Bourrie, M.2
Fabre, I.3
Roque, C.4
Joyeux, H.5
Berger, Y.6
Fabre, G.7
-
36
-
-
0031765907
-
Role of P-glycoprotein and cytochrome P450 3A in limiting oral absorption of peptides and peptidomimetics
-
VJ Wacher, JA Silvennan, Y Zhang, LZ Benet. Role of P-glycoprotein and cytochrome P450 3A in limiting oral absorption of peptides and peptidomimetics. J Phann Sci 87: 1322-1330, 1998.
-
(1998)
J Phann Sci
, vol.87
, pp. 1322-1330
-
-
Wacher, V.J.1
Silvennan, J.A.2
Zhang, Y.3
Benet, L.Z.4
-
37
-
-
0030945754
-
Expression ofenzymatically active CYP3A4 by Caco-2 cells grown on extracellular matrix-coated penneable supports in the presence of 1 alpha, 25-dihydroxyvitarnin D3
-
P Schmiedlin-Ren, KE Thummel, JM Fisher, MF Paine, KS Lown, PB Watkins. Expression ofenzymatically active CYP3A4 by Caco-2 cells grown on extracellular matrix-coated penneable supports in the presence of 1 alpha, 25-dihydroxyvitarnin D3. Mol Phannacol 51: 741-754, 1997.
-
(1997)
Mol Phannacol
, vol.51
, pp. 741-754
-
-
Schmiedlin-Ren, P.1
Thummel, K.E.2
Fisher, J.M.3
Paine, M.F.4
Lown, K.S.5
Watkins, P.B.6
-
38
-
-
0030465760
-
Development of Caco-2 cells expressing high levels of cDNA-derived cytochrome P4503A4
-
CL Crespi, BW Penman, M Hu. Development of Caco-2 cells expressing high levels of cDNA-derived cytochrome P4503A4. Phann Res 13: 1635-1641, 1996.
-
(1996)
Phann Res
, vol.13
, pp. 1635-1641
-
-
Crespi, C.L.1
Penman, B.W.2
Hu, M.3
-
39
-
-
0032885491
-
Transport and metabolic characterization of Caco-2 cells expressing CYP3A4 and CYP3A4 plus oxidoreductase
-
M Hu, Y Li, CM Davitt, SM Huang, K Thummel, BW Penman, CL Crespi. Transport and metabolic characterization of Caco-2 cells expressing CYP3A4 and CYP3A4 plus oxidoreductase. Pharm Res 16: 1352-1359, 1999.
-
(1999)
Pharm Res
, vol.16
, pp. 1352-1359
-
-
Hu, M.1
Li, Y.2
Davitt, C.M.3
Huang, S.M.4
Thummel, K.5
Penman, B.W.6
Crespi, C.L.7
-
40
-
-
0029028792
-
Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: Implications for drug delivery and activity in cancer chemotherapy
-
VJ Wacher, CY Wu, LZ Benet. Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy. Mol Carcinog 13: 129-134, 1995.
-
(1995)
Mol Carcinog
, vol.13
, pp. 129-134
-
-
Wacher, V.J.1
Wu, C.Y.2
Benet, L.Z.3
-
41
-
-
0033007704
-
Effects of intestinal CYP3A4 and P-glycoprotein on oral drug absorption-theoretical approach
-
K Ito, H Kusuhara, Y Sugiyama. Effects of intestinal CYP3A4 and P-glycoprotein on oral drug absorption-theoretical approach. Phann Res 16: 225-231, 1999.
-
(1999)
Phann Res
, vol.16
, pp. 225-231
-
-
Ito, K.1
Kusuhara, H.2
Sugiyama, Y.3
-
42
-
-
0042840641
-
Primary structure and functional expression of the apical organic cation transporter from kidney epithelial LLC-PKI cells
-
D Grundemann, J Babin-Ebell, F Martel, N Ording, A Schmidt, E Schomig. Primary structure and functional expression of the apical organic cation transporter from kidney epithelial LLC-PKI cells. J Biol Chem 272: 10408-10413, 1997.
-
(1997)
J Biol Chem
, vol.272
, pp. 10408-10413
-
-
Grundemann, D.1
Babin-Ebell, J.2
Martel, F.3
Ording, N.4
Schmidt, A.5
Schomig, E.6
-
43
-
-
0027300108
-
Transport of organic anion in the OK kidney epithelial cell line
-
R Hori, M Okamura, A Takayama, K Hirozane, M Takano. Transport of organic anion in the OK kidney epithelial cell line. Am J Physiol 264: F975-980, 1993.
-
(1993)
Am J Physiol
, vol.264
, pp. F975-980
-
-
Hori, R.1
Okamura, M.2
Takayama, A.3
Hirozane, K.4
Takano, M.5
-
44
-
-
0025816860
-
Transport of organic cations by a renal epithelial cell line (OK)
-
G Yuan, RJ Ott, C Salgado, KM Giacomini. Transport of organic cations by a renal epithelial cell line (OK). J Biol Chem 266: 8978-8986, 1991.
-
(1991)
J Biol Chem
, vol.266
, pp. 8978-8986
-
-
Yuan, G.1
Ott, R.J.2
Salgado, C.3
Giacomini, K.M.4
-
45
-
-
0028225394
-
p-Arninohippurate transport in apical and basolateral membranes of the OK kidney epithelial cells
-
M Takano, K Hirozane, M Okamura, A Takayama, J Nagai, R Hori. p-Arninohippurate transport in apical and basolateral membranes of the OK kidney epithelial cells. J Pharmacol Exp Ther 269: 970-975, 1994.
-
(1994)
J Pharmacol Exp Ther
, vol.269
, pp. 970-975
-
-
Takano, M.1
Hirozane, K.2
Okamura, M.3
Takayama, A.4
Nagai, J.5
Hori, R.6
-
46
-
-
0031863860
-
Efflux of intracellular alphaketoglutarate via p-aminohippurate/dicarboxylate exchange in OK kidney epithelial cells
-
J Nagai, I Yano, Y Hashimoto, M Takano, K Inui. Efflux of intracellular alphaketoglutarate via p-aminohippurate/dicarboxylate exchange in OK kidney epithelial cells. J Pharmacol Exp Ther 285: 422-427, 1998.
-
(1998)
J Pharmacol Exp Ther
, vol.285
, pp. 422-427
-
-
Nagai, J.1
Yano, I.2
Hashimoto, Y.3
Takano, M.4
Inui, K.5
-
47
-
-
0026669192
-
Functional involvement of P-glycoprotein in blood-brain barrier
-
T Tatsuta, M Naito, T Oh-hara, I Sugawara, T Tsuruo. Functional involvement of P-glycoprotein in blood-brain barrier. J Biol Chem 267: 20383-20391, 1992.
-
(1992)
J Biol Chem
, vol.267
, pp. 20383-20391
-
-
Tatsuta, T.1
Naito, M.2
Oh-Hara, T.3
Sugawara, I.4
Tsuruo, T.5
-
48
-
-
0034452792
-
mRNA expression and transport characterization of conditionally immortalized rat brain capillary endothelial cell lines: A new in vitro bbb model for drug targeting
-
KI Hosoya, T Terasaki, K Tetsuka, T Nagura, S Ontsuki, H Takanaga, M Veda, N Yanai, M Obitani, T Terasaki. mRNA expression and transport characterization of conditionally immortalized rat brain capillary endothelial cell lines: A new in vitro bbb model for drug targeting. J Drug Target 8: 357-370, 2000.
-
(2000)
J Drug Target
, vol.8
, pp. 357-370
-
-
Hosoya, K.I.1
Terasaki, T.2
Tetsuka, K.3
Nagura, T.4
Ontsuki, S.5
Takanaga, H.6
Veda, M.7
Yanai, N.8
Obitani, M.9
Terasaki, T.10
-
49
-
-
0029822580
-
Functional expression of P-glycoprotein in an immortalized cell line of rat brain endothelial cells, RBE4
-
DJ Begley, D Lechardeur, ZD Chen, C Rollinson, MBardoul, F Roux, D Scherman, NJ Abbott. Functional expression of P-glycoprotein in an immortalized cell line of rat brain endothelial cells, RBE4. J Neurochem 67: 988-995, 1996.
-
(1996)
J Neurochem
, vol.67
, pp. 988-995
-
-
Begley, D.J.1
Lechardeur, D.2
Chen, Z.D.3
Rollinson, C.4
Bardoul, M.5
Roux, F.6
Scherman, D.7
Abbott, N.J.8
-
50
-
-
0028892249
-
Comparisons of P-glycoprotein expression in isolated rat brain microvessels and in primary cultures of endothelial cells derived from microvasculature of rat brain, epididymal fat pad and from aorta
-
MA Barrand, KJ Robertson, SF von Weikersthal. Comparisons of P-glycoprotein expression in isolated rat brain microvessels and in primary cultures of endothelial cells derived from microvasculature of rat brain, epididymal fat pad and from aorta. FEBS Lett 374: 179-183, 1995.
-
(1995)
FEBS Lett
, vol.374
, pp. 179-183
-
-
Barrand, M.A.1
Robertson, K.J.2
von Weikersthal, S.F.3
-
51
-
-
0031891475
-
Multidrug resistance-related transport proteins in isolated human brain microvessels and in cells cultured from these isolates
-
S Seetharaman, MA Barrand, L Maskell, RJ Scheper. Multidrug resistance-related transport proteins in isolated human brain microvessels and in cells cultured from these isolates. J Neurochem 70: 1151-1159, 1998.
-
(1998)
J Neurochem
, vol.70
, pp. 1151-1159
-
-
Seetharaman, S.1
Barrand, M.A.2
Maskell, L.3
Scheper, R.J.4
-
52
-
-
0031724003
-
Mrpl multidrug resistance-associated protein and P-glycoprotein expression in rat brain microvessel endothelial cells
-
A Regina, A Koman, M Piciotti, B El Hafny, MS Center, R Bergmann, PO Couraud, F Roux. Mrpl multidrug resistance-associated protein and P-glycoprotein expression in rat brain microvessel endothelial cells. J Neurochem 71: 705-715, 1998.
-
(1998)
J Neurochem
, vol.71
, pp. 705-715
-
-
Regina, A.1
Koman, A.2
Piciotti, M.3
El Hafny, B.4
Center, M.S.5
Bergmann, R.6
Couraud, P.O.7
Roux, F.8
-
53
-
-
0033026478
-
Hepatobiliary transport governs overall elimination of peptidic endothelin antagonists in rats
-
Y Kato, S Akhteruzzaman, A Hisaka, Y Sugiyama. Hepatobiliary transport governs overall elimination of peptidic endothelin antagonists in rats. J Pharmacol Exp Ther 288: 568-574, 1999.
-
(1999)
J Pharmacol Exp Ther
, vol.288
, pp. 568-574
-
-
Kato, Y.1
Akhteruzzaman, S.2
Hisaka, A.3
Sugiyama, Y.4
-
54
-
-
0030726508
-
Preclinical evaluation of drug-drug interaction potential: Present status of the application of primary human hepatocytes in the evaluation of cytochrome P450 induction
-
AP Li, P Maurel, MJ Gomez-Lechon, LC Cheng, M Jurima-Romet. Preclinical evaluation of drug-drug interaction potential: present status of the application of primary human hepatocytes in the evaluation of cytochrome P450 induction. Chem Biol Interact 107: 5-16, 1997.
-
(1997)
Chem Biol Interact
, vol.107
, pp. 5-16
-
-
Li, A.P.1
Maurel, P.2
Gomez-Lechon, M.J.3
Cheng, L.C.4
Jurima-Romet, M.5
-
55
-
-
0033008799
-
Present status of the application ofcryopreserved hepatocytes in the evaluation of xenobiotics: Consensus of an international expert panel
-
AP Li, PD Gorycki, JG Hengstler, GL Kedderis, HG Koebe, R Rahmani, G de Sousas, JM Silva, P Skett. Present status of the application ofcryopreserved hepatocytes in the evaluation of xenobiotics: consensus of an international expert panel. Chem Biol Interact 121: 117-123, 1999.
-
(1999)
Chem Biol Interact
, vol.121
, pp. 117-123
-
-
Li, A.P.1
Gorycki, P.D.2
Hengstler, J.G.3
Kedderis, G.L.4
Koebe, H.G.5
Rahmani, R.6
de Sousas, G.7
Silva, J.M.8
Skett, P.9
-
56
-
-
0032968777
-
Cryopreserved human hepatocytes: Characterization of drug-metabolizing enzyme activities and applications in higher throughput screening assays for hepatotoxicity, metabolic stability, and drug-drug interaction potential
-
AP Li, C Lu, JA Brent, C Pham, A Fackett, CE Ruegg, PM Silber. Cryopreserved human hepatocytes: characterization of drug-metabolizing enzyme activities and applications in higher throughput screening assays for hepatotoxicity, metabolic stability, and drug-drug interaction potential. Chem Biol Interact 121: 17-35, 1999.
-
(1999)
Chem Biol Interact
, vol.121
, pp. 17-35
-
-
Li, A.P.1
Lu, C.2
Brent, J.A.3
Pham, C.4
Fackett, A.5
Ruegg, C.E.6
Silber, P.M.7
-
57
-
-
0028001860
-
Formation of extensive canalicular net- works by rat hepatocytes cultured in collagen-sandwich configuration
-
EL LeCluyse, KL Audus, JH Hochman. Formation of extensive canalicular net- works by rat hepatocytes cultured in collagen-sandwich configuration. Am J Physiol 266: C1764-1774, 1994.
-
(1994)
Am J Physiol
, vol.266
, pp. C1764-1774
-
-
LeCluyse, E.L.1
Audus, K.L.2
Hochman, J.H.3
-
58
-
-
0033017134
-
Correlation of biliary excretion in sandwich-cultured rat hepatocytes and in vivo in rats
-
X Liu, JP Chism, EL LeCluyse, KR Brouwer, KL Brouwer. Correlation of biliary excretion in sandwich-cultured rat hepatocytes and in vivo in rats. Drug Metab Dispos 27: 637-644, 1999.
-
(1999)
Drug Metab Dispos
, vol.27
, pp. 637-644
-
-
Liu, X.1
Chism, J.P.2
LeCluyse, E.L.3
Brouwer, K.R.4
Brouwer, K.L.5
-
60
-
-
4243801613
-
Normal viability and altered pharmacokinetics in mice lacking mdrl-type (drug-transporting) P-glycoproteins
-
AH Schinkel, U Mayer, E Wagenaar, CAAM Mol, L van Deemter, 1JM Smit, MA van der Valk, AC Voordouw, HSpits, O van Tellingen, JMJM Zijlmans, WE Fibbe, P Borst. Normal viability and altered pharmacokinetics in mice lacking mdrl-type (drug-transporting) P-glycoproteins. Proc Natl Acad Sci USA 94: 4028-4033, 1997.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 4028-4033
-
-
Schinkel, A.H.1
Mayer, U.2
Wagenaar, E.3
Mol, C.A.A.M.4
van Deemter, L.5
Smit, J.M.6
van der Valk, M.A.7
Voordouw, A.C.8
Spits, H.9
van Tellingen, O.10
Zijlmans, J.M.J.M.11
Fibbe, W.E.12
Borst, P.13
-
61
-
-
20244386956
-
Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein
-
J Wijnholds, REvers, MR van Leusden, CA Mol, GJ Zaman, U Mayer, JH Beijnen, M van der Valk, P Krimpenfort, P Borst. Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein. Nat Med 3: 1275-1279, 1997.
-
(1997)
Nat Med
, vol.3
, pp. 1275-1279
-
-
Wijnholds, J.1
Evers, R.2
van Leusden, M.R.3
Mol, C.A.4
Zaman, G.J.5
Mayer, U.6
Beijnen, J.H.7
van der Valk, M.8
Krimpenfort, P.9
Borst, P.10
-
62
-
-
0023900477
-
Separate transport systems for biliary secretion of sulfated and unsulfated bile acids in the rat
-
F Kuipers, M Enserink, R Havinga, AB van der Steen, MJ Hardonk, J Fevery, RJ Vonk. Separate transport systems for biliary secretion of sulfated and unsulfated bile acids in the rat. J Clin Invest 81: 1593-1599, 1988.
-
(1988)
J Clin Invest
, vol.81
, pp. 1593-1599
-
-
Kuipers, F.1
Enserink, M.2
Havinga, R.3
van der Steen, A.B.4
Hardonk, M.J.5
Fevery, J.6
Vonk, R.J.7
-
63
-
-
0021804301
-
Hereditary chronic conjugated hyperbilirubinemia in mutant rats caused by defective hepatic anion transport
-
PL Jansen, WH Peters, WH Lamers. Hereditary chronic conjugated hyperbilirubinemia in mutant rats caused by defective hepatic anion transport. Hepatology 5: 573-579, 1985.
-
(1985)
Hepatology
, vol.5
, pp. 573-579
-
-
Jansen, P.L.1
Peters, W.H.2
Lamers, W.H.3
-
64
-
-
0026519238
-
A new rat mutant with chronic conjugated hyperbilirubinemia and renal glomerular lesions
-
S Hosokawa, O Tagaya, T Mikami, Y Nozaki, A Kawaguchi, K Yamatsu, M Shamoto. A new rat mutant with chronic conjugated hyperbilirubinemia and renal glomerular lesions. Lab Animal Sci 42: 27-34, 1992.
-
(1992)
Lab Animal Sci
, vol.42
, pp. 27-34
-
-
Hosokawa, S.1
Tagaya, O.2
Mikami, T.3
Nozaki, Y.4
Kawaguchi, A.5
Yamatsu, K.6
Shamoto, M.7
-
65
-
-
0029822980
-
Effect of antisense oligonucleotides on the expression of hepatocellular bile acid and organic anion uptake systems in Xenopus laevis oocytes
-
B Hagenbuch, BF Scharschmidt, PJ Meier. Effect of antisense oligonucleotides on the expression of hepatocellular bile acid and organic anion uptake systems in Xenopus laevis oocytes. Biochem J 316: 901-904, 1996.
-
(1996)
Biochem J
, vol.316
, pp. 901-904
-
-
Hagenbuch, B.1
Scharschmidt, B.F.2
Meier, P.J.3
-
66
-
-
15144346706
-
The predominant contribution of oligopeptide transporter PepTl to intestinal absorption of beta-Iactam antibiotics in the rat small intestine
-
I Tarnai, T Nakanishi, K Hayashi, T Terao, Y Sai, T Shiraga, K Miyamoto, E Takeda, H Higashida, A Tsuji. The predominant contribution of oligopeptide transporter PepTl to intestinal absorption of beta-Iactam antibiotics in the rat small intestine. J Pharm Pharmacol 49: 796-801, 1997.
-
(1997)
J Pharm Pharmacol
, vol.49
, pp. 796-801
-
-
Tarnai, I.1
Nakanishi, T.2
Hayashi, K.3
Terao, T.4
Sai, Y.5
Shiraga, T.6
Miyamoto, K.7
Takeda, E.8
Higashida, H.9
Tsuji, A.10
-
67
-
-
0032422456
-
Contribution of sodium taurocholate co-transporting polypeptide to the uptake of its possible substrates into rat hepatocytes
-
H Kouzuki, H Suzuki, K Ito, R Ohashi, Y Sugiyama. Contribution of sodium taurocholate co-transporting polypeptide to the uptake of its possible substrates into rat hepatocytes. J Pharmacol Exp Ther 286: 1043-1050, 1998.
-
(1998)
J Pharmacol Exp Ther
, vol.286
, pp. 1043-1050
-
-
Kouzuki, H.1
Suzuki, H.2
Ito, K.3
Ohashi, R.4
Sugiyama, Y.5
-
68
-
-
0033063815
-
Contribution of organic anion transporting polypeptide to uptake of its possible substrates into rat hepatocytes
-
H Kouzuki, H Suzuki, K Ito, R Ohashi, Y Sugiyama. Contribution of organic anion transporting polypeptide to uptake of its possible substrates into rat hepatocytes. J Pharmacol Exp Ther 288: 627-634, 1999.
-
(1999)
J Pharmacol Exp Ther
, vol.288
, pp. 627-634
-
-
Kouzuki, H.1
Suzuki, H.2
Ito, K.3
Ohashi, R.4
Sugiyama, Y.5
-
69
-
-
0030763035
-
Cloning and characterization of two human polyspecific organic cation transporters
-
V Gorboulev, JC Ulzheimer, A Akhoundova, I Ulzheimer-Teuber, U Karbach, S Quester, C Baumann, F Lang, AE Busch, H Koepsell. Cloning and characterization of two human polyspecific organic cation transporters. DNA Cell Biol 16: 871-881, 1997.
-
(1997)
DNA Cell Biol
, vol.16
, pp. 871-881
-
-
Gorboulev, V.1
Ulzheimer, J.C.2
Akhoundova, A.3
Ulzheimer-Teuber, I.4
Karbach, U.5
Quester, S.6
Baumann, C.7
Lang, F.8
Busch, A.E.9
Koepsell, H.10
-
70
-
-
0028063302
-
Drug excretion mediated by a new prototype of polyspecific transporter
-
D Grundemann, V Gorboulev, S Gambaryan, M Veyhl, H Koepsell. Drug excretion mediated by a new prototype of polyspecific transporter. Nature 372: 549-552, 1994.
-
(1994)
Nature
, vol.372
, pp. 549-552
-
-
Grundemann, D.1
Gorboulev, V.2
Gambaryan, S.3
Veyhl, M.4
Koepsell, H.5
-
71
-
-
0032581363
-
Membrane 10- calization of the electrogenic cation transporter roctl in rat liver
-
F Meyer-Wentrup, U Karback, V Gorvoulev, P Arndt, H Koepsell. Membrane 10- calization of the electrogenic cation transporter roctl in rat liver. Biochem Biophys Res Commun 248: 673-678, 1998.
-
(1998)
Biochem Biophys Res Commun
, vol.248
, pp. 673-678
-
-
Meyer-Wentrup, F.1
Karback, U.2
Gorvoulev, V.3
Arndt, P.4
Koepsell, H.5
-
72
-
-
0032456205
-
Functional characteristics and membrane localization of rat multispecific organic cation transporters, octl and oct2, mediating tumular secretion of cationic drugs
-
Y Urakami, M Okuda, S Masuda, H Saito, K Inui. Functional characteristics and membrane localization of rat multispecific organic cation transporters, octl and oct2, mediating tumular secretion of cationic drugs. J Pharmacol Exp Ther 287: 800-805, 1998.
-
(1998)
J Pharmacol Exp Ther
, vol.287
, pp. 800-805
-
-
Urakami, Y.1
Okuda, M.2
Masuda, S.3
Saito, H.4
Inui, K.5
-
73
-
-
0031893146
-
Organic cation transporters in intestine, kidney, liver, and brain
-
H Koepsell. Organic cation transporters in intestine, kidney, liver, and brain. Annu Rev Physiol 60: 243-266, 1998.
-
(1998)
Annu Rev Physiol
, vol.60
, pp. 243-266
-
-
Koepsell, H.1
-
74
-
-
12644278786
-
Electrogenic properties and substrate specificity of the polyspecific rat cation transporter rOCTI
-
AE Busch, S Quester, JC Ulzheimer, S Waldegger, V Gorboulev, P Arndt, F Lang, H Koepsell. Electrogenic properties and substrate specificity of the polyspecific rat cation transporter rOCTI. J Biol Chem 271: 32599-32604, 1996.
-
(1996)
J Biol Chem
, vol.271
, pp. 32599-32604
-
-
Busch, A.E.1
Quester, S.2
Ulzheimer, J.C.3
Waldegger, S.4
Gorboulev, V.5
Arndt, P.6
Lang, F.7
Koepsell, H.8
-
75
-
-
0031450152
-
A reevaluation of substrate specificity of the rat cation transporter rOCTI
-
G Nagel, C Yolk, T Friedrich, JC Ulzheimer, E Bamberg, H Koepsell. A reevaluation of substrate specificity of the rat cation transporter rOCTI. J Biol Chem 272: 31953-31956, 1997.
-
(1997)
J Biol Chem
, vol.272
, pp. 31953-31956
-
-
Nagel, G.1
Yolk, C.2
Friedrich, T.3
Ulzheimer, J.C.4
Bamberg, E.5
Koepsell, H.6
-
76
-
-
0032569029
-
Cloning and functional characterization of a potential-sensitive, polyspecific organic cation transporter (OCT3) most abundantly expressed in placenta
-
R Kekuda, PD Prasad, X Wu, HWang, YJ Fei, FH Leibach, V Ganapathy. Cloning and functional characterization of a potential-sensitive, polyspecific organic cation transporter (OCT3) most abundantly expressed in placenta. J Biol Chem 273: 15971-15979, 1998.
-
(1998)
J Biol Chem
, vol.273
, pp. 15971-15979
-
-
Kekuda, R.1
Prasad, P.D.2
Wu, X.3
Wang, H.4
Fei, Y.J.5
Leibach, F.H.6
Ganapathy, V.7
-
77
-
-
0042886894
-
Selective substrates for non-neuronal monoamine transporters
-
D Grundemann, G Liebich, N Kiefer, S Koster, E Schomig. Selective substrates for non-neuronal monoamine transporters. Mol Pharmacol 56: 1-10, 1999.
-
(1999)
Mol Pharmacol
, vol.56
, pp. 1-10
-
-
Grundemann, D.1
Liebich, G.2
Kiefer, N.3
Koster, S.4
Schomig, E.5
-
78
-
-
0028140393
-
Expression cloning of a rat liver Na(+)-independent organic anion transporter
-
E Jacquemin, B Hagenbuch, B Stieger, AWWolkoff, PJ Meier. Expression cloning of a rat liver Na(+)-independent organic anion transporter. Proc Natl Acad Sci USA 91: 133-137, 1994.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 133-137
-
-
Jacquemin, E.1
Hagenbuch, B.2
Stieger, B.3
Wolkoff, A.W.4
Meier, P.J.5
-
79
-
-
16044374493
-
Immunologic distribution of an organic anion transport protein in rat liver and kidney
-
AJ Bergwerk, X Shi, AC Ford, N Kanai, E Jacquemin, RD Burk, S Bai, PM Novikoff, B Stieger, PJ Meier, VL Schuster, AW Wolkoff. Immunologic distribution of an organic anion transport protein in rat liver and kidney. Am J Physiol 271: G231-238, 1996.
-
(1996)
Am J Physiol
, vol.271
, pp. G231-238
-
-
Bergwerk, A.J.1
Shi, X.2
Ford, A.C.3
Kanai, N.4
Jacquemin, E.5
Burk, R.D.6
Bai, S.7
Novikoff, P.M.8
Stieger, B.9
Meier, P.J.10
Schuster, V.L.11
Wolkoff, A.W.12
-
80
-
-
0031022620
-
The choroid plexus epithelium is the site of the organic anion transport protein in the brain
-
RH Angeletti, PM Novikoff, SR Juvvadi, JM Fritschy, PJ Meier, AW Wolkoff. The choroid plexus epithelium is the site of the organic anion transport protein in the brain. Proc Natl Acad Sci USA 94: 283-286, 1997.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 283-286
-
-
Angeletti, R.H.1
Novikoff, P.M.2
Juvvadi, S.R.3
Fritschy, J.M.4
Meier, P.J.5
Wolkoff, A.W.6
-
81
-
-
0032825736
-
Polyspecific organic anion transporting polypeptides mediate hepatic uptake of amphipathic type II organic cations
-
JE van Montfoort, B Hagenbuch, KE Fattinger, MI M, GM Groothuis, DK Meijer, PJ Meier. Polyspecific organic anion transporting polypeptides mediate hepatic uptake of amphipathic type II organic cations. J Pharmacol Exp Ther 291: 147-152, 1999.
-
(1999)
J Pharmacol Exp Ther
, vol.291
, pp. 147-152
-
-
van Montfoort, J.E.1
Hagenbuch, B.2
Fattinger, K.E.3
Mi, M.4
Groothuis, G.M.5
Meijer, D.K.6
Meier, P.J.7
-
82
-
-
0030753125
-
Molecular aspects of hepatobiliary transport
-
M Muller, PL Jansen. Molecular aspects of hepatobiliary transport. Am J Physiol 272: G1285-1303, 1997.
-
(1997)
Am J Physiol
, vol.272
, pp. G1285-1303
-
-
Muller, M.1
Jansen, P.L.2
-
83
-
-
0030725999
-
Substrate specificity of sinusoidal bile acid and organic anion uptake systems in rat and human liver
-
PJ Meier, U Eckhardt, A Schroeder, B Hagenbuch, B Stieger. Substrate specificity of sinusoidal bile acid and organic anion uptake systems in rat and human liver. Hepatol 26: 1667-1677, 1997.
-
(1997)
Hepatol
, vol.26
, pp. 1667-1677
-
-
Meier, P.J.1
Eckhardt, U.2
Schroeder, A.3
Hagenbuch, B.4
Stieger, B.5
-
84
-
-
0032568838
-
Identification of glutathione as a driving force and leukotriene C4 as a substrate for oatpl, the hepatic sinusoidal organic solute transporter
-
L Li, TK Lee, PJ Meier, N Ballatori. Identification of glutathione as a driving force and leukotriene C4 as a substrate for oatpl, the hepatic sinusoidal organic solute transporter: J Biol Chem 273: 16184-16191, 1998.
-
(1998)
J Biol Chem
, vol.273
, pp. 16184-16191
-
-
Li, L.1
Lee, T.K.2
Meier, P.J.3
Ballatori, N.4
-
85
-
-
0033054241
-
Immunohistochemical distribution and functional characterization of an organic anion transporting polypeptide 2 (oatp2)
-
M Kakyo, H Sakagami, T Nishio, D Nakai, R Nakagomi, T Tokui, T Naitoh, S Matsuno, T Abe, H Yawo. Immunohistochemical distribution and functional characterization of an organic anion transporting polypeptide 2 (oatp2). FEBS Lett 445: 343-346, 1999.
-
(1999)
FEBS Lett
, vol.445
, pp. 343-346
-
-
Kakyo, M.1
Sakagami, H.2
Nishio, T.3
Nakai, D.4
Nakagomi, R.5
Tokui, T.6
Naitoh, T.7
Matsuno, S.8
Abe, T.9
Yawo, H.10
-
86
-
-
0032819955
-
Localization and function of the organic anion-transporting polypeptide oatp2 in rat liver
-
C Reichel, B Gao, J Van Montfoort, V Cattori, C Rahner, B Hagenbuch, B Stieger, T Kamisako, PJ Meier. Localization and function of the organic anion-transporting polypeptide oatp2 in rat liver. Gastroenterol 117: 688-695, 1999.
-
(1999)
Gastroenterol
, vol.117
, pp. 688-695
-
-
Reichel, C.1
Gao, B.2
Van Montfoort, J.3
Cattori, V.4
Rahner, C.5
Hagenbuch, B.6
Stieger, B.7
Kamisako, T.8
Meier, P.J.9
-
87
-
-
0030886124
-
Isolation of a multispecific organic anion and cardiac glycoside transporter from rat brain
-
B Noe, B Hagenbuch, B Stieger, PJ Meier. Isolation of a multispecific organic anion and cardiac glycoside transporter from rat brain. Proc Nail Acad Sci USA 94: 10346-10350, 1997.
-
(1997)
Proc Nail Acad Sci USA
, vol.94
, pp. 10346-10350
-
-
Noe, B.1
Hagenbuch, B.2
Stieger, B.3
Meier, P.J.4
-
88
-
-
15444342300
-
Molecular characterization and tissue distribution of a new organic anion transporter subtype (oatp3) that transports thyroid hormones and taurocholate and comparison with oatp2
-
T Abe, M Kakyo, H Sakagami, T Tokui, T Nishio, M Tanemoto, H Nomura, SC Hebert, S Matsuno, H Kondo, H Yawo. Molecular characterization and tissue distribution of a new organic anion transporter subtype (oatp3) that transports thyroid hormones and taurocholate and comparison with oatp2. J Biol Chem 273: 22395-22401, 1998.
-
(1998)
J Biol Chem
, vol.273
, pp. 22395-22401
-
-
Abe, T.1
Kakyo, M.2
Sakagami, H.3
Tokui, T.4
Nishio, T.5
Tanemoto, M.6
Nomura, H.7
Hebert, S.C.8
Matsuno, S.9
Kondo, H.10
Yawo, H.11
-
89
-
-
0032943652
-
Cloning and functional characterization of a new multispecific organic anion transporter, OATK2, in rat kidney
-
S Masuda, K Ibaramoto, A Takeuchi, H Saito, Y Hashimoto, KI Inui. Cloning and functional characterization of a new multispecific organic anion transporter, OATK2, in rat kidney. Mol Pharmacol 55: 743-752, 1999.
-
(1999)
Mol Pharmacol
, vol.55
, pp. 743-752
-
-
Masuda, S.1
Ibaramoto, K.2
Takeuchi, A.3
Saito, H.4
Hashimoto, Y.5
Inui, K.I.6
-
90
-
-
0029786681
-
Cloning and functional characterization of a novel rat organic anion transporter mediating basolateral uptake of methotrexate in the kidney
-
H Saito, S Masuda, K Inui. Cloning and functional characterization of a novel rat organic anion transporter mediating basolateral uptake of methotrexate in the kidney. J Biol Chem 271: 20719-20725, 1996.
-
(1996)
J Biol Chem
, vol.271
, pp. 20719-20725
-
-
Saito, H.1
Masuda, S.2
Inui, K.3
-
91
-
-
0032859340
-
Localization of the organic anion transporting polypeptide 2 (oatp2) in capillary endothelium and choroid plexus epithelium of rat brain
-
B Gao, B Stieger, B No, JM Fritschy, PJ Meier. Localization of the organic anion transporting polypeptide 2 (oatp2) in capillary endothelium and choroid plexus epithelium of rat brain. J Histochem Cytochem 47: 1255-1264, 1999.
-
(1999)
J Histochem Cytochem
, vol.47
, pp. 1255-1264
-
-
Gao, B.1
Stieger, B.2
No, B.3
Fritschy, J.M.4
Meier, P.J.5
-
92
-
-
0030296762
-
Passage of peptides across the blood-brain barrier: Pathopysiological perspectives
-
WA Banks, AJ Kastin. Passage of peptides across the blood-brain barrier: pathopysiological perspectives. Life Sci 59: 1923-1943, 1996.
-
(1996)
Life Sci
, vol.59
, pp. 1923-1943
-
-
Banks, W.A.1
Kastin, A.J.2
-
93
-
-
0031589135
-
mRNA distribution and membrane localization of the OAT-Kl organic anion transporter in rat renal tubules
-
S Masuda, H Saito, H Nonoguchi, K Tomita, K Inui. mRNA distribution and membrane localization of the OAT-Kl organic anion transporter in rat renal tubules. FEBS Lett 407: 127-131, 1997.
-
(1997)
FEBS Lett
, vol.407
, pp. 127-131
-
-
Masuda, S.1
Saito, H.2
Nonoguchi, H.3
Tomita, K.4
Inui, K.5
-
94
-
-
0029091022
-
Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver
-
GA Kullak-Ublick, B Hagenbuch, B Stieger, CO Schteingart, AF Hofmann, AW Wolkoff, PJ Meier. Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver. Gastroenterology 109: 1274-1282, 1995.
-
(1995)
Gastroenterology
, vol.109
, pp. 1274-1282
-
-
Kullak-Ublick, G.A.1
Hagenbuch, B.2
Stieger, B.3
Schteingart, C.O.4
Hofmann, A.F.5
Wolkoff, A.W.6
Meier, P.J.7
-
95
-
-
0030296680
-
Multispecific amphipathic substrate transport by an organic anion transporter of human liver
-
X Bossuyt, M Muller, PJ Meier. Multispecific amphipathic substrate transport by an organic anion transporter of human liver. J Hepatol 25: 733-738, 1996.
-
(1996)
J Hepatol
, vol.25
, pp. 733-738
-
-
Bossuyt, X.1
Muller, M.2
Meier, P.J.3
-
96
-
-
0040368659
-
Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1
-
T Abe, M Kakyo, T Tokui, R Nakagomi, T Nishio, D Nakai, H Nomura, M Unno, M Suzuki, T Naitoh, S Matsuno, H Yawo. Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1. J Biol Chem 274: 17159-17163, 1999.
-
(1999)
J Biol Chem
, vol.274
, pp. 17159-17163
-
-
Abe, T.1
Kakyo, M.2
Tokui, T.3
Nakagomi, R.4
Nishio, T.5
Nakai, D.6
Nomura, H.7
Unno, M.8
Suzuki, M.9
Naitoh, T.10
Matsuno, S.11
Yawo, H.12
-
97
-
-
0037733365
-
A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane
-
J Konig, Y Cui, AT Nies, O Keppler. A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane. Am J Physiol 278: G0156-G164, 2000.
-
(2000)
Am J Physiol
, vol.278
, pp. G0156-G164
-
-
Konig, J.1
Cui, Y.2
Nies, A.T.3
Keppler, O.4
-
98
-
-
0033601257
-
A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters
-
B Hsiang, Y Zhu, Z Wang, Y Wu, V Sasseville, WP Yang, TG Kirchgessner. A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters. J Biol Chem 274: 37161-37168, 1999.
-
(1999)
J Biol Chem
, vol.274
, pp. 37161-37168
-
-
Hsiang, B.1
Zhu, Y.2
Wang, Z.3
Wu, Y.4
Sasseville, V.5
Yang, W.P.6
Kirchgessner, T.G.7
-
99
-
-
0032869932
-
Molecular characterization and functional regulation of a novel rat liver-specific organic anion transporter rlst1
-
M Kakyo, M Unno, T Tokui, R Nakagomi, T Nishio, H Iwasashi, D Nakai, M Seki, M Suzuki, T Naitoh, S Matsuno, H Yawo, T Abe. Molecular characterization and functional regulation of a novel rat liver-specific organic anion transporter rlst1. Gastroenterology 117: 770-775, 1999.
-
(1999)
Gastroenterology
, vol.117
, pp. 770-775
-
-
Kakyo, M.1
Unno, M.2
Tokui, T.3
Nakagomi, R.4
Nishio, T.5
Iwasashi, H.6
Nakai, D.7
Seki, M.8
Suzuki, M.9
Naitoh, T.10
Matsuno, S.11
Yawo, H.12
Abe, T.13
-
100
-
-
0032574043
-
Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new eDNA clones from brain which can code for large proteins in vitro
-
T Nagase, K Ishikawa, N Miyajima, A Tanaka, H Kotani, N Nomura, D Ohara. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new eDNA clones from brain which can code for large proteins in vitro. DNA Res 5: 31-39, 1998.
-
(1998)
DNA Res
, vol.5
, pp. 31-39
-
-
Nagase, T.1
Ishikawa, K.2
Miyajima, N.3
Tanaka, A.4
Kotani, H.5
Nomura, N.6
Ohara, D.7
-
101
-
-
0020273461
-
Renal organic anion transport system: Pharmacological, physiological, and biochemical aspects
-
JV Moller, MI Sheikh. Renal organic anion transport system: pharmacological, physiological, and biochemical aspects. Pharmacol Rev 34: 315-358, 1983.
-
(1983)
Pharmacol Rev
, vol.34
, pp. 315-358
-
-
Moller, J.V.1
Sheikh, M.I.2
-
102
-
-
0027380852
-
Renal transport mechanisms for xenobiotics: Chemicals and drugs
-
KJ Ullrich, G Rumrich. Renal transport mechanisms for xenobiotics: chemicals and drugs. Clin Invest 71: 843-848, 1993.
-
(1993)
Clin Invest
, vol.71
, pp. 843-848
-
-
Ullrich, K.J.1
Rumrich, G.2
-
103
-
-
0032780906
-
The interaction and transport of beta-Iactam antibiotics with the cloned rat renal organic anion transporter 1
-
S Jariyawat, T Sekine, M Takeda, N Apiwattanakul, Y Kanai, S Sophasan, H Endou. The interaction and transport of beta-Iactam antibiotics with the cloned rat renal organic anion transporter 1. J Pharmacol Exp Ther 290: 672-677, 1999.
-
(1999)
J Pharmacol Exp Ther
, vol.290
, pp. 672-677
-
-
Jariyawat, S.1
Sekine, T.2
Takeda, M.3
Apiwattanakul, N.4
Kanai, Y.5
Sophasan, S.6
Endou, H.7
-
104
-
-
0032931612
-
Transport properties of nonsteroidal anti-inflammatory drugs by organic anion transporter 1 expressed in Xenopus laevis oocytes
-
N Apiwattanakul, T Sekine, A Chairoungdua, Y Kanai, N Nakajima, S Sophasan, H Endou. Transport properties of nonsteroidal anti-inflammatory drugs by organic anion transporter 1 expressed in Xenopus laevis oocytes. Mol Pharmacol 55: 847-854, 1999.
-
(1999)
Mol Pharmacol
, vol.55
, pp. 847-854
-
-
Apiwattanakul, N.1
Sekine, T.2
Chairoungdua, A.3
Kanai, Y.4
Nakajima, N.5
Sophasan, S.6
Endou, H.7
-
105
-
-
0033060904
-
Transport of ochratoxin A by renal multispecific organic anion transporter 1
-
M Tsuda, T Sekine, M Takeda, SH Cha, Y Kanai, M Kimura, H Endou. Transport of ochratoxin A by renal multispecific organic anion transporter 1. J Pharmacol Exp Ther 289: 1301-1305, 1999.
-
(1999)
J Pharmacol Exp Ther
, vol.289
, pp. 1301-1305
-
-
Tsuda, M.1
Sekine, T.2
Takeda, M.3
Cha, S.H.4
Kanai, Y.5
Kimura, M.6
Endou, H.7
-
106
-
-
0030855487
-
Expression cloning and characterization of a novel multispecific organic anion transporter
-
T Sekine, N Watanabe, M Hosoyamada, Y Kanai, H Endou. Expression cloning and characterization of a novel multispecific organic anion transporter. J Biol Chem 272: 18526-18529, 1997.
-
(1997)
J Biol Chem
, vol.272
, pp. 18526-18529
-
-
Sekine, T.1
Watanabe, N.2
Hosoyamada, M.3
Kanai, Y.4
Endou, H.5
-
107
-
-
0030781076
-
Expression cloning and characterization of ROATI. The basolatal organic anion transporter in rat kidney
-
DH Sweet, NA Wolff, JB Pritchard. Expression cloning and characterization of ROATI. The basolatal organic anion transporter in rat kidney. J Biol Chem 272: 30088-30095, 1997.
-
(1997)
J Biol Chem
, vol.272
, pp. 30088-30095
-
-
Sweet, D.H.1
Wolff, N.A.2
Pritchard, J.B.3
-
108
-
-
0032979273
-
Immunohistochemical localization of multispecific renal organic anion transporter 1 in rat kidney
-
A Tojo, T Sekine, N Nakajima, M Hosoyamada, Y Kanai, K Kimura, H Endou. Immunohistochemical localization of multispecific renal organic anion transporter 1 in rat kidney. J Am Soc Nephrol 10: 464-471, 1999.
-
(1999)
J Am Soc Nephrol
, vol.10
, pp. 464-471
-
-
Tojo, A.1
Sekine, T.2
Nakajima, N.3
Hosoyamada, M.4
Kanai, Y.5
Kimura, K.6
Endou, H.7
-
109
-
-
0033532065
-
Molecular cloning and characterization of a new multispecific organic anion transporterfrom rat brain
-
H Kusuhara, T Sekine, N Utsunomiya-Tate, M Tsuda, R Kojima, SH Cha, Y Sugiyama, Y Kanai, H Endou. Molecular cloning and characterization of a new multispecific organic anion transporterfrom rat brain. J Biol Chem 274: 13675-13680, 1999.
-
(1999)
J Biol Chem
, vol.274
, pp. 13675-13680
-
-
Kusuhara, H.1
Sekine, T.2
Utsunomiya-Tate, N.3
Tsuda, M.4
Kojima, R.5
Cha, S.H.6
Sugiyama, Y.7
Kanai, Y.8
Endou, H.9
-
110
-
-
17144449057
-
Identification of multispecific organic anion transporter 2 expressed predominantly in the liver
-
T Sekine, SH Cha, M Tsuda, N Apiwattanakul, N Nakajima, Y Kanai, H Endou. Identification of multispecific organic anion transporter 2 expressed predominantly in the liver. FEBS Lett 429: 179-182, 1998.
-
(1998)
FEBS Lett
, vol.429
, pp. 179-182
-
-
Sekine, T.1
Cha, S.H.2
Tsuda, M.3
Apiwattanakul, N.4
Nakajima, N.5
Kanai, Y.6
Endou, H.7
-
111
-
-
0000518648
-
Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta
-
SH Cha, T Sekine, H Kusuhara, E Yu, JY Kim, DK Kim, Y Sugiyama, Y Kanai, H Endou. Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta. J Biol Chem 275: 4507-4512, 2000.
-
(2000)
J Biol Chem
, vol.275
, pp. 4507-4512
-
-
Cha, S.H.1
Sekine, T.2
Kusuhara, H.3
Yu, E.4
Kim, J.Y.5
Kim, D.K.6
Sugiyama, Y.7
Kanai, Y.8
Endou, H.9
-
112
-
-
0033574034
-
Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3)
-
JE Race, SM Grassl, WJ Williams, EJ Holtzman. Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3). Biochem Biophys Res Commun 255: 508-514, 1999.
-
(1999)
Biochem Biophys Res Commun
, vol.255
, pp. 508-514
-
-
Race, J.E.1
Grassl, S.M.2
Williams, W.J.3
Holtzman, E.J.4
-
113
-
-
0027378438
-
Bisubstrates: Substances that interact with renal contraluminal organic anion and organic cation transport systems. I. Amines, piperidines, piperazines, azepines, pyridines, quinolines, imidazoles, thiazoles, guanidines and hydrazines
-
KJ Ullrich, G Rumrich, C David, G Fritzsch. Bisubstrates: substances that interact with renal contraluminal organic anion and organic cation transport systems. I. Amines, piperidines, piperazines, azepines, pyridines, quinolines, imidazoles, thiazoles, guanidines and hydrazines. Pflugers Arch 425: 280-299, 1993.
-
(1993)
Pflugers Arch
, vol.425
, pp. 280-299
-
-
Ullrich, K.J.1
Rumrich, G.2
David, C.3
Fritzsch, G.4
-
114
-
-
0031434178
-
Cloning and characterization of a novel human pH-dependent organic cation transporter, OCTNI
-
I Tarnai, H Yabuuchi, J Nezu, Y Sai, A Oku, M Shimane, A Tsuji. Cloning and characterization of a novel human pH-dependent organic cation transporter, OCTNI. FEBS Lett 419: 107-111, 1997.
-
(1997)
FEBS Lett
, vol.419
, pp. 107-111
-
-
Tarnai, I.1
Yabuuchi, H.2
Nezu, J.3
Sai, Y.4
Oku, A.5
Shimane, M.6
Tsuji, A.7
-
115
-
-
0032935034
-
Novel membrane transporter OCTNI mediates multispecific, bidirectional, and pHdependent transport of organic cations
-
H Yabuuchi I Tarnai, J Nezu, K Sakamoto, A Oku, M Shimane, Y Sai, A Tsuji. Novel membrane transporter OCTNI mediates multispecific, bidirectional, and pHdependent transport of organic cations. J Pharmacol Exp Ther 289: 768-773, 1999.
-
(1999)
J Pharmacol Exp Ther
, vol.289
, pp. 768-773
-
-
Yabuuchi, H.1
Tarnai, I.2
Nezu, J.3
Sakamoto, K.4
Oku, A.5
Shimane, M.6
Sai, Y.7
Tsuji, A.8
-
116
-
-
0032577202
-
cDNA sequence, transport function, and genomic organization of human OCTN2, a new member of the organic cation transporter family
-
X Wu, PD Prasad, FH Leibach, V Ganapathy. cDNA sequence, transport function, and genomic organization of human OCTN2, a new member of the organic cation transporter family. Biochem Biophys Res Commun 246: 589-595, 1998.
-
(1998)
Biochem Biophys Res Commun
, vol.246
, pp. 589-595
-
-
Wu, X.1
Prasad, P.D.2
Leibach, F.H.3
Ganapathy, V.4
-
117
-
-
0032493741
-
Molecular and functional identification of sodium ion-dependent, high affinity human camitine transporter OCTN2
-
I Tarnai, R Ohashi, J Nezu, H Yabuuchi, A Oku, M Shimane, Y Sai, A Tsuji. Molecular and functional identification of sodium ion-dependent, high affinity human camitine transporter OCTN2. J Biol Chem 273: 20378-20382, 1998.
-
(1998)
J Biol Chem
, vol.273
, pp. 20378-20382
-
-
Tarnai, I.1
Ohashi, R.2
Nezu, J.3
Yabuuchi, H.4
Oku, A.5
Shimane, M.6
Sai, Y.7
Tsuji, A.8
-
118
-
-
0031868466
-
Genetic disorders of camitine metabolism and their nutritional management
-
J Kerner, C Hoppel. Genetic disorders of camitine metabolism and their nutritional management. Annu Rev Nutr 18: 179-206, 1998.
-
(1998)
Annu Rev Nutr
, vol.18
, pp. 179-206
-
-
Kerner, J.1
Hoppel, C.2
-
119
-
-
0027166659
-
Camitine metabolism and human camitine deficiency
-
V Tanphaichitr, P Leelahagul. Camitine metabolism and human camitine deficiency. Nutrition 9: 246-254, 1993.
-
(1993)
Nutrition
, vol.9
, pp. 246-254
-
-
Tanphaichitr, V.1
Leelahagul, P.2
-
120
-
-
0032953645
-
Primary systemic camitine deficiency is caused by mutations in a gene encoding sodium ion-dependent camitine transporter
-
J Nezu, I Tarnai, A Oku, R Ohashi, H Yabuuchi, N Hashimoto, H Nikaido, Y Sai, A Koizumi, Y Shoji, G Takada, T Matsuishi, M Yoshino, H Kato, T Ohura, G Tsujimoto, J Hayakawa, M Shimane, A Tsuji. Primary systemic camitine deficiency is caused by mutations in a gene encoding sodium ion-dependent camitine transporter. Nat Genet 21: 91-94, 1999.
-
(1999)
Nat Genet
, vol.21
, pp. 91-94
-
-
Nezu, J.1
Tarnai, I.2
Oku, A.3
Ohashi, R.4
Yabuuchi, H.5
Hashimoto, N.6
Nikaido, H.7
Sai, Y.8
Koizumi, A.9
Shoji, Y.10
Takada, G.11
Matsuishi, T.12
Yoshino, M.13
Kato, H.14
Ohura, T.15
Tsujimoto, G.16
Hayakawa, J.17
Shimane, M.18
Tsuji, A.19
-
121
-
-
0032767691
-
Functional characteristics and tissue distribution pattern of organic cation transporter 2 (OCTN2), an organic cation/carnitine transporter
-
X Wu, W Huang, PD Prasad, P Seth, DP Rajan, FH Leibach, J Chen, SJ Conway, V Ganapathy. Functional characteristics and tissue distribution pattern of organic cation transporter 2 (OCTN2), an organic cation/carnitine transporter. J Pharmacol Exp Ther 290: 1482-1492, 1999.
-
(1999)
J Pharmacol Exp Ther
, vol.290
, pp. 1482-1492
-
-
Wu, X.1
Huang, W.2
Prasad, P.D.3
Seth, P.4
Rajan, D.P.5
Leibach, F.H.6
Chen, J.7
Conway, S.J.8
Ganapathy, V.9
-
122
-
-
0032696186
-
Na(+)-dependent camitine transport by organic cation transporter (OCTN2): Its pharmacological and toxicological relevance
-
R Ohashi, I Tarnai, H Yabuuchi, JI Nezu, A Oku, Y Sai, M Shimane, A Tsuji, Na(+)-dependent camitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance. J Pharmacol Exp Ther 291 : 778-784, 1999.
-
(1999)
J Pharmacol Exp Ther
, vol.291
, pp. 778-784
-
-
Ohashi, R.1
Tarnai, I.2
Yabuuchi, H.3
Nezu, J.I.4
Oku, A.5
Sai, Y.6
Shimane, M.7
Tsuji, A.8
-
123
-
-
0034695673
-
Beta-Iactam antibiotics as substrates for OCTN2, an organic cation/camitine transporter
-
ME Ganapathy, W Huang, DP Rajan, AL Carter, M Sugawara, K Iseki, FH Leibach, V Ganapathy. Beta-Iactam antibiotics as substrates for OCTN2, an organic cation/camitine transporter. J Biol Chem 275: 1699-1707, 2000.
-
(2000)
J Biol Chem
, vol.275
, pp. 1699-1707
-
-
Ganapathy, M.E.1
Huang, W.2
Rajan, D.P.3
Carter, A.L.4
Sugawara, M.5
Iseki, K.6
Leibach, F.H.7
Ganapathy, V.8
-
124
-
-
0028333611
-
Expression cloning of a mammalian proton-coupled oligopeptide transporter
-
YJ Fei, Y Kanai, S Nussberger, V Ganapathy, FH Leibach, MF Romero, SK Singh, WF Boron, MA Hediger. Expression cloning of a mammalian proton-coupled oligopeptide transporter. Nature 368: 563-566, 1994.
-
(1994)
Nature
, vol.368
, pp. 563-566
-
-
Fei, Y.J.1
Kanai, Y.2
Nussberger, S.3
Ganapathy, V.4
Leibach, F.H.5
Romero, M.F.6
Singh, S.K.7
Boron, W.F.8
Hediger, M.A.9
-
125
-
-
0029979149
-
Immuno-Iocalization of H+Ipeptide cotransporter in rat digestive tract
-
H Ogihara, H Saito, BC Shin, T Terado, S Takenoshita, Y Nagamachi, K Inui, K Takata. Immuno-Iocalization of H+Ipeptide cotransporter in rat digestive tract. Biochem Biophys Res Commun 220: 848-852, 1996.
-
(1996)
Biochem Biophys Res Commun
, vol.220
, pp. 848-852
-
-
Ogihara, H.1
Saito, H.2
Shin, B.C.3
Terado, T.4
Takenoshita, S.5
Nagamachi, Y.6
Inui, K.7
Takata, K.8
-
126
-
-
0032967296
-
3rd Localization ofPEPTI and PEPT2 proton-coupled oligopeptide transporter mRNA and protein in rat kidney
-
H Shen, DE Smith, T Yang, YG Huang, JB Schnermann, FC Brosius. 3rd Localization ofPEPTI and PEPT2 proton-coupled oligopeptide transporter mRNA and protein in rat kidney. Am J Physiol 276: F658-655, 1999.
-
(1999)
Am J Physiol
, vol.276
, pp. F655-F658
-
-
Shen, H.1
Smith, D.E.2
Yang, T.3
Huang, Y.G.4
Schnermann, J.B.5
Brosius, F.C.6
-
127
-
-
0031053682
-
Stoichiometry and pH dependence of the rabbit proton-dependent oligopeptide transporter PepTl
-
A Steel, S Nussberger, MF Romero, WF Boron, CA Boyd, MA Hediger. Stoichiometry and pH dependence of the rabbit proton-dependent oligopeptide transporter PepTl. J Physiol 498: 563-569, 1997.
-
(1997)
J Physiol
, vol.498
, pp. 563-569
-
-
Steel, A.1
Nussberger, S.2
Romero, M.F.3
Boron, W.F.4
Boyd, C.A.5
Hediger, M.A.6
-
128
-
-
84962464696
-
Minimal molecular determinants of substrates for recognition by the intestinal peptide transporter
-
F Doring, J Will, S Amasheh, W Clauss, H Ahlbrecht, H Daniel. Minimal molecular determinants of substrates for recognition by the intestinal peptide transporter. J Biol Chem 273: 23211-23218, 1998.
-
(1998)
J Biol Chem
, vol.273
, pp. 23211-23218
-
-
Doring, F.1
Will, J.2
Amasheh, S.3
Clauss, W.4
Ahlbrecht, H.5
Daniel, H.6
-
129
-
-
0027768955
-
Pharmacokinetics of the acyclovir pro-drug valaciclovir after escalating single- and multiple-dose administration to normal volunteers
-
SWeller, MR Blum, M Doucette, T Burnette, DM Cederberg, P de Miranda, ML Smiley. Pharmacokinetics of the acyclovir pro-drug valaciclovir after escalating single- and multiple-dose administration to normal volunteers. Clin Pharmacol Ther 54: 595-605, 1993.
-
(1993)
Clin Pharmacol Ther
, vol.54
, pp. 595-605
-
-
Weller, S.1
Blum, M.R.2
Doucette, M.3
Burnette, T.4
Cederberg, D.M.5
de Miranda, P.6
Smiley, M.L.7
-
130
-
-
0031981201
-
Carrier-mediated intestinal absorption of valacyclovir, the L-valyl ester prodrug of acyclovir: L. Interactions with peptides, organic anions and organic cations in rats
-
PJ Shinko, PV Sinko, PV Balimane. Carrier-mediated intestinal absorption of valacyclovir, the L-valyl ester prodrug of acyclovir: l. Interactions with peptides, organic anions and organic cations in rats. Biopharm Drug Dispos 19: 209-217, 1998.
-
(1998)
Biopharm Drug Dispos
, vol.19
, pp. 209-217
-
-
Shinko, P.J.1
Sinko, P.V.2
Balimane, P.V.3
-
131
-
-
0028883462
-
Absolute bioavailability and metabolic disposition of valaciclovir, the L-valyl ester of acyclovir, following oral administration to humans
-
J Soul-Lawton, E Seaber, NOn, R Wootton, PRolan, J Posner. Absolute bioavailability and metabolic disposition of valaciclovir, the L-valyl ester of acyclovir, following oral administration to humans. Antimicrob Agents Chemother 39: 2759-2764, 1995.
-
(1995)
Antimicrob Agents Chemother
, vol.39
, pp. 2759-2764
-
-
Soul-Lawton, J.1
Seaber, E.2
On, N.3
Wootton, R.4
Rolan, P.5
Posner, J.6
-
132
-
-
0032546467
-
Valacyclovir: A substrate for the intestinal and renal peptide transporters PEPTI and PEPTI
-
ME Ganapathy, W Huang, H Wang, V Ganapathy, FH Leibach. Valacyclovir: a substrate for the intestinal and renal peptide transporters PEPTI and PEPTI. Biochern Biophys Res Commun 246: 470-475, 1998.
-
(1998)
Biochern Biophys Res Commun
, vol.246
, pp. 470-475
-
-
Ganapathy, M.E.1
Huang, W.2
Wang, H.3
Ganapathy, V.4
Leibach, F.H.5
-
133
-
-
0031662109
-
5'-Amino acid esters of antiviral nucleosides, acyclovir, and AZT are absorbed by the intestinal PEPTI peptide transporter
-
H Han, RL de Vrueh, JK Rhie, KM Covitz, PL Smith, CP Lee, DM Oh, W Sadee, GL Amidon. 5'-Amino acid esters of antiviral nucleosides, acyclovir, and AZT are absorbed by the intestinal PEPTI peptide transporter. Pharm Res 15: 1154-1159, 1998.
-
(1998)
Pharm Res
, vol.15
, pp. 1154-1159
-
-
Han, H.1
de Vrueh, R.L.2
Rhie, J.K.3
Covitz, K.M.4
Smith, P.L.5
Lee, C.P.6
Oh, D.M.7
Sadee, W.8
Amidon, G.L.9
-
134
-
-
0031773397
-
Improvement of L-dopa absorption by dipeptidyl derivation, utilizing peptide transporter PepTl
-
I Tarnai, T Nakanishi, H Nakahara, Y Sai, V Ganapathy, FH Leibach, A Tsuji. Improvement of L-dopa absorption by dipeptidyl derivation, utilizing peptide transporter PepTl. J Pharm Sci 87: 1542-1546, 1998.
-
(1998)
J Pharm Sci
, vol.87
, pp. 1542-1546
-
-
Tarnai, I.1
Nakanishi, T.2
Nakahara, H.3
Sai, Y.4
Ganapathy, V.5
Leibach, F.H.6
Tsuji, A.7
-
135
-
-
0029919966
-
Molecular cloning and tissue distribution of rat peptide transporter PEPT2
-
H Saito, T Terada, M Okuda, S Sasaki, K Inu L Molecular cloning and tissue distribution of rat peptide transporter PEPT2. Biochim Biophys Acta 1280: 173-177, 1996.
-
(1996)
Biochim Biophys Acta
, vol.1280
, pp. 173-177
-
-
Saito, H.1
Terada, T.2
Okuda, M.3
Sasaki, S.4
Inu, K.L.5
-
136
-
-
0030026812
-
Expression cloning and functional characterization of the kidney cortex high-affinity proton-coupled peptide transporter
-
M BoH, M Herget, M Wagener, WM Weber, D Markovich, J Biber, W Clauss, H Murer, H Daniel. Expression cloning and functional characterization of the kidney cortex high-affinity proton-coupled peptide transporter. Proc Natl Acad Sci USA 93: 284-289, 1996.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 284-289
-
-
Bo, M.1
Herget, M.2
Wagener, M.3
Weber, W.M.4
Markovich, D.5
Biber, J.6
Clauss, W.7
Murer, H.8
Daniel, H.9
-
137
-
-
0031713192
-
Tubular localization and tissue distribution of peptide transporters in rat kidney
-
DE Smith, A Pavlova, UV Berger, MA Hediger, T Yang, YG Huan, JB Schnermann. Tubular localization and tissue distribution of peptide transporters in rat kidney. Pharm Res 15: 1244-1249, 1998.
-
(1998)
Pharm Res
, vol.15
, pp. 1244-1249
-
-
Smith, D.E.1
Pavlova, A.2
Berger, U.V.3
Hediger, M.A.4
Yang, T.5
Huan, Y.G.6
Schnermann, J.B.7
-
138
-
-
0003119124
-
The peptide transporter PepTI is expressed in rat brain and mediates the accumulation of the florescent dipeptide derivative
-
ST Dieck, H Heuer, J Ehrchen, COtto, K Bauer. The peptide transporter PepTI is expressed in rat brain and mediates the accumulation of the florescent dipeptide derivative. Glia 25: 10-20, 1998.
-
(1998)
Glia
, vol.25
, pp. 10-20
-
-
Dieck, S.T.1
Heuer, H.2
Ehrchen, J.3
Otto, C.4
Bauer, K.5
-
139
-
-
0033613850
-
Stoichiometry and kinetics of the highaffinity H+-coupled peptide transporter PepTI
-
XZ Chen, T Zhu, DE Smith, MA Hediger. Stoichiometry and kinetics of the highaffinity H+-coupled peptide transporter PepTI. J Biol Chem 274: 2773-2779, 1999.
-
(1999)
J Biol Chem
, vol.274
, pp. 2773-2779
-
-
Chen, X.Z.1
Zhu, T.2
Smith, D.E.3
Hediger, M.A.4
-
140
-
-
0030661969
-
Recognition of beta-Iactam antibiotics by rat peptide transporter, PEPTl and PEPT2, in LLC-PKI cells
-
T Terada, H Saito, M Mukai, K Inui. Recognition of beta-Iactam antibiotics by rat peptide transporter, PEPTl and PEPT2, in LLC-PKI cells. Am J Physiol 273: F706-F711, 1997.
-
(1997)
Am J Physiol
, vol.273
, pp. F706-F711
-
-
Terada, T.1
Saito, H.2
Mukai, M.3
Inui, K.4
-
141
-
-
0028822394
-
Proton/peptide cotransporter (pEPT 2) from human kidney: Functional characterization and chromosomal localization
-
S Ramamoorthy, W Liu, YY Ma, TL Yang-Feng, V Ganapathy, FH Leibach, Proton/peptide cotransporter (pEPT 2) from human kidney: functional characterization and chromosomal localization. Biochim Biophys Acta 1240: 1-4, 1995.
-
(1995)
Biochim Biophys Acta
, vol.1240
, pp. 1-4
-
-
Ramamoorthy, S.1
Liu, W.2
Ma, Y.Y.3
Yang-Feng, T.L.4
Ganapathy, V.5
Leibach, F.H.6
-
142
-
-
0032430799
-
Interaction of beta-Iactam antibiotics with H+ peptide cotransporters in rat renal brush border membranes
-
K Takahasi, N Nakamura, T Terada, T Okano, T Futami, H Saito, K Inu L Interaction of beta-Iactam antibiotics with H+ peptide cotransporters in rat renal brush border membranes. J Pharmcol Exp Ther 286: 1037-1042, 1998.
-
(1998)
J Pharmcol Exp Ther
, vol.286
, pp. 1037-1042
-
-
Takahasi, K.1
Nakamura, N.2
Terada, T.3
Okano, T.4
Futami, T.5
Saito, H.6
Inu, K.L.7
-
143
-
-
0029896232
-
Expression of a renal type I sodium/phosphate transporter (NaPi1) induces a conductance in Xenopus oocytes permeable for organic and inorganic anions
-
AE Busch, A Schuster, S Waldegger, CA Wagner, G Zempel, S Broer, J Biber, H Murer, F Lang. Expression of a renal type I sodium/phosphate transporter (NaPi1) induces a conductance in Xenopus oocytes permeable for organic and inorganic anions. Proc Natl Acad Sci USA 93: 5347-5351, 1996.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 5347-5351
-
-
Busch, A.E.1
Schuster, A.2
Waldegger, S.3
Wagner, C.A.4
Zempel, G.5
Broer, S.6
Biber, J.7
Murer, H.8
Lang, F.9
-
144
-
-
0032160713
-
Hepatic sinusoidal membrane transport of anionic drugs mediated by anion transporter Nptl
-
H Yabuuchi, I Tarnai, K Morita, T Kouda, K Miyamoto, E Takeda, A Tsuji. Hepatic sinusoidal membrane transport of anionic drugs mediated by anion transporter Nptl. J Pharmacol Exp Ther 286: 1391-1396, 1998.
-
(1998)
J Pharmacol Exp Ther
, vol.286
, pp. 1391-1396
-
-
Yabuuchi, H.1
Tarnai, I.2
Morita, K.3
Kouda, T.4
Miyamoto, K.5
Takeda, E.6
Tsuji, A.7
-
145
-
-
0015893137
-
Active outward transport of daunomycin in resistant Ehrlich ascites tumor cells
-
K Dano. Active outward transport of daunomycin in resistant Ehrlich ascites tumor cells. Biochim Biophys Acta 323: 466-483, 1973.
-
(1973)
Biochim Biophys Acta
, vol.323
, pp. 466-483
-
-
Dano, K.1
-
146
-
-
0018200435
-
Mechanisms of resistance to daunorubicin in Ehrlich ascites tumor cells
-
T Skovsgaard. Mechanisms of resistance to daunorubicin in Ehrlich ascites tumor cells. Cancer Res 38: 1785-1791, 1978.
-
(1978)
Cancer Res
, vol.38
, pp. 1785-1791
-
-
Skovsgaard, T.1
-
147
-
-
0029082150
-
Hepatobiliary secretion of organic compounds: Molecular mechanisms of membrane transport
-
RPJ Oude Elferink, DKF Meijer, F Kuipers, PLM Jansen, AK Groen, GMM Groothuis. Hepatobiliary secretion of organic compounds: molecular mechanisms of membrane transport. Biochim Biophys Acta 1241: 215-268, 1995.
-
(1995)
Biochim Biophys Acta
, vol.1241
, pp. 215-268
-
-
Oude Elferink, R.P.J.1
Meijer, D.K.F.2
Kuipers, F.3
Jansen, P.L.M.4
Groen, A.K.5
Groothuis, G.M.M.6
-
148
-
-
0342618583
-
Renal secretion of xenobiotics mediated by Pglycoprotein: Importance to renal function in health and exploitation for targeted drug delivery to epithelial cysts in polycystic kidney disease
-
NL Simons, J Hunter, MA Jepson. Renal secretion of xenobiotics mediated by Pglycoprotein: importance to renal function in health and exploitation for targeted drug delivery to epithelial cysts in polycystic kidney disease. Adv Drug Deliv Rev 25: 243-256, 1997.
-
(1997)
Adv Drug Deliv Rev
, vol.25
, pp. 243-256
-
-
Simons, N.L.1
Hunter, J.2
Jepson, M.A.3
-
149
-
-
0343247810
-
Blood-brain barrier function of P-glycoprotein
-
A Tsuji, I Tarnai. Blood-brain barrier function of P-glycoprotein. Adv Drug Deliv Rev 25: 285-298, 1997.
-
(1997)
Adv Drug Deliv Rev
, vol.25
, pp. 285-298
-
-
Tsuji, A.1
Tarnai, I.2
-
150
-
-
0343488673
-
Intestinalsecretion of drugs. The role of P-glycoprotein and related drug efflux sstems in limiting oral drug absorption
-
J Hunter, BH Hirst. Intestinalsecretion of drugs. The role of P-glycoprotein and related drug efflux sstems in limiting oral drug absorption. Adv Drug Deliv Rev 25: 129-157, 1997.
-
(1997)
Adv Drug Deliv Rev
, vol.25
, pp. 129-157
-
-
Hunter, J.1
Hirst, B.H.2
-
151
-
-
0031026780
-
Brain microvascular and astrocyte localization of P-glycoprotein
-
WM Pardridge, PL Golden, YS Kang, U Bickel. Brain microvascular and astrocyte localization of P-glycoprotein. J Neurochem 68: 1278-1285, 1997.
-
(1997)
J Neurochem
, vol.68
, pp. 1278-1285
-
-
Pardridge, W.M.1
Golden, P.L.2
Kang, Y.S.3
Bickel, U.4
-
152
-
-
0030001378
-
P-glycoproteins and multidrug resistance
-
WT Bellamy. P-glycoproteins and multidrug resistance. Ann Rev Pharmacol Toxicol 36: 161-183, 1996.
-
(1996)
Ann Rev Pharmacol Toxicol
, vol.36
, pp. 161-183
-
-
Bellamy, W.T.1
-
153
-
-
0027218689
-
Biochemistry of multidrug resistance mediated by the multidrug transporter
-
MM Gottesman, I Pastan. Biochemistry of multidrug resistance mediated by the multidrug transporter. Ann Rev Biochem 62: 385-427, 1993.
-
(1993)
Ann Rev Biochem
, vol.62
, pp. 385-427
-
-
Gottesman, M.M.1
Pastan, I.2
-
154
-
-
0029560753
-
Genetic analysis of the multidrug transporter
-
MM Gottesman, CA Hrycyna, PV Schoenlein, UA Germann, I Pastan. Genetic analysis of the multidrug transporter. Ann Rev Genet 29: 607-649, 1995.
-
(1995)
Ann Rev Genet
, vol.29
, pp. 607-649
-
-
Gottesman, M.M.1
Hrycyna, C.A.2
Schoenlein, P.V.3
Germann, U.A.4
Pastan, I.5
-
156
-
-
0031691234
-
The role of P-glycoprotein and canalicular multispecific organic anion transporter in the hepatobiliary excretion of drugs
-
H Kusuhara, H Suzuki, Y Sugiyama. The role of P-glycoprotein and canalicular multispecific organic anion transporter in the hepatobiliary excretion of drugs. J Pharm Sci 87: 1025-1040, 1998.
-
(1998)
J Pharm Sci
, vol.87
, pp. 1025-1040
-
-
Kusuhara, H.1
Suzuki, H.2
Sugiyama, Y.3
-
157
-
-
0027363563
-
Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease
-
JJ Smit, AH Schinkel, RPJ Oude Elferink, AK Groen, E Wagenaar, L van Deemter, CAAM Mol, R Ottenhoff, NM van der Lugt, MA van Roon, MA van der Valk, GJ Offerhaus, AJM Berns, P Borst. Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease. Cell 75: 451-462, 1993.
-
(1993)
Cell
, vol.75
, pp. 451-462
-
-
Smit, J.J.1
Schinkel, A.H.2
Oude Elferink, R.P.J.3
Groen, A.K.4
Wagenaar, E.5
van Deemter, L.6
Mol, C.A.A.M.7
Ottenhoff, R.8
van der Lugt, N.M.9
van Roon, M.A.10
van der Valk, M.A.11
Offerhaus, G.J.12
Berns, A.J.M.13
Borst, P.14
-
158
-
-
0028307550
-
Phosphatidylcholine translocase: A physiological role for the mdr2 gene
-
S Ruetz, P Gros. Phosphatidylcholine translocase: a physiological role for the mdr2 gene. Cell 77: 1071-1081, 1994.
-
(1994)
Cell
, vol.77
, pp. 1071-1081
-
-
Ruetz, S.1
Gros, P.2
-
159
-
-
0030052748
-
P-Glycoprotein confers methotrexate resistance in 3T6 cells with deficient carrier-mediated methotrexate uptake
-
D de Graaf, RC Sharma, EB Mechetner, RT Schimke, IB Roninson. P-Glycoprotein confers methotrexate resistance in 3T6 cells with deficient carrier-mediated methotrexate uptake. Proc Natl Acad Sci USA 93: 1238-1242, 1996.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 1238-1242
-
-
de Graaf, D.1
Sharma, R.C.2
Mechetner, E.B.3
Schimke, R.T.4
Roninson, I.B.5
-
160
-
-
13344277328
-
Involvement of MDRI p- glycoprotein in multifactorial resistance to methotrexate
-
MD Norris, D De Graaf, M Haber, M Kavallaris, J Madafiglio, J Gilbert, E Kwan, BW Stewart, EB Mechetner, AV Gudkov, IB Roninson. Involvement of MDRI p- glycoprotein in multifactorial resistance to methotrexate. Int Natl Cancer 65: 613-619, 1996.
-
(1996)
Int Natl Cancer
, vol.65
, pp. 613-619
-
-
Norris, M.D.1
De Graaf, D.2
Haber, M.3
Kavallaris, M.4
Madafiglio, J.5
Gilbert, J.6
Kwan, E.7
Stewart, B.W.8
Mechetner, E.B.9
Gudkov, A.V.10
Roninson, I.B.11
-
161
-
-
0344267659
-
Possible involvement of P-glycoprotein in biliary excretion of CPT-II in rats
-
XY Chu, Y Kato, Y Sugiyama. Possible involvement of P-glycoprotein in biliary excretion of CPT-II in rats. Drug Metab Dispos 27: 440-441, 1999.
-
(1999)
Drug Metab Dispos
, vol.27
, pp. 440-441
-
-
Chu, X.Y.1
Kato, Y.2
Sugiyama, Y.3
-
162
-
-
0031726338
-
Adenosine triphosphate-dependent transport of estradiol-17-beta(beta-D-glucuronide) in membrane vesicles by MDRI expressed in insect cells
-
L Huang, T Hoffman, M Vore. Adenosine triphosphate-dependent transport of estradiol-17-beta(beta-D-glucuronide) in membrane vesicles by MDRI expressed in insect cells. Hepatology 28: 1371-1377, 1998.
-
(1998)
Hepatology
, vol.28
, pp. 1371-1377
-
-
Huang, L.1
Hoffman, T.2
Vore, M.3
-
163
-
-
0028229150
-
Disruption of the mouse mdrla P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs
-
AH Schinkel, JJ Smit, O van Tellingen, JH Beijnen, E Wagenaar, L van Deemter, CAAM Mol, MA van der Valk, EC Robanus-Maandag, HP te Riele, AJM Berns, P Borst. Disruption of the mouse mdrla P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs. Cell 77: 491-502, 1994.
-
(1994)
Cell
, vol.77
, pp. 491-502
-
-
Schinkel, A.H.1
Smit, J.J.2
van Tellingen, O.3
Beijnen, J.H.4
Wagenaar, E.5
van Deemter, L.6
Mol, C.A.A.M.7
van der Valk, M.A.8
Robanus-Maandag, E.C.9
te Riele, H.P.10
Berns, A.J.M.11
Borst, P.12
-
164
-
-
0031921312
-
Contribution of the murine mdrl a P-glycoprotein to hepatobiliary and intestinal elimination of cationic drugs as measured in mice with an mdrla gene disruption
-
JW Smit, AH Schinkel, M Muller, B Weert, DKF Meijer. Contribution of the murine mdrl a P-glycoprotein to hepatobiliary and intestinal elimination of cationic drugs as measured in mice with an mdrla gene disruption. Hepatology 27: 1056-1063, 1998.
-
(1998)
Hepatology
, vol.27
, pp. 1056-1063
-
-
Smit, J.W.1
Schinkel, A.H.2
Muller, M.3
Weert, B.4
Meijer, D.K.F.5
-
165
-
-
0029860174
-
Substantial excretion of digoxin via the intestinal mucosa and prevention of long-term digoxin accumulation in the brain by the mdr la P-glycoprotein
-
U Mayer, E Wagenaar, JH Beijnen, JW Smit, DK Meijer, J van Asperen, P Borst, AH Schinkel. Substantial excretion of digoxin via the intestinal mucosa and prevention of long-term digoxin accumulation in the brain by the mdr la P-glycoprotein. Br J Pharmacol 119: 1038-1044, 1996.
-
(1996)
Br J Pharmacol
, vol.119
, pp. 1038-1044
-
-
Mayer, U.1
Wagenaar, E.2
Beijnen, J.H.3
Smit, J.W.4
Meijer, D.K.5
van Asperen, J.6
Borst, P.7
Schinkel, A.H.8
-
166
-
-
12644278301
-
Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine
-
A Sparreboom, J van Asperen, U Mayer, AH Schinkel, JW Smit, DK Meijer, P Borst, WJ Nooijen, JH Beijnen, O van Tellingen. Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine. Proc Natl Acad Sci USA 94: 2031-2035, 1997.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 2031-2035
-
-
Sparreboom, A.1
van Asperen, J.2
Mayer, U.3
Schinkel, A.H.4
Smit, J.W.5
Meijer, D.K.6
Borst, P.7
Nooijen, W.J.8
Beijnen, J.H.9
van Tellingen, O.10
-
167
-
-
53149137813
-
Comparative studies to determine the selective inhibitors for P-glycoprotein and cytochrome P450 3A4
-
available from
-
M Achira, H Suzuki, K Ito, Y Sugiyama. Comparative studies to determine the selective inhibitors for P-glycoprotein and cytochrome P450 3A4. AAPS Pharm Sci I, 1999. (available from http://www.pharmsci.org/journal)
-
(1999)
AAPS Pharm Sci I
-
-
Achira, M.1
Suzuki, H.2
Ito, K.3
Sugiyama, Y.4
-
168
-
-
0030817412
-
P-glycoprotein mediates the efflux of quinidine across the blood-brain barrier
-
H Kusuhara, H Suzuki, T Terasaki, A Kakee, M Lemaire, Y Sugiyama P-glycoprotein mediates the efflux of quinidine across the blood-brain barrier. J Pharmacol Exp Ther 283: 574-580, 1997.
-
(1997)
J Pharmacol Exp Ther
, vol.283
, pp. 574-580
-
-
Kusuhara, H.1
Suzuki, H.2
Terasaki, T.3
Kakee, A.4
Lemaire, M.5
Sugiyama, Y.6
-
169
-
-
0029892497
-
P-Glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs
-
AH Schinkel, E Wagenaar, CAAM Mol, L van Deemter. P-Glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs. J Clin Invest 97: 2517-2524, 1996.
-
(1996)
J Clin Invest
, vol.97
, pp. 2517-2524
-
-
Schinkel, A.H.1
Wagenaar, E.2
Mol, C.A.A.M.3
van Deemter, L.4
-
170
-
-
0028825399
-
Absence of the mdrIa P-glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A
-
AH Schinkel, E Wagenaar, L van Deemter, CAAM Mol, P Borst. Absence of the mdrIa P-glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A. J Clin Invest 96: 1698-1705, 1995.
-
(1995)
J Clin Invest
, vol.96
, pp. 1698-1705
-
-
Schinkel, A.H.1
Wagenaar, E.2
van Deemter, L.3
Mol, C.A.A.M.4
Borst, P.5
-
171
-
-
0031757312
-
BBB transport and P-glycoprotein functionality using MDRIA (- /-) and wild-type mice. Total brain versus microdialysis concentration profiles of rhodamine-123
-
EC de Lange, G de Bock, AH Schinkel, AG de Boer, DD Breimer. BBB transport and P-glycoprotein functionality using MDRIA (- /-) and wild-type mice. Total brain versus microdialysis concentration profiles of rhodamine-123. Pharm Res 15: 1657-1665, 1998.
-
(1998)
Pharm Res
, vol.15
, pp. 1657-1665
-
-
de Lange, E.C.1
de Bock, G.2
Schinkel, A.H.3
de Boer, A.G.4
Breimer, D.D.5
-
172
-
-
0027095653
-
Overexpression of a transporter gene in a multidrug- resistant human lung cancer cell line
-
SP Cole, G Bhardwaj, JH Gerlach, JE Mackie, CE Grant, KC Almquist, AJ Stewart, EU Kurz, AM Duncan, RG Deeley. Overexpression of a transporter gene in a multidrug- resistant human lung cancer cell line. Science 258: 1650-1654, 1992.
-
(1992)
Science
, vol.258
, pp. 1650-1654
-
-
Cole, S.P.1
Bhardwaj, G.2
Gerlach, J.H.3
Mackie, J.E.4
Grant, C.E.5
Almquist, K.C.6
Stewart, A.J.7
Kurz, E.U.8
Duncan, A.M.9
Deeley, R.G.10
-
173
-
-
0027960078
-
Pharmacological characterization of multidrug resistant MRP-transfected human tumor cells
-
SPC Cole, KE Sparks, K Fraser, DW Loe, CE Grant, GM Wilson, RG Deeley. Pharmacological characterization of multidrug resistant MRP-transfected human tumor cells. Cancer Res 54: 5902-5910, 1994.
-
(1994)
Cancer Res
, vol.54
, pp. 5902-5910
-
-
Cole, S.P.C.1
Sparks, K.E.2
Fraser, K.3
Loe, D.W.4
Grant, C.E.5
Wilson, G.M.6
Deeley, R.G.7
-
174
-
-
0030775395
-
Pharmacological characterization of the murine and human orthologs of multidrug-resistance protein in transfected human embryonic kidney cells
-
BD Stride, CE Grant, DW Loe, DR Hipfner, SPC Cole, RG Deeley. Pharmacological characterization of the murine and human orthologs of multidrug-resistance protein in transfected human embryonic kidney cells. Mol Pharmacol 52: 344-353, 1997.
-
(1997)
Mol Pharmacol
, vol.52
, pp. 344-353
-
-
Stride, B.D.1
Grant, C.E.2
Loe, D.W.3
Hipfner, D.R.4
Cole, S.P.C.5
Deeley, R.G.6
-
175
-
-
0027172915
-
Analysis of the expression of MRP, the gene for a new putative transmembrane drug transporter, in human multidrug resistant lung cancer cell lines
-
GJ Zaman, CH Versantvoort, JJ Smit, EW Eijdems, M de Haas, AJ Smith, HJ Broxterman, NH Mulder, EG de Vries, F Baas, P Borst. Analysis of the expression of MRP, the gene for a new putative transmembrane drug transporter, in human multidrug resistant lung cancer cell lines. Cancer Res 53: 1747-1750, 1993.
-
(1993)
Cancer Res
, vol.53
, pp. 1747-1750
-
-
Zaman, G.J.1
Versantvoort, C.H.2
Smit, J.J.3
Eijdems, E.W.4
de Haas, M.5
Smith, A.J.6
Broxterman, H.J.7
Mulder, N.H.8
de Vries, E.G.9
Baas, F.10
Borst, P.11
-
176
-
-
0030058257
-
Functional expression of the multidrug resistance-associated protein in the yeast Saccharomyces cerevisiae
-
S Ruetz, M Brault, C Kast, C Hemenway, J Heitman, CE Grant, SP Cole, RG Deeley, P Gros. Functional expression of the multidrug resistance-associated protein in the yeast Saccharomyces cerevisiae. J Biol Chem 271: 4154-4160, 1996.
-
(1996)
J Biol Chem
, vol.271
, pp. 4154-4160
-
-
Ruetz, S.1
Brault, M.2
Kast, C.3
Hemenway, C.4
Heitman, J.5
Grant, C.E.6
Cole, S.P.7
Deeley, R.G.8
Gros, P.9
-
177
-
-
0029954845
-
Biology of the multidrug resistance-associated protein, MRP
-
DW Loe, RG Deeley, SPC Cole. Biology of the multidrug resistance-associated protein, MRP. Eur J Cancer 32A: 945-957, 1996.
-
(1996)
Eur J Cancer
, vol.32A
, pp. 945-957
-
-
Loe, D.W.1
Deeley, R.G.2
Cole, S.P.C.3
-
178
-
-
0030063480
-
Transport of glutathione, glucuronate, and sulfate conjugates by the MRP gene-encoded conjugate export pump
-
G Jedlitschky, I Leier, U Buchholz, K Bamouin, G Kurz, D Keppler. Transport of glutathione, glucuronate, and sulfate conjugates by the MRP gene-encoded conjugate export pump. Cancer Res 56: 988-994, 1996.
-
(1996)
Cancer Res
, vol.56
, pp. 988-994
-
-
Jedlitschky, G.1
Leier, I.2
Buchholz, U.3
Bamouin, K.4
Kurz, G.5
Keppler, D.6
-
179
-
-
0029095763
-
Role of glutathione in the export of compounds from cells by the multidrug-resistance-associated protein
-
GJ Zaman, J Lankelma, D van Tellingen, J Beijnen, H Dekker, C Paulusma, RPJ Dude Elferink, F Baas, P Borst. Role of glutathione in the export of compounds from cells by the multidrug-resistance-associated protein. Proc Natl Acad Sci USA 92: 7690-7694, 1995.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 7690-7694
-
-
Zaman, G.J.1
Lankelma, J.2
van Tellingen, D.3
Beijnen, J.4
Dekker, H.5
Paulusma, C.6
Dude Elferink, R.P.J.7
Baas, F.8
Borst, P.9
-
180
-
-
0029029449
-
Regulation by glutathione of drug transport in multidrug-resistant human lung tumor cell lines overexpressing multidrug resistance-associated protein
-
CH Versantvoort, HJ Broxterman, T Bagrij, RJ Scheper, PR Twentyman. Regulation by glutathione of drug transport in multidrug-resistant human lung tumor cell lines overexpressing multidrug resistance-associated protein. Br J Cancer 72: 82-89, 1995.
-
(1995)
Br J Cancer
, vol.72
, pp. 82-89
-
-
Versantvoort, C.H.1
Broxterman, H.J.2
Bagrij, T.3
Scheper, R.J.4
Twentyman, P.R.5
-
181
-
-
0030009305
-
Multidrug resistance protein (MRP)mediated transport of leukotriene C4 and chemotherapeutic agents in membrane vesicles. Demonstration of glutathione-dependent vincristine transport
-
DW Loe, KC Almquist, RG Deeley, SP Cole. Multidrug resistance protein (MRP)mediated transport of leukotriene C4 and chemotherapeutic agents in membrane vesicles. Demonstration of glutathione-dependent vincristine transport. J Biol Chem 271: 9675-9682, 1996.
-
(1996)
J Biol Chem
, vol.271
, pp. 9675-9682
-
-
Loe, D.W.1
Almquist, K.C.2
Deeley, R.G.3
Cole, S.P.4
-
182
-
-
0029821995
-
Multidrug resistance mediated by the multidrug resistance protein (MRP) gene
-
D Lautier, Y Canitrot, RG Deeley, SPC Cole. Multidrug resistance mediated by the multidrug resistance protein (MRP) gene. Biochem Pharmacol 52: 967-977, 1996.
-
(1996)
Biochem Pharmacol
, vol.52
, pp. 967-977
-
-
Lautier, D.1
Canitrot, Y.2
Deeley, R.G.3
Cole, S.P.C.4
-
183
-
-
0032211417
-
Multidrug resistance mediated by the ATP-binding cassette transporter protein MRP
-
SP Cole, RG Deeley. Multidrug resistance mediated by the ATP-binding cassette transporter protein MRP. Bioessays 20: 931-940, 1998.
-
(1998)
Bioessays
, vol.20
, pp. 931-940
-
-
Cole, S.P.1
Deeley, R.G.2
-
184
-
-
0031156379
-
Function, evolution and structure of multidrug resistance protein (MRP)
-
RG Deeley, SP Cole. Function, evolution and structure of multidrug resistance protein (MRP). Semin Cancer Biol 8: 193-204, 1997.
-
(1997)
Semin Cancer Biol
, vol.8
, pp. 193-204
-
-
Deeley, R.G.1
Cole, S.P.2
-
185
-
-
0029995238
-
Basolateral localization and export activity of the human multidrug resistance-associated protein in polarized pig kidney cells
-
REvers, GJ Zaman, L van Deemter, H Jansen, J Calafat, LC Domen, RPJ Dude Elferink, P Borst, AH Schinkel. Basolateral localization and export activity of the human multidrug resistance-associated protein in polarized pig kidney cells. J Clin Invest 97: 1211-1218, 1996.
-
(1996)
J Clin Invest
, vol.97
, pp. 1211-1218
-
-
Evers, R.1
Zaman, G.J.2
van Deemter, L.3
Jansen, H.4
Calafat, J.5
Domen, L.C.6
Dude Elferink, R.P.J.7
Borst, P.8
Schinkel, A.H.9
-
186
-
-
0033975098
-
Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier
-
J Wijnholds, EC de Lange, GL Scheffer, OJ van Den Berg, CA Mol, M van Der Valk, AH Schinkel, RJ Scheper, DD Breimer, P Borst. Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier. J Clin Invest 105: 279-285, 2000.
-
(2000)
J Clin Invest
, vol.105
, pp. 279-285
-
-
Wijnholds, J.1
de Lange, E.C.2
Scheffer, G.L.3
van Den Berg, O.J.4
Mol, C.A.5
van Der Valk, M.6
Schinkel, A.H.7
Scheper, R.J.8
Breimer, D.D.9
Borst, P.10
-
187
-
-
0032967070
-
Transepithelial transport of organic anions across the choroid plexus: Possible involvement of organic anion transporter and multidrug resistance-associated protein
-
J Nishino, H Suzuki, D Sugiyama, T Kitazawa, K Ito, M Hanano, Y Sugiyama. Transepithelial transport of organic anions across the choroid plexus: possible involvement of organic anion transporter and multidrug resistance-associated protein. J Pharmacol Exp Ther 290: 289-294, 1999.
-
(1999)
J Pharmacol Exp Ther
, vol.290
, pp. 289-294
-
-
Nishino, J.1
Suzuki, H.2
Sugiyama, D.3
Kitazawa, T.4
Ito, K.5
Hanano, M.6
Sugiyama, Y.7
-
188
-
-
0033616684
-
Choroid plexus epithelial expression ofMDR1 P-glycoprotein and multidrug resistance-associated protein contribute to the blood-cerebrospinal-fluid drug-permeability barrier
-
VV Rao, JL Dahlheimer, ME Bardgett, AZ Snyder, RA Finch, AC Sartorelli, D Piwnica-Worms. Choroid plexus epithelial expression ofMDR1 P-glycoprotein and multidrug resistance-associated protein contribute to the blood-cerebrospinal-fluid drug-permeability barrier. Proc Natl Acad Sci USA 96: 3900-3905, 1999.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 3900-3905
-
-
Rao, V.V.1
Dahlheimer, J.L.2
Bardgett, M.E.3
Snyder, A.Z.4
Finch, R.A.5
Sartorelli, A.C.6
Piwnica-Worms, D.7
-
189
-
-
0033178980
-
Demonstration of a coupled metabolism-efflux process at the choroid plexus as a mechanism of brain protection toward xenobiotics
-
N Strazielle. JF Ghersi-Egea. Demonstration of a coupled metabolism-efflux process at the choroid plexus as a mechanism of brain protection toward xenobiotics. J Neurosci 19: 6275-6289. 1999.
-
(1999)
J Neurosci
, vol.19
, pp. 6275-6289
-
-
Strazielle, N.1
Ghersi-Egea, J.F.2
-
190
-
-
0000053197
-
-
T Mikami, T Nozaki, O Tagaya. S Hosokawa, T Nakura, H Hori, S Kondou. Cong Anom 26: 250-251. 1986.
-
(1986)
Cong Anom
, vol.26
, pp. 250-251
-
-
Mikami, T.1
Nozaki, T.2
Tagaya, O.3
Hosokawa, S.4
Nakura, T.5
Hori, H.6
Kondou, S.7
-
191
-
-
0032145320
-
Bile acid and xenobiotic transporters in liver
-
B Stieger, PJ Meier. Bile acid and xenobiotic transporters in liver. Curr Opin Cell Biol 10: 462-467, 1998.
-
(1998)
Curr Opin Cell Biol
, vol.10
, pp. 462-467
-
-
Stieger, B.1
Meier, P.J.2
-
192
-
-
0032434272
-
Excretion of GSSG and glutathione conjugates mediated by MRPI and cMOAT/MRP2
-
H Suzuki, Y Sugiyama. Excretion of GSSG and glutathione conjugates mediated by MRPI and cMOAT/MRP2. Semin Liver Dis 18: 359-376. 1998.
-
(1998)
Semin Liver Dis
, vol.18
, pp. 359-376
-
-
Suzuki, H.1
Sugiyama, Y.2
-
193
-
-
0344927562
-
Conjugate export pumps of the multidrug resistance protein (MRP) family: Localization. substrate specificity. and MRP2-mediated drug resistance
-
J Konig, AT Nies, Y Cui, I Leier, D Keppler. Conjugate export pumps of the multidrug resistance protein (MRP) family: localization. substrate specificity. and MRP2-mediated drug resistance. Biochim Biophys Acta 1461: 377-394, 1999.
-
(1999)
Biochim Biophys Acta
, vol.1461
, pp. 377-394
-
-
Konig, J.1
Nies, A.T.2
Cui, Y.3
Leier, I.4
Keppler, D.5
-
195
-
-
0344258381
-
Multidrug resistance- associated protein subfamily transporters and drug resistance
-
M Kuwano, S Toh, T Uchiumi, H Takano. K Kohno. M Wada. Multidrug resistance- associated protein subfamily transporters and drug resistance. Anticancer Drug Des 14: 123-131, 1999.
-
(1999)
Anticancer Drug Des
, vol.14
, pp. 123-131
-
-
Kuwano, M.1
Toh, S.2
Uchiumi, T.3
Takano, H.4
Kohno, K.5
Wada, M.6
-
196
-
-
0029981430
-
Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene
-
CC Paulusma, PJ Bosma, OJ Zaman. CT Bakker, MOtter. GL Scheffer. RJ Scheper. P Borst. RP Oude Elferink. Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene. Science 271: 1126-1128, 1996.
-
(1996)
Science
, vol.271
, pp. 1126-1128
-
-
Paulusma, C.C.1
Bosma, P.J.2
Zaman, O.J.3
Bakker, C.T.4
Otter, M.5
Scheffer, G.L.6
Scheper, R.J.7
Borst, P.8
Oude Elferink, R.P.9
-
197
-
-
0031031247
-
Molecular cloning of canalicular multispecific organic anion transporter defective in EHBR
-
K Ito. H Suzuki, T Hirohashi, K Kume, T Shimizu. Y Sugiyama. Molecular cloning of canalicular multispecific organic anion transporter defective in EHBR. Am J Physiol 272: 016-22, 1997.
-
(1997)
Am J Physiol
, vol.272
, pp. 16-22
-
-
Ito, K.1
Suzuki, H.2
Hirohashi, T.3
Kume, K.4
Shimizu, T.5
Sugiyama, Y.6
-
198
-
-
0040761368
-
cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp. reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats
-
M Buchler, J Konig, M Brom, J Kartenbeck, H Spring, T Horie, D Keppler. cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp. reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats. J Biol Chem 271: 15091-15098, 1996.
-
(1996)
J Biol Chem
, vol.271
, pp. 15091-15098
-
-
Buchler, M.1
Konig, J.2
Brom, M.3
Kartenbeck, J.4
Spring, H.5
Horie, T.6
Keppler, D.7
-
199
-
-
0029986408
-
Absence of the canalicular isoform of the MRP gene-encoded conjugate export pump from the hepatocytes in Dubin-Johnson syndrome
-
J Kartenbeck, U Leuschner, R Mayer, D Keppler. Absence of the canalicular isoform of the MRP gene-encoded conjugate export pump from the hepatocytes in Dubin-Johnson syndrome. Hepatol 23: 1061-1066, 1996.
-
(1996)
Hepatol
, vol.23
, pp. 1061-1066
-
-
Kartenbeck, J.1
Leuschner, U.2
Mayer, R.3
Keppler, D.4
-
200
-
-
0024418887
-
Hepatic, intestinal and renal transport of I-naphthol-beta-D-glucuronide in mutant rats with hereditary-conjugated hyperbilirubinemia
-
MH de Vries, FA Redegeld, AS Koster, J Noordhoek, JG de Haan, RP Oude Elferink, PL Jansen. Hepatic, intestinal and renal transport of I-naphthol-beta-D-glucuronide in mutant rats with hereditary-conjugated hyperbilirubinemia. NaunynSchmiedebergs Arch Pharmacol 340: 588-592, 1989.
-
(1989)
NaunynSchmiedebergs Arch Pharmacol
, vol.340
, pp. 588-592
-
-
de Vries, M.H.1
Redegeld, F.A.2
Koster, A.S.3
Noordhoek, J.4
de Haan, J.G.5
Oude Elferink, R.P.6
Jansen, P.L.7
-
201
-
-
0033958156
-
Involvement of an organic anion transporter (canalicular multispecific organic anion transporterl multidrug resistance-associated protein 2) in gastrointestinal secretion of glutathione conjugates in rats
-
Y Gotoh, H Suzuki, S Kinoshita, T Hirohashi, Y Kato, Y Sugiyama. Involvement of an organic anion transporter (canalicular multispecific organic anion transporterl multidrug resistance-associated protein 2) in gastrointestinal secretion of glutathione conjugates in rats. J Pharmacol Exp Ther 292: 433-439, 2000.
-
(2000)
J Pharmacol Exp Ther
, vol.292
, pp. 433-439
-
-
Gotoh, Y.1
Suzuki, H.2
Kinoshita, S.3
Hirohashi, T.4
Kato, Y.5
Sugiyama, Y.6
-
202
-
-
0033985306
-
Function and expression of multidrug resistance-associated protein family in human colon adenocarcinoma cells (Caco-2)
-
T Hirohashi, H Suzuki, XY Chu, I Tarnai, A Tsuji, Y Sugiyama. Function and expression of multidrug resistance-associated protein family in human colon adenocarcinoma cells (Caco-2). J Pharmacol Exp Ther 292: 265-270, 2000.
-
(2000)
J Pharmacol Exp Ther
, vol.292
, pp. 265-270
-
-
Hirohashi, T.1
Suzuki, H.2
Chu, X.Y.3
Tarnai, I.4
Tsuji, A.5
Sugiyama, Y.6
-
203
-
-
9544233652
-
A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation
-
K Taniguchi, M Wada, K Kohno, T Nakamura, T Kawabe, M Kawakami, K Kagotani. K Okumura, S Akiyama. M Kuwano. A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation. Cancer Res 56: 4124-4129, 1996.
-
(1996)
Cancer Res
, vol.56
, pp. 4124-4129
-
-
Taniguchi, K.1
Wada, M.2
Kohno, K.3
Nakamura, T.4
Kawabe, T.5
Kawakami, M.6
Kagotani, K.7
Okumura, K.8
Akiyama, S.9
Kuwano, M.10
-
204
-
-
0031468814
-
A canalicular multispecific organic anion transporter (cMOAT) antisense eDNA enhances drug sensitivity in human hepatic cancer cells
-
K Koike, T Kawabe, T Tanaka, S Toh, T Uchiumi, M Wada, S Akiyama, MOno, M Kuwano. A canalicular multispecific organic anion transporter (cMOAT) antisense eDNA enhances drug sensitivity in human hepatic cancer cells. Cancer Res 57: 5475-5479, 1997.
-
(1997)
Cancer Res
, vol.57
, pp. 5475-5479
-
-
Koike, K.1
Kawabe, T.2
Tanaka, T.3
Toh, S.4
Uchiumi, T.5
Wada, M.6
Akiyama, S.7
Ono, M.8
Kuwano, M.9
-
205
-
-
0032974409
-
Primary active transport of organic anions on bile canalicular membrane in humans
-
K Niinuma, Y Kato, H Suzuki, CA Tyson, V Weizer, JE Dabbs, R Froehlich, CE Green, Y Sugiyama. Primary active transport of organic anions on bile canalicular membrane in humans. Am J Physiol 276: GI153-1164, 1999.
-
(1999)
Am J Physiol
, vol.276
, pp. GI153-1164
-
-
Niinuma, K.1
Kato, Y.2
Suzuki, H.3
Tyson, C.A.4
Weizer, V.5
Dabbs, J.E.6
Froehlich, R.7
Green, C.E.8
Sugiyama, Y.9
-
206
-
-
0031838805
-
cDNA cloning and inducible expression of human multidrug resistance associated protein 3 (MRP3)
-
Y Kiuchi, H Suzuki, T Hirohashi, CA Tyson, Y Sugiyama. cDNA cloning and inducible expression of human multidrug resistance associated protein 3 (MRP3). FEBS Lett 433: 149-152, 1998.
-
(1998)
FEBS Lett
, vol.433
, pp. 149-152
-
-
Kiuchi, Y.1
Suzuki, H.2
Hirohashi, T.3
Tyson, C.A.4
Sugiyama, Y.5
-
207
-
-
0032501054
-
Isolation of a novel human canalicular multispecific organic anion transporter, cMOAT2/MRP3, and its expression in cisplatin-resistant cancer cells with decreased ATP-dependent drug transport
-
T Uchiumi, E Hinoshita, S Haga, T Nakamura, T Tanaka, S Toh, M Furukawa, T Kawabe, M Wada, K Kagotani, K Okumura, K Kohno, S Akiyama, M Kuwano. Isolation of a novel human canalicular multispecific organic anion transporter, cMOAT2/MRP3, and its expression in cisplatin-resistant cancer cells with decreased ATP-dependent drug transport. Biochem Biophys Res Commun 252: 103-110, 1998.
-
(1998)
Biochem Biophys Res Commun
, vol.252
, pp. 103-110
-
-
Uchiumi, T.1
Hinoshita, E.2
Haga, S.3
Nakamura, T.4
Tanaka, T.5
Toh, S.6
Furukawa, M.7
Kawabe, T.8
Wada, M.9
Kagotani, K.10
Okumura, K.11
Kohno, K.12
Akiyama, S.13
Kuwano, M.14
-
208
-
-
0033591235
-
Characterization of the transport properties of cloned rat multidrug resistance-associated protein 3 (MRP3)
-
T Hirohashi, H Suzuki, Y Sugiyama. Characterization of the transport properties of cloned rat multidrug resistance-associated protein 3 (MRP3). J Biol Chem 274: 15181-15185, 1999.
-
(1999)
J Biol Chem
, vol.274
, pp. 15181-15185
-
-
Hirohashi, T.1
Suzuki, H.2
Sugiyama, Y.3
-
209
-
-
0033066688
-
MRP3, a new ATP-binding cassette protein localized to the canalicular domain of the hepatocyte
-
DF Ortiz, S Li, R Iyer, X Zhang, P Novikoff, JM Arias. MRP3, a new ATP-binding cassette protein localized to the canalicular domain of the hepatocyte. Am J Physiol 276: G1493-1500, 1999.
-
(1999)
Am J Physiol
, vol.276
, pp. G1493-1500
-
-
Ortiz, D.F.1
Li, S.2
Iyer, R.3
Zhang, X.4
Novikoff, P.5
Arias, J.M.6
-
210
-
-
0032926354
-
Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatocyte membrane
-
J Konig, DRost, Y Cui, D Keppler. Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatocyte membrane. Hepatology 29: 1156-1163, 1999.
-
(1999)
Hepatology
, vol.29
, pp. 1156-1163
-
-
Konig, J.1
Rost, D.2
Cui, Y.3
Keppler, D.4
-
211
-
-
0034723163
-
ATP-dependent transport of bile salts by rat multidrug resistance-associated protein 3 (Mrp3)
-
T Hirohashi, H Suzuki, H Takikawa, Y Sugiyama. ATP-dependent transport of bile salts by rat multidrug resistance-associated protein 3 (Mrp3). J Biol Chem 275: 2905-2910, 2000.
-
(2000)
J Biol Chem
, vol.275
, pp. 2905-2910
-
-
Hirohashi, T.1
Suzuki, H.2
Takikawa, H.3
Sugiyama, Y.4
-
214
-
-
0025007511
-
Pharmacology of drugs that alter multidrug resistance in cancer
-
JM Ford, WN Hail. Pharmacology of drugs that alter multidrug resistance in cancer. Pharmacol Rev 42: 155-199, 1990.
-
(1990)
Pharmacol Rev
, vol.42
, pp. 155-199
-
-
Ford, J.M.1
Hail, W.N.2
-
215
-
-
0028935166
-
Modulators of multidrug resistance. Preclinical studies
-
JM Ford. Modulators of multidrug resistance. Preclinical studies. Hematol Oncol Clin North America 9: 337-361, 1995.
-
(1995)
Hematol Oncol Clin North America
, vol.9
, pp. 337-361
-
-
Ford, J.M.1
-
216
-
-
0028711167
-
In vivo models of P-glycoprotein-mediated multidrug resistance
-
MM Gottesman, GH Mickisch, I Pastan. In vivo models of P-glycoprotein-mediated multidrug resistance. Cancer Treat Res 73: 107-128, 1994.
-
(1994)
Cancer Treat Res
, vol.73
, pp. 107-128
-
-
Gottesman, M.M.1
Mickisch, G.H.2
Pastan, I.3
-
217
-
-
0026611746
-
Pharmacologic interactions between the resistance-modifying cyclosporine SDZ PSC 833 and etoposide (VP 16-213) enhance in vivo cytostatic activity and toxicity
-
RP Keller, HJ Altermatt, P Donatsch, H Zihlmann, JA Laissue, PC Hiestand. Pharmacologic interactions between the resistance-modifying cyclosporine SDZ PSC 833 and etoposide (VP 16-213) enhance in vivo cytostatic activity and toxicity. Int Natl Cancer 51 : 433-438, 1992.
-
(1992)
Int Natl Cancer
, vol.51
, pp. 433-438
-
-
Keller, R.P.1
Altermatt, H.J.2
Donatsch, P.3
Zihlmann, H.4
Laissue, J.A.5
Hiestand, P.C.6
-
218
-
-
0030918044
-
Effect of the P-glycoprotein inhibitor, SDZ PSC 833, on the blood and brain pharmacokinetics of colchicine
-
S Desrayaud, P Guntz, JM Scherrmann, M Lemaire. Effect of the P-glycoprotein inhibitor, SDZ PSC 833, on the blood and brain pharmacokinetics of colchicine. Life Sci 61: 153-163, 1997.
-
(1997)
Life Sci
, vol.61
, pp. 153-163
-
-
Desrayaud, S.1
Guntz, P.2
Scherrmann, J.M.3
Lemaire, M.4
-
219
-
-
0027998226
-
In vivo evidence for ATP-dependent and P-glycoprotein-mediated transport of cyclosporin A at the blood-brain barrier
-
A Sakata, J Tarnai, K Kawazu, Y Deguchi, T Ohnishi, A Saheki, A Tsuji. In vivo evidence for ATP-dependent and P-glycoprotein-mediated transport of cyclosporin A at the blood-brain barrier. Biochem Pharamacol 48: 1989-1992, 1994.
-
(1994)
Biochem Pharamacol
, vol.48
, pp. 1989-1992
-
-
Sakata, A.1
Tarnai, J.2
Kawazu, K.3
Deguchi, Y.4
Ohnishi, T.5
Saheki, A.6
Tsuji, A.7
-
220
-
-
0028998552
-
Effect of the P-glycoprotein inhibitor, cyclosporin A, on the distribution of rhodamine-123 to the brain: An in vivo microdialysis study in freely moving rats
-
Q Wang, H Yang, OW Miller, WF Elmquist. Effect of the P-glycoprotein inhibitor, cyclosporin A, on the distribution of rhodamine-123 to the brain: an in vivo microdialysis study in freely moving rats. Biochem Biophys Res Commun 211: 719-726, 1995.
-
(1995)
Biochem Biophys Res Commun
, vol.211
, pp. 719-726
-
-
Wang, Q.1
Yang, H.2
Miller, O.W.3
Elmquist, W.F.4
-
221
-
-
4243501701
-
The effect of LY-335979 on the distribution kinetics of quinidine to the brain: An in vivo microdialysis study in freely moving rats
-
Q Wang, H Yang, WF Elmquist. The effect of LY-335979 on the distribution kinetics of quinidine to the brain: an in vivo microdialysis study in freely moving rats. Pharm Res 13: S-456, 1996.
-
(1996)
Pharm Res
, vol.13
, pp. S-456
-
-
Wang, Q.1
Yang, H.2
Elmquist, W.F.3
-
222
-
-
0025092259
-
Interactions in the renal and biliary elimination of digoxin: Stereoselective difference between quinine and quinidine
-
A Hedman, B Angelin, A Arvidsson, R Oahlqvist, B Nilsson. Interactions in the renal and biliary elimination of digoxin: stereoselective difference between quinine and quinidine. Clin Pharmacol Ther 47: 20-26, 1990.
-
(1990)
Clin Pharmacol Ther
, vol.47
, pp. 20-26
-
-
Hedman, A.1
Angelin, B.2
Arvidsson, A.3
Oahlqvist, R.4
Nilsson, B.5
-
223
-
-
0026092531
-
Oigoxin-verapamil interaction: Reduction of biliary but not renal digoxin clearance in humans
-
A Hedman, B Angelin, A Arvidsson, O Beck, R Dahlqvist, B Nilsson, M Olsson, K Schenck-Gustafsson. Oigoxin-verapamil interaction: reduction of biliary but not renal digoxin clearance in humans. Clin Pharmacol Ther 49: 256-262, 1991.
-
(1991)
Clin Pharmacol Ther
, vol.49
, pp. 256-262
-
-
Hedman, A.1
Angelin, B.2
Arvidsson, A.3
Beck, O.4
Dahlqvist, R.5
Nilsson, B.6
Olsson, M.7
Schenck-Gustafsson, K.8
-
224
-
-
0022338030
-
Effects of verapamil, diltiazem, and nifedipine on plasma levels and renal excretions of digitoxin
-
J Kuhlmann. Effects of verapamil, diltiazem, and nifedipine on plasma levels and renal excretions of digitoxin. Clin Pharmacol Ther 38: 667-673, 1985.
-
(1985)
Clin Pharmacol Ther
, vol.38
, pp. 667-673
-
-
Kuhlmann, J.1
-
225
-
-
0031836110
-
Characterization of the uptake of rocuronium and digoxin in human hepatocytes: Carrier specificity and comparison with in vivo data
-
Polinga, M Merema, IH Hof, MJ Slooff, JH Proost, DK Meijer, GM Groothuis. Characterization of the uptake of rocuronium and digoxin in human hepatocytes: carrier specificity and comparison with in vivo data. J Pharmacol Exp Ther 285: 506-510, 1998.
-
(1998)
J Pharmacol Exp Ther
, vol.285
, pp. 506-510
-
-
Polinga, M.M.1
Hof, I.H.2
Slooff, M.J.3
Proost, J.H.4
Meijer, D.K.5
Groothuis, G.M.6
-
226
-
-
0031926050
-
Stereoselective inhibition by the diasteromers quinidine and quinine of uptake of cardiac glycosides into isolated rat hepatocytes
-
A Hedman, OK Meijer. Stereoselective inhibition by the diasteromers quinidine and quinine of uptake of cardiac glycosides into isolated rat hepatocytes. J Pharm Sci 87: 457-461, 1998.
-
(1998)
J Pharm Sci
, vol.87
, pp. 457-461
-
-
Hedman, A.1
Meijer, O.K.2
-
227
-
-
0027818964
-
Role of P-glycoprotein in renal tubular secretion of digoxin in the isolated perfused rat kidney
-
R Hori, N Okamura, TAiba, Y Tanigawara. Role of P-glycoprotein in renal tubular secretion of digoxin in the isolated perfused rat kidney. J Pharmacol Exp Ther 266: 1620-1625, 1993.
-
(1993)
J Pharmacol Exp Ther
, vol.266
, pp. 1620-1625
-
-
Hori, R.1
Okamura, N.2
Aiba, T.3
Tanigawara, Y.4
-
228
-
-
0033514320
-
Inhibition of P-glycoprotein- mediated drug transport: A unifying mechanism to explain the interaction between digoxin and quinidine
-
MF Fromm, RB Kim, CM Stein, GR Wilkinson, DM Roden. Inhibition of P-glycoprotein- mediated drug transport: A unifying mechanism to explain the interaction between digoxin and quinidine. Circulation 99: 552-557, 1999.
-
(1999)
Circulation
, vol.99
, pp. 552-557
-
-
Fromm, M.F.1
Kim, R.B.2
Stein, C.M.3
Wilkinson, G.R.4
Roden, D.M.5
-
229
-
-
0031900997
-
Role of P-glycoprotein as a secretory mechanism in quinidine absorption from rat small intestine
-
Y Emi, D Tsunashima, K Ogawara, K Higaki, T Kimura. Role of P-glycoprotein as a secretory mechanism in quinidine absorption from rat small intestine. J Pharm Sci 87: 295-299, 1998.
-
(1998)
J Pharm Sci
, vol.87
, pp. 295-299
-
-
Emi, Y.1
Tsunashima, D.2
Ogawara, K.3
Higaki, K.4
Kimura, T.5
-
230
-
-
0031908050
-
Grapefruit juice enhances the bioavailability of the HIV protease inhibitor saquinavir in man
-
HH Kupferschmidt, KE Fattinger, HR Ha, F Follath, S Krahenbuhl. Grapefruit juice enhances the bioavailability of the HIV protease inhibitor saquinavir in man. Br J Clin Pharmacol 45: 355-359, 1998.
-
(1998)
Br J Clin Pharmacol
, vol.45
, pp. 355-359
-
-
Kupferschmidt, H.H.1
Fattinger, K.E.2
Ha, H.R.3
Follath, F.4
Krahenbuhl, S.5
-
231
-
-
7144257182
-
Pharmacokinetic interactions between two human immunodeficiency virus protease inhibitors, ritonavir and saquinavir
-
A Hsu, GR Granneman, G Cao, L Carothers, T el-Shourbagy, P Baroldi, K Erdman, F Brown, E Sun, JM Leonard. Pharmacokinetic interactions between two human immunodeficiency virus protease inhibitors, ritonavir and saquinavir. Clin Pharmacol Ther 63: 453-464, 1998.
-
(1998)
Clin Pharmacol Ther
, vol.63
, pp. 453-464
-
-
Hsu, A.1
Granneman, G.R.2
Cao, G.3
Carothers, L.4
el-Shourbagy, T.5
Baroldi, P.6
Erdman, K.7
Brown, F.8
Sun, E.9
Leonard, J.M.10
-
232
-
-
0031024382
-
Selective biotransformation of the human immunodeficiency virus protease inhibitor saquinavir by human small-intestinal cytochrome P4503A4: Potential contribution to high first-pass metabolism
-
ME Fitzsimmons, JM Collins. Selective biotransformation of the human immunodeficiency virus protease inhibitor saquinavir by human small-intestinal cytochrome P4503A4: potential contribution to high first-pass metabolism. Drug Metab Dispos 25: 256-266, 1997.
-
(1997)
Drug Metab Dispos
, vol.25
, pp. 256-266
-
-
Fitzsimmons, M.E.1
Collins, J.M.2
-
233
-
-
0030852009
-
Differential inhibition of cytochrome P450 isoforms by the protease inhibitors, ritonavir, saquinavir and indinavir
-
VA Eagling, OJ Back, MG Barry. Differential inhibition of cytochrome P450 isoforms by the protease inhibitors, ritonavir, saquinavir and indinavir. Br J Clin Pharmacol 44: 190-194, 1997.
-
(1997)
Br J Clin Pharmacol
, vol.44
, pp. 190-194
-
-
Eagling, V.A.1
Back, O.J.2
Barry, M.G.3
-
234
-
-
0031896882
-
Active apical secretory efflux of the HIV protease inhibitors saquinavir and ritonavir in Caco-2 cell monolayers
-
J Alsenz, H Steffen, R Alex., Active apical secretory efflux of the HIV protease inhibitors saquinavir and ritonavir in Caco-2 cell monolayers. Pharm Res 15: 423-428, 1998.
-
(1998)
Pharm Res
, vol.15
, pp. 423-428
-
-
Alsenz, J.1
Steffen, H.2
Alex, R.3
-
235
-
-
0033064071
-
Increase in cerivastatin systemic exposure after single and multiple dosing in cyclosporine-treated kidney transplant recipients
-
W Muck, I Mai, L Fritsche, K Ochmann, G Rohde, S Unger, A Johne, S Bauer, K Budde, I Roots, HH Neumayer, J Kuhlmann. Increase in cerivastatin systemic exposure after single and multiple dosing in cyclosporine-treated kidney transplant recipients. Clin Pharmacol Ther 65: 251-261, 1999.
-
(1999)
Clin Pharmacol Ther
, vol.65
, pp. 251-261
-
-
Muck, W.1
Mai, I.2
Fritsche, L.3
Ochmann, K.4
Rohde, G.5
Unger, S.6
Johne, A.7
Bauer, S.8
Budde, K.9
Roots, I.10
Neumayer, H.H.11
Kuhlmann, J.12
-
236
-
-
1842338712
-
Absolute and relative bioavailability of the HMG-CoA reductase inhibitor cerivastatin
-
W Much, W Ritter, K Ochmann, S Unger, G Ahr, W Wingender, J Kuhlmann. Absolute and relative bioavailability of the HMG-CoA reductase inhibitor cerivastatin. Int J Clin Pharmacol Ther 35: 255-260, 1997.
-
(1997)
Int J Clin Pharmacol Ther
, vol.35
, pp. 255-260
-
-
Much, W.1
Ritter, W.2
Ochmann, K.3
Unger, S.4
Ahr, G.5
Wingender, W.6
Kuhlmann, J.7
-
237
-
-
0030893455
-
Metabolism of cerivastatin by human liver microsomes in vitro. Characterization of primary metabolic pathways and of cytochrome P450 isozymes involved
-
M Boberg, R Angerbauer, P Fey, WK Kanhai, W Karl, A Kern, J Ploschke, M Radtke. Metabolism of cerivastatin by human liver microsomes in vitro. Characterization of primary metabolic pathways and of cytochrome P450 isozymes involved. Drug Metab Dispos 25: 321-331, 1997.
-
(1997)
Drug Metab Dispos
, vol.25
, pp. 321-331
-
-
Boberg, M.1
Angerbauer, R.2
Fey, P.3
Kanhai, W.K.4
Karl, W.5
Kern, A.6
Ploschke, J.7
Radtke, M.8
-
238
-
-
0031969657
-
Influence of erythromycin pre- and co-treatment on single-dose pharmacokinetics of the HMG-CoA reductase inhibitor cerivastatin
-
W Muck, K Ochmann, G Rohde, S Unger, J Kuhlmann. Influence of erythromycin pre- and co-treatment on single-dose pharmacokinetics of the HMG-CoA reductase inhibitor cerivastatin. Eur J Clin Pharmacol 53: 469-473, 1998.
-
(1998)
Eur J Clin Pharmacol
, vol.53
, pp. 469-473
-
-
Muck, W.1
Ochmann, K.2
Rohde, G.3
Unger, S.4
Kuhlmann, J.5
-
239
-
-
0023845228
-
Protein distribution diet restores motor function in patients with dopa-resistant “off” period
-
JH Pincus, K Barry. Protein distribution diet restores motor function in patients with dopa-resistant “off” period. Neurology 38: 481-483, 1988.
-
(1988)
Neurology
, vol.38
, pp. 481-483
-
-
Pincus, J.H.1
Barry, K.2
-
240
-
-
0022454431
-
Characterization of the large neutral amino acid transport system of bovine brain microvessel endothelial cell monolayers
-
KL Audus, RT Borchardt. Characterization of the large neutral amino acid transport system of bovine brain microvessel endothelial cell monolayers. J Neurochem 47: 484-488, 1986.
-
(1986)
J Neurochem
, vol.47
, pp. 484-488
-
-
Audus, K.L.1
Borchardt, R.T.2
-
241
-
-
0023130976
-
Facilitated transport of melphalan at the rat blood-brain barrier by the large neutral amino acid carrier system
-
NH Greig, S Momma, DJ Sweeney, QR Smith, SI Rapoport. Facilitated transport of melphalan at the rat blood-brain barrier by the large neutral amino acid carrier system. Cancer Res 47: 1571-1576, 1987.
-
(1987)
Cancer Res
, vol.47
, pp. 1571-1576
-
-
Greig, N.H.1
Momma, S.2
Sweeney, D.J.3
Smith, Q.R.4
Rapoport, S.I.5
-
242
-
-
84931672608
-
Effect of probenecid on excretion of bromosulphthalein
-
SH Blondheim. Effect of probenecid on excretion of bromosulphthalein. J Clin Invest 7: 529-532, 1955.
-
(1955)
J Clin Invest
, vol.7
, pp. 529-532
-
-
Blondheim, S.H.1
-
244
-
-
0016413786
-
Inhibition of renal tubular transport of methotrexate by probenecid
-
RS Bourke, G Chheda, A Bremer, O Watanabe, DB Tower. Inhibition of renal tubular transport of methotrexate by probenecid. Cancer Res 35: 110-116, 1975.
-
(1975)
Cancer Res
, vol.35
, pp. 110-116
-
-
Bourke, R.S.1
Chheda, G.2
Bremer, A.3
Watanabe, O.4
Tower, D.B.5
-
245
-
-
0021364392
-
Effect of penicillin on the renal tubular secretion of methotrexate in the monkey
-
WM Williams, TS Chen, KC Huang. Effect of penicillin on the renal tubular secretion of methotrexate in the monkey. Cancer Res 44: 1913-1917, 1984.
-
(1984)
Cancer Res
, vol.44
, pp. 1913-1917
-
-
Williams, W.M.1
Chen, T.S.2
Huang, K.C.3
-
246
-
-
0023129704
-
Drug inhibition of penicillin tubular secretion: Concordance between in vitro and clinical findings
-
DW Nierenerg. Drug inhibition of penicillin tubular secretion: concordance between in vitro and clinical findings. J Pharmacol Exp Ther 240: 712-716, 1987.
-
(1987)
J Pharmacol Exp Ther
, vol.240
, pp. 712-716
-
-
Nierenerg, D.W.1
-
247
-
-
0031923577
-
A physiologically based kidney model for the renal clearance of ranitidine and the interaction with cimetidine and probenecid in the dog
-
SP Boom, I Meyer, AC Wouterse, FG Russel. A physiologically based kidney model for the renal clearance of ranitidine and the interaction with cimetidine and probenecid in the dog. Biopharm Drug Dispos 19: 199-208, 1998.
-
(1998)
Biopharm Drug Dispos
, vol.19
, pp. 199-208
-
-
Boom, S.P.1
Meyer, I.2
Wouterse, A.C.3
Russel, F.G.4
-
248
-
-
0028822282
-
Effect of probenecid on the distribution and elimination of ciprofloxacin in humans
-
U Jaehde, F Sorgel, A Reiter, G Sigl, KG Naber, W Schunack. Effect of probenecid on the distribution and elimination of ciprofloxacin in humans. Clin Phamacol Ther 58: 532-541, 1995.
-
(1995)
Clin Phamacol Ther
, vol.58
, pp. 532-541
-
-
Jaehde, U.1
Sorgel, F.2
Reiter, A.3
Sigl, G.4
Naber, K.G.5
Schunack, W.6
-
250
-
-
0025868537
-
Dose-dependent absorption and elimination of cefadroxil in man
-
TM Garrigues, U Martin, IE Peris-Ribera, LF Prescott. Dose-dependent absorption and elimination of cefadroxil in man. Eur J Clin Phannacol 41: 179-183, 1991.
-
(1991)
Eur J Clin Phannacol
, vol.41
, pp. 179-183
-
-
Garrigues, T.M.1
Martin, U.2
Peris-Ribera, I.E.3
Prescott, L.F.4
-
251
-
-
0026758261
-
Structural specificity of mucosal-cell transport and metabo- lism of peptide drugs: Implication for oral peptide drug delivery
-
JPF Bai, GL Amidon. Structural specificity of mucosal-cell transport and metabo- lism of peptide drugs: implication for oral peptide drug delivery. Pharm Res 9: 969-978, 1992.
-
(1992)
Pharm Res
, vol.9
, pp. 969-978
-
-
Bai, J.P.F.1
Amidon, G.L.2
-
252
-
-
0002570237
-
Sulfaphenazole-induced hypoglycaemic attacks in tolbutamide treated diabetics
-
LK Christensen, JM Hansen, M Kristensen. Sulfaphenazole-induced hypoglycaemic attacks in tolbutamide treated diabetics. Lancet 2: 1298-1301, 1963.
-
(1963)
Lancet
, vol.2
, pp. 1298-1301
-
-
Christensen, L.K.1
Hansen, J.M.2
Kristensen, M.3
-
255
-
-
84880505647
-
Physiological based pharmacokinetics of drug-drug interaction: A study of tolbutamide-sulfonamide interaction in rats
-
O Sugita, Y Sawada, Y Sugiyama, T Iga, M Hanano. Physiological based pharmacokinetics of drug-drug interaction: a study of tolbutamide-sulfonamide interaction in rats. J Pharmcokin Biopharm 10: 297-316, 1982.
-
(1982)
J Pharmcokin Biopharm
, vol.10
, pp. 297-316
-
-
Sugita, O.1
Sawada, Y.2
Sugiyama, Y.3
Iga, T.4
Hanano, M.5
-
256
-
-
0031693676
-
Efflux transport of tolubutamide across the blood-brain barrier
-
H Takanaga, H Murakami, N Koyabu, H Matsuo, M Naito, T Tsuruo, Y Sawada. Efflux transport of tolubutamide across the blood-brain barrier. J Pharm Pharmcol 50: 1027-1033, 1998.
-
(1998)
J Pharm Pharmcol
, vol.50
, pp. 1027-1033
-
-
Takanaga, H.1
Murakami, H.2
Koyabu, N.3
Matsuo, H.4
Naito, M.5
Tsuruo, T.6
Sawada, Y.7
-
257
-
-
0023933136
-
Effects of basic drugs on the hepatic transport of cardiac glycosides in rats
-
K Okudaira, Y Sawada, Y Sugiyama, T Iga, M Hanano. Effects of basic drugs on the hepatic transport of cardiac glycosides in rats. Biochem Pharmacol 37: 2949-2955, 1988.
-
(1988)
Biochem Pharmacol
, vol.37
, pp. 2949-2955
-
-
Okudaira, K.1
Sawada, Y.2
Sugiyama, Y.3
Iga, T.4
Hanano, M.5
-
258
-
-
0027936743
-
Epoxide metabolite of quinine and inhibition of the multidrug resistance pump in human leukemic Iymphoblasts
-
PW Wigler, KL Lyon, K Patterson, AJ Loggia, H Diazarauzo, MS Reddy, JM Cook. Epoxide metabolite of quinine and inhibition of the multidrug resistance pump in human leukemic Iymphoblasts. Mol Pharmacol 46: 563-567, 1994.
-
(1994)
Mol Pharmacol
, vol.46
, pp. 563-567
-
-
Wigler, P.W.1
Lyon, K.L.2
Patterson, K.3
Loggia, A.J.4
Diazarauzo, H.5
Reddy, M.S.6
Cook, J.M.7
-
259
-
-
0031738505
-
Dose-dependent effects of PSC 833 on its tissue distribution and on the biliary excretion of endogenous substrates in rats
-
S Song, H Suzuki, R Kawai, C Tanaka, I Akasaka, Y Sugiyama. Dose-dependent effects of PSC 833 on its tissue distribution and on the biliary excretion of endogenous substrates in rats. Drug Metab Dispos 26: 1128-1133, 1998.
-
(1998)
Drug Metab Dispos
, vol.26
, pp. 1128-1133
-
-
Song, S.1
Suzuki, H.2
Kawai, R.3
Tanaka, C.4
Akasaka, I.5
Sugiyama, Y.6
-
260
-
-
0031984212
-
Role of lipoprotein in the plasma binding of SDZ PSC 833, a novel multidrug resistance-reversing cyclosporin
-
N Simon, E Dailly, S Combes, E Malaurie, M Lemaire, JP Tillement, S Urien. Role of lipoprotein in the plasma binding of SDZ PSC 833, a novel multidrug resistance-reversing cyclosporin. Br J Clin Pharmacol 45: 173-175, 1998.
-
(1998)
Br J Clin Pharmacol
, vol.45
, pp. 173-175
-
-
Simon, N.1
Dailly, E.2
Combes, S.3
Malaurie, E.4
Lemaire, M.5
Tillement, J.P.6
Urien, S.7
-
261
-
-
0025935235
-
Restoration of daunomycin retention in multidrug-resistant P388 cells by submicromolar concentrations of SDZ PSC 833, a nonimmunosuppressive cyclosporin derivative
-
D Boesch, K Muller, A Pourtier-Manzanedo, FLoor. Restoration of daunomycin retention in multidrug-resistant P388 cells by submicromolar concentrations of SDZ PSC 833, a nonimmunosuppressive cyclosporin derivative. Exp Cell Res 196: 26-32, 1991.
-
(1991)
Exp Cell Res
, vol.196
, pp. 26-32
-
-
Boesch, D.1
Muller, K.2
Pourtier-Manzanedo, A.3
Loor, F.4
-
262
-
-
0028249946
-
ATP-dependent export pumps and their inhibition by cyclosporins
-
M Bohme, G Jedlitschky, I Leier, M Buchler, D Keppler. ATP-dependent export pumps and their inhibition by cyclosporins. Adv Enzyme Regulation 34: 371-380, 1994.
-
(1994)
Adv Enzyme Regulation
, vol.34
, pp. 371-380
-
-
Bohme, M.1
Jedlitschky, G.2
Leier, I.3
Buchler, M.4
Keppler, D.5
-
263
-
-
0031459990
-
Interactions of nonsteroidal anti-inflammatory drugs with rat renal organic anion transporter, OAT-KI
-
S Masuda, H Saito, K Inui. Interactions of nonsteroidal anti-inflammatory drugs with rat renal organic anion transporter, OAT-KI. J Pharmacol Exp Ther 283: 1039-1042, 1997.
-
(1997)
J Pharmacol Exp Ther
, vol.283
, pp. 1039-1042
-
-
Masuda, S.1
Saito, H.2
Inui, K.3
-
265
-
-
0029876334
-
Transient expression of oatp organic anion transporter in mammalian cells: Identification of candidate substrates
-
N Kanai, R Lu, Y Bao, AW Wolkoff, VL Schuster. Transient expression of oatp organic anion transporter in mammalian cells: identification of candidate substrates. Am J Physiol 270: F319-325, 1996.
-
(1996)
Am J Physiol
, vol.270
, pp. F319-325
-
-
Kanai, N.1
Lu, R.2
Bao, Y.3
Wolkoff, A.W.4
Schuster, V.L.5
-
266
-
-
0025336413
-
Defective ATP-dependent bile canalicular transport of organic anions in mutant (TR-) rats with conjugated hyperbilirubinemia
-
T Kitamura, P Jansen, C Hardenbrook, Y Kamimoto, Z Gatmaitan, JM Arias. Defective ATP-dependent bile canalicular transport of organic anions in mutant (TR-) rats with conjugated hyperbilirubinemia. Proc Natl Acad Sci USA 87: 3557-3561, 1990.
-
(1990)
Proc Natl Acad Sci USA
, vol.87
, pp. 3557-3561
-
-
Kitamura, T.1
Jansen, P.2
Hardenbrook, C.3
Kamimoto, Y.4
Gatmaitan, Z.5
Arias, J.M.6
-
267
-
-
0023807777
-
Characterization ofthe oral absorption of beta-Iactam antibi- otics. I. Cephalosporins: Detennination of intrinsic membrane absorption parameters in the rat intestine in situ
-
PJ Sinko, GL Amidon. Characterization ofthe oral absorption of beta-Iactam antibi- otics. I. Cephalosporins: detennination of intrinsic membrane absorption parameters in the rat intestine in situ. Pharm Res 5: 645-650, 1988.
-
(1988)
Pharm Res
, vol.5
, pp. 645-650
-
-
Sinko, P.J.1
Amidon, G.L.2
-
268
-
-
0030597159
-
Monoamine neurotransmitter transport mediated by the polyspecific cation transporter rOCTI
-
AE Busch, S Quester, JC Ulzheimer, V Gorboulev, A Akhoundova, S Waldegger, F Lang, HKoepsell. Monoamine neurotransmitter transport mediated by the polyspecific cation transporter rOCTI. FEBS Lett 395: 153-156, 1996.
-
(1996)
FEBS Lett
, vol.395
, pp. 153-156
-
-
Busch, A.E.1
Quester, S.2
Ulzheimer, J.C.3
Gorboulev, V.4
Akhoundova, A.5
Waldegger, S.6
Lang, F.7
Koepsell, H.8
-
269
-
-
0031657914
-
Catecholamine transport by the organic cation transporter type 1 (OCTI)
-
T Breidert, F Spitzenberger, D Grundemann, E Schomig. Catecholamine transport by the organic cation transporter type 1 (OCTI). Br J Phannacol 125: 218-224, 1998.
-
(1998)
Br J Phannacol
, vol.125
, pp. 218-224
-
-
Breidert, T.1
Spitzenberger, F.2
Grundemann, D.3
Schomig, E.4
-
270
-
-
0031846917
-
Functional characterization of an organic cation transporter (hOCTI) in a transiently transfected human cell line (HeLa)
-
L Zhang, ME Schaner, KM Giacomini. Functional characterization of an organic cation transporter (hOCTI) in a transiently transfected human cell line (HeLa). J Phannacol Exp Ther 286: 354-361, 1998.
-
(1998)
J Phannacol Exp Ther
, vol.286
, pp. 354-361
-
-
Zhang, L.1
Schaner, M.E.2
Giacomini, K.M.3
-
271
-
-
0030915085
-
Cloning and functional expression of a human liver organic canion transporter
-
L Zhang, MJ Dresser, AT Gray, SC Yost, S Terashita, KM Giacomini. Cloning and functional expression of a human liver organic canion transporter. Mol Pharmacol 51: 913-921, 1997.
-
(1997)
Mol Pharmacol
, vol.51
, pp. 913-921
-
-
Zhang, L.1
Dresser, M.J.2
Gray, A.T.3
Yost, S.C.4
Terashita, S.5
Giacomini, K.M.6
-
272
-
-
0030590117
-
eDNA cloning and functional expression of a novel rat kidney organic cation transporter, OCTI
-
M Okuda, H Saito, Y Urakami, M Takano, K Inu L eDNA cloning and functional expression of a novel rat kidney organic cation transporter, OCTI. Biochem Biophys Res Commun 224: 500-507, 1996.
-
(1996)
Biochem Biophys Res Commun
, vol.224
, pp. 500-507
-
-
Okuda, M.1
Saito, H.2
Urakami, Y.3
Takano, M.4
Inu, K.L.5
-
273
-
-
0032553546
-
Transport of monoamine transmitters by the organic cation transporter type 2, OCT2
-
D Grundemann, S Koster, N Kiefer, T Breidert, M Engelhardt, F Spitzenberger, N Obermuller, E Schomig. Transport of monoamine transmitters by the organic cation transporter type 2, OCT2. J Biol Chem 273: 30915-30920, 1998.
-
(1998)
J Biol Chem
, vol.273
, pp. 30915-30920
-
-
Grundemann, D.1
Koster, S.2
Kiefer, N.3
Breidert, T.4
Engelhardt, M.5
Spitzenberger, F.6
Obermuller, N.7
Schomig, E.8
-
274
-
-
0031824347
-
Human neurons express the polyspecific cation transporter hOCTI, which translocates monoamine neurotransmitters, amantadine, and memantine
-
AE Busch, U Karbach, D Miska, V Gorboulev, A Akhoundova, C Volk, P Arndt, JC Ulzheimer, MS Sonders, C Baumann, S Waldegger, F Lang, H Koepsell. Human neurons express the polyspecific cation transporter hOCTI, which translocates monoamine neurotransmitters, amantadine, and memantine. Mol Pharmacol 54: 342-352, 1998.
-
(1998)
Mol Pharmacol
, vol.54
, pp. 342-352
-
-
Busch, A.E.1
Karbach, U.2
Miska, D.3
Gorboulev, V.4
Akhoundova, A.5
Volk, C.6
Arndt, P.7
Ulzheimer, J.C.8
Sonders, M.S.9
Baumann, C.10
Waldegger, S.11
Lang, F.12
Koepsell, H.13
-
275
-
-
0033950653
-
Genomic interval engineering of mice identifies a novel modulator of triglyceride production
-
Y Zhu, MC Jong, KA Frazer, E Gong, RM Krauss, JF Cheng, D Boffelli, EM Rubin. Genomic interval engineering of mice identifies a novel modulator of triglyceride production. Proc Natl Acad Sci USA 97: 1137-1142, 2000.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 1137-1142
-
-
Zhu, Y.1
Jong, M.C.2
Frazer, K.A.3
Gong, E.4
Krauss, R.M.5
Cheng, J.F.6
Boffelli, D.7
Rubin, E.M.8
-
276
-
-
0032553006
-
Molecular cloning and characterization of high-affinity camitine transporter from rat intestine
-
T Sekine, H Kusuhara, N Utsunomiya-Tate, M Tsuda, Y Sugiyama, Y Kanai, H Endou. Molecular cloning and characterization of high-affinity camitine transporter from rat intestine. Biochem Biophys Res Commun 251: 586-591, 1998.
-
(1998)
Biochem Biophys Res Commun
, vol.251
, pp. 586-591
-
-
Sekine, T.1
Kusuhara, H.2
Utsunomiya-Tate, N.3
Tsuda, M.4
Sugiyama, Y.5
Kanai, Y.6
Endou, H.7
-
277
-
-
15844387507
-
The peptide-based thrombin inhibitor CRC 220 is a new substrate of the basolateral rat liver organic anion-transporting polypeptide
-
U Eckhardt, IA Horz, E Petzinger, W Stuber, M Reers, G Dickneite, H Daniel, M Wagener, B Hagenbuch, B Stieger, PJ Meier. The peptide-based thrombin inhibitor CRC 220 is a new substrate of the basolateral rat liver organic anion-transporting polypeptide. Hepatology 24: 380-384, 1996.
-
(1996)
Hepatology
, vol.24
, pp. 380-384
-
-
Eckhardt, U.1
Horz, I.A.2
Petzinger, E.3
Stuber, W.4
Reers, M.5
Dickneite, G.6
Daniel, H.7
Wagener, M.8
Hagenbuch, B.9
Stieger, B.10
Meier, P.J.11
-
278
-
-
0032957616
-
Polyspecific substrate uptake by the hepatic organic anion transporter Oatp1 in stably transfected CHO cells
-
U Eckhardt, A Schroeder, B Stieger, M Hochli, L Landmann, R Tynes, PI Meier, B Hagenbuch. Polyspecific substrate uptake by the hepatic organic anion transporter Oatp1 in stably transfected CHO cells. Am I Physiol 276: G1037-1042, 1999.
-
(1999)
Am I Physiol
, vol.276
, pp. G1037-1042
-
-
Eckhardt, U.1
Schroeder, A.2
Stieger, B.3
Hochli, M.4
Landmann, L.5
Tynes, R.6
Meier, P.I.7
Hagenbuch, B.8
-
279
-
-
17344364101
-
The modified dipeptide, enalapril, an angiotensin-converting enzyme inhibitor, is transported by the rat liver organic anion transport protein
-
KS Pang, PJ Wang, AY Chung, AW Wolkoff. The modified dipeptide, enalapril, an angiotensin-converting enzyme inhibitor, is transported by the rat liver organic anion transport protein. Hepatology 28: 1341-1346, 1998.
-
(1998)
Hepatology
, vol.28
, pp. 1341-1346
-
-
Pang, K.S.1
Wang, P.J.2
Chung, A.Y.3
Wolkoff, A.W.4
-
280
-
-
0030437929
-
Uptake of the mycotoxin ochratoxin A in liver cells occurs via the cloned organic anion transporting polypeptide
-
M Kontaxi, U Echkardt, B Hagenbuch, B Stieger, PJ Meier, E Petzinger. Uptake of the mycotoxin ochratoxin A in liver cells occurs via the cloned organic anion transporting polypeptide. I Pharmacol Exp Ther 279: 1507-1513, 1996.
-
(1996)
I Pharmacol Exp Ther
, vol.279
, pp. 1507-1513
-
-
Kontaxi, M.1
Echkardt, U.2
Hagenbuch, B.3
Stieger, B.4
Meier, P.J.5
Petzinger, E.6
-
281
-
-
0032455502
-
Transport of temocaprilat into rat hepatocytes: Role of organic anion transporting polypeptide
-
H Ishizuka, K Konno, H Naganuma, K Nishimura, H Kouzuki, H Suzuki, B Stieger, PJ Meier, Y Sugiyama. Transport of temocaprilat into rat hepatocytes: role of organic anion transporting polypeptide. J Pharmacol Exp Ther 287: 37-42, 1998.
-
(1998)
J Pharmacol Exp Ther
, vol.287
, pp. 37-42
-
-
Ishizuka, H.1
Konno, K.2
Naganuma, H.3
Nishimura, K.4
Kouzuki, H.5
Suzuki, H.6
Stieger, B.7
Meier, P.J.8
Sugiyama, Y.9
-
282
-
-
0033058448
-
Pravastatin, an HMG-CoA reductase inhibitor, is transported by rat organic anion transporting polypeptide, oatp2
-
T Tokui, D Nakai, R Nakagomi, H Yawo, T Abe, Y Sugiyama. Pravastatin, an HMG-CoA reductase inhibitor, is transported by rat organic anion transporting polypeptide, oatp2. Pharm Res 16: 904-908, 1999.
-
(1999)
Pharm Res
, vol.16
, pp. 904-908
-
-
Tokui, T.1
Nakai, D.2
Nakagomi, R.3
Yawo, H.4
Abe, T.5
Sugiyama, Y.6
-
283
-
-
0032856603
-
The antiviral nucleotide analogs cidofovir and adefovir are novel substrates for human and rat renal organic anion transporter 1
-
T Cihlar, DC Lin, JB Pritchard, MD Fuller, DB Mendel, DH Sweet. The antiviral nucleotide analogs cidofovir and adefovir are novel substrates for human and rat renal organic anion transporter 1. Mol Pharmacol 56: 570-580, 1999.
-
(1999)
Mol Pharmacol
, vol.56
, pp. 570-580
-
-
Cihlar, T.1
Lin, D.C.2
Pritchard, J.B.3
Fuller, M.D.4
Mendel, D.B.5
Sweet, D.H.6
-
284
-
-
0032919287
-
Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney
-
M Hosoyamada, T Sekine, Y Kanai, H Endou. Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney. Am J Physiol 276: F122-128, 1999.
-
(1999)
Am J Physiol
, vol.276
, pp. F122-128
-
-
Hosoyamada, M.1
Sekine, T.2
Kanai, Y.3
Endou, H.4
-
285
-
-
0032995116
-
Cloning of the human kidney PAH transporter: Narrow substrate specificity and regulation by protein kinase C
-
R Lu, BS Chan, VL Schuster. Cloning of the human kidney PAH transporter: narrow substrate specificity and regulation by protein kinase C. Am J Physiol 276: F295-303, 1999.
-
(1999)
Am J Physiol
, vol.276
, pp. F295-303
-
-
Lu, R.1
Chan, B.S.2
Schuster, V.L.3
-
286
-
-
0029552114
-
Cloning and characterization of a rat H+/peptide cotransporter mediating absorption of beta-lactam antibiotics in the intestine and kidney
-
H Saito, M Okuda, T Terada, S Sasaki, K Inui. Cloning and characterization of a rat H+/peptide cotransporter mediating absorption of beta-lactam antibiotics in the intestine and kidney. J Pharmacol Exp Ther 275: 1631-1637, 1995.
-
(1995)
J Pharmacol Exp Ther
, vol.275
, pp. 1631-1637
-
-
Saito, H.1
Okuda, M.2
Terada, T.3
Sasaki, S.4
Inui, K.5
-
287
-
-
0029782485
-
Carrier-mediated intestinal transport of drugs
-
A Tsuji, I Tarnai. Carrier-mediated intestinal transport of drugs. Pharm Res 13: 963-977, 1996.
-
(1996)
Pharm Res
, vol.13
, pp. 963-977
-
-
Tsuji, A.1
Tarnai, I.2
-
288
-
-
0027967880
-
Expression cloning of a cDNA from rabbit small intestine related to proton-coupled transport of peptides, beta-lactam antibiotics and ACE-inhibitors
-
M Boll, D Markovich, WM Weber, H Korte, H Daniel, H Murer. Expression cloning of a cDNA from rabbit small intestine related to proton-coupled transport of peptides, beta-lactam antibiotics and ACE-inhibitors. Pflugers Arch 429: 146-149, 1994.
-
(1994)
Pflugers Arch
, vol.429
, pp. 146-149
-
-
Boll, M.1
Markovich, D.2
Weber, W.M.3
Korte, H.4
Daniel, H.5
Murer, H.6
-
289
-
-
0028826927
-
Differential recognition of beta-lactam antibiotics by intestinal and renal peptide transporters, PEPT I and PEPT2
-
ME Ganapathy, M Brandsch, PD Prasad, V Ganapathy, FH Leibach. Differential recognition of beta-lactam antibiotics by intestinal and renal peptide transporters, PEPT I and PEPT2. J Biol Chem 270: 25672-25677, 1995.
-
(1995)
J Biol Chem
, vol.270
, pp. 25672-25677
-
-
Ganapathy, M.E.1
Brandsch, M.2
Prasad, P.D.3
Ganapathy, V.4
Leibach, F.H.5
-
290
-
-
0030892709
-
Interaction of anionic cephalosporins with the intestinal and renal peptide transporters PEPT 1 and PEPT 2
-
ME Ganapathy, PD Prasad, B Mackenzie, V Ganapathy, PH Leibach. Interaction of anionic cephalosporins with the intestinal and renal peptide transporters PEPT 1 and PEPT 2. Biochim Biophys Acta 1324: 296-308, 1997.
-
(1997)
Biochim Biophys Acta
, vol.1324
, pp. 296-308
-
-
Ganapathy, M.E.1
Prasad, P.D.2
Mackenzie, B.3
Ganapathy, V.4
Leibach, P.H.5
-
291
-
-
0028920129
-
Human intestinal H+/peptide cotransporter. Cloning, functional expression, and chromosomal localization
-
R Liang, YI Fei, PD Prasad, S Ramamoorthy, H Han, TL Yang-Feng, MA Hediger, V Ganapathy, FH Leibach. Human intestinal H+/peptide cotransporter. Cloning, functional expression, and chromosomal localization. J Biol Chem 270: 6456-6463, 1995.
-
(1995)
J Biol Chem
, vol.270
, pp. 6456-6463
-
-
Liang, R.1
Fei, Y.I.2
Prasad, P.D.3
Ramamoorthy, S.4
Han, H.5
Yang-Feng, T.L.6
Hediger, M.A.7
Ganapathy, V.8
Leibach, F.H.9
-
292
-
-
0029036084
-
Molecular cloning of PEPT 2, a new member of the W/peptide cotransporter family, from human kidney
-
WLiu, R Liang, S Ramamoorthy, YJ Fei, ME Ganapathy, MA Hediger, V Ganapathy, FH Leibach. Molecular cloning of PEPT 2, a new member of the W/peptide cotransporter family, from human kidney. Biochim Biophys Acta 1235: 461-466, 1995.
-
(1995)
Biochim Biophys Acta
, vol.1235
, pp. 461-466
-
-
Liu, W.1
Liang, R.2
Ramamoorthy, S.3
Fei, Y.J.4
Ganapathy, M.E.5
Hediger, M.A.6
Ganapathy, V.7
Leibach, F.H.8
-
293
-
-
0031874816
-
Complete in vivo reversal of P-glycoprotein pump function in the blood-brain barrier visualized with positron emission tomography
-
NH Hendrikse, AH Schinkel, EG de Vries, E Fluks, WT Van der Graaf, AT Willemsen, W Vaalburg, EJ Franssen. Complete in vivo reversal of P-glycoprotein pump function in the blood-brain barrier visualized with positron emission tomography. Br J Pharmacol 124: 1413-1418, 1998.
-
(1998)
Br J Pharmacol
, vol.124
, pp. 1413-1418
-
-
Hendrikse, N.H.1
Schinkel, A.H.2
de Vries, E.G.3
Fluks, E.4
Van der Graaf, W.T.5
Willemsen, A.T.6
Vaalburg, W.7
Franssen, E.J.8
-
294
-
-
0031834184
-
Effect of the Mdrla P-glycoprotein gene disruption on the tissue distribution of SDZ PSC 833, a multidrug resistance-reversing agent, in mice
-
S Desrayaud, EC De Lange, M Lemaire, A Bruelisauer, AG De Boer, DD Breimer. Effect of the Mdrla P-glycoprotein gene disruption on the tissue distribution of SDZ PSC 833, a multidrug resistance-reversing agent, in mice. J Pharmacol Exp Ther 285: 438-443, 1998.
-
(1998)
J Pharmacol Exp Ther
, vol.285
, pp. 438-443
-
-
Desrayaud, S.1
De Lange, E.C.2
Lemaire, M.3
Bruelisauer, A.4
De Boer, A.G.5
Breimer, D.D.6
-
295
-
-
0032807119
-
P-glycoprotein-dependent disposition kinetics of tacrolimus: Studies in mdrla knockout mice
-
K Yokogawa, M Takahashi, I Tarnai, H Konishi, M Nomura, S Moritani, K Miya- moto, A Tsuji. P-glycoprotein-dependent disposition kinetics of tacrolimus: studies in mdrla knockout mice. Pharm Res 16: 1213-1218, 1999.
-
(1999)
Pharm Res
, vol.16
, pp. 1213-1218
-
-
Yokogawa, K.1
Takahashi, M.2
Tarnai, I.3
Konishi, H.4
Nomura, M.5
Moritani, S.6
Miya-Moto, K.7
Tsuji, A.8
-
296
-
-
0032518290
-
The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV1 protease inhibitors
-
RB Kim, MF Fromm, C Wandel, B Leake, AJ Wood, DM Roden, GR Wilkinson. The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV1 protease inhibitors. J Clin Invest 101: 289-294, 1998.
-
(1998)
J Clin Invest
, vol.101
, pp. 289-294
-
-
Kim, R.B.1
Fromm, M.F.2
Wandel, C.3
Leake, B.4
Wood, A.J.5
Roden, D.M.6
Wilkinson, G.R.7
-
297
-
-
0032889057
-
Increased accumulation of doxorubicin and doxorubicinol in cardiac tissue of mice lacking mdrla P-glycoprotein
-
J van Asperen, O van Tellingen, F Tijssen, AH Schinkel, JH Beijnen. Increased accumulation of doxorubicin and doxorubicinol in cardiac tissue of mice lacking mdrla P-glycoprotein. Br J Cancer 79: 108-113, 1999.
-
(1999)
Br J Cancer
, vol.79
, pp. 108-113
-
-
van Asperen, J.1
van Tellingen, O.2
Tijssen, F.3
Schinkel, A.H.4
Beijnen, J.H.5
-
298
-
-
0032960014
-
Role of blood-brain barrier P-glycoprotein in limiting brain accumulation and sedative side effects of asimadoline, a peripherally acting analgaesic drug
-
JW Jonker, E Wagenaar, L van Deemter, R Gottschlich, HM Bender, J Dasenbrock, AH Schinkel. Role of blood-brain barrier P-glycoprotein in limiting brain accumulation and sedative side effects of asimadoline, a peripherally acting analgaesic drug. Br J Pharmacol 127: 43-50, 1999.
-
(1999)
Br J Pharmacol
, vol.127
, pp. 43-50
-
-
Jonker, J.W.1
Wagenaar, E.2
van Deemter, L.3
Gottschlich, R.4
Bender, H.M.5
Dasenbrock, J.6
Schinkel, A.H.7
-
299
-
-
0032968064
-
Efflux transport of a new quinolone antibacterial agent, HSR-903, across the blood-brain barrier
-
M Murata, I Tarnai, H Kato, O Nagata, A Tsuji. Efflux transport of a new quinolone antibacterial agent, HSR-903, across the blood-brain barrier. J Pharmacol Exp Ther 290: 51-57, 1999.
-
(1999)
J Pharmacol Exp Ther
, vol.290
, pp. 51-57
-
-
Murata, M.1
Tarnai, I.2
Kato, H.3
Nagata, O.4
Tsuji, A.5
-
300
-
-
0032804327
-
Role of P-glycoprotein on the CNS disposition of amprenavir (141 W94), an HIV protease inhibitor
-
JW Polli, JL Jarrett, SD Studenberg, IE Humphreys, SW Dennis, KR Brouwer, JL Woolley. Role of P-glycoprotein on the CNS disposition of amprenavir (141 W94), an HIV protease inhibitor. Pharm Res 16: 1206-1212, 1999.
-
(1999)
Pharm Res
, vol.16
, pp. 1206-1212
-
-
Polli, J.W.1
Jarrett, J.L.2
Studenberg, S.D.3
Humphreys, I.E.4
Dennis, S.W.5
Brouwer, K.R.6
Woolley, J.L.7
-
301
-
-
0032781499
-
Enhanced transport of anticancer agents and leukotriene C4 by the human canalicular multispecific organic anion transporter (cMOAT/MRP2)
-
T Kawabe, ZS Chen, M Wada, T Uchiumi, MOno, S Akiyama, M Kuwano. Enhanced transport of anticancer agents and leukotriene C4 by the human canalicular multispecific organic anion transporter (cMOAT/MRP2). FEBS Lett 456: 327-331, 1999.
-
(1999)
FEBS Lett
, vol.456
, pp. 327-331
-
-
Kawabe, T.1
Chen, Z.S.2
Wada, M.3
Uchiumi, T.4
Ono, M.5
Akiyama, S.6
Kuwano, M.7
-
302
-
-
0032769284
-
Transport of monoglucuronosyl and bisglucuronosyl bilirubin by recombinant human and rat multidrug resistance protein 2
-
T Kamisako, I Leier, Y Cui, J Konig, U Buchholz, J Hummel-Eisenbeiss, D Keppler. Transport of monoglucuronosyl and bisglucuronosyl bilirubin by recombinant human and rat multidrug resistance protein 2. Hepatology 30: 485-490, 1999.
-
(1999)
Hepatology
, vol.30
, pp. 485-490
-
-
Kamisako, T.1
Leier, I.2
Cui, Y.3
Konig, J.4
Buchholz, U.5
Hummel-Eisenbeiss, J.6
Keppler, D.7
-
303
-
-
0019835513
-
Dose-dependent kinetics of probenecid in rhesus monkeys- intravenous bolus studies
-
CWN Chiang, LZ Benet. Dose-dependent kinetics of probenecid in rhesus monkeys- intravenous bolus studies. Pharmacology 23: 326-336, 1981.
-
(1981)
Pharmacology
, vol.23
, pp. 326-336
-
-
Chiang, C.W.N.1
Benet, L.Z.2
-
304
-
-
0018093505
-
Kinetics studies on the renal transport of probenecid in vitro
-
MI Sheikh, J Maxild. Kinetics studies on the renal transport of probenecid in vitro. Biochim Biophys Acta 514: 356-361, 1978.
-
(1978)
Biochim Biophys Acta
, vol.514
, pp. 356-361
-
-
Sheikh, M.I.1
Maxild, J.2
-
305
-
-
0034595593
-
Identification of organic anion transporting polypeptide 4 (Oatp4) as a major full-length isoform of the liver-specific transporter-l (r1st-l) in rat liver
-
V Cattori, B Hagenbuch, N Hagenbuch, B Stieger, R Ha, KE Winterhalter, PJ Meier. Identification of organic anion transporting polypeptide 4 (Oatp4) as a major full-length isoform of the liver-specific transporter-l (r1st-l) in rat liver. FEBS Lett 474: 242-245, 2000.
-
(2000)
FEBS Lett
, vol.474
, pp. 242-245
-
-
Cattori, V.1
Hagenbuch, B.2
Hagenbuch, N.3
Stieger, B.4
Ha, R.5
Winterhalter, K.E.6
Meier, P.J.7
-
306
-
-
0003566325
-
Hepatic uptake of bilirubin and its conjutates by the human organic anion-transporting polypeptide 2 (symbol SLC21A6)
-
Y Cui, J Konig, II Leier, U Buchholz, D Keppler. Hepatic uptake of bilirubin and its conjutates by the human organic anion-transporting polypeptide 2 (symbol SLC21A6). J Biol Chem 27: 27, 2000.
-
(2000)
J Biol Chem
, vol.27
, pp. 27
-
-
Cui, Y.1
Konig, J.2
Leier, I.I.3
Buchholz, U.4
Keppler, D.5
-
307
-
-
0034725617
-
Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide
-
J Konig, Y Cui, AT Nies, D Keppler. Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide. J Biol Chem 275: 23161-23168, 2000.
-
(2000)
J Biol Chem
, vol.275
, pp. 23161-23168
-
-
Konig, J.1
Cui, Y.2
Nies, A.T.3
Keppler, D.4
-
308
-
-
0035125407
-
Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver
-
GA Kullak-Ublick, MG Ismair, B Steiger, L Landmann, R Huber, F Pizzagalli, K Fattinger, PJ Meier, B Hagenbuch. Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology 120: 525-533, 2001.
-
(2001)
Gastroenterology
, vol.120
, pp. 525-533
-
-
Kullak-Ublick, G.A.1
Ismair, M.G.2
Steiger, B.3
Landmann, L.4
Huber, R.5
Pizzagalli, F.6
Fattinger, K.7
Meier, P.J.8
Hagenbuch, B.9
-
309
-
-
0035039326
-
Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney
-
SH Cha, T Sekine, J Fukushima, Y Kanai, Y Kobayashi, T Goya, H Endou. Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney. Mol Pharmacol 59: 1277-1286, 2001.
-
(2001)
Mol Pharmacol
, vol.59
, pp. 1277-1286
-
-
Cha, S.H.1
Sekine, T.2
Fukushima, J.3
Kanai, Y.4
Kobayashi, Y.5
Goya, T.6
Endou, H.7
|