메뉴 건너뛰기




Volumn 90, Issue 2, 2005, Pages 884-892

Gonadotropin-releasing hormone antagonist Cetrorelix down-regulates proliferating cell nuclear antigen and epidermal growth factor expression and up-regulates apoptosis in association with enhanced poly(adenosine 5′-diphosphate-ribose) polymerase expression in cultured human leiomyoma cells

Author keywords

[No Author keywords available]

Indexed keywords

CETRORELIX; CYCLINE; EPIDERMAL GROWTH FACTOR; GONADORELIN ANTAGONIST; GONADORELIN RECEPTOR; MESSENGER RNA; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHENOL DERIVATIVE;

EID: 14044252941     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2004-1591     Document Type: Article
Times cited : (21)

References (50)
  • 2
    • 0030317737 scopus 로고    scopus 로고
    • GnRH agonists and uterine leiomyomas
    • Broekmans FJ 1996 GnRH agonists and uterine leiomyomas. Hum Reprod 3:3-25
    • (1996) Hum Reprod , vol.3 , pp. 3-25
    • Broekmans, F.J.1
  • 3
    • 0035182258 scopus 로고    scopus 로고
    • The actions of luteinizing hormone-releasing hormone agonists, antagonists, and cytotoxic analogues on the luteinizing hormone-releasing hormone receptors on the pituitary and tumors
    • Schally AV, Halmos G, Rekasi Z, Arencibia-Jimenez JM 2001 The actions of luteinizing hormone-releasing hormone agonists, antagonists, and cytotoxic analogues on the luteinizing hormone-releasing hormone receptors on the pituitary and tumors. Infertility Reprod Med Clin North Am 12:17-44
    • (2001) Infertility Reprod Med Clin North Am , vol.12 , pp. 17-44
    • Schally, A.V.1    Halmos, G.2    Rekasi, Z.3    Arencibia-Jimenez, J.M.4
  • 4
    • 0027485121 scopus 로고
    • Rapid regression of uterine leiomyomas in response to daily administration of gonadotropin-releasing hormone antagonist
    • Kettel LM, Rivier J, Murphy AA, Vale W, Morales AJ, Yen SSC 1993 Rapid regression of uterine leiomyomas in response to daily administration of gonadotropin-releasing hormone antagonist. Fertil Steril 60:642-646
    • (1993) Fertil Steril , vol.60 , pp. 642-646
    • Kettel, L.M.1    Rivier, J.2    Murphy, A.A.3    Vale, W.4    Morales, A.J.5    Yen, S.S.C.6
  • 7
    • 85006282703 scopus 로고    scopus 로고
    • Preoperative reduction of uterine fibroids in only 16 days by administration of a gonadotropin-releasing hormone antagonist (Cetrorelix)
    • Felberbaum RE, Küpker W, Krapp M, Gehl B, Ludwig M, Diedrich K 2001 Preoperative reduction of uterine fibroids in only 16 days by administration of a gonadotropin-releasing hormone antagonist (Cetrorelix). Reprod Biomed Online 3:14-18
    • (2001) Reprod Biomed Online , vol.3 , pp. 14-18
    • Felberbaum, R.E.1    Küpker, W.2    Krapp, M.3    Gehl, B.4    Ludwig, M.5    Diedrich, K.6
  • 9
    • 1842636790 scopus 로고    scopus 로고
    • Effect of long-term treatment with low doses of the LHRH antagonist Cetrorelix on pituitary receptors for LHRH and gonadal axis in male and female rats
    • Horvath JE, Toller GL, Schally AV, Bajo A-M, Groot K 2004 Effect of long-term treatment with low doses of the LHRH antagonist Cetrorelix on pituitary receptors for LHRH and gonadal axis in male and female rats. Proc Natl Acad Sci USA 101:4996-5001
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 4996-5001
    • Horvath, J.E.1    Toller, G.L.2    Schally, A.V.3    Bajo, A.-M.4    Groot, K.5
  • 11
    • 0029823957 scopus 로고    scopus 로고
    • Gonadotropin-releasing hormone (GnRH) and GnRH receptor gene expression in human myometrium and leiomyomata and the direct action of GnRH analogs on myometrial smooth muscle cells and interaction with ovarian steroids in vitro
    • Chegini N, Rong H, Dou Q, Kipersztok S, Williams RS 1996 Gonadotropin-releasing hormone (GnRH) and GnRH receptor gene expression in human myometrium and leiomyomata and the direct action of GnRH analogs on myometrial smooth muscle cells and interaction with ovarian steroids in vitro. J Clin Endocrinol Metab 81:3215-3221
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 3215-3221
    • Chegini, N.1    Rong, H.2    Dou, Q.3    Kipersztok, S.4    Williams, R.S.5
  • 12
    • 0031063029 scopus 로고    scopus 로고
    • Effects of a GnRH analogue on human smooth muscle cells cultured from normal myometrial and from uterine leiomyomal tissues
    • Kobayashi Y, Zhai YL, Iinuma M, Horiuchi A, Nikaido T, Fujii S 1997 Effects of a GnRH analogue on human smooth muscle cells cultured from normal myometrial and from uterine leiomyomal tissues. Mol Hum Reprod 3:91-99
    • (1997) Mol Hum Reprod , vol.3 , pp. 91-99
    • Kobayashi, Y.1    Zhai, Y.L.2    Iinuma, M.3    Horiuchi, A.4    Nikaido, T.5    Fujii, S.6
  • 13
    • 0036204393 scopus 로고    scopus 로고
    • Down-regulation of proliferation and up-regulation of apoptosis by gonadotropin-releasing hormone agonist in cultured uterine leiomyoma cells
    • Wang Y, Matsuo H, Kurachi O, Maruo T 2002 Down-regulation of proliferation and up-regulation of apoptosis by gonadotropin-releasing hormone agonist in cultured uterine leiomyoma cells. Eur J Endocrinol 146:447-456
    • (2002) Eur J Endocrinol , vol.146 , pp. 447-456
    • Wang, Y.1    Matsuo, H.2    Kurachi, O.3    Maruo, T.4
  • 14
    • 0029920507 scopus 로고    scopus 로고
    • The expression of gonadotropin-releasing hormone and its receptor in endometrial cancer, and its relevance as an autocrine growth factor
    • Chatzaki E, Bax CMR, Eidne KA, Anderson L, Grudzinskas G, Gallagher CJ 1996 The expression of gonadotropin-releasing hormone and its receptor in endometrial cancer, and its relevance as an autocrine growth factor. Cancer Res 56:2059-2065
    • (1996) Cancer Res , vol.56 , pp. 2059-2065
    • Chatzaki, E.1    Bax, C.M.R.2    Eidne, K.A.3    Anderson, L.4    Grudzinskas, G.5    Gallagher, C.J.6
  • 15
    • 0030923675 scopus 로고    scopus 로고
    • The genes for gonadotropin-releasing hormone and its receptor are expressed in human breast with fibrocystic disease and cancer
    • Kottler M-L, Starzec A, Carre M-C, Lagarde J-P, Martin A, Counis R 1997 The genes for gonadotropin-releasing hormone and its receptor are expressed in human breast with fibrocystic disease and cancer. Int J Cancer 71:595-599
    • (1997) Int J Cancer , vol.71 , pp. 595-599
    • Kottler, M.-L.1    Starzec, A.2    Carre, M.-C.3    Lagarde, J.-P.4    Martin, A.5    Counis, R.6
  • 16
    • 0031906485 scopus 로고    scopus 로고
    • Expression of mRNA for luteinizing hormone-releasing hormone receptors and epidermal growth factor receptors in human cancer cell lines
    • Lamharzi N, Halmos G, Armatis P, Schally AV 1998 Expression of mRNA for luteinizing hormone-releasing hormone receptors and epidermal growth factor receptors in human cancer cell lines. Int J Oncol 12:671-675
    • (1998) Int J Oncol , vol.12 , pp. 671-675
    • Lamharzi, N.1    Halmos, G.2    Armatis, P.3    Schally, A.V.4
  • 17
    • 0031876636 scopus 로고    scopus 로고
    • Decrease in the level and mRNA expression of LH-RH and EGF receptors after treatment with LH-RH antagonist Cetrorelix in DU-145 prostate tumor xenografts in nude mice
    • Lamharzi N, Halmos G, Jungwirth A, Schally AV 1998 Decrease in the level and mRNA expression of LH-RH and EGF receptors after treatment with LH-RH antagonist Cetrorelix in DU-145 prostate tumor xenografts in nude mice. Int J Oncol 13:429-435
    • (1998) Int J Oncol , vol.13 , pp. 429-435
    • Lamharzi, N.1    Halmos, G.2    Jungwirth, A.3    Schally, A.V.4
  • 19
    • 0033303530 scopus 로고    scopus 로고
    • The luteinizing hormone-releasing hormone receptor in human prostate cancer cells: Messenger ribonucleic acid expression, molecular size, and signal transduction pathway
    • Limonta P, Moretti RM, Marelli MM, Dondi D, Parenti M, Motta M 1999 The luteinizing hormone-releasing hormone receptor in human prostate cancer cells: messenger ribonucleic acid expression, molecular size, and signal transduction pathway. Endocrinology 140:5250-5256
    • (1999) Endocrinology , vol.140 , pp. 5250-5256
    • Limonta, P.1    Moretti, R.M.2    Marelli, M.M.3    Dondi, D.4    Parenti, M.5    Motta, M.6
  • 20
    • 0034186201 scopus 로고    scopus 로고
    • Luteinizing hormone-releasing hormone as an autocrine growth factor in ES-2 ovarian cancer cell line
    • Arencibia JM, Schally AV 2000 Luteinizing hormone-releasing hormone as an autocrine growth factor in ES-2 ovarian cancer cell line. Int J Oncol 16:1009-1013
    • (2000) Int J Oncol , vol.16 , pp. 1009-1013
    • Arencibia, J.M.1    Schally, A.V.2
  • 21
    • 0034487528 scopus 로고    scopus 로고
    • Autocrine role of gonadotropin-releasing hormone and its receptor in ovarian cancer cell growth
    • Kang SK, Cheng KW, Nathwani PS, Choi K-C, Leung PCK 2000 Autocrine role of gonadotropin-releasing hormone and its receptor in ovarian cancer cell growth. Endocrine 13:297-304
    • (2000) Endocrine , vol.13 , pp. 297-304
    • Kang, S.K.1    Cheng, K.W.2    Nathwani, P.S.3    Choi, K.-C.4    Leung, P.C.K.5
  • 23
    • 0036965115 scopus 로고    scopus 로고
    • Expression of gonadotropin-releasing hormone II (GnRH-III receptor in human endometrial and ovarian cancer cells and effects of GnRH-II on tumor cell proliferation
    • Gründlker C, Günthert AR, Millar RP, Emons G 2002 Expression of gonadotropin-releasing hormone II (GnRH-III receptor in human endometrial and ovarian cancer cells and effects of GnRH-II on tumor cell proliferation. J Clin Endocrinol Metab 87:1427-1430
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 1427-1430
    • Gründlker, C.1    Günthert, A.R.2    Millar, R.P.3    Emons, G.4
  • 24
    • 0036182849 scopus 로고    scopus 로고
    • Expression of receptors for luteinizing hormone-releasing hormone in human ovarian and endometrial cancers: Frequency, autoregulation, and correlation with direct antiproliferative activity of luteinizing hormone-releasing hormone analogues
    • Völker P, Gründker C, Schmidt O, Schulz K-D, Emons G 2002 Expression of receptors for luteinizing hormone-releasing hormone in human ovarian and endometrial cancers: frequency, autoregulation, and correlation with direct antiproliferative activity of luteinizing hormone-releasing hormone analogues. Am J Obstet Gynecol 186:171-179
    • (2002) Am J Obstet Gynecol , vol.186 , pp. 171-179
    • Völker, P.1    Gründker, C.2    Schmidt, O.3    Schulz, K.-D.4    Emons, G.5
  • 25
    • 0036164170 scopus 로고    scopus 로고
    • Biology of the gonadotropin-releasing hormone system in gynecological cancers
    • Gründlker C, Günthert AR, Westphalen S, Emons G 2002 Biology of the gonadotropin-releasing hormone system in gynecological cancers. Eur J Endocrinol 146:1-14
    • (2002) Eur J Endocrinol , vol.146 , pp. 1-14
    • Gründlker, C.1    Günthert, A.R.2    Westphalen, S.3    Emons, G.4
  • 27
    • 4344637399 scopus 로고    scopus 로고
    • Role of gonadotropin-releasing hormone (GnRH) in ovarian cancer
    • Gründlker C, Emons G 2003 Role of gonadotropin-releasing hormone (GnRH) in ovarian cancer. Reprod Biol Endocrinol 1:65-71
    • (2003) Reprod Biol Endocrinol , vol.1 , pp. 65-71
    • Gründlker, C.1    Emons, G.2
  • 28
    • 2942530441 scopus 로고    scopus 로고
    • Sex steroidal regulation of uterine leiomyoma growth and apoptosis
    • Maruo T, Ohara N, Wang J, Matsuo H 2004 Sex steroidal regulation of uterine leiomyoma growth and apoptosis. Hum Reprod Update 10:207-220
    • (2004) Hum Reprod Update , vol.10 , pp. 207-220
    • Maruo, T.1    Ohara, N.2    Wang, J.3    Matsuo, H.4
  • 29
    • 0025992990 scopus 로고
    • Presence of messenger ribonucleic acid for epidermal growth factor (EGF) and EGF receptor demonstrable in monolayer cell cultures of myometria and leiomyomata
    • Yeh J, Rein M, Nowak R 1991 Presence of messenger ribonucleic acid for epidermal growth factor (EGF) and EGF receptor demonstrable in monolayer cell cultures of myometria and leiomyomata. Fertil Steril 56:997-1000
    • (1991) Fertil Steril , vol.56 , pp. 997-1000
    • Yeh, J.1    Rein, M.2    Nowak, R.3
  • 30
    • 0028212465 scopus 로고
    • Quantification of messenger ribonucleic acid for epidermal growth factor in human myometrium and leiomyomata using reverse transcriptase polymerase chain reaction
    • Harrison-Woolrych ML, Charnock-Jones DS, Smith SK 1994 Quantification of messenger ribonucleic acid for epidermal growth factor in human myometrium and leiomyomata using reverse transcriptase polymerase chain reaction. J Clin Endocrinol Metab 78:1179-1184
    • (1994) J Clin Endocrinol Metab , vol.78 , pp. 1179-1184
    • Harrison-Woolrych, M.L.1    Charnock-Jones, D.S.2    Smith, S.K.3
  • 31
    • 0031763790 scopus 로고    scopus 로고
    • Up-regulation by progesterone of proliferating cell nuclear antigen and epidermal growth factor expression in human uterine leiomyoma
    • Shimomura Y, Matsuo H, Samoto T, Maruo T 1998 Up-regulation by progesterone of proliferating cell nuclear antigen and epidermal growth factor expression in human uterine leiomyoma. J Clin Endocrinol Metab 83:2192-2198
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 2192-2198
    • Shimomura, Y.1    Matsuo, H.2    Samoto, T.3    Maruo, T.4
  • 32
    • 10344248844 scopus 로고    scopus 로고
    • Luteinizing hormone-releasing hormone agonists interfere with the stimulatory actions of epidermal growth factor in human prostatic cancer cell lines, LNCaP and DU 145
    • Moretti RM, Marelli MM, Dondi D, Poletti A, Martini L, Motta M, Limonta P 1996 Luteinizing hormone-releasing hormone agonists interfere with the stimulatory actions of epidermal growth factor in human prostatic cancer cell lines, LNCaP and DU 145. J Clin Endocrinol Metab 81:3930-3937
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 3930-3937
    • Moretti, R.M.1    Marelli, M.M.2    Dondi, D.3    Poletti, A.4    Martini, L.5    Motta, M.6    Limonta, P.7
  • 33
    • 0032821184 scopus 로고    scopus 로고
    • Growth inhibition of experimental pancreatic cancers and sustained reduction in epidermal growth factor receptors during therapy with hormonal peptide analogs
    • Szepesházi K, Halmos G, Schallý AV, Arencibia JM, Groot K, Vadillo-Buenfil M, Rodriguez-Martin E 1999 Growth inhibition of experimental pancreatic cancers and sustained reduction in epidermal growth factor receptors during therapy with hormonal peptide analogs. J Cancer Res Clin Oncol 125:444-452
    • (1999) J Cancer Res Clin Oncol , vol.125 , pp. 444-452
    • Szepesházi, K.1    Halmos, G.2    Schallý, A.V.3    Arencibia, J.M.4    Groot, K.5    Vadillo-Buenfil, M.6    Rodriguez-Martin, E.7
  • 34
    • 0033842808 scopus 로고    scopus 로고
    • Luteinizing hormone-releasing hormone agonist Triptorelin and antagonist Cetrorelix inhibit EGF-induced c-fos expression in human gynecological cancers
    • Gründlker C, Völker P, Schulz K-D, Emons G 2000 Luteinizing hormone-releasing hormone agonist Triptorelin and antagonist Cetrorelix inhibit EGF-induced c-fos expression in human gynecological cancers. Gynecol Oncol 78: 194-202
    • (2000) Gynecol Oncol , vol.78 , pp. 194-202
    • Gründlker, C.1    Völker, P.2    Schulz, K.-D.3    Emons, G.4
  • 35
    • 0035964475 scopus 로고    scopus 로고
    • Inhibition of growth of ES-2 human ovarian cancers by bombesin antagonist RC-3095, and luteinizing hormone-releasing hormone antagonist Cetrorelix
    • Chatzistamou I, Schally AV, Szepeshazi K, Groot K, Hebert F, Arencibia JM 2001 Inhibition of growth of ES-2 human ovarian cancers by bombesin antagonist RC-3095, and luteinizing hormone-releasing hormone antagonist Cetrorelix. Cancer Lett 171:37-45
    • (2001) Cancer Lett , vol.171 , pp. 37-45
    • Chatzistamou, I.1    Schally, A.V.2    Szepeshazi, K.3    Groot, K.4    Hebert, F.5    Arencibia, J.M.6
  • 38
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford MM 1976 A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 40
    • 0029816592 scopus 로고    scopus 로고
    • Coupling of gonadotropin-releasing hormone receptor to Gi protein in human reproductive tract tumors
    • Imai A, Takagi H, Horibe S, Fuseya T, Tamaya T 1996 Coupling of gonadotropin-releasing hormone receptor to Gi protein in human reproductive tract tumors. J Clin Endocrinol Metab 81:3249-3253
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 3249-3253
    • Imai, A.1    Takagi, H.2    Horibe, S.3    Fuseya, T.4    Tamaya, T.5
  • 41
    • 0030067871 scopus 로고    scopus 로고
    • Evidence for coupling of phosphotyrosine phosphatase to gonadotropin-releasing hormone receptor in ovarian carcinoma membrane
    • Imai A, Takagi H, Furui T, Horibe S, Fuseya T, Tamaya T 1996 Evidence for coupling of phosphotyrosine phosphatase to gonadotropin-releasing hormone receptor in ovarian carcinoma membrane. Cancer 77:132-137
    • (1996) Cancer , vol.77 , pp. 132-137
    • Imai, A.1    Takagi, H.2    Furui, T.3    Horibe, S.4    Fuseya, T.5    Tamaya, T.6
  • 42
    • 0028071856 scopus 로고
    • Inhibitory effects of analogs of luteinizing hormone-releasing hormone on the growth of the androgen-independent Dunning R-3327-AT-1 rat prostate cancer
    • Pinski J, Reile H, Halmos G, Groot K, Schally AV 1994 Inhibitory effects of analogs of luteinizing hormone-releasing hormone on the growth of the androgen-independent Dunning R-3327-AT-1 rat prostate cancer. Int J Cancer 59:51-55
    • (1994) Int J Cancer , vol.59 , pp. 51-55
    • Pinski, J.1    Reile, H.2    Halmos, G.3    Groot, K.4    Schally, A.V.5
  • 44
    • 0032052309 scopus 로고    scopus 로고
    • Effects of LHRH-analogues on mitogenic signal transduction in cancer cells
    • Emons G, Muller V, Oltmann O, Schulz KD 1998 Effects of LHRH-analogues on mitogenic signal transduction in cancer cells. J Steroid Biochem Mol Biol 65:199-206
    • (1998) J Steroid Biochem Mol Biol , vol.65 , pp. 199-206
    • Emons, G.1    Muller, V.2    Oltmann, O.3    Schulz, K.D.4
  • 45
    • 0026692109 scopus 로고
    • Sustained release formulations of luteinizing hormone-releasing hormone antagonist SB-75 inhibit proliferation and enhance apoptotic cell death of human prostate carcinoma (PC-82) in male nude mice
    • Redding TW, Schally AV, Radulovic S, Milovanovic S, Szepeshazi K, Isaacs JT 1992 Sustained release formulations of luteinizing hormone-releasing hormone antagonist SB-75 inhibit proliferation and enhance apoptotic cell death of human prostate carcinoma (PC-82) in male nude mice. Cancer Res 52:2538-2544
    • (1992) Cancer Res , vol.52 , pp. 2538-2544
    • Redding, T.W.1    Schally, A.V.2    Radulovic, S.3    Milovanovic, S.4    Szepeshazi, K.5    Isaacs, J.T.6
  • 47
    • 0033551699 scopus 로고    scopus 로고
    • Role of poly(ADP-ribose) polymerase (PARP) cleavage in apoptosis. Caspases 3-resistant PARP mutant increases rates of apoptosis in transfected cells
    • Boulares AH, Yakovlev AG, Ivanova V, Stoica BA, Wang G, Iyer S, Smulson M 1999 Role of poly(ADP-ribose) polymerase (PARP) cleavage in apoptosis. Caspases 3-resistant PARP mutant increases rates of apoptosis in transfected cells. J Biol Chem 274:22932-22940
    • (1999) J Biol Chem , vol.274 , pp. 22932-22940
    • Boulares, A.H.1    Yakovlev, A.G.2    Ivanova, V.3    Stoica, B.A.4    Wang, G.5    Iyer, S.6    Smulson, M.7
  • 48
    • 0036499892 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase: Killer or conspirator? The 'suicide hypothesis' revisited
    • Chiarugi A 2002 Poly(ADP-ribose) polymerase: killer or conspirator? The 'suicide hypothesis' revisited. Trends Pharmacol Sci 23:122-129
    • (2002) Trends Pharmacol Sci , vol.23 , pp. 122-129
    • Chiarugi, A.1
  • 49
    • 0036022402 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase-1 cleavage during apoptosis: An update
    • Soldani C, Scovassi AI 2002 Poly(ADP-ribose) polymerase-1 cleavage during apoptosis: an update. Apoptosis 7:321-328
    • (2002) Apoptosis , vol.7 , pp. 321-328
    • Soldani, C.1    Scovassi, A.I.2
  • 50
    • 0038449141 scopus 로고    scopus 로고
    • PARP-1, a determinant of cell survival in response to DNA damage
    • Bouchard VJ, Rouleau M, Poirier GG 2003 PARP-1, a determinant of cell survival in response to DNA damage. Exp Hematol 31:446-454
    • (2003) Exp Hematol , vol.31 , pp. 446-454
    • Bouchard, V.J.1    Rouleau, M.2    Poirier, G.G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.