Poor prognosis in proteinuric type 2 diabetic patients with retinopathy: Insights from the RENAAL study

QJM: An International Journal of Medicine

Volumn 98, Issue 2, 2005, Pages 119-126

  Parving, H H ^a,b   Mogensen, C E ^c   Thomas, M C ^e   Brenner, B M ^d   Cooper, M E ^e  

^a STENO DIABETES CENTER   (Denmark)

^b AARHUS UNIVERSITY   (Denmark)

^c Aarhus Kommunehospital   (Denmark)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

^e BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; ANGIOTENSIN 2 RECEPTOR ANTAGONIST; CREATININE; HEMOGLOBIN; INSULIN; LOSARTAN; PROTEIN;

ADULT; AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DIABETIC MICROANGIOPATHY; DIABETIC NEPHROPATHY; DIABETIC RETINOPATHY; EYE FUNDUS; FEMALE; GLOMERULUS FILTRATION; HEMOGLOBIN DETERMINATION; HUMAN; KIDNEY FAILURE; MAJOR CLINICAL STUDY; MALE; MORTALITY; MULTIVARIATE ANALYSIS; NON INSULIN DEPENDENT DIABETES MELLITUS; OPHTHALMOSCOPY; PRIORITY JOURNAL; PROGNOSIS; PROTEINURIA; RISK ASSESSMENT; STATISTICAL ANALYSIS; SYSTOLIC BLOOD PRESSURE;

EID: 14044250920     PISSN: 14602725     EISSN: None     Source Type: Journal    
DOI: 10.1093/qjmed/hci017     Document Type: Article

References (20)

1. Østerby R, Gall M-A, Schmitz A, Nielsen FS, Nyberg G, Pawing H-H. Glomerular structure and function in proteinuric Type 2 (non-insulin-dependent) diabetic patients. Diabetologia 1993; 36 1064-70.
2. Parving H-H, Gall M-A, Skøtt P, Jørgensen HE, Løkkegaard H, Jørgensen F, et al. Prevalence and causes of albuminuria in non-insulin-dependent diabetic patients. Kidney Int 1992; 41:758-62.
3. Fioretto P, Mauer SM, Brocco E, Velussi M, Frigato F, Muollo B, et al. Patterns of renal injury in NIDDM patients with microalbuminuria. Diabetologia 1996; 39:1569-76.
4. Schwartz MM, Lewis EJ, Leonard-Martin T, Breyer Lewis J, Battle D, The Collaborative Study Group. Renal pathology patterns in type II diabetes mellitus: relationship with retinopathy. Nephrol Dial Transplant 1998; 13:2547-52.
5. Gall M-A, Nielsen FS, Smidt UM, Parving H-H. The course of kidney function in type 2 (non-insulin-dependent) diabetic patients with diabetic nephropathy. Diabetologia 1993; 36:1071-8.
6. Brocco E, Fioretto P, Mauer SM, Saller A, Carraro A, Frigato F, et al. Renal structure and function in non-insulin dependent diabetic patients with microalbuminuria. Kidney Int 1997; 63 S40-4.
7. Christensen PK, Larsen S, Horn T, Olsen S, Parving H-H. Renal function and structure in albuminuric type 2 diabetic patients without retinopathy. Nephrol Dial Transplant 2001; 16:2337-47.
8. Trevisan R, Vedovato, M, Mazzon C, Coracina A, Iori E, Tiengo A, et al. Concomitance of diabetic retinopathy and proteinuria accelerates the rate of decline of kidney function in type 2 diabetic patients. Diabetes Care 2002; 25:2026-31.
9. Christensen PK, Larsen S, Horn T, Olsen S, Parving H-H. The causes of albuminuria in patients with type 2 diabetes without diabetic retinopathy. Kidney Int 2000; 58:1719-31.
10. Wong TY, Klein R, Couper DJ, Cooper LS, Shahar E, Hubbard LD et al. Retinal microvascular abnormalities and incident stroke: the Atherosclerosis Risk in Communities Study. Lancet 2001; 358 1134-40.
11. Wong TY, Klein R, Sharrett AR, Duncan BB, Couper DJ, Tielsch JM, et al. Retinal arteriolar narrowing and risk of coronary heart disease in men and women. The Atherosclerosis Risk in Communities Study. JAMA 2002; 287:1153-9.
12. Brenner BM, Cooper ME, de Zeeuw D, Keane WF, Mitch WE, Parving H-H, et al. Effects of Losartan on Renal and Cardiovascular outcomes in patients with type 2 diabetes and nephropathy. N Engl J Med 2001; 345:861-9.
13. Brenner BM, Cooper ME, de Zeeuw D, Grunfeld JP, Keane WF, Kurokawa K, et al. The Losartan renal protection study - rationale, study design and baseline characteristics of RENAAL (Reduction of Endpoints in NIDDM with the Angiotensin II Antagonist Losartan). J Renin Angiotensin Aldosterone System 2000; 1:328-35.
14. Deckert T, Feldt-Rasmussen B, Borch-Johnsen K, Jensen T, Kofoed-Enevoldsen A. Albuminuria reflects widespread vascular damage. The Steno hypothesis. Diabetologia 1989; 32:219-26.
15. Rodby I, Gilbert R. The presence of retinopathy is associated with poor renal cardiovascular outcomes in type II diabetic nephropathy. J Am Soc Nephrol 2002; 13:644-5A.
16. Rossing P, Hougaard P, Parving H-H. Risk factors for development of incipient and overt diabetic nephropathy in Type 1 diabetic patients. Diabetes Care 2002; 25:859-64.
17. Gall M-A, Hougaard P, Borch-Johnsen K, Parving H-H. Risk factors for development of incipient and overt diabetic nephropathy in patients with non-insulin dependent diabetes mellitus: prospective, observational study. Br Med J 1997; 314:783-8.
18. Parving H-H. Initiation and progression of diabetic nephropathy. N Engl J Med 1996; 335:1682-3.
19. Klein R, Sharrett AR, Klein BE, Chambless LE, Cooper LS, Hubbard LD et al. Are retinal arteriolar abnormalities related to atherosclerosis?: The Atherosclerosis Risk in Communities Study. Arterioscler Thromb Vasc Biol 2000; 20:1644-50.
20. Kastrup J. The diabetic arteriole: The impact of diabetic microangiopathy on microcirculatory control. Dan Med Bull 1988; 35:334-45.