The human diving response, its function, and its control

Scandinavian Journal of Medicine and Science in Sports

Volumn 15, Issue 1, 2005, Pages 3-12

  Foster, G E ^a   Sheel, A W ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Apnea; Asphyxia; Bradycardia; Breath hold diving

Indexed keywords

ADAPTATION; APNEA; ASPHYXIA; BRADYCARDIA; CARDIOPULMONARY HEMODYNAMICS; CARDIOVASCULAR FUNCTION; CHEMOSENSITIVITY; DIVING; ENDOCRINE FUNCTION; FACE; HUMAN; HYPOTHESIS; HYPOXIA; IMMERSION; LUNG VENTILATION; LUNG VOLUME; OXYGEN CONSUMPTION; RESPIRATORY SYSTEM; REVIEW; STIMULUS; STIMULUS RESPONSE; SYMPATHETIC TONE; VASOCONSTRICTION;

ANOXIA; BRADYCARDIA; CAROTID BODY; CATECHOLAMINES; CHEMORECEPTORS; DIVING; HUMANS; IMMERSION; LUNG; LUNG VOLUME MEASUREMENTS; OXYGEN CONSUMPTION; VASOCONSTRICTION;

EID: 13944283051     PISSN: 09057188     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0838.2005.00440.x     Document Type: Review

References (80)

1. Andersson J, Schagatay E. Arterial oxygen desaturation during apnea in humans. Undersea Hyperb Med 1998a: 25: 21-25.
2. Andersson J, Schagatay E. Effects of lung volume and involuntary breathing movements on the human diving response. Eur J Appl Physiol 1998b: 77: 19-24.
3. Andersson J, Schagatay E, Gislen A, Holm B. Cardiovascular responses to cold-water immersions of the forearm and face, and their relationship to apnoea. Eur J Appl Physiol 2000: 83: 566-572.
4. Andersson JP, Liner MH, Runow E, Schagatay EK. Diving response and arterial oxygen saturation during apnea and exercise in breath-hold divers. J Appl Physiol 2002: 93: 882-886.
5. Andersson J, Liner MH, Fredsted A, Schagatay E. Cardiovascular and respiratory responses to apneas with and without face immersion in exercising humans. J Appl Physiol 2004: 96: 1005-1010.
6. Angell-James J, Daly MDB. Cardiovascular responses in apnoeic asphyxia: role of arterial chemoreceptors and the modification of their effects by a pulmonary vagal inflation reflex. J Physiol 1969: 201: 87-104.
7. Angell-James JE, Elsner R, Daly MDB. Lung inflation: effects on heart rate, respiration, and vagal afferent activity in seals. Am J Physiol 1981: 240: H190-H198.
8. Asmussen E, Kristiansson NG. The "diving bradycardia" in exercising man. Acta Physiol Scand 1968: 73: 527-535.
9. Bakovic D, Valic Z, Eterovic D, Vukovic I, Obad A, Marinovic-Terzic I, Dujic Z. Spleen volume and blood flows response to repeated breath-hold apneas. J Appl Physiol 2003: 95: 1460-1466.
10. Bjurstrom RL, Schoene RB. Control of ventilation in elite synchronized swimmers. J Appl Physiol 1987: 63: 1019-1024.
11. Butler PJ, Jones DR. Physiology of diving of birds and mammals. Physiol Rev 1997: 77: 837-899.
12. Choukroun ML, Marene P. Adjustments in oxygen transport during head-out immersion in water at different temperatures. J Appl Physiol 1990: 68: 1475-1480.
13. Craig AB, Medd WL. Man's responses to breath-hold exercise in air and in water. J Appl Physiol 1968: 24: 773-777.
14. Daly MDB. Peripheral arterial chemoreceptors and respiratory- cardiovascular integration. Monogr Physiol Soc 1997: 46.
15. Davis FM, Graves MP, Guy HJ, Prisk GK, Tanner TE. Carbon dioxide response and breath-hold times in underwater hockey players. Undersea Biomed Res 1987: 14: 527-534.
16. Delapille P, Verin E, Tourny-Chollet C, Pasquis P. Ventilatory responses to hypercapnia in divers and non-divers: effects of posture and immersion. Eur J Appl Physiol 2001: 86: 97-103.
17. Donnelly DF. Are oxygen dependent K + channels essential for carotid body chemo-transduction? Respir Physiol 1997: 110: 211-218.
18. Elsner R, Gooden B. Diving and asphyxia. A comparative study of animals and man. Monogr Physiol Soc 1983: 40: 1-168.
19. Elsner R, Gooden BA, Robinson SM. Arterial blood gas changes and the diving response in man. Aust J Exp Biol Med Sci 1971: 49: 435-444.
20. Espersen K, Frandsen H, Lorentzen T, Kanstrup IL, Christensen NJ. The human spleen as an erythrocyte reservoir in diving-related interventions. J Appl Physiol 2002: 92: 2071-2079.
21. Fagius J, Sundlöf G. The diving response in man: effects on sympathetic activity in muscle and skin nerve fascicles. J Physiol 1986: 377: 429-443.
22. Fagius J, Traversa R. Human sympathetic nerve activity to glabrous skin does not increase during simulated diving. Acta Physiol Scand 1994: 152: 249-258.
23. Ferretti G. Extreme human breath-hold diving. Eur J Appl Physiol 2001: 84: 254-271.
24. Ferrigno M, Ferretti G, Ellis A, Warkander D, Costa M, Cerretelli P, Lundgren CE. Cardiovascular changes during deep breath-hold dives in a pressure chamber. J Appl Physiol 1997: 83: 1282-1290.
25. Garcia-Rio F, Pino J, Ramirez T, Alvaro D, Alonso A, Villasante C, Villamor J. Inspiratory neural drive response to hypoxia adequately estimates peripheral chemosensitivity in OSAHS patients. Eur Respir J 2002: 20: 724-732.
26. Gauda EB. Gene expression in peripheral arterial chemoreceptors. Microsc Res Tech 2002: 59: 153-167.
27. Gooden BA. Mechanism of the human diving response. Integr Physiol Behav Sci 1994: 29: 6-16.
28. Grassi B, Ferretti G, Costa M, Ferrigno M, Panzacchi A, Lundgren CE, Marconi C, Cerretelli P. Ventilatory responses to hypercapnia and hypoxia in elite breath-hold divers. Respir Physiol 1994: 97: 323-332.
29. Gross PM, Whipp BJ, Davidson JT, Koyal SN, Wasserman K. Role of the carotid bodies in the heart rate response to breath holding in man. J Appl Physiol 1976: 41: 336-340.
30. Hayashi N, Yoshida T. Water immersion delays the oxygen uptake response to sitting arm-cranking in humans. Eur J Appl Physiol 1999: 80: 132-138.
31. Hayashi N, Ishihara M, Tanaka A, Osumi T, Yoshida T. Face immersion increases vagal activity as assessed by heart rate variability. Eur J Appl Physiol 1997: 76: 394-399.
32. Hermes-Lima M, Zenteno-Savin T. Animal response to drastic changes in oxygen availability and physiological oxdiative stress. Comp Biochem Physiol 2002: 133: 537-556.
33. Hochachka PW. Brain, lung, and heart functions during diving and recovery. Science 1981: 212: 509-514.
34. Hoka S, Bosnjak ZJ, Arimura H, Kampine JP. Regional venous outflow, blood volume, and sympathetic nerve activity during severe hypoxia. Am J Physiol 1989: 256: H162-H170.
35. Hong SK. Diving physiology. In: Wood SC, eds. Comparative pulmonary physiology. New York: Marcel Dekker, Inc, 1989: 39, 787-802.
36. Hong SK, Lin YC, Lally DA, Yim BJB, Kominami N, Hong PW, Moore TO. Alveolar gas exchanges and cardiovascular functions during breath holding with air. J Appl Physiol 1971: 30: 540-547.
37. Hong SK, Rennie DW, Park YS. Cold acclimatization and deacclimatization in Korean women divers. Exerc Sports Sci Rev 1986: 14: 231-268.
38. Hurford WE, Hong SK, Park YS, Ahn DW, Shiraki K, Mohri M, Zapol WM. Splenic contraction during breath-hold diving in the Korean ama. J Appl Physiol 1990: 69: 932-936.
39. Jones DR, Purves MJ. The carotid body in the duck and the consequences of its denervation upon the cardiac responses to immersion. J Physiol 1970: 211: 279-294.
40. Joulia F, Steinberg JG, Wolff F, Gavarry O, Jammes Y. Reduced oxidative stress and blood lactic acidosis in trained breath-hold human divers. Respir Physiol Neurobiol 2002: 133: 121-130.
41. Journeay W, Reardon F, Kenny G. Cardiovascular responses to apneic facial immersion during altered cardiac filling. J Appl Physiol 2003: 94: 2249-2254.
42. Kang DH, Kim PK, Kang BS, Song SH, Hong SK. Energy metabolism and body temperature in the Ama. J Appl Physiol 1965: 20: 46-50.
43. Khayat RR, Przybylowski T, Meyer KC, Skatrud JB, Morgan BJ. Role of sensory input from the lungs in control of muscle sympathetic nerve activity during and after apnea in humans. J Appl Physiol 2004: 97: 635-640.
44. Kohnlein T, Welte T, Tan L, Elliott M. Central sleep apnoea syndrome in patients with chronic heart disease: a critical review of the current literature. Thorax 2002: 57: 547-554.
45. Kuwahira I, Kamiya U, Iwamoto T, Moue Y, Urano T, Ohta Y, Gonzalez N. Splenic contraction-induced reversible increase in hemoglobin concentration in intermittent hypoxia. J Appl Physiol 1999: 86: 181-187.
46. Kuwahira I, Kamiya U, Iwamoto T, Ishii M, Moue Y, Ohta Y, Gonzalez NC. alpha2-Adrenergic-receptor response in reversible increase in hemoglobin concentration in intermittent hypoxia. Pathophysiology 2000: 7: 165-169.
47. Leuenberger UA, Hardy JC, Herr MD, Gray KS, Sinoway LI. Hypoxia augments apnea-induced peripheral vasoconstriction in humans. J Appl Physiol 2001: 90: 1516-1522.
48. Lin YC, Shida KK, Hong SK. Effects of hypercapnia, hypoxia, and rebreathing on heart rate response during apnea. J Appl Physiol 1983: 54: 166-171.
49. Lindholm P, Linnarsson D. Pulmonary gas exchange during apnoea in exercising men. Eur J Appl Physiol 2002: 86: 487-491.
50. Lindholm P, Sundblad P, Linnarsson D. Oxygen-conserving effects of apnea in exercising men. J Appl Physiol 1999: 87: 2122-2127.
51. Lindholm P, Nordh J, Linnarsson D. Role of hypoxemia for the cardiovascular responses to apnea during exercise. Am J Physiol 2002: 283: R1227-R1235.
52. Liner MH, Linnarsson D. Tissue oxygen and carbon dioxide stores and breath-hold diving in humans. J Appl Physiol 1994: 77: 542-547.
53. Liner MH, Ferrigno M, Lundgren CEG. Alveolar gas exchange during simulated breath-hold diving to 20 m. Undersea Hyperb Med 1993: 20: 27-38.
54. Marsh N, Askew D, Beer K, Gerke M, Muller D, Reichman C. Relative contributions of voluntary apnoea, exposure to cold and face immersion in water to diving bradycardia in humans. Clin Exp Pharmacol Physiol 1995: 73: 886-887.
55. Masuda Y, Yoshida A, Hayashi F, Sasaki K, Honda Y. The ventilatory responses to hypoxia and hypercapnia in the Ama. Jpn J Physiol 1981: 31: 187-197.
56. Mukhtar MR, Patrick JM. Ventilatory drive during face immersion in man. J Physiol 1986: 370: 13-24.
57. Pan AW, He J, Kinouchi Y, Yamaguchi H, Miyamoto H. Blood flow in the carotid artery during breath-holding in relation to diving bradycardia. Eur J Appl Physiol 1997: 75: 388-395.
58. Perini R, Milesi S, Biancardi L, Pendergast DR, Veicsteinas A. Heart rate variability in exercising humans: effect of water immersion. Eur J Appl Physiol 1998: 77: 326-332.
59. Ray C, Saito M The cardiopulmonary baroreflex. In: Saltin B, Boushel R, Secher N, Mitchell J, eds. Exercise and circulation in health and disease. Champaign, IL: Human Kinetics, 2000: 43-52.
60. Rey N. Afferent structures involved in heart response to diving reflex. Acta Physiol Lat Am 1971: 21: 235-243.
61. Schagatay E, Andersson J. Diving response and apneic time in humans. Undersea Hyperb Med 1998: 25: 13-19.
62. Schagatay E, Holm B. Effects of water and ambient air temperatures on human diving bradycardia. Eur J Appl Physiol 1996: 73: 1-6.
63. Schagatay E, Van Kampen M, Emanuelsson S, Holm B. Effects of physical and apnea training on apneic time and the diving response in humans. Eur J Appl Physiol 2000: 82: 161-169.
64. Schagatay E, Andersson JP, Hallen M, Palsson B. Selected contribution: role of spleen emptying in prolonging apneas in humans. J Appl Physiol 2001: 90: 1623-1629.
65. Schuitema K, Holm B. The role of different facial areas in eliciting human diving bradycardia. Acta Physiol Scand 1988: 132: 119-120.
66. Seals DR, Suwarno NO, Dempsey JA. Influence of lung volume on sympathetic nerve discharge in normal humans. Circ Res 1990: 67: 130-141.
67. Seals DR, Suwarno NO, Joyner MJ, Iber C, Copeland JG, Dempsey JA. Respiratory modulation of muscle sympathetic nerve activity in intact and lung denervated humans. Circ Res 1993: 72: 440-454.
68. Somers VK, Mark AL, Abboud FM. Interaction of baroreceptor and chemoreceptor reflex control of sympathetic nerve activity in normal humans. J Clin Invest 1991: 87: 1953-1957.
69. Song SH, Lee WK, Chung YA, Hong SK. Mechanism of apneic bradycardia in man. J Appl Physiol 1969: 27: 323-327.
70. Spicuzza L, Benardi L, Calciati A, Ugo Di Maria G. Autonomic modulation of heart rate during obstructive versus central apneas in patients with sleep-disordered breathing. Am J Respir Crit Care Med 2002: 167: 902-910.
71. St. Croix CM, Satoh M, Morgan BJ, Skatrud JB, Dempsey JA. Role of respiratory motor output in within-breath modulation of muscle sympathetic nerve activity in humans. Circ Res 1999: 85: 457-469.
72. Sterba JA, Lundgren CEG. Breath-hold duration in man and the diving response induced by face immersion. Undersea Biomed Res 1988: 15: 361-375.
73. Stewart IB, Warburton DER, Hodges ANH, Lyster DM, Mckenzie DC. Cardiovascular and splenic responses to exercise in humans. J Appl Physiol 2003: 94: 1619-1626.
74. Stromme SB, Kerem D, Elsner R. Diving bradycardia during rest and exercise and its relation to physical fitness. J Appl Physiol 1970: 28: 614-621.
75. Vacca C, Cifaldi S, Pizzuti GP, Colantuoni A, Salzano G. Chemoreceptor stimulation in diving bradycardia of ducks. Folia Vet Lat 1977: 7: 55-63.
76. Veasey S. Molecular and physiologic basis of obstructive sleep apnea. Clin Chest Med 2003: 24: 179-193.
77. Whitelaw WA, Mcbride B, Amar J, Corbet K. Respiratory neuromuscular output during breath holding. J Appl Physiol 1981: 50: 435-443.
78. Wolf S, Schneider RA, Groover ME. Further studies on the circulatory and metabolic alterations of the oxygen-conserving (diving) reflex in man. Trans Assoc Am Physicians 1965: 78: 242-254.
79. Wolk R, Somers V. Cardiovascular consequences of obstructive sleep apnea. Clin Chest Med 2003: 24: 195-205.
80. Xie A, Skatrud JB, Crabtree DC, Puleo DS, Goodman BM, Morgan BJ. Neurocirculatory consequences of intermittent asphyxia in humans. J Appl Physiol 2000: 89: 1333-1339.