Transformation of methyl N-methyl-N-(6-substituted-5-nitro-4-pyrimidinyl) aminoacetates into 4-methylamino-5-nitrosopyrimidines and 9-methylpurin-8-ones

Tetrahedron Letters

Volumn 46, Issue 11, 2005, Pages 1841-1844

  Susvilo, Inga ^a   Brukstus, Algirdas ^a   Tumkevicius, Sigitas ^a  

^a VILNIUS UNIVERSITY   (Lithuania)

Author keywords

Cyclisation; N Methyl N (6 substituted 5 nitro 4 pyrimidinyl)aminoacetates; Nitrosopyrimidines; Purines; Rearrangement

Indexed keywords

FUNCTIONAL GROUP; GLYCINE DERIVATIVE; OXIDE; PURINE DERIVATIVE; PYRIMIDINE DERIVATIVE;

ARTICLE; CHEMICAL MODIFICATION; REACTION ANALYSIS; RING CLOSING METATHESIS;

EID: 13944282101     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2005.01.119     Document Type: Article

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18. 4 requires C, 39.84; H, 4.60; N, 29.04)
19. General procedure for the synthesis of compounds 4-6 and 10-12. To a suspension of compounds 1-3 and 7-9 (5 mmol) in the corresponding alcohol (5 mL) a solution of the appropriate sodium alkoxide in alcohol, prepared from sodium (0.115 g, 5 mmol) and alcohol (3 mL), was added dropwise with stirring. The reaction mixture was stirred at room temperature for 2 h. The precipitate was filtered off, washed with water and recrystallised to give compounds 4-6 and 10-12
20. 5O requires C, 57.63; H, 4.84; N, 30.55)
21. 3. Crystallographic data for structure 4 have been deposited at the Cambridge Crystallographic Data Centre (CCDC number 252806)
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