Can the stem cell mobilization technique influence CD34+ cell collection efficiency of leukapheresis procedures in patients with hematologic malignancies?

Bone Marrow Transplantation

Volumn 35, Issue 3, 2005, Pages 243-246

  Gidron, A ^a   Verma, A ^a   Doyle, M ^a   Boggio, L ^a   Evens, A ^a   Gordon, L ^a   Singhal, S ^a   Tallman, M ^a   Wlliams, S ^a   Winter, J ^a   Mehta, J ^a,b  

^a NORTHWESTERN UNIVERSITY   (United States)

^b NONE   (United States)

Author keywords

CD34+ cells; Cell separator; Collection efficiency; Leukapheresis

Indexed keywords

ANTINEOPLASTIC AGENT; CD34 ANTIGEN; GROWTH FACTOR;

ADULT; AGED; ARTICLE; AUTOLOGOUS STEM CELL TRANSPLANTATION; CD34 SELECTION; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; FLOW CYTOMETRY; HEMATOLOGIC MALIGNANCY; HUMAN; LEUKAPHERESIS; LEUKOCYTE COUNT; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MULTIPLE REGRESSION; PERIPHERAL LYMPHOCYTE; PREDICTION; PRIORITY JOURNAL; STEM CELL MOBILIZATION; TREATMENT OUTCOME;

ADULT; AGED; ANTIGENS, CD34; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; FEMALE; GROWTH SUBSTANCES; HEMATOLOGIC NEOPLASMS; HEMATOPOIETIC STEM CELL MOBILIZATION; HUMANS; LEUKAPHERESIS; LEUKOCYTE COUNT; MALE; MIDDLE AGED; PERIPHERAL BLOOD STEM CELL TRANSPLANTATION; REGRESSION ANALYSIS; RETROSPECTIVE STUDIES; TRANSPLANTATION, AUTOLOGOUS;

EID: 13944279952     PISSN: 02683369     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bmt.1704781     Document Type: Article

References (7)

1. Körbling M. Mobilization regimens for harvesting autologous and allogeneic peripheral blood stem cells. In: Atkinson K, Champlin R, Ritz J, Fibbe WE, Ljungman P, Brenner MK, eds. Clinical Bone Marrow and Blood Stem Cell Transplantation, 3rd ed. Cambridge University Press: Cambridge, 2004; pp 383-403.
2. Mehta J, Singhal S, Gordon L et al. Cobe spectra is superior to Fenwal CS 3000 Plus for collection of hematopoietic stem cells. Bone Marrow Transplant 2002; 29: 563-567.
3. Mehta J, Oyama Y, Winter J et al. CD34+ cell collection efficiency does not correlate with the pre-leukapharesis hematocrit. Bone Marrow Transplant 2001; 28: 597-601.
4. Sarkodee-Adoo C, Taran I, Guo C et al. Influence of preapheresis clinical factors on the efficiency of CD34+ cell collection by large volume apheresis. Bone Marrow Transplant 2003; 31: 851-855.
5. Sutherland DR, Anderson L, Keeney M et al. The ISHAGE guidelines for CD34+ cell determination by flow cytometry. International Society of Hematotherapy and Graft Engineering. J Hematother 1996; 5: 213-226.
6. Heuft HG, Dubiel M, Rick O et al. Inverse relationship between patient peripheral blood CD34+ cell counts and collection efficiency for CD34+ cells in two automated leukapharesis systems. Transfusion 2001; 41: 1008-1013.
7. Ford CD, Lehman C, Strupp A, Kelley L. Comparison of CD34+ cell collection efficiency on the COBE spectra and Fenwal CS-3000 Plus. J Clin Apheresis 2002; 17: 17-20.