Synthesis of (±)-2-O-[4′-(N-9″-purinyl)butyl] myo-inositol 1,4,5-tris(phosphate), a potent full agonist at the D-myo-inositol 1,4,5-tris(phosphate) receptor

Journal of Medicinal Chemistry

Volumn 48, Issue 4, 2005, Pages 1251-1255

  Moris, Marc Antoine ^a   Caron, Annabelle Z ^b   Guillemette, Gaétan ^b   Rognan, Didier ^a   Schmitt, Martine ^a   Schlewer, Gilbert ^a  

^a Laboratoire de Pharmacochimie   (France)

^b UNIVERSITÉ DE SHERBROOKE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

2 O [4' (N 9'' PURINYL)BUTYL]MYOINOSITOL 1,4,5 TRISPHOSPHATE; ADENOPHOSTIN A; ADENOPHOSTIN B; CALCIUM; INOSITOL 1,4,5 TRISPHOSPHATE DERIVATIVE; INOSITOL 1,4,5 TRISPHOSPHATE RECEPTOR; UNCLASSIFIED DRUG; 2 O (4' (N 9'' PURINYL)BUTYL) MYO INOSITOL 1,4,5 TRIS(PHOSPHATE); 2-O-(4'-(N-9''-PURINYL)BUTYL) MYO-INOSITOL 1,4,5-TRIS(PHOSPHATE); CALCIUM CHANNEL; CELL RECEPTOR; DRUG DERIVATIVE; INOSITOL 1,4,5 TRISPHOSPHATE; PURINE DERIVATIVE;

ADRENAL CORTEX; AGONIST; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; COW; DRUG BINDING SITE; DRUG STRUCTURE; DRUG SYNTHESIS; ENDOPLASMIC RETICULUM; IC 50; MICROSOME; NONHUMAN; PHARMACOPHORE; SECOND MESSENGER; STRUCTURE ACTIVITY RELATION; ANIMAL; CATTLE; CELL LINE; CHEMISTRY; CONFORMATION; CYTOLOGY; DRUG EFFECT; DRUG POTENTIATION; IN VITRO STUDY; METABOLISM; PANCREAS; PERMEABILITY; RADIOASSAY; STEREOISOMERISM; SYNTHESIS; ULTRASTRUCTURE;

ADRENAL CORTEX; ANIMALS; CALCIUM; CALCIUM CHANNELS; CATTLE; CELL LINE; ENDOPLASMIC RETICULUM; INOSITOL 1,4,5-TRISPHOSPHATE; MICROSOMES; MOLECULAR CONFORMATION; PANCREAS; PERMEABILITY; PURINES; RADIOLIGAND ASSAY; RECEPTORS, CYTOPLASMIC AND NUCLEAR; STEREOISOMERISM;

EID: 13944275173     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm049458s     Document Type: Article

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