Inhibition of vascular endothelial growth factor (VEGF) does not affect early renal changes in a rat model of lean type 2 diabetes

Hormone and Metabolic Research

Volumn 37, Issue 1, 2005, Pages 21-25

  Schrijvers, B F ^a,b   De Vriese, A S ^b,c   Tilton, R G ^d   Van De Voorde, J ^e   Denner, L ^d   Lameire, N H ^b   Flyvbjerg, A ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b GHENT UNIVERSITY HOSPITAL   (Belgium)

^c Renal Unit   (Belgium)

^d University of Texas Medical Branch School of Medicine   (United States)

^e GHENT UNIVERSITY   (Belgium)

Author keywords

Endothelial nitric oxide synthase (eNOS); Glomerular volume; Goto Kakizaki (GK) rat; Kidney growth; VEGF antibody (ab)

Indexed keywords

ALBUMIN; CREATININE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLUCOSE; IMMUNOGLOBULIN G; INSULIN; PLACEBO; VASCULOTROPIN; VASCULOTROPIN ANTIBODY; VASCULOTROPIN INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; CREATININE CLEARANCE; DIABETIC NEPHROPATHY; DISEASE MODEL; DRUG EFFECT; FEMALE; FOOD INTAKE; GLOMERULUS; GLUCOSE BLOOD LEVEL; INSULIN BLOOD LEVEL; KIDNEY; KIDNEY MASS; LEAN BODY WEIGHT; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; RAT STRAIN; URINARY EXCRETION; VOLUMETRY;

ALBUMINURIA; ANIMALS; BLOOD GLUCOSE; BODY COMPOSITION; CREATININE; DIABETES MELLITUS, TYPE 2; DIABETIC NEPHROPATHIES; DISEASE MODELS, ANIMAL; FEMALE; KIDNEY; KIDNEY GLOMERULUS; LIVER; MYOCARDIUM; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE III; ORGAN SIZE; RANDOM ALLOCATION; RATS; RATS, INBRED STRAINS; RATS, WISTAR; THINNESS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

ANIMALIA; GLOMERULUS; RATTUS NORVEGICUS;

EID: 13944274471     PISSN: 00185043     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2005-861027     Document Type: Article

References (26)

1. Zimmet P. The burden of type 2 diabetes: are we doing enough? Diabetes Metab 2003; 29: 6S9-6S18
2. Harvey JN. Trends in the prevalence of diabetic nephropathy in type 1 and type 2 diabetes. Curr Opin Nephrol Hypertens 2003; 12: 317-322
3. Flyvbjerg A. Putative pathophysiological role of growth factors and cytokines in experimental diabetic kidney disease. Diabetologia 2000; 43: 1205-1223
4. De Vriese AS, Tilton RG, Elger M, Stephan CC, Kriz W, Lameire NH. Antibodies against vascular endothelial growth factor improve early renal dysfunction in experimental diabetes. J Am Soc Nephrol 2001; 12: 993-1000
5. Flyvbjerg A, Dagnæs-Hansen F, De Vriese AS, Schrijvers BF, Tilton RG, Rasch R. Amelioration of long-term renal changes in obese type 2 diabetic mice by a neutralizing vascular endothelial growth factor antibody. Diabetes 2002; 51: 3090-3094
6. Boehm BO, Lang G, Feldmann B, Kurkhaus A, Rosinger S, Volpert O, Lang GK, Bouck N. Proliferative diabetic retinopathy is associated with a low level of the natural ocular anti-angiogenic agent pigment epithelium-derived factor (PEDF) in aqueous humor. A pilot study. Horm Metab Res 2003; 35: 382-386
7. Schrijvers BF, De Vriese AS, Van de Voorde J, Rasch R, Lameire NH, Flyvbjerg A. Long-term renal changes in the Goto-Kakizaki rat, a model of lean type 2 diabetes. Nephrol Dial Transplant 2004; 19: 1-6
8. Hood JD, Meininger CJ, Ziche M, Granger HJ. VEGF upregulates ecNOS message, protein, and NO production in human endothelial cells. Am J Physiol 1998; 274: H1054-H1058
9. Tilton RG, Chang KC, LeJeune WS, Stephan CC, Brock TA, Williamson JR. Role for nitric oxide in the hyperpermeability and hemodynamic changes induced by intravenous VEGF. Invest Ophthalmol Vis Sci 1999; 40: 689-696
10. Tilton RG, Kawamura T, Chang KC, Ido Y, Bjercke RJ, Stephan CC, Brock TA, Williamson JR. Vascular dysfunction induced by elevated glucose levels in rats is mediated by vascular endothelial growth factor. J Clin Invest 1997; 99: 2192-2202
11. Christensen C, Ørskov H. Rapid screening PEG radioimmunoassay for quantification of pathological microalbuminuria. Diabetic Nephrology 1984; 3: 92-94
12. Gundersen HJ, Bagger P, Bendtsen TF, Evans SM, Korbo L, Marcussen N, Moller A, Nielsen K, Nyengaard JR, Pakkenberg B. The new stereological tools: disector, fractionator, nucleator and point sampled intercepts and their use in pathological research and diagnosis. APMIS 1988; 96: 857-881
13. Weibel ER. Stereologic methods. Practical methods for biological morphometry. London: Academic Press, 1979: 51-57
14. Cha DR, Kim NH, Yoon JW, Jo SK, Cho WY, Kim HK, Won NH. Role of vascular endothelial growth factor in diabetic nephropathy. Kidney Int Suppl 2000; 77: S104-S112
15. Miele C, Rochford JJ, Filippa N, Giorgetti-Peraldi S, van Obberghen E. Insulin and insulin-like growth factor-I induce vascular endothelial growth factor mRNA expression via different signaling pathways. J Biol Chem 2000; 275: 21 695-21 702
16. Stallmeyer B, Pfeilschifter J, Frank S. Systemically and topically supplemented leptin fails to reconstitute a normal angiogenic response during skin repair in diabetic ob/ob mice. Diabetologia 2001; 44: 471-479
17. Cooper ME, Vranes D, Youssef S, Stacker SA, Cox AJ, Rizkalla B, Casley DJ, Bach LA, Kelly DJ, Gilbert RE. Increased renal expression of vascular endothelial growth factor (VEGF) and its receptor VEGFR-2 in experimental diabetes. Diabetes 1999; 48: 2229-2239
18. Chou E, Suzuma I, Way KJ, Opland D, Clermont AC, Naruse K, Suzuma K, Bowling NL, Vlahos CJ, Aiello LP, King GL. Decreased cardiac expression of vascular endothelial growth factor and its receptors in insulin-resistant and diabetic states: a possible explanation for impaired collateral formation in cardiac tissue. Circulation 2002; 105: 373-379
19. Schrijvers BF, Rasch R, Tilton RG, Flyvbjerg A. High protein-induced glomerular hypertrophy is vascular endothelial growth factor-dependent. Kidney Int 2002; 61: 1600-1604
20. Flyvbjerg A, Schrijvers BF, De Vriese AS, Tilton RG, Rasch R. Compensatory glomerular growth after unilateral nephrectomy is VEGF dependent. Am J Physiol Endocrinol Metab 2002; 283: E362-E366
21. Goto Y, Kakizaki M, Masaki N. Spontaneous diabetes produced by selective breeding of normal wistar rats. Proc Japan Acad 1975; 51: 80-85
22. Ling ZC, Efendic S, Wibom R, Abdel-Halim SM, Östenson CG, Landau BR, Khan A. Glucose metabolism in Goto-Kakizaki rat islets. Endocrinology 1998; 139: 2670-2675
23. Wolf G, Chen S, Han DC, Ziyadeh FN. Leptin and renal disease. Am J Kidney Dis 2002; 39: 1-11
24. Christofori G, Naik P, Hanahan D. Vascular endothelial growth factor and its receptors, flt-1 and flk-1, are expressed in normal pancreatic islets and throughout islet cell tumorigenesis. Mol Endocrinol 1995; 9: 1760-1770
25. Öberg-Welsh C, Sandler S, Andersson A, Welsh M. Effects of vascular endothelial growth factor on pancreatic duct cell replication and the insulin production of fetal islet-like cell clusters in vitro. Mol Cell Endocrinol 1997; 126: 125-132
26. Lammert E, Gu G, McLaughlin M, Brown D, Brekken R, Murtaugh LC, Gerber HP, Ferrara N, Melton DA. Role of VEGF-A in vascularization of pancreatic islets. Curr Biol 2003; 13: 1070-1074