Polyacetylenic compounds, ACAT inhibitors from the roots of Panax ginseng

Journal of Agricultural and Food Chemistry

Volumn 53, Issue 4, 2005, Pages 919-922

  Rho, Mun Chual ^a   Lee, Hyun Sun ^a   Lee, Seung Woong ^a   Chang, Jong Sun ^a   Kwon, Oh Eok ^a   Chung, Mi Yeon ^a   Kim, Young Kook ^a  

^a Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

Author keywords

Acyl CoA: cholesterol acyltransferase (ACAT); Atherosclerosis; Cholesteryl ester; Panax ginseng; Polyacetylenes

Indexed keywords

CHOLESTEROL ACYLTRANSFERASE INHIBITOR; GINSENG EXTRACT; NATURAL PRODUCT; PETROLEUM ETHER; POLYACETYLENE DERIVATIVE;

ANIMAL CELL; ARTICLE; CHEMICAL COMPOSITION; CONTROLLED STUDY; DRUG ISOLATION; ENZYME INHIBITION; GINSENG; IC 50; INFRARED RADIATION; LIVER MICROSOME; MASS SPECTROMETRY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; RAT; SPECTROSCOPY; STRUCTURE ANALYSIS; ULTRAVIOLET RADIATION;

ACETYLENE; ALKYNES; ANIMALS; DIYNES; ENZYME INHIBITORS; EPOXY COMPOUNDS; MICROSOMES, LIVER; MOLECULAR STRUCTURE; PANAX; PLANT ROOTS; POLYACETYLENES; POLYMERS; RATS; STEROL O-ACYLTRANSFERASE;

PANAX GINSENG;

EID: 13944252483     PISSN: 00218561     EISSN: None     Source Type: Journal    
DOI: 10.1021/jf040370x     Document Type: Article

References (21)

1. Doshi, R.; Wu, J.; Fishelevich, R.; Rodriguez, A. Update on the role of acyl-CoA: cholesterol acyltransferase inhibitors in atherosclerosis. Expert. Opin. Ther. Patents 2001, 11, 1655-1662.
2. Ohgami, N.; Kuniyasu, A.; Furukawa, K.; Miyazaki, A.; Hakamata, H.; Horiuchi, S.; Nakayama, H. Glibenclamide acts as an inhibitor of acyl-CoA: cholesterol acyltransferase enzyme. Biochem. Biophys. Res. Commun. 2000, 277, 412-422.
3. Chang, T. Y.; Chang, C. C. Y.; Cheng, D. Acyl-coenzyme A: cholesterol acyltransferase. Annu. Rev. Biochem. 1997, 66, 613-638.
4. Heinonen, T. M. Acyl coenzyme A: cholesterol acyltransferase inhibition: potential atherosclerosis therapy or springboard for other discoveries?. Expert Opin. Investig. Drugs 2002, 11, 1519-1527.
5. Oelkers, P.; Behari, A.; Cromley, D.; Billheimer, J. T.; Sturley, S. L. Characterization of two human genes encoding acyl coenzyme A: cholesterol acyltransferase-related enzymes. J. Biol. Chem. 1998, 273, 26765-26771.
6. Chang, T. Y.; Chang C. C. Y.; Lin, S.; Yu, C.; Li, B. L.; Miyazaki, A. Roles of acyl-coenzyme A: cholesterol acyltransferase-1 and -2. Curr. Opin. Lipid. 2001, 12, 289-296.
7. Giovannoni, M. P.; Piaz, V. D.; Vergelli, C.; Barlocco, D. Selective ACAT inhibitors as promising antihyperlipidemic, antiatherosclerotic and anti-alzheimer drugs. Mini-Rev. Med. Chem. 2003, 3, 576-584.
8. Jung, B. S.; Shin, M. K. In Encyclopedia of illustrated Korean natural drugs, Araliaceae. Kwon S. B., Ed.; Seoul: Young Lim Sa, 1998; pp 439-443.
9. Kim, Y. K.; Lee, H. W.; Son, K. H.; Kwon, B. M.; Jeong, T. S.; Lee, D. H.; Shin, J.; Seo, Y.; Kim, S. U.; Bok, S. H. GERI-BP002-A, novel inhibitor of acyl-CoA: cholesterol acyltransferase produced by Aspergillus fumigatus F93. J. Antibiot. 1996, 49, 31-36.
10. Sliskovic, D. R.; Picard, J. A.; Krause, B. R. ACAT inhibitors: The search for a novel and effective treatment of hypercholesterolemia and atherosclerosis. Prog. Med. Chem. 2002, 39, 121-171.
11. Lee, S. W.; Kim, K.; Rho, M. C.; Chung, M. Y.; Kim, Y. H.; Lee, H. S.; Kim, Y. K. New polyacetylenes, DGAT inhibitors from the roots of Panax ginseng. Planta Med. 2004, 70, 197-200.
12. Bohlmann, F.; Burkhardt, T.; Zdero, C. Naturally Occurring Acetylenes; Academic Press: London, 1973; p 4.
13. Oh, J. H.; Lee, H. S.; Rho, M. C.; Kim, Y. K.; Lee, H. K.; Lee, W. S.; Kim, J. N.; Lee, S.; Jung. S. H. Total synthesis and absolute stereochemistry of (9R, 10S)-epoxyheptadecan-4,6-diyn-3-one, a diacylglycerol acyltransferase inhibitor from Panax ginseng. Tetrahedron Lett. 2004, 45, 7077-7079.
14. Kwon, O. E.; Rho, M. C.; Song, H. Y.; Lee, S. W.; Chung, M. Y.; Lee, J. H. Kim, Y. H.; Lee, H. S.; Kim, Y. K. Phenylpyropene A and B, new inhibitors of acyl-CoA: cholesterol acyltransfetase produced by Penicillium griseofulvum F1959. J. Antibiot. 2002, 55, 1004-1008.
15. Hirakura, K.; Monta, M.; Nakajima, K.; Ikeya, Y.; Mitsuhashi, H. Polyacetylenes from the roots of Panax ginseng. Phytochemistry 1991, 30, 3327-3333.
16. Kwon, B. M.; Nam, J. Y.; Lee, S. H.; Jeong, T. S.; Kim, Y. K.; Bok, S. H. Isolation of cholesteryl ester transfer protein inhibitors from Panax ginseng roots. Chem. Pharm. Bull. 1996, 44, 444-445.
17. Kwon, B. M.; Ro, S. H.; Kim, M. K.; Nam, J. Y.; Jung, H. J.; Lee, I. R.; Kim, Y. K.; Bok, S. H. Polyacetylene analogues, isolated from hairy roots of Panax ginseng, inhibit acyl-CoA: cholesterol acyltransferase. Planta Med. 1997, 63, 552-553.
18. Kim, S. H.; Park, K. S. Effects of Panax ginseng extract on lipid metabolism in humans. Pharmacol. Res. 2003, 48, 511-513.
19. Muwalla, M. M.; Abuirmmeileh, N. M. Suppression of avian hepatic cholesterogenesis by dietary ginseng. J. Nutr. Biochem. 1991, 7, 518-521.
20. Qureshi, A. A.; Aburimeileh, N.; Din, Z. Z.; Ahmad, Y.; Burger, W. C.; Elson, C. E. Suppression of cholesterogenesis and reduction of LDL cholesterol by dietary ginseng and its fractions in chicken liver. Atherosclerosis 1983, 48, 81-94.
21. Smith, S. J.; Cases, S.; Jensen, D. R.; Chen, H. C.; Sande, E.; Tow, B.; Sanan, D. A.; Raber, J.; Eckel, R. H.; Farese, R. V. Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat. Nat. Genet. 2000, 25, 87-90.