Autoantigenic epitopes on platelet glycoproteins

International Journal of Hematology

Volumn 81, Issue 2, 2005, Pages 100-105

  Tomiyama, Yoshiaki ^a,c   Kosugi, Satoru ^b  

^a OSAKA UNIVERSITY   (Japan)

^b TOYONAKA MUNICIPAL HOSPITAL   (Japan)

^c OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Autoantibody; Glanzmann thrombasthenia; GPIIb IIIa; Thrombocytopenia

Indexed keywords

AUTOANTIGEN; EPITOPE; FIBRINOGEN RECEPTOR; GLYCOPROTEIN; GLYCOPROTEIN IB; GLYCOPROTEIN IIB; THROMBOCYTE ANTIBODY;

AMINO TERMINAL SEQUENCE; ANTIBODY BLOOD LEVEL; AUTOIMMUNE DISEASE; BETA PROPELLER DOMAIN; CELL DESTRUCTION; IDIOPATHIC THROMBOCYTOPENIC PURPURA; PATHOPHYSIOLOGY; PROTEIN DOMAIN; PROTEIN LOCALIZATION; REVIEW; THROMBOCYTE; THROMBOCYTE LYSIS;

AUTOANTIBODIES; AUTOANTIGENS; EPITOPES; HUMANS; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; PLATELET MEMBRANE GLYCOPROTEINS; PURPURA, THROMBOCYTOPENIC, IDIOPATHIC;

EID: 13944249447     PISSN: 09255710     EISSN: None     Source Type: Journal    
DOI: 10.1532/IJH97.04193     Document Type: Review

References (38)

1. McMillan R. Chronic idiopathic thrombocytopenic purpura. N Engl J Med. 1981;304:1135-1147.
2. George JN, El-Harase MA, Raskob GE. Chronic idiopathic thrombocytopenic purpura. N Engl J Med. 1994;331:1207-1211.
3. Karpatkin S. Autoimmune (idiopathic) thrombocytopenic purpura. Lancet. 1997;349:1531-1536.
4. Cines DB, Blanchette VS. Immune thrombocytopenic purpura. N Engl J Med. 2002;346:995-1008.
5. van Leeuwen EF, van der Ven JTJ, Engelfreit CP, von dem Borne AE. Specificity of autoantibodies in autoimmune thrombocytopenia. Blood. 1982;59:23-26.
6. Phillips DR, Agin PP. Platelet plasma membrane glycoproteins. Evidence for the presence of nonequivalent disulfide bonds using nonreduced-reduced two-dimensional gel electrophoresis. J Biol Chem. 1977;252:2121-2126.
7. Tomiyama Y, Shiraga M, Shattil SJ. Platelet membrane proteins as adhesion receptors. In: Gresele P, Page C, Fuster V, Vermylen J, eds. Platelets in Thrombotic and Non-thrombotic Disorders: Pathophysiology, Pharmacology and Therapeutics. Cambridge, UK: Cambridge; 2002:80-92.
8. Savage B, Almus-Jacobs F, Ruggeri ZM. Specific synergy of multiple substrate-receptor interactions in platelet thrombus formation under flow. Cell. 1998;94:657-666.
9. Hynes RO. Integrins: versatility, modulation, and signaling in cell adhesion. Cell. 1992;69:11-25.
10. Kunicki TJ, Newman PJ. The molecular immunology of human platelet proteins. Blood. 1992;80:1386-1404.
11. a alloantigen on platelet membrane glycoprotein lib [in Japanese]. Rinsho Ketsueki. 1989;30:2129-2133.
12. Kelton JG, Powers PJ, Carter CJ. A prospective study of the usefulness of the measurement of platelet-associated IgG for the diagnosis of idiopathic thrombocytopenic purpura. Blood. 1982;60:1050-1053.
13. 3 deficiency. Int J Hematol. 2000;72:448-454.
14. Varon D, Karpatkin S. A monoclonal anti-platelet antibody with decreased reactivity for autoimmune thrombocytopenic platelets. Proc Natl Acad Sci U S A. 1983;80:6992-6995.
15. Woods VL Jr, Oh EH, Mason D, McMillan R. Autoantibodies against the platelet glycoprotein IIb/IIIa complex in patients with chronic ITP. Blood. 1984;63:368-375.
16. McMillan R, Tani P, Millard F, Berchtold P, Renshow L, Woods VL Jr. Platelet-associated and plasma anti-glycoprotein autoantibodies in chronic ITR Blood. 1987;70:1040-1045.
17. Kiefel V, Santoso S, Kaufmann E, Mueller-Eckhardt C. Autoantibodies against platelet glycoprotein Ib/IX: a frequent finding in autoimmune thrombocytopenic purpura. Br J Haetnatol. 1991;79:256-262.
18. Beardsley DS, Spiegel JE, Jacobs MM, Handin RI, Lux SE. Platelet membrane glycoprotein IIIa contains target antigens that bind anti-platelet antibodies in immune thrombocytopenias. J Clin Invest. 1984;74:1701-1707.
19. Tomiyama Y, Kurata Y, Mizutani H, et al. Platelet glycoprotein lib as a target antigen in two patients with chronic idiopathic thrombocytopenic purpura. Br J Haematol. 1987;66:535-538.
20. Tomiyama Y, Take H, Honda S, et al. Demonstration of platelet antigens that bind platelet-associated autoantibodies in chronic ITP by direct immunoprecipitation procedure. Br J Haematol. 1990;75:92-98.
21. Kosugi S, Tomiyama Y, Shiraga M, et al. Platelet-associated anti-glycoprotein (GP) IIb-IIIa autoantibodies in chronic immune thrombocytopenic purpura mainly recognize cation-dependent conformations: comparison with the epitopes of serum autoantibodies. Thromb Haemost. 1996;75:339-345.
22. Brighton TA, Evans S, Castaldi PA, Chesterman CN, Chong BH. Prospective evaluation of the clinical usefulness of an antigen-specific assay (MAIPA) in idiopathic thrombocytopenic purpura and other immune thrombocytopenias. Blood. 1996;88:194-201.
23. McMillan R, Wang L, Tani P. Prospective evaluation of the immunobead assay for the diagnosis of adult chronic immune thrombocytopenic purpura (ITP). J Thromb Haemost. 2003;1:485-491.
24. Kiefel V, Santoso S, Mueller-Eckhardt C. Serological, biochemical, and molecular aspects of platelet autoantigens. Semin Hematol. 1992;29:26-33.
25. Sugiyama T, Okuma M, Ushikubi F, et al. A novel platelet aggregating factor found in a patient with defective collagen-induced platelet aggregation and autoimmune thrombocytopenia. Blood. 1987;69:1712-1720.
26. Boylan B, Chen H, Rathore V, et al. Anti-GPVI-associated ITP: an acquired platelet disorder caused by autoantibody-mediated clearance of the GPVI/FcRγ-chain complex from the human platelet surface. Blood. 2004;104:1350-1355.
27. Fujisawa K, McMillan R. Platelet-associated antibody to glycoprotein IIb/IIIa from chronic immune thrombocytopenic purpura patients often binds to divalent cation-dependent antigens. Blood. 1993;81:1284-1289.
28. Bowditch RD, Tani P, McMillan R. Reactivity of autoantibodies from chronic ITP patients with recombinant glycoprotein IIIa peptides. Br J Haematol. 1995;91:178-184.
29. 3 antibodies in chronic immune thrombocytopenic purpura. Thromb Haemost. 2001;85:36-41.
30. 3. Science. 2001;294:339-345.
31. Xiao T, Takagi J, Coller BS, Wang JH, Springer TA. Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics. Nature. 2004;432:59-67.
32. 3 integrin mutation abolishes ligand binding and alters divalent cation-dependent conformation. Science. 1990;249:915-918.
33. IIb subunit is associated with a variant of Glanzmann thrombasthenia. J Clin Invest. 1998;102:1183-1192.
34. Kosugi S, Tomiyama Y, Honda S, et al. Platelet-associated anti-GPIIb-IIIa autoantibodies in chronic immune thrombocytopenic purpura recognizing epitopes close to the ligand-binding site of glycoprotein (GP) IIb. Blood. 2001;98:1819-1827.
35. IIb between amino acids L1 and Q459. Br J Haematol. 2002;118:1132-1136.
36. Kekomaki R, Dawson B, McFarland J, Kunicki TJ. Localization of human platelet autoantigens to the cysteine-rich region of glycoprotein IIIa. J Clin Invest. 1991;88:847-854.
37. Fujisawa K, O'Tool TE, Tani P, et al. Autoantibodies to the presumptive cytoplasmic domain of platelet glycoprotein IIIa in patients with chronic immune thrombocytopenic purpura. Blood. 1991;77:2207-2213.
38. Fujisawa K, Tani P, O'Toole TE, Ginsberg MH, McMillan R. Different specificities of platelet-associated and plasma autoantibodies to platelet GPIIb-IIIa in patients with chronic immune thrombocytopenic purpura. Blood. 1992;79:1441-1446