Effect of cyclosporin A and tetrandrine on rhodamine 123 accumulationin in bovine brain capillary endothelial cells

Chinese Pharmacological Bulletin

Volumn 20, Issue 11, 2004, Pages 1265-1268

  Bao, Jin Feng ^a   Liu, Guo Qing ^b   Xu, Qun Yuan ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Blood brain barrier; Brain capillary endothelial cell; Cyclosporin A; P glycoprotein; Rhodamine 123; Tetrandrine

Indexed keywords

CYCLOSPORIN A; FLUORESCENT DYE; GLYCOPROTEIN P; RHODAMINE 123; TETRANDRINE;

ANIMAL CELL; ARTICLE; BLOOD BRAIN BARRIER; BRAIN CAPILLARY; BRAIN CAPILLARY ENDOTHELIUM CELL; CAPILLARY ENDOTHELIUM; CELL MEMBRANE TRANSPORT; DOSE RESPONSE; DRUG ACCUMULATION; DRUG EFFECT; ENDOTHELIUM CELL; ISOTOPE LABELING; MONOLAYER CULTURE; NONHUMAN; PROTEIN FUNCTION;

EID: 13844321294     PISSN: 10011978     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Fojo AT. Expression of multidrug resistance gene in human tumors and tissues[J]. Proc Natl Acad Sci USA, 1987, 84(1):265.
2. Thiebaut F, Tsuruo T, Hamada H et al. Cellular localization of the multidrug-resistance gene P-glycoprotein in normal human tissue [J]. Proc Natl Acad Sci USA, 1987, 84(21):7735
3. Cordon-Cardo C, O'Brien J P, Casals D et al. Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites[J]. Proc Natl Acad Sci USA, 1989, 86 (2):695.
4. Dun Y, Murakami H, Koyabu N et al. Dostribution of domperidone into the rat brain is increased by brain ischaemia or treatment with P-glycoprotein inhibitor verapamil [J]. J Pharm Pharmacol, 2002, 54(5):729.
5. Williams SK, Gillis JF, Matthews MA et al. Isolation and characterization of brain endothelial cells: morphology and enzyme activity[J]. J Neurochem, 1980, 35(2):374
6. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding[J]. Anal Biochem, 1976, 72(2):248.
7. Fontaine M, Elmquist WF, Miller DW. Use of Rhodamine-123 to examine the functional activity of P-glycoprotein in primary cultured brain microvessel endothelial cell monolayers [J]. Life Sci, 1996, 59(18):1521.
8. Schinkel AH, Smit JJM, Tellingen O et al. Disruption of the mouse mdr 1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increase sensitivity to drugs [J]. Cell, 1994, 77(4):491.
9. Schinlel AH, Wagemeaar E, Van Deemter L et al. Absence of the mdr1 a P-glycoprotein in mice affects tissue distribution and pharmacokinetics of dexame-thasone, digoxin and cyclosporin [J]. J Clin Invest, 1995, 96:1698.
10. Wang QY, Yang H, Miller DW et al. Effect of the P-glycoprotein inhibitor, cyclosporin A, on the distribution of Rhodamine-123 to the brain:an in vivo microdialysis study in freely moving rats[J]. Biochem Biophy Res Commu, 1995, 211(3):719.
11. Desrayaud S, Guntz P, Scherrmann JM et al. Effect of the P-glycoprotein inhibitor SDZ PSC 833, on the blood and brain pharmacokinetics of colchicine[J]. Life Sci, 1997, 61(2):153.