Structure-activity relationship for aryl and heteroaryl boronic acid inhibitors of hormone-sensitive lipase

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 6, 2005, Pages 2305-2312

  Ebdrup, Søren ^a   Jacobsen, Poul ^a   Farrington, Anupma Dhanda ^a   Vedsø, Per ^a  

^a NOVO NORDISK A S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

(2 BENZYLOXY 5 CHLOROPHENYL)BORONIC ACID; (2 BENZYLOXY 5 FLUOROPHENYL)BORONIC ACID; 2 (5 CHLOROTHIOPHEN 2 YL) 4,4,5,5 TETRAMETHYL[1,3,2]DIOXABOROLANE; 2 (5 CHLOROTHIOPHEN 2 YL) 5,5 DIMETHYL[1,3,2]DIOXABORINANE; 2 (5 CHLOROTHIOPHEN 2 YL)[1,3,6,2]DIOXAZABOROCANE; 3 (3 METHYLBUTYLSULFAMOYL)BENZENEBORONIC ACID; 3 (3,3 DIMETHYLBUTYLSULFAMOYL)BENZENEBORONIC ACID; 3 (BUTYLMETHYLSULFAMOYL)BENZENEBORONIC ACID; 3 (METHYLPHENETHYLSULFAMOYL)BENZENEBORONIC ACID; 3 (PHENETHYLSULFAMOYL)BENZENEBORONIC ACID; 3 BENZYLSULFAMOYLBENZENEBORONIC ACID; 3 CYCLOHEXYLMETHYLSULFAMOYLBENZENEBORONIC ACID; 3 [5 (5,5 DIMETHYL[1,3,2]DIOXABORINAN 2 YL)THIOPHEN 2 YL]ACRYLIC ACID ETHYL ESTER; 5 (5,5 DIMETHYL[1,3,2]DIOXABORINAN 2 YL)THIOPHENE 2 SULFONIC ACID TERT BUTYLAMIDE; 5 BROMOTHIOPHENE 2 BORONIC ACID; BORONIC ACID DERIVATIVE; ESTERASE INHIBITOR; HORMONE SENSITIVE LIPASE; UNCLASSIFIED DRUG;

ARTICLE; DRUG ACTIVITY; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; ENZYME INHIBITION; IC 50; IN VITRO STUDY; INHIBITION KINETICS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

EID: 13844314649     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.12.042     Document Type: Article

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