Synthesis and antibacterial activity of mechanism-based inhibitors of KDO8P synthase and DAH7P synthase

Carbohydrate Research

Volumn 340, Issue 4, 2005, Pages 529-537

  Grison, Claude ^a,b   Petek, Sylvain ^a,c   Finance, Chantal ^a   Coutrot, Philippe ^a  

^a NANCY UNIVERSITÉ   (France)

^b INSTITUT CHARLES GERHARDT   (France)

^c UNIVERSITÉ DE LORRAINE   (France)

Author keywords

2 Glycosyl 2 hydroxyphosphonopropanoic acid; Antibacterial activity; DAH7P synthase; KDO8P synthase; Lipopolysaccharide; Shikimate pathway

Indexed keywords

BACTERIA; ENZYMES; INORGANIC ACIDS; SYNTHESIS (CHEMICAL);

ANTI-INFECTIOUS AGENTS; ANTIBACTERIAL PROPERTIES; INTERMEDIATE SUBSTRATES; PHOSPHOENOLPYRUVATES (PEP);

ENZYME INHIBITION;

2 C DIETHOXYPHOSPHORYLMETHYL 3 DEOXY DEXTRO GLUCOHEPTANOIC ACID; 2 C DIETHOXYPHOSPHORYLMETHYL 3 DEOXY DEXTRO GLYCERO DEXTRO GULOOCTANOIC ACID; 2 C DIETHOXYPHOSPHORYLMETHYL 3 DEOXY DEXTRO GLYCERO DEXTRO IDOOCTANOIC ACID; 2 C DIETHOXYPHOSPHORYLMETHYL 3 DEOXY DEXTRO MANNOHEPTANOIC ACID; 2 C PHOSPHONOMETHYL 3 DEOXY DEXTRO GLUCOHEPTANOIC ACID; 2 C PHOSPHONOMETHYL 3 DEOXY DEXTRO GLYCERO DEXTRO GULOOCTANOIC ACID; 2 C PHOSPHONOMETHYL 3 DEOXY DEXTRO GLYCERO DEXTRO IDOOCTANOIC ACID; 2 C PHOSPHONOMETHYL 3 DEOXY DEXTRO MANNOHEPTANOIC ACID; 3 DEOXY DEXTRO ARABINO 2 HEPTULOSONATE 7 PHOSPHATE SYNTHASE; 3 DEOXY DEXTRO MANNO 2 OCTULOSONATE 8 PHOSPHATE SYNTHASE; ANTIINFECTIVE AGENT; ENZYME INHIBITOR; SYNTHETASE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG MECHANISM; DRUG SYNTHESIS; ENZYME SUBSTRATE; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; NONHUMAN; OLEFINATION; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; STEREOCHEMISTRY;

3-DEOXY-7-PHOSPHOHEPTULONATE SYNTHASE; ALDEHYDE-LYASES; ANTI-BACTERIAL AGENTS; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; GRAM-NEGATIVE BACTERIA; MASS SPECTROMETRY; MOLECULAR STRUCTURE; PENTOSEPHOSPHATES; PHOSPHOENOLPYRUVATE; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; SUGAR PHOSPHATES;

EID: 13844308668     PISSN: 00086215     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.carres.2004.11.019     Document Type: Article

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